16 Questions
Which of the following is a clinical sign of severe anemia?
Pallor of mucous membranes
What is the stable storage form of iron that stains blue with Perls Prussian Blue?
Hemosiderin
What test is used to identify hemoglobin variants in sickle cell disease?
High performance liquid chromatography (HPLC)
What is the recommended treatment for sickle cell disease to prevent infections?
Vaccines
Which type of beta thalassemia is characterized by absent beta globin synthesis?
Beta Thalassemia Major
What is a characteristic facial feature of Beta Thalassemia Major?
Protuberant maxilla
What is the feature of Iron Deficiency Anemia (IDA) in terms of serum ferritin?
Low serum ferritin
What is the significance of peripheral blood smear in Sickle Cell Disease?
Irreversible sickled cells
What is the role of Erythropoietin (EPO) in late stages of erythropoiesis?
Stimulates erythroid proliferation, maturation, and Hb production
What is the common cause of microcytic anemia due to asynchronous nuclear maturation?
Megaloblastic anemia
Which nutrient deficiency can lead to megaloblastic maturation?
Vitamin B12 (cyanocobalamin)
What is the role of reticulocytes in anemia?
Reticulocytes are increased in recovery from bleeding
What is the classification of anemia based on Mean Corpuscular Volume (MCV) if decreased?
Microcytic
Which pathway is associated with red blood cell metabolism?
Hexose monophosphate shunt (pentose phosphate pathway)
What are the transcription factors activated by Erythropoietin (EPO) on erythroid committed precursors?
GATA-1 and FOG-1
What is the role of Erythropoietin (EPO) in enhancing transferrin receptor?
EPO enhances transferrin receptor
Test your knowledge of erythropoietin (EPO) and anemia with this quiz. Explore the role of EPO in activating transcription factors and its effects on erythroid committed precursors. Learn about the clinical presentation and measurements associated with anemia.
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