Equine Diarrhea: Diagnosis and Causes
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A horse presents with acute diarrhea. Based on the provided differentials, which of the following is LEAST likely to be the primary cause?

  • Potomac Horse Fever
  • Cyathostomiasis (correct)
  • Salmonellosis
  • Antibiotic-induced colitis

Which of the following infectious agents is NOT directly listed as a differential diagnosis for diarrhea in large animals in this material?

  • Salmonellosis
  • Trichostrongyles (correct)
  • Clostridiosis
  • Rotavirus

A horse is diagnosed with colitis secondary to antibiotic use. Which of the following best describes this condition?

  • Infectious in origin and requires immediate treatment.
  • A non-infectious cause of acute diarrhea. (correct)
  • Likely caused by helminth infection and poor pasture management.
  • Always results in a chronic, unresolvable condition.

Considering the provided differential diagnoses, what is a primary differentiating factor between acute and chronic diarrhea in adult horses?

<p>The duration and specific infectious or non-infectious agents involved. (A)</p> Signup and view all the answers

Which of the following conditions would be LEAST likely to be associated with chronic diarrhea in an adult horse?

<p>Potomac Horse Fever (D)</p> Signup and view all the answers

A horse presents with signs of colic and acute diarrhea after consuming a large amount of grain. Which of the following is the most likely cause of the diarrhea, based on the provided information?

<p>Grain overload (D)</p> Signup and view all the answers

You suspect a horse has a non-infectious cause of chronic diarrhea. Which of the following diagnostic tests would be LEAST helpful in determining the underlying cause, based on the provided information?

<p>Fecal culture for Salmonella (B)</p> Signup and view all the answers

A horse exhibits acute diarrhea and signs of systemic illness. Which of the following differentials would warrant immediate isolation of the affected animal?

<p>Salmonellosis (C)</p> Signup and view all the answers

A horse presents with acute, bloody diarrhea following antimicrobial therapy. Clostridium perfringens or Clostridium difficile are suspected. Which diagnostic approach would be MOST appropriate to support a diagnosis of clostridiosis?

<p>Fecal ELISA or PCR to detect toxin genes, indicating the presence of a toxin-producing strain. (A)</p> Signup and view all the answers

Clostridium perfringens is considered a normal inhabitant of the equine gut. What is the primary reason that it can still cause disease?

<p>Certain types produce exotoxins under specific conditions, leading to intestinal damage. (C)</p> Signup and view all the answers

Which of the following scenarios would MOST likely predispose a horse to an overgrowth of Clostridium difficile or Clostridium perfringens in the intestinal tract?

<p>Administration of broad-spectrum antibiotics for a respiratory infection. (A)</p> Signup and view all the answers

A veterinarian performs a necropsy on a horse that died suddenly after exhibiting signs of severe colitis. Which finding would be MOST suggestive of Clostridium-associated disease?

<p>An overwhelming number of Gram-positive rods in the intestinal mucosa. (A)</p> Signup and view all the answers

Why is fecal culture alone insufficient for diagnosing a Clostridium perfringens infection in horses?

<p><em>Clostridium perfringens</em> is considered a normal inhabitant of the intestinal flora in horses. (D)</p> Signup and view all the answers

How do the toxins produced by Clostridium difficile primarily cause disease in horses?

<p>By disrupting the intestinal barrier through inflammation, necrosis, and hypersecretion. (D)</p> Signup and view all the answers

Which factor makes horses particularly vulnerable to Clostridium-associated diarrhea compared to other animals?

<p>Horses have a less acidic stomach environment, promoting bacterial survival. (B)</p> Signup and view all the answers

A horse owner is concerned about preventing Clostridiosis on their farm. What is the most important recommendation you can give them, based on the information provided?

<p>Ensure gradual dietary changes and judicious use of antimicrobials. (D)</p> Signup and view all the answers

Which of the following plants is NOT typically associated with toxicity in horses?

<p>Orchard Grass (A)</p> Signup and view all the answers

A horse with chronic diarrhea is suspected of having a cyathostome infection. Which clinical sign is LEAST likely to be associated with this condition?

<p>Peripheral eosinophilia (B)</p> Signup and view all the answers

Why might fecal egg counts be an unreliable diagnostic tool for cyathostome infections in horses with chronic diarrhea?

<p>The horse might be in the prepatent period or have encysted larvae. (B)</p> Signup and view all the answers

What is the most significant risk associated with sudden mass emergence of encysted cyathostome larvae in a horse's gut?

<p>Severe acute diarrhea with mucosal damage (B)</p> Signup and view all the answers

A horse with a history of regular deworming presents with chronic diarrhea and weight loss. How does this anthelmintic history influence the diagnosis of cyathostomiasis?

<p>It can help increase or decrease suspicion but cannot definitively rule out the diagnosis. (B)</p> Signup and view all the answers

A horse is diagnosed with cyathostomiasis and treated with an anthelmintic. What additional management practice is most important for long-term control of the infection?

<p>Regular monitoring of fecal egg counts and strategic deworming (B)</p> Signup and view all the answers

In what season are larvae most likely to emerge from the mucosa in horses in the northern hemisphere?

<p>Late winter/spring (D)</p> Signup and view all the answers

What is the general prognosis for horses diagnosed with cyathostome infections, assuming appropriate treatment and management?

<p>Variable, depending on infestation and anthelmintic resistance, but generally good (D)</p> Signup and view all the answers

Which of the following mechanisms primarily contributes to NSAID-induced mucosal ulceration in the equine gastrointestinal tract?

<p>Inhibition of cyclooxygenase and suppression of intestinal prostaglandins. (D)</p> Signup and view all the answers

A horse presents with a history of phenylbutazone use, decreased albumin levels, and ventral edema. Which of the following conditions is most likely?

<p>Right dorsal colitis secondary to NSAID use. (C)</p> Signup and view all the answers

A horse with chronic NSAID-induced colitis is suspected of having a stricture in the right dorsal colon. Which clinical sign would most likely support this suspicion?

<p>Signs of colon obstruction. (A)</p> Signup and view all the answers

Which diagnostic finding would be most supportive of a diagnosis of NSAID-induced right dorsal colitis in a horse?

<p>Focal thickening of the right dorsal colon on ultrasound. (C)</p> Signup and view all the answers

A horse is being evaluated for possible NSAID-induced kidney injury. Which of the following findings on a urinalysis or renal ultrasonography would be most consistent with this condition?

<p>Isosthenuria. (D)</p> Signup and view all the answers

When diagnosing NSAID-induced colitis, it is most important to:

<p>Rule out other potential causes of the horse's clinical signs. (D)</p> Signup and view all the answers

Which of the following is the most important consideration when determining the prognosis for a horse with NSAID-induced colitis?

<p>The presence of concurrent gastric ulceration or kidney injury. (D)</p> Signup and view all the answers

Why might a horse with focal right dorsal colitis not initially present with diarrhea?

<p>The colon damage is insufficient to disrupt normal fecal consistency. (A)</p> Signup and view all the answers

A horse presents with colic, enteritis, and laminitis a day after unexpectedly gaining access to a large quantity of grain. Which of the following is the MOST likely underlying cause?

<p>Grain overload causing rapid fermentation and lactic acid buildup. (C)</p> Signup and view all the answers

What is the primary reason laminitis commonly occurs as a consequence of grain overload in horses?

<p>Endotoxins released into the bloodstream affect the sensitive laminae in the hooves. (B)</p> Signup and view all the answers

A horse shows clinical signs of colic and mild diarrhea. Upon rectal palpation, a small colon impaction is detected. What is the significance of testing this horse for Salmonella?

<p>Identifying a potential cause or complication of the impaction. (D)</p> Signup and view all the answers

Which of the following is the MOST critical preventative measure to advise horse owners to avoid grain overload?

<p>Store grain in secure locations inaccessible to horses. (B)</p> Signup and view all the answers

A few minutes after a routine vaccination, a horse begins to exhibit signs of mild colic and diarrhea. What is the MOST likely cause of these clinical signs?

<p>Anaphylactic reaction to the vaccine. (B)</p> Signup and view all the answers

When evaluating a horse presenting with colic and colitis, what diagnostic step is crucial to rule out a common cause of these signs?

<p>Rectal palpation to assess for impactions. (D)</p> Signup and view all the answers

A horse is diagnosed with grain overload. What factor is MOST indicative of a poorer prognosis?

<p>The horse displays severe clinical signs and has consumed a large amount of grain. (A)</p> Signup and view all the answers

In cases of impactions accompanied by diarrhea, what is the primary diagnostic challenge?

<p>Differentiating between primary colitis leading to impaction and impaction-induced colitis. (B)</p> Signup and view all the answers

Which clinical sign is most commonly observed in horses diagnosed with inflammatory bowel disease (IBD)?

<p>Weight loss despite a normal or increased appetite. (B)</p> Signup and view all the answers

Hypoproteinemia and ventral edema are potential clinical findings in horses with IBD. Which form of IBD is least likely to present with these signs?

<p>Eosinophilic enteritis (A)</p> Signup and view all the answers

A horse with IBD is suspected to have a partial intestinal obstruction. Which form of IBD is most likely associated with this complication?

<p>Eosinophilic enteritis (A)</p> Signup and view all the answers

A horse presents with chronic weight loss, and IBD is suspected. An oral absorption test using glucose is performed. Which post-administration blood glucose result would support a diagnosis of malabsorption?

<p>A blood glucose concentration increase of 60% above the resting level at 120 minutes. (D)</p> Signup and view all the answers

Which diagnostic method offers the highest sensitivity for confirming a diagnosis of IBD in horses?

<p>Full-thickness surgical biopsy via laparotomy (C)</p> Signup and view all the answers

What is the primary limitation of obtaining duodenal biopsies via endoscopy for diagnosing IBD in horses?

<p>Low sensitivity in detecting IBD (B)</p> Signup and view all the answers

Which statement best describes the overall prognosis for horses diagnosed with IBD?

<p>Guarded to poor, especially in the long term. (A)</p> Signup and view all the answers

Which form of IBD generally carries the most favorable prognosis in horses?

<p>Eosinophilic enteritis (A)</p> Signup and view all the answers

A horse is suspected of having IBD. After a 12-hour fast, a baseline blood sample is collected, and 1 g/kg of D-xylose is administered via nasogastric tube. Blood samples are then collected every 30 minutes for 2 hours. What is the purpose of this test?

<p>To assess the absorptive capacity of the small intestine (A)</p> Signup and view all the answers

Which of the following is NOT a typical characteristic of inflammatory bowel disease (IBD) in horses?

<p>Increased appetite and weight gain (C)</p> Signup and view all the answers

Which of the following is a potential cause or association with inflammatory bowel disease (IBD) in horses?

<p>Mycobacterium spp. infection (B)</p> Signup and view all the answers

A horse with MEED is most likely to present with which additional clinical sign, besides weight loss?

<p>Dermatopathy (A)</p> Signup and view all the answers

The subcategories of IBD in horses are primarily differentiated based on what characteristic?

<p>The predominant type of cell infiltrating the intestinal wall (D)</p> Signup and view all the answers

What is the primary reason diarrhea is not a common clinical sign in most cases of IBD in horses?

<p>IBD primarily affects the small intestine. (B)</p> Signup and view all the answers

Which statement accurately reflects the role of rectal biopsies in diagnosing IBD in horses?

<p>Rectal biopsies have good specificity but lack sensitivity for diagnosing IBD. (C)</p> Signup and view all the answers

Flashcards

Differential Diagnosis

List of possible diseases that could be causing a patient's symptoms.

Colitis

Inflammation of the colon, often leading to diarrhea.

Enteritis

Inflammation of the small intestine.

Enterocolitis

Inflammation of both the colon and small intestine.

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Salmonellosis

Disease caused by Salmonella bacteria.

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Antibiotic-induced Colitis

Inflammation of the intestine caused by the overuse of antibiotics.

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NSAID-induced Colitis

Inflammation of the intestine caused by the overuse of NSAIDs.

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Colitis X

Colitis caused by an unknown agent.

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Clostridium Characteristics

Anaerobic, gram-positive, rod-shaped, spore-forming bacteria.

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C. perfringens in Horses

Considered normal intestinal flora in horses; some types secrete harmful exotoxins.

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C. perfringens Exotoxins

C. perfringens types that secrete exotoxins causing inflammation, hemorrhage and/or necrosis.

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C. difficile in Horses

Not considered normal intestinal flora; some strains secrete toxins A and/or B.

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Clostridium toxin A

Enterotoxin causing tissue damage and hypersecretion.

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Clostridium toxin B

Cytotoxin causing inflammation and necrosis

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Factors Promoting Clostridial Overgrowth

Stress, immunosuppression, diet change and/or antimicrobial therapy.

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Diagnosing Clostridiosis

Toxin identification by fecal ELISA, cytotoxin assay, or toxin gene PCR.

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NSAID Colitis Mechanism

NSAIDs inhibit cyclooxygenase, suppressing intestinal prostaglandins critical for mucosal health and blood flow.

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Common NSAID Culprit

Excessive doses of NSAIDs, especially phenylbutazone, are commonly associated with NSAID-induced colitis in horses.

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Most Sensitive Colon Area

Right dorsal colon.

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Common Concurrent Signs

Gastric ulceration and renal papillary necrosis

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Early Sign of NSAID Colitis

Decreasing albumin levels (leading to ventral edema).

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Chronic NSAID Colitis

Fibrosis and stricture formation in the right dorsal colon, leading to signs of colon obstruction.

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Diagnosing NSAID Colitis

History of NSAID use and clinical signs.

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Ultrasound Finding

Focal thickening of the right dorsal colon.

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Grain Overload

Rapid fermentation in the gut due to excessive grain intake, leading to lactic acid buildup and changes in gut flora.

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Grain Overload Signs

Colic, enteritis, endotoxemia/SIRS, and potential laminitis.

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Diagnosing Grain Overload

Consider in horses with access to concentrates; rule out other causes.

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Grain Overload Prognosis

Variable; depends on the amount ingested and clinical signs.

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Impaction

Accumulation of ingesta, often in the cecum, large colon, or small colon, potentially leading to colitis.

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Impaction signs

Diarrhea can be present with mild/moderate strength. Roughly 30% of horses with a small colon impaction will test positive for Salmonella.

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Diagnosing Impaction

Rectal palpation to check for blockages.

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Anaphylaxis Signs (Horse)

Severe colic, diarrhea, shock, and potential death.

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Cyathostome Lifecycle

Ingestion of L3 larvae that migrate into the cecum and colon mucosa, maturing, and then returning to the lumen or encysting as hypobiotic L3 larvae.

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Cyathostome Clinical Signs

Mild, chronic, waxing and waning diarrhea; can mimic Salmonella; failure to thrive.

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Cyathostome Pathogenesis

Inflammation of the mucosa due to encysted larvae.

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Larval Exodus

Damage to the mucosa caused by the sudden mass exodus of encysted larvae.

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Diagnosing Cyathostomes

Observation of larvae in feces and high fecal egg counts (though absence doesn't rule it out).

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Cyathostome Prognosis

Variable, depends on infestation level and anthelmintic resistance, but generally good.

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Cyathostome Prevention

Regular fecal egg count monitoring and strategic deworming.

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Toxic Plants for Horses

Oak, Buttercups, Pokeweed, Chinaberry, Nightshades, Caster bean, black locust, rosary pea

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Inflammatory Bowel Disease (IBD)

Descriptive term for infiltrative diseases affecting the small intestine, leading to malabsorption and protein loss.

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Common Clinical Signs of IBD

Weight loss despite good appetite, hypoproteinemia, and potential ventral edema.

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Subcategories of Equine IBD

Lymphocytic-plasmacytic, Eosinophilic, Multicentric epitheliotrophic eosinophilic disease (MEED), Granulomatous.

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Potential Causes of Equine IBD

The exact cause is unknown, but may be linked to Mycobacterium spp., internal parasites, or food allergies.

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Clinical Suspicion of IBD

Weight loss with good appetite, small intestinal thickening, and possible hypoproteinemia.

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Initial Diagnostic Steps for IBD

Abdominal ultrasound or rectal exam to reveal intestinal wall thickening.

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Bloodwork Findings in IBD

Anemia of chronic disease and/or hypoproteinemia (less common with eosinophilic form).

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Oral Absorption Tests (Glucose or D-Xylose)

Used to assess nutrient absorption from the small intestine.

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Definitive IBD Diagnosis

Mural biopsy with histopathology.

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IBD Biopsy Locations

Duodenal, rectal, or full-thickness surgical biopsies.

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Sensitivity of IBD Biopsy Techniques

Duodenal and rectal biopsies have low sensitivity, but good specificity, while full-thickness surgical biopsies are more sensitive.

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General IBD Prognosis

Guarded to poor, especially long-term.

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Prognosis of Eosinophilic Enteritis

Tends to have the best prognosis if responsive to treatment or surgically resectable.

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IBD Pathophysiology

Infiltration of the intestinal mucosa/submucosa, leads to malabsorption and hypoproteinemia.

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Intestinal Obstruction in IBD

Thickened intestines can lead to this, especially with the focal eosinophilic form.

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Study Notes

  • Diarrhea is defined by increased fluidity, frequency, and/or volume of bowel movements.
  • Mechanisms include inflammation, hypersecretion, malabsorption, osmotic overload and motility or pressure changes.
  • Diagnosing diarrhea includes recognizing the history and signalment, describing the findings, diagnostic tests and relating the etiology, pathophysiology, diagnosis and prognosis.

Objectives

  • Recognizing diagnostic abilities of large animals, diagnosis of signalment and the history of the related illness.
  • Describing risk factors, clinical signs, and common clinicopathologic findings of large animals with diarrhea.
  • Recognizing when to use and how to interpret additional diagnostic tests (diagnostic imaging, infectious disease testing, etc.) for the assessment of diarrhea in large animals.
  • Differential diagnosis of diseases causing diarrhea should be formulated.
  • The signalment, history, clinical findings, and diagnostic test results should help create a narrow differential diagnosis list for diarrhea in large animals.
  • Etiology and pathophysiology should help identify diagnoses as well as compare specific diseases.

Signalment

  • Signalment: species include horses,ruminants, and camelids
  • Signalment: age includes adult and neonate/juvenile.

Timeline

  • History should account for acute or chronic onset

History

  • Other specifics include the severity of the clinical signs, the presence of certain risk factors

Risk Factors

  • Host factors include health/immune status, diet, medications, vaccinations
  • Environmental factors encompass surroundings and their management
  • Pathogen risk will be covered more in depth with differentials.

Clinical Signs Definitons

  • Colitis definition: inflammation of the large intestines; leading to diarrhea
  • Enteritis is inflammation of the small intestines; it does not typically lead to diarrhea by itself, except in neonates/juveniles.

Equine Clinical Signs

  • Equine species can be normal formed, semi or soft formed, cow-patty consistency, and/or watery.

Cattle Clinical Signs

  • Scoring scale: 1 to 5, 1 being liquid to watery and 5 being dry and lumpy log.

Small Ruminants and Camelid Clinical Signs

  • Can be separated/formed pellets, clumped/formed pellets, segmented log, smooth log or liquid/watery composition.

Acute Clinical Signs

  • Commonly Lethargy, decreased or absent appetite, and/or Fever, can have variable diarrhea and, potentially, variable pain.
  • Dehydration: look for dry mucous membranes, pro-longed skin tent, Tachycardia, delayed jugular refill, and reduced urine production.

Hypovolemic Shock Clinical Signs

  • obtunded to stuporous state, mucous membranes appear pale, poor peripheral pulse strength with increased pulse-rate, prolonged capillary refill and cold or cool distal extremities.

Systemic Inflammatory Response Syndrome

  • Possible systemic Inflammatory Response Syndrome (SIRS) can occur, creating Distributive Shock. -Clinical signs to consider include - obtunded to stuporous state, hyperemic mucous membranes often with toxic line, prolonged capillary refill time, poor peripheral pulse strength, cool or cold distal extremities and tachycardia.

Systemic inflammation sequelae Clinical Signs

  • Intestinal inflammation such as decrease to oncotic pressure to ventral edema and systemic inflammation such as lamintis and/or coagulopathies.

Chronic Clinical Signs

  • Variable appetite and diarrhea along with weight loss, and even protein loss leading to ventral edema.

Clinical Pathology: Point of Care

  • PCV/TS, Lactate, Ketones, glucose

Clinical Pathology Tests

  • A blood test could be a Complete blood count, fibrinogen and/or acid-base. And Chemestry would also be beneficial for the Electrolytes.

Acute Cases: Clinical Pathology

  • Leukopenia characterized by neutropenia with a left shift and toxic changes, Hypoproteinemia, hyperketonemia, Metabolic acidosis, and Hemoconcentration, Azotemia, Inflammatory markers, Hyponatremia, hypochloremia, and hypokalemia, and/or Hypocalcemia.

Chronic Cases: Clinical Pathology

  • It may have clinically significant findings, there may be possible signs of chronic disease.
  • Look for Anemia, Inflammation markers, mature neutrophilia (leukocytosis), and/or Hypoalbuminemia

Diagnostic Imaging tests

  • Transabdominal ultrasound and/or abdominal radiography

Clinical Sign tests

  • Transrectal abdominal palpation and Intubation

Fecal Diagnostics

  • Gross evaluation, culture, miscellaneous fecal assays , parasitology, and/or PCR.

Miscellaneous Tests

  • Culture (tissue) and Peritoneal fluid analysis, absorption tests, Histopathology (tissue) and/or Serology.

Differential Diagnoses by Species

  • Signalment includes species, age, chronicity as well as whether the disease in question is infectious or not
  • DAMNIT-V scheme

Adult Equine Differential Diagnoses - Acute

  • Salmonellosis, Clostridiosis, Equine coronavirus and/or other Toxicities.

Adult Equine Differential Diagnoses - Chronic

  • Cyathostomiasis, Sand Enteropahty and/or intestinal Lymphoma and other non intestinal causes.

Equine Differential Diagnoses - Neonate/Juvenile - Acute

  • Septicemia, Rotavirus and/or foal heat diarrhea and/or Strongyloides

Equine Differential Diagnoses - Neonate/Juvenile - Chronic

  • Non intestinal causes and/or Lawsonia, sand entropathy, and/or nutritional

Adult Ruminants & Camelids Differential Diagnoses - Acute

  • Salmonellosis, Clostridiosis, Bovine coronavirus and/or Bovine viral diarrhea virus.

Adult Ruiminants & Camelids Differential Diagnoses - Chronic

  • Paratuberculosis, trichostrpngyles, and/or Inflammatory bowel disease and/or others

Neonate/Juvenile Differential Diagoses - Acute

  • E. Coli, Rotavirus, and/or C. Diff and other viruses

Neonate/Juvenile Differential Diagnoses - Chronic

  • Coccidia and Giardia

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Explore the causes, diagnosis, and differentiating factors of acute and chronic diarrhea in horses. Identify infectious agents, non-infectious conditions, and diagnostic tests for equine diarrhea. Understand the impact of diet and antibiotic use on horse health.

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