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EPO and Anemia Quiz

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Questions and Answers

Which of the following is a clinical sign of severe anemia?

Pallor of mucous membranes (correct)

Increased hemoglobin levels

Excessive bleeding

Hypertension

What is the stable storage form of iron that stains blue with Perls Prussian Blue?

Transferrin

Serum iron

Hemosiderin (correct)

Ferritin

What test is used to identify hemoglobin variants in sickle cell disease?

High performance liquid chromatography (HPLC) (correct)

Serum iron studies

Tissue iron studies

Newborn screening

What is the recommended treatment for sickle cell disease to prevent infections?

Vaccines Signup and view all the answers

Which type of beta thalassemia is characterized by absent beta globin synthesis?

Beta Thalassemia Major Signup and view all the answers

What is a characteristic facial feature of Beta Thalassemia Major?

Protuberant maxilla Signup and view all the answers

What is the feature of Iron Deficiency Anemia (IDA) in terms of serum ferritin?

Low serum ferritin Signup and view all the answers

What is the significance of peripheral blood smear in Sickle Cell Disease?

Irreversible sickled cells Signup and view all the answers

What is the role of Erythropoietin (EPO) in late stages of erythropoiesis?

Stimulates erythroid proliferation, maturation, and Hb production Signup and view all the answers

What is the common cause of microcytic anemia due to asynchronous nuclear maturation?

Megaloblastic anemia Signup and view all the answers

Which nutrient deficiency can lead to megaloblastic maturation?

Vitamin B12 (cyanocobalamin) Signup and view all the answers

What is the role of reticulocytes in anemia?

Reticulocytes are increased in recovery from bleeding Signup and view all the answers

What is the classification of anemia based on Mean Corpuscular Volume (MCV) if decreased?

Microcytic Signup and view all the answers

Which pathway is associated with red blood cell metabolism?

Hexose monophosphate shunt (pentose phosphate pathway) Signup and view all the answers

What are the transcription factors activated by Erythropoietin (EPO) on erythroid committed precursors?

GATA-1 and FOG-1 Signup and view all the answers

What is the role of Erythropoietin (EPO) in enhancing transferrin receptor?

EPO enhances transferrin receptor Signup and view all the answers