Estrogens and Androgens: Hormones Quiz

Which hormones are naturally involved in the development of primary and secondary sexual characteristics at puberty?

What is the therapeutic use of Estrogens and Androgens?

From which compound are Estrogens and Androgens synthesized?

Estrogens and Androgens are naturally involved in the development of primary and secondary sexual characteristics at puberty?

Estrogens and Androgens are only produced by the adrenal glands?

Antagonists of Estrogens and Androgens are used for the treatment or prevention of hormone responsive cancers?

Which natural estrogen is primarily found in the ovaries of premenopausal women?

From which compound are most estrone and estriol formed in the liver?

During which period is estriol primarily present?

Estriol is primarily present during pregnancy?

Most estrone and estriol are formed in the liver from estradiol?

Estradiol is primarily found in the ovaries of premenopausal women?

What is the primary mechanism of action for synthetic estrogens?

What is the therapeutic use of postmenopausal hormone therapy (HT) involving estrogens?

What is the additional requirement for women with intact uterus undergoing postmenopausal hormone therapy (HT) involving estrogens?

Synthetic estrogens bind with high affinity to specific nuclear proteins interacting with DNA RNA synthesis proteins needed for physiologic functions. (True/False)

Postmenopausal hormone therapy involving estrogens is used for menopausal symptoms such as vasomotor instability and urogenital tract atrophy. (True/False)

Vaginal estrogens are used for women with urogenital symptoms as part of postmenopausal hormone therapy. (True/False)

What is the primary use of a combination of estrogen and progestogen for contraception?

Which type of estrogen is stored in adipose tissue and released slowly due to its fat solubility?

What is the primary route of metabolism for natural estrogens when taken orally?

Natural estrogens are rapidly metabolized and partially inactivated when taken orally. (True/False)

Vaginal estrogens are used for women with urogenital symptoms as part of postmenopausal hormone therapy. (True/False)

Synthetic estrogens are stored in adipose tissue and released slowly due to their fat solubility. (True/False)

What is the primary route of metabolism for natural estrogens when taken orally?

Which type of estrogen is stored in adipose tissue and released slowly due to its fat solubility?

Orally administered estradiol is primarily metabolized to estrone and estriol?

Estrogens are primarily bound to plasma albumin or sex hormone binding globulin?

Estrone and estriol are primarily metabolized by hepatic CYP 450 enzymes?

Which adverse effect is commonly associated with estrogens?

Estrogens can lead to fluid retention. (True/False)

Estrogens can cause myocardial infarction. (True/False)

Breast and endometrial cancer are adverse effects of estrogens. (True/False)

Which selective estrogen receptor modulator (SERM) competes with estrogen on the estrogen receptor in breast tissue and breast tumors?

Which SERM has estrogen agonist activity in bone and lowers serum total cholesterol and LDL?

Which SERM interferes with the negative feedback of estrogens on the hypothalamus, leading to ovulation?

Tamoxifen and raloxifene compete with estrogen on estrogen receptor in breast tissue.

Raloxifene has estrogen agonist activity in bone.

Clomiphene is a partial estrogen antagonist interfering with the negative feedback of estrogens on the hypothalamus ovulation.

Which selective estrogen receptor modulator (SERM) is used for the prevention and treatment of osteoporosis?

What is the therapeutic use of tamoxifen?

Which selective estrogen receptor modulator (SERM) is used for symptoms of menopausal women with an intact uterus?

Raloxifene is primarily used for the prevention and treatment of osteoporosis. (True/False)

Clomiphene is used for infertility. (True/False)

Estrogen can cause myocardial infarction. (True/False)

Which selective estrogen receptor modulator (SERM) is primarily used for the prevention and treatment of osteoporosis?

What is the primary adverse effect associated with tamoxifen use?

Which enzyme metabolizes selective estrogen receptor modulators (SERMs) into active metabolites?

What is the primary adverse effect associated with raloxifene use?

Tamoxifen is primarily metabolized by CYP 450 enzymes.

Raloxifene is primarily used for the prevention and treatment of osteoporosis.

Clomiphene is used for the treatment of infertility.

Synthetic estrogens are stored in adipose tissue and released slowly due to their fat solubility.

Which enzyme metabolizes selective estrogen receptor modulators (SERMs) into active metabolites?

What is the primary adverse effect associated with tamoxifen use?

Which SERM has estrogen agonist activity in bone and lowers serum total cholesterol and LDL?

Which compound is primarily produced in response to LH by males and females?

Which hormone binds with high affinity to specific nuclear proteins interacting with DNA RNA synthesis proteins needed for physiologic functions?

What hormones are naturally involved in the development of primary and secondary sexual characteristics at puberty?

What is the primary therapeutic use of progestogens?

What is the primary route of metabolism for natural estrogens when taken orally?

What is the primary route of metabolism for micronized preparation of progesterone when taken orally?

What is the primary therapeutic use of progestogens?

What is the main difference in metabolism between synthetic progestins and micronized preparation of progesterone?

Micronized preparation of progesterone is rapidly absorbed orally. (True/False)

Synthetic progestins are less rapidly metabolized. (True/False)

Estriol is primarily present during pregnancy. (True/False)

Raloxifene has estrogen agonist activity in bone. (True/False)

Which progestogen has the longest half-life?

Which adverse effect is specifically associated with 19-nortestosterone derivatives?

Which progestogen carries the risk of hyperkalemia when used with drugs that increase potassium levels?

Which progestogen is an antiprogestin used for the termination of pregnancy when combined with misoprostol?

Progestogens have a longer half-life when administered intramuscularly compared to orally. (True/False)

Hirsutism and acne are adverse effects associated with 19-nortestosterone derivatives. (True/False)

Drospirenone may raise serum potassium levels and pose a risk of hyperkalemia when combined with drugs that increase potassium. (True/False)

Mifepristone is an antiprogestin used for the termination of pregnancy when combined with misoprostol. (True/False)

What is the primary mechanism of action for progestins in contraception?

What is a contraindication for the use of oral contraceptives?

Which adverse effect is specifically associated with estrogens and smoking in women over the age of 35?

Estrogens negatively affect FSH release. (True/False)

Progestins thicken the cervical mucus. (True/False)

Oral contraceptives are contraindicated in the presence of liver disease. (True/False)

Which of thr following is correct type of contraceptive contains both estrogen and progestin?

Which hormone is the most common estrogen in combination oral contraceptives?

Which enzyme metabolizes selective estrogen receptor modulators (SERMs) into active metabolites?

Which type of hormonal contraceptive is specifically recommended for breastfeeding women or those who have intolerance to estrogen containing products?

Which contraceptive method has the potential adverse effect of weight gain and osteoporosis/fractures if used for more than 2 years?

What is the primary hormone involved in the postcoital or emergency contraception method using a single high dose of levonorgestrel within 72 hours?

Progestin only pills are suitable for women who are breastfeeding or have intolerance to estrogen containing products. (True/False)

Injectable progestin can lead to weight gain and osteoporosis after prolonged use. (True/False)

Long acting reversible contraceptives include progestin implants and progestin intrauterine device. (True/False)

Emergency contraception with a single high dose of levonorgestrel can be used within 5 days of unprotected intercourse. (True/False)

What is the most important androgen synthesized in the testis, ovaries, and adrenal glands in males and females?

Which function is NOT required for androgens like testosterone, 5 α dihydrotestosterone, and dehydroepiandrosterone?

Which androgen is primarily involved in the normal maturation of male and sperm production?

Testosterone is the most important androgen synthesized in the testis, ovaries, and adrenal glands in males and females. (True/False)

Clomiphene is used for infertility. (True/False)

Hirsutism and acne are adverse effects associated with 19-nortestosterone derivatives. (True/False)

Danazol has weak androgenic activity but has antiestrogenic activity as well.

Testosterone only (or its derivative) is used in females with menopausal symptoms unresponsive to estrogen alone.

Anabolic steroids are treatment of chronic wasting due to HIV or cancer.

Which route of administration for testosterone results in more lipid solubility and prolonged duration of action?

Testosterone derivatives with 17α alkylation undergo less hepatic metabolism and can be administered orally.

Oxandrolone and oxymetholone are testosterone derivatives with 17 α alkylation,DHT enabling oral administration.

Testosterone derivatives like methyltestosterone and fluoxymesterone are primarily administered via transdermal patches or topical gels.

Androgens can cause abnormal sexual maturation and growth disturbances in children. (True/False)

Estrogens can cause myocardial infarction. (True/False)

What is a potential adverse effect of androgens in females?

Which hormone binds with high affinity to specific nuclear proteins, interacting with DNA RNA synthesis proteins needed for physiologic functions?