Erythrocyte Morphology and Hemoglobin

What is the score assigned to erythrocyte morphology when a severe increase in abnormal erythrocytes is observed in each microscopic field?

In erythrocyte grading, what does a score of 2+ typically signify?

At what hemoglobin concentration does the hemoglobin level in adults (male) typically fall?

How much oxygen can 1 gram of hemoglobin carry?

What age group is indicated to have a hemoglobin reference range of 12 to 15 g/dL?

Which statement accurately describes the synthesis of hemoglobin in red blood cells?

Who identified hemoglobin as the respiratory protein in 1862?

What is the molecular weight of hemoglobin approximately?

Grading Erythrocyte Morphology

Erythrocyte morphology grading uses a scale of 0 to 4+.
0: Normal appearance or slight variation in erythrocytes.
1+: Only a small population of erythrocytes displays slight abnormality.
2+: More than occasional numbers of abnormal erythrocytes are seen in a microscopic field; equivalent to moderately increased.
3+: Severe increase in abnormal erythrocytes in each microscopic field; equivalent to many.
4+: The most severe state of erythrocytic abnormality, with the abnormality prevalent throughout each microscopic field.

Hemoglobin

Hemoglobin is the main component of red blood cells (approximately 95% of cytoplasmic content).
Also known as respiratory pigment.
Concentration of Hb in RBCs is approximately 34 g/dL.
Molecular weight is approximately 64,000 Daltons.
Felix Seyler identified the respiratory protein hemoglobin in 1862.
About 65% of cytoplasmic hemoglobin is produced before the nucleus is extruded. The remaining 35% is synthesized in early reticulocytes.
Single most common complex organic molecule in vertebrates.
1 gram of hemoglobin can carry 1.34 mL of O₂.
1 gram of hemoglobin can carry a constant 3.47 mg of iron.

Hemoglobin Reference Ranges

Children (8 to 13 years): 12 to 15 g/dL (conventional) / 120 to 150 g/L (SI)
Adult (male): 14 to 18 g/dL (conventional) / 140 to 180 g/L (SI)
Adult (female): 12 to 15 g/dL (conventional) / 120 to 150 g/L (SI)

This quiz covers the grading of erythrocyte morphology from normal to severe abnormalities as well as important facts regarding hemoglobin, the primary component of red blood cells. You will learn about the grading scale, concentrations, and historical context related to hemoglobin. Test your knowledge on these crucial topics in hematology.