EPO and Anemia Quiz

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Questions and Answers

Which of the following is a clinical sign of severe anemia?

  • Pallor of mucous membranes (correct)
  • Increased hemoglobin levels
  • Excessive bleeding
  • Hypertension

What is the stable storage form of iron that stains blue with Perls Prussian Blue?

  • Transferrin
  • Serum iron
  • Hemosiderin (correct)
  • Ferritin

What test is used to identify hemoglobin variants in sickle cell disease?

  • High performance liquid chromatography (HPLC) (correct)
  • Serum iron studies
  • Tissue iron studies
  • Newborn screening

What is the recommended treatment for sickle cell disease to prevent infections?

<p>Vaccines (A)</p> Signup and view all the answers

Which type of beta thalassemia is characterized by absent beta globin synthesis?

<p>Beta Thalassemia Major (D)</p> Signup and view all the answers

What is a characteristic facial feature of Beta Thalassemia Major?

<p>Protuberant maxilla (A)</p> Signup and view all the answers

What is the feature of Iron Deficiency Anemia (IDA) in terms of serum ferritin?

<p>Low serum ferritin (B)</p> Signup and view all the answers

What is the significance of peripheral blood smear in Sickle Cell Disease?

<p>Irreversible sickled cells (B)</p> Signup and view all the answers

What is the role of Erythropoietin (EPO) in late stages of erythropoiesis?

<p>Stimulates erythroid proliferation, maturation, and Hb production (D)</p> Signup and view all the answers

What is the common cause of microcytic anemia due to asynchronous nuclear maturation?

<p>Megaloblastic anemia (A)</p> Signup and view all the answers

Which nutrient deficiency can lead to megaloblastic maturation?

<p>Vitamin B12 (cyanocobalamin) (D)</p> Signup and view all the answers

What is the role of reticulocytes in anemia?

<p>Reticulocytes are increased in recovery from bleeding (A)</p> Signup and view all the answers

What is the classification of anemia based on Mean Corpuscular Volume (MCV) if decreased?

<p>Microcytic (A)</p> Signup and view all the answers

Which pathway is associated with red blood cell metabolism?

<p>Hexose monophosphate shunt (pentose phosphate pathway) (B)</p> Signup and view all the answers

What are the transcription factors activated by Erythropoietin (EPO) on erythroid committed precursors?

<p>GATA-1 and FOG-1 (B)</p> Signup and view all the answers

What is the role of Erythropoietin (EPO) in enhancing transferrin receptor?

<p>EPO enhances transferrin receptor (A)</p> Signup and view all the answers

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