Podcast
Questions and Answers
A horse presents with acute diarrhea. Based on the provided differentials, which of the following is LEAST likely to be the primary cause?
A horse presents with acute diarrhea. Based on the provided differentials, which of the following is LEAST likely to be the primary cause?
- Potomac Horse Fever
- Cyathostomiasis (correct)
- Salmonellosis
- Antibiotic-induced colitis
Which of the following infectious agents is NOT directly listed as a differential diagnosis for diarrhea in large animals in this material?
Which of the following infectious agents is NOT directly listed as a differential diagnosis for diarrhea in large animals in this material?
- Salmonellosis
- Trichostrongyles (correct)
- Clostridiosis
- Rotavirus
A horse is diagnosed with colitis secondary to antibiotic use. Which of the following best describes this condition?
A horse is diagnosed with colitis secondary to antibiotic use. Which of the following best describes this condition?
- Infectious in origin and requires immediate treatment.
- A non-infectious cause of acute diarrhea. (correct)
- Likely caused by helminth infection and poor pasture management.
- Always results in a chronic, unresolvable condition.
Considering the provided differential diagnoses, what is a primary differentiating factor between acute and chronic diarrhea in adult horses?
Considering the provided differential diagnoses, what is a primary differentiating factor between acute and chronic diarrhea in adult horses?
Which of the following conditions would be LEAST likely to be associated with chronic diarrhea in an adult horse?
Which of the following conditions would be LEAST likely to be associated with chronic diarrhea in an adult horse?
A horse presents with signs of colic and acute diarrhea after consuming a large amount of grain. Which of the following is the most likely cause of the diarrhea, based on the provided information?
A horse presents with signs of colic and acute diarrhea after consuming a large amount of grain. Which of the following is the most likely cause of the diarrhea, based on the provided information?
You suspect a horse has a non-infectious cause of chronic diarrhea. Which of the following diagnostic tests would be LEAST helpful in determining the underlying cause, based on the provided information?
You suspect a horse has a non-infectious cause of chronic diarrhea. Which of the following diagnostic tests would be LEAST helpful in determining the underlying cause, based on the provided information?
A horse exhibits acute diarrhea and signs of systemic illness. Which of the following differentials would warrant immediate isolation of the affected animal?
A horse exhibits acute diarrhea and signs of systemic illness. Which of the following differentials would warrant immediate isolation of the affected animal?
A horse presents with acute, bloody diarrhea following antimicrobial therapy. Clostridium perfringens or Clostridium difficile are suspected. Which diagnostic approach would be MOST appropriate to support a diagnosis of clostridiosis?
A horse presents with acute, bloody diarrhea following antimicrobial therapy. Clostridium perfringens or Clostridium difficile are suspected. Which diagnostic approach would be MOST appropriate to support a diagnosis of clostridiosis?
Clostridium perfringens is considered a normal inhabitant of the equine gut. What is the primary reason that it can still cause disease?
Clostridium perfringens is considered a normal inhabitant of the equine gut. What is the primary reason that it can still cause disease?
Which of the following scenarios would MOST likely predispose a horse to an overgrowth of Clostridium difficile or Clostridium perfringens in the intestinal tract?
Which of the following scenarios would MOST likely predispose a horse to an overgrowth of Clostridium difficile or Clostridium perfringens in the intestinal tract?
A veterinarian performs a necropsy on a horse that died suddenly after exhibiting signs of severe colitis. Which finding would be MOST suggestive of Clostridium-associated disease?
A veterinarian performs a necropsy on a horse that died suddenly after exhibiting signs of severe colitis. Which finding would be MOST suggestive of Clostridium-associated disease?
Why is fecal culture alone insufficient for diagnosing a Clostridium perfringens infection in horses?
Why is fecal culture alone insufficient for diagnosing a Clostridium perfringens infection in horses?
How do the toxins produced by Clostridium difficile primarily cause disease in horses?
How do the toxins produced by Clostridium difficile primarily cause disease in horses?
Which factor makes horses particularly vulnerable to Clostridium-associated diarrhea compared to other animals?
Which factor makes horses particularly vulnerable to Clostridium-associated diarrhea compared to other animals?
A horse owner is concerned about preventing Clostridiosis on their farm. What is the most important recommendation you can give them, based on the information provided?
A horse owner is concerned about preventing Clostridiosis on their farm. What is the most important recommendation you can give them, based on the information provided?
Which of the following plants is NOT typically associated with toxicity in horses?
Which of the following plants is NOT typically associated with toxicity in horses?
A horse with chronic diarrhea is suspected of having a cyathostome infection. Which clinical sign is LEAST likely to be associated with this condition?
A horse with chronic diarrhea is suspected of having a cyathostome infection. Which clinical sign is LEAST likely to be associated with this condition?
Why might fecal egg counts be an unreliable diagnostic tool for cyathostome infections in horses with chronic diarrhea?
Why might fecal egg counts be an unreliable diagnostic tool for cyathostome infections in horses with chronic diarrhea?
What is the most significant risk associated with sudden mass emergence of encysted cyathostome larvae in a horse's gut?
What is the most significant risk associated with sudden mass emergence of encysted cyathostome larvae in a horse's gut?
A horse with a history of regular deworming presents with chronic diarrhea and weight loss. How does this anthelmintic history influence the diagnosis of cyathostomiasis?
A horse with a history of regular deworming presents with chronic diarrhea and weight loss. How does this anthelmintic history influence the diagnosis of cyathostomiasis?
A horse is diagnosed with cyathostomiasis and treated with an anthelmintic. What additional management practice is most important for long-term control of the infection?
A horse is diagnosed with cyathostomiasis and treated with an anthelmintic. What additional management practice is most important for long-term control of the infection?
In what season are larvae most likely to emerge from the mucosa in horses in the northern hemisphere?
In what season are larvae most likely to emerge from the mucosa in horses in the northern hemisphere?
What is the general prognosis for horses diagnosed with cyathostome infections, assuming appropriate treatment and management?
What is the general prognosis for horses diagnosed with cyathostome infections, assuming appropriate treatment and management?
Which of the following mechanisms primarily contributes to NSAID-induced mucosal ulceration in the equine gastrointestinal tract?
Which of the following mechanisms primarily contributes to NSAID-induced mucosal ulceration in the equine gastrointestinal tract?
A horse presents with a history of phenylbutazone use, decreased albumin levels, and ventral edema. Which of the following conditions is most likely?
A horse presents with a history of phenylbutazone use, decreased albumin levels, and ventral edema. Which of the following conditions is most likely?
A horse with chronic NSAID-induced colitis is suspected of having a stricture in the right dorsal colon. Which clinical sign would most likely support this suspicion?
A horse with chronic NSAID-induced colitis is suspected of having a stricture in the right dorsal colon. Which clinical sign would most likely support this suspicion?
Which diagnostic finding would be most supportive of a diagnosis of NSAID-induced right dorsal colitis in a horse?
Which diagnostic finding would be most supportive of a diagnosis of NSAID-induced right dorsal colitis in a horse?
A horse is being evaluated for possible NSAID-induced kidney injury. Which of the following findings on a urinalysis or renal ultrasonography would be most consistent with this condition?
A horse is being evaluated for possible NSAID-induced kidney injury. Which of the following findings on a urinalysis or renal ultrasonography would be most consistent with this condition?
When diagnosing NSAID-induced colitis, it is most important to:
When diagnosing NSAID-induced colitis, it is most important to:
Which of the following is the most important consideration when determining the prognosis for a horse with NSAID-induced colitis?
Which of the following is the most important consideration when determining the prognosis for a horse with NSAID-induced colitis?
Why might a horse with focal right dorsal colitis not initially present with diarrhea?
Why might a horse with focal right dorsal colitis not initially present with diarrhea?
A horse presents with colic, enteritis, and laminitis a day after unexpectedly gaining access to a large quantity of grain. Which of the following is the MOST likely underlying cause?
A horse presents with colic, enteritis, and laminitis a day after unexpectedly gaining access to a large quantity of grain. Which of the following is the MOST likely underlying cause?
What is the primary reason laminitis commonly occurs as a consequence of grain overload in horses?
What is the primary reason laminitis commonly occurs as a consequence of grain overload in horses?
A horse shows clinical signs of colic and mild diarrhea. Upon rectal palpation, a small colon impaction is detected. What is the significance of testing this horse for Salmonella?
A horse shows clinical signs of colic and mild diarrhea. Upon rectal palpation, a small colon impaction is detected. What is the significance of testing this horse for Salmonella?
Which of the following is the MOST critical preventative measure to advise horse owners to avoid grain overload?
Which of the following is the MOST critical preventative measure to advise horse owners to avoid grain overload?
A few minutes after a routine vaccination, a horse begins to exhibit signs of mild colic and diarrhea. What is the MOST likely cause of these clinical signs?
A few minutes after a routine vaccination, a horse begins to exhibit signs of mild colic and diarrhea. What is the MOST likely cause of these clinical signs?
When evaluating a horse presenting with colic and colitis, what diagnostic step is crucial to rule out a common cause of these signs?
When evaluating a horse presenting with colic and colitis, what diagnostic step is crucial to rule out a common cause of these signs?
A horse is diagnosed with grain overload. What factor is MOST indicative of a poorer prognosis?
A horse is diagnosed with grain overload. What factor is MOST indicative of a poorer prognosis?
In cases of impactions accompanied by diarrhea, what is the primary diagnostic challenge?
In cases of impactions accompanied by diarrhea, what is the primary diagnostic challenge?
Which clinical sign is most commonly observed in horses diagnosed with inflammatory bowel disease (IBD)?
Which clinical sign is most commonly observed in horses diagnosed with inflammatory bowel disease (IBD)?
Hypoproteinemia and ventral edema are potential clinical findings in horses with IBD. Which form of IBD is least likely to present with these signs?
Hypoproteinemia and ventral edema are potential clinical findings in horses with IBD. Which form of IBD is least likely to present with these signs?
A horse with IBD is suspected to have a partial intestinal obstruction. Which form of IBD is most likely associated with this complication?
A horse with IBD is suspected to have a partial intestinal obstruction. Which form of IBD is most likely associated with this complication?
A horse presents with chronic weight loss, and IBD is suspected. An oral absorption test using glucose is performed. Which post-administration blood glucose result would support a diagnosis of malabsorption?
A horse presents with chronic weight loss, and IBD is suspected. An oral absorption test using glucose is performed. Which post-administration blood glucose result would support a diagnosis of malabsorption?
Which diagnostic method offers the highest sensitivity for confirming a diagnosis of IBD in horses?
Which diagnostic method offers the highest sensitivity for confirming a diagnosis of IBD in horses?
What is the primary limitation of obtaining duodenal biopsies via endoscopy for diagnosing IBD in horses?
What is the primary limitation of obtaining duodenal biopsies via endoscopy for diagnosing IBD in horses?
Which statement best describes the overall prognosis for horses diagnosed with IBD?
Which statement best describes the overall prognosis for horses diagnosed with IBD?
Which form of IBD generally carries the most favorable prognosis in horses?
Which form of IBD generally carries the most favorable prognosis in horses?
A horse is suspected of having IBD. After a 12-hour fast, a baseline blood sample is collected, and 1 g/kg of D-xylose is administered via nasogastric tube. Blood samples are then collected every 30 minutes for 2 hours. What is the purpose of this test?
A horse is suspected of having IBD. After a 12-hour fast, a baseline blood sample is collected, and 1 g/kg of D-xylose is administered via nasogastric tube. Blood samples are then collected every 30 minutes for 2 hours. What is the purpose of this test?
Which of the following is NOT a typical characteristic of inflammatory bowel disease (IBD) in horses?
Which of the following is NOT a typical characteristic of inflammatory bowel disease (IBD) in horses?
Which of the following is a potential cause or association with inflammatory bowel disease (IBD) in horses?
Which of the following is a potential cause or association with inflammatory bowel disease (IBD) in horses?
A horse with MEED is most likely to present with which additional clinical sign, besides weight loss?
A horse with MEED is most likely to present with which additional clinical sign, besides weight loss?
The subcategories of IBD in horses are primarily differentiated based on what characteristic?
The subcategories of IBD in horses are primarily differentiated based on what characteristic?
What is the primary reason diarrhea is not a common clinical sign in most cases of IBD in horses?
What is the primary reason diarrhea is not a common clinical sign in most cases of IBD in horses?
Which statement accurately reflects the role of rectal biopsies in diagnosing IBD in horses?
Which statement accurately reflects the role of rectal biopsies in diagnosing IBD in horses?
Flashcards
Differential Diagnosis
Differential Diagnosis
List of possible diseases that could be causing a patient's symptoms.
Colitis
Colitis
Inflammation of the colon, often leading to diarrhea.
Enteritis
Enteritis
Inflammation of the small intestine.
Enterocolitis
Enterocolitis
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Salmonellosis
Salmonellosis
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Antibiotic-induced Colitis
Antibiotic-induced Colitis
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NSAID-induced Colitis
NSAID-induced Colitis
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Colitis X
Colitis X
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Clostridium Characteristics
Clostridium Characteristics
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C. perfringens in Horses
C. perfringens in Horses
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C. perfringens Exotoxins
C. perfringens Exotoxins
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C. difficile in Horses
C. difficile in Horses
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Clostridium toxin A
Clostridium toxin A
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Clostridium toxin B
Clostridium toxin B
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Factors Promoting Clostridial Overgrowth
Factors Promoting Clostridial Overgrowth
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Diagnosing Clostridiosis
Diagnosing Clostridiosis
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NSAID Colitis Mechanism
NSAID Colitis Mechanism
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Common NSAID Culprit
Common NSAID Culprit
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Most Sensitive Colon Area
Most Sensitive Colon Area
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Common Concurrent Signs
Common Concurrent Signs
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Early Sign of NSAID Colitis
Early Sign of NSAID Colitis
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Chronic NSAID Colitis
Chronic NSAID Colitis
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Diagnosing NSAID Colitis
Diagnosing NSAID Colitis
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Ultrasound Finding
Ultrasound Finding
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Grain Overload
Grain Overload
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Grain Overload Signs
Grain Overload Signs
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Diagnosing Grain Overload
Diagnosing Grain Overload
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Grain Overload Prognosis
Grain Overload Prognosis
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Impaction
Impaction
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Impaction signs
Impaction signs
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Diagnosing Impaction
Diagnosing Impaction
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Anaphylaxis Signs (Horse)
Anaphylaxis Signs (Horse)
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Cyathostome Lifecycle
Cyathostome Lifecycle
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Cyathostome Clinical Signs
Cyathostome Clinical Signs
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Cyathostome Pathogenesis
Cyathostome Pathogenesis
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Larval Exodus
Larval Exodus
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Diagnosing Cyathostomes
Diagnosing Cyathostomes
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Cyathostome Prognosis
Cyathostome Prognosis
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Cyathostome Prevention
Cyathostome Prevention
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Toxic Plants for Horses
Toxic Plants for Horses
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Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD)
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Common Clinical Signs of IBD
Common Clinical Signs of IBD
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Subcategories of Equine IBD
Subcategories of Equine IBD
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Potential Causes of Equine IBD
Potential Causes of Equine IBD
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Clinical Suspicion of IBD
Clinical Suspicion of IBD
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Initial Diagnostic Steps for IBD
Initial Diagnostic Steps for IBD
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Bloodwork Findings in IBD
Bloodwork Findings in IBD
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Oral Absorption Tests (Glucose or D-Xylose)
Oral Absorption Tests (Glucose or D-Xylose)
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Definitive IBD Diagnosis
Definitive IBD Diagnosis
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IBD Biopsy Locations
IBD Biopsy Locations
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Sensitivity of IBD Biopsy Techniques
Sensitivity of IBD Biopsy Techniques
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General IBD Prognosis
General IBD Prognosis
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Prognosis of Eosinophilic Enteritis
Prognosis of Eosinophilic Enteritis
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IBD Pathophysiology
IBD Pathophysiology
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Intestinal Obstruction in IBD
Intestinal Obstruction in IBD
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Study Notes
- Diarrhea is defined by increased fluidity, frequency, and/or volume of bowel movements.
- Mechanisms include inflammation, hypersecretion, malabsorption, osmotic overload and motility or pressure changes.
- Diagnosing diarrhea includes recognizing the history and signalment, describing the findings, diagnostic tests and relating the etiology, pathophysiology, diagnosis and prognosis.
Objectives
- Recognizing diagnostic abilities of large animals, diagnosis of signalment and the history of the related illness.
- Describing risk factors, clinical signs, and common clinicopathologic findings of large animals with diarrhea.
- Recognizing when to use and how to interpret additional diagnostic tests (diagnostic imaging, infectious disease testing, etc.) for the assessment of diarrhea in large animals.
- Differential diagnosis of diseases causing diarrhea should be formulated.
- The signalment, history, clinical findings, and diagnostic test results should help create a narrow differential diagnosis list for diarrhea in large animals.
- Etiology and pathophysiology should help identify diagnoses as well as compare specific diseases.
Signalment
- Signalment: species include horses,ruminants, and camelids
- Signalment: age includes adult and neonate/juvenile.
Timeline
- History should account for acute or chronic onset
History
- Other specifics include the severity of the clinical signs, the presence of certain risk factors
Risk Factors
- Host factors include health/immune status, diet, medications, vaccinations
- Environmental factors encompass surroundings and their management
- Pathogen risk will be covered more in depth with differentials.
Clinical Signs Definitons
- Colitis definition: inflammation of the large intestines; leading to diarrhea
- Enteritis is inflammation of the small intestines; it does not typically lead to diarrhea by itself, except in neonates/juveniles.
Equine Clinical Signs
- Equine species can be normal formed, semi or soft formed, cow-patty consistency, and/or watery.
Cattle Clinical Signs
- Scoring scale: 1 to 5, 1 being liquid to watery and 5 being dry and lumpy log.
Small Ruminants and Camelid Clinical Signs
- Can be separated/formed pellets, clumped/formed pellets, segmented log, smooth log or liquid/watery composition.
Acute Clinical Signs
- Commonly Lethargy, decreased or absent appetite, and/or Fever, can have variable diarrhea and, potentially, variable pain.
- Dehydration: look for dry mucous membranes, pro-longed skin tent, Tachycardia, delayed jugular refill, and reduced urine production.
Hypovolemic Shock Clinical Signs
- obtunded to stuporous state, mucous membranes appear pale, poor peripheral pulse strength with increased pulse-rate, prolonged capillary refill and cold or cool distal extremities.
Systemic Inflammatory Response Syndrome
- Possible systemic Inflammatory Response Syndrome (SIRS) can occur, creating Distributive Shock. -Clinical signs to consider include - obtunded to stuporous state, hyperemic mucous membranes often with toxic line, prolonged capillary refill time, poor peripheral pulse strength, cool or cold distal extremities and tachycardia.
Systemic inflammation sequelae Clinical Signs
- Intestinal inflammation such as decrease to oncotic pressure to ventral edema and systemic inflammation such as lamintis and/or coagulopathies.
Chronic Clinical Signs
- Variable appetite and diarrhea along with weight loss, and even protein loss leading to ventral edema.
Clinical Pathology: Point of Care
- PCV/TS, Lactate, Ketones, glucose
Clinical Pathology Tests
- A blood test could be a Complete blood count, fibrinogen and/or acid-base. And Chemestry would also be beneficial for the Electrolytes.
Acute Cases: Clinical Pathology
- Leukopenia characterized by neutropenia with a left shift and toxic changes, Hypoproteinemia, hyperketonemia, Metabolic acidosis, and Hemoconcentration, Azotemia, Inflammatory markers, Hyponatremia, hypochloremia, and hypokalemia, and/or Hypocalcemia.
Chronic Cases: Clinical Pathology
- It may have clinically significant findings, there may be possible signs of chronic disease.
- Look for Anemia, Inflammation markers, mature neutrophilia (leukocytosis), and/or Hypoalbuminemia
Diagnostic Imaging tests
- Transabdominal ultrasound and/or abdominal radiography
Clinical Sign tests
- Transrectal abdominal palpation and Intubation
Fecal Diagnostics
- Gross evaluation, culture, miscellaneous fecal assays , parasitology, and/or PCR.
Miscellaneous Tests
- Culture (tissue) and Peritoneal fluid analysis, absorption tests, Histopathology (tissue) and/or Serology.
Differential Diagnoses by Species
- Signalment includes species, age, chronicity as well as whether the disease in question is infectious or not
- DAMNIT-V scheme
Adult Equine Differential Diagnoses - Acute
- Salmonellosis, Clostridiosis, Equine coronavirus and/or other Toxicities.
Adult Equine Differential Diagnoses - Chronic
- Cyathostomiasis, Sand Enteropahty and/or intestinal Lymphoma and other non intestinal causes.
Equine Differential Diagnoses - Neonate/Juvenile - Acute
- Septicemia, Rotavirus and/or foal heat diarrhea and/or Strongyloides
Equine Differential Diagnoses - Neonate/Juvenile - Chronic
- Non intestinal causes and/or Lawsonia, sand entropathy, and/or nutritional
Adult Ruminants & Camelids Differential Diagnoses - Acute
- Salmonellosis, Clostridiosis, Bovine coronavirus and/or Bovine viral diarrhea virus.
Adult Ruiminants & Camelids Differential Diagnoses - Chronic
- Paratuberculosis, trichostrpngyles, and/or Inflammatory bowel disease and/or others
Neonate/Juvenile Differential Diagoses - Acute
- E. Coli, Rotavirus, and/or C. Diff and other viruses
Neonate/Juvenile Differential Diagnoses - Chronic
- Coccidia and Giardia
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Description
Explore the causes, diagnosis, and differentiating factors of acute and chronic diarrhea in horses. Identify infectious agents, non-infectious conditions, and diagnostic tests for equine diarrhea. Understand the impact of diet and antibiotic use on horse health.