Erythropoiesis Quiz

Stages of Erythropoiesis and Characteristics of Each Stage

• Rubriblast is the largest and first identifiable cell of erythropoiesis, with a round to oval nucleus and dark blue cytoplasm.
• Prorubricyte has a chromatin-condensed nucleus with a richer blue cytoplasm and detectable hemoglobin synthesis.
• Rubricyte has a reduced nucleus with pink-stained cytoplasm, reflecting hemoglobin accumulation and decreasing RNA.
• Metarubricyte has a tightly condensed nucleus that is extruded from the cell, with acidophilic cytoplasm indicating large quantities of hemoglobin.
• Reticulocyte is a polychromatic erythrocyte with no nucleus, remaining in the bone marrow for two days and one day in the peripheral blood.
• Stress or shift reticulocytes appear during acute bleeding, demonstrating immature RBCs in the peripheral blood.
• Mature erythrocyte appears as a salmon pink-staining cell with central pallor and an average diameter of 6 to 8 um.
• The nucleus takes up much of the cell in the rubriblast stage, with a N:C ratio of 8:1.
• The prorubricyte stage has a N:C ratio of about 6:1 and contains many cytoplasmic organelles that mask the minute amount of hemoglobin pigmentation.
• Rubricyte stage is the last stage capable of undergoing mitosis and has a length of 30 hours.
• Metarubricyte stage has a length of 48 hours and is characterized by a pyknotic nucleus and extrusion of the nucleus from the cell.
• Radioactive chromium (51Cr) can be used to determine the survivability of erythrocytes.

Stages of Erythropoiesis and Characteristics of Each Stage

• Rubriblast is the largest and first identifiable cell of erythropoiesis, with a round to oval nucleus and dark blue cytoplasm.
• Prorubricyte has a chromatin-condensed nucleus with a richer blue cytoplasm and detectable hemoglobin synthesis.
• Rubricyte has a reduced nucleus with pink-stained cytoplasm, reflecting hemoglobin accumulation and decreasing RNA.
• Metarubricyte has a tightly condensed nucleus that is extruded from the cell, with acidophilic cytoplasm indicating large quantities of hemoglobin.
• Reticulocyte is a polychromatic erythrocyte with no nucleus, remaining in the bone marrow for two days and one day in the peripheral blood.
• Stress or shift reticulocytes appear during acute bleeding, demonstrating immature RBCs in the peripheral blood.
• Mature erythrocyte appears as a salmon pink-staining cell with central pallor and an average diameter of 6 to 8 um.
• The nucleus takes up much of the cell in the rubriblast stage, with a N:C ratio of 8:1.
• The prorubricyte stage has a N:C ratio of about 6:1 and contains many cytoplasmic organelles that mask the minute amount of hemoglobin pigmentation.
• Rubricyte stage is the last stage capable of undergoing mitosis and has a length of 30 hours.
• Metarubricyte stage has a length of 48 hours and is characterized by a pyknotic nucleus and extrusion of the nucleus from the cell.
• Radioactive chromium (51Cr) can be used to determine the survivability of erythrocytes.