Erythropoiesis and Hormone Regulation

Which hormone is produced by the ovaries and has an inhibitory effect on erythropoiesis?

What is the primary function of erythropoietin (EPO)?

How long does it take for CFU-E to transition to Rubriblast?

What is the earliest committed progenitor cell in red blood cell development?

Which hormone is primarily responsible for stimulating erythropoiesis among testosterone, growth hormone, and prolactin?

During erythropoiesis, which stage is immediately after CFU-E?

Which of the following stages is not a precursor in the maturation of red blood cells?

Hormone Production and Stimulation

Growth hormone is produced by the anterior pituitary gland and stimulates EPOiesis.
Testosterone is produced by Leydig cells in the testes and stimulates EPOiesis.
Prolactin is produced by the pituitary gland and stimulates EPOiesis.
Estrogen is produced by the ovaries and inhibits EPOiesis.

RBC Maturation Stages

BFU-E (Burst Forming Unit Erythroid) is the earliest committed progenitor.
CFU-E (Colony Forming Unit Erythroid) is a later stage.
Progression from BFU-E to CFU-E takes one week (7 days).
Progression from CFU-E to Rubriblast takes one week.
Altogether, it takes approximately 18 to 21 days for a BFU-E to mature into an erythrocyte. Six days of this time is spent as easily-recognized precursors in the bone marrow.

Stages of Erythropoiesis

Rubriblastic Stage:
- Rubriblast
- Prorubricyte
- Rubricyte
- Metarubricyte
Normoblastic Stage:
- Pronormoblast
- Basophilic Normoblast or Early Normoblast
- Polychromatophilic Normoblast or Intermediate Normoblast
- Orthochromatic Normoblast or Late Normoblast
Erythroblastic Stage:
- Proerythroblast
- Basophilic Erythroblast or Early Erythroblast
- Polychromatophilic Erythroblast or Intermediate Erythroblast
- Orthochromatic Erythroblast or Late Erythroblast
Reticulocyte Stage:
- Reticulocyte (same color cytoplasm as mature RBC)
Mature Erythrocyte:
- Mature erythrocyte (final stage)

This quiz covers the key aspects of hormone production and its impact on erythropoiesis, including the stages of red blood cell maturation. It explores the role of various hormones, such as growth hormone and testosterone, and the specific stages involved in erythrocyte development. Test your understanding of these essential biological processes.