Epithelial Tissue: Cells and Polarity

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Questions and Answers

[Blank] cells are characterized according to shape and dimensions.

Epithelial

Epithelial cells exhibit distinct polarity, having three domains: apical, basal, and ______.

lateral

The ______ surface of epithelial cells rests on the basement membrane.

basal

The basal lamina is composed of glycoproteins, collagen, and ______.

<p>proteoglycans</p> Signup and view all the answers

The reticular lamina contains collagen ______ fibers and is produced by fibroblasts.

<p>III</p> Signup and view all the answers

Tight/Occluding Junctions, also known as ______, seal adjacent cells to prevent passive flow of materials.

<p>Zonula Occludens</p> Signup and view all the answers

Enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junction by inhibiting insertion of claudin molecules of intestinal cells.

<p>tight</p> Signup and view all the answers

[Blank] junctions are sites of strong cell adhesion on the lateral surface of epithelial cells.

<p>Anchoring</p> Signup and view all the answers

Gap junctions, also known as ______ permit the exchange of small molecules between cells.

<p>nexus</p> Signup and view all the answers

[Blank] are finger-like cytoplasmic projections of epithelial tissue specialized for absorption.

<p>Microvilli</p> Signup and view all the answers

The internal structure of microvilli contains a core of actin filaments and ______-binding proteins.

<p>actin</p> Signup and view all the answers

Celiac disease leads to loss of microvilli brush border in the small intestine due to an immune reaction against wheat protein ______.

<p>gluten</p> Signup and view all the answers

[Blank] are seen on absorptive epithelial cells lining the male reproductive system and sensory cells of the inner ear.

<p>Stereocilia</p> Signup and view all the answers

[Blank] are long, larger than microvilli, and exhibit beating patterns to move materials on cuboidal or columnar cells.

<p>Cilia</p> Signup and view all the answers

A primary cilium, unlike motile cilia, detects light, odor, motion, and the flow of ______.

<p>liquid</p> Signup and view all the answers

Covering or ______ epithelia are classified based on the number of cell layers and the shape of the cells.

<p>lining</p> Signup and view all the answers

A ______ is a group of similarly specialized cells that work together to perform a specific function.

<p>tissue</p> Signup and view all the answers

The term 'epithelial' comes from 'epi' meaning upon, and 'thele' meaning ______.

<p>nipple</p> Signup and view all the answers

[Blank]: cells are in close contact with each other.

<p>Cellularity</p> Signup and view all the answers

Epithelial tissues are supported by ______ tissue, which provides them with nutrients and metabolites.

<p>connective</p> Signup and view all the answers

Epithelial tissues are ______ but innervated.

<p>avascular</p> Signup and view all the answers

[Blank] is a characteristic of epithelial tissue that enables quick repair via high mitotic rate.

<p>Regeneration</p> Signup and view all the answers

Epithelial cells are ______ polyhedral cells that adhere strongly to one another and to the extracellular matrix.

<p>aggregated</p> Signup and view all the answers

[Blank] cells are tall and column-shaped, with the height greater than the width, typically found in absorptive or secretory tissues.

<p>Columnar</p> Signup and view all the answers

Epithelial tissue is often classified based on cell layers: simple, indicating a single layer, or ______, indicating multiple layers.

<p>stratified</p> Signup and view all the answers

The basement membrane is located between the ______ tissue and connective tissue.

<p>epithelial</p> Signup and view all the answers

Apical, basal, and lateral are all names of ______ domains.

<p>epithelial</p> Signup and view all the answers

The basal lamina supports the epithelium by filtration and attachment, and it is composed mainly of ______, glycoproteins, and proteoglycans.

<p>collagen</p> Signup and view all the answers

A defining feature of cuboidal cells compared to columnar cells of epithelial tissue is that the height of the cuboidal cells is roughly ______ to the width.

<p>equal</p> Signup and view all the answers

The paracellular pathway controlled by tight junctions is important in the epithelia of various organs, and the pathway is regulated by proteins such as ______ and claudins.

<p>occludin</p> Signup and view all the answers

Desmosomes and adherens junctions are the main types of ______ junctions, crucial for adhesion in epithelial tissues.

<p>anchoring</p> Signup and view all the answers

Actin filaments are typically found inside of the sterocilia as a ______ structure.

<p>core</p> Signup and view all the answers

The epithelial tissue lines the ______ tract organs, and it serves as a barrier and carries out absorption and protection.

<p>GI</p> Signup and view all the answers

Connexins are what help in the intercellular space, so that ______ junctions can occur.

<p>gap</p> Signup and view all the answers

Tissues can be classified into: epithelial, connective, muscle and ______.

<p>nervous</p> Signup and view all the answers

Cuboidal cells are abundant on either columnar or ______ cells and are long.

<p>columnar</p> Signup and view all the answers

[Blank] epithelium are located in the oesophagus.

<p>Stratified squamous</p> Signup and view all the answers

[Blank] are composed of small amounts of connective tissues.

<p>Epithelial</p> Signup and view all the answers

[Blank] are specialized regions on the cell surface.

<p>Domains</p> Signup and view all the answers

Intercellular adhesion and other junctions of epithelial tissue, contain tight occluding junctions, that help seal adjacent cells, therefore passive flow of material in cells are ______.

<p>prevented</p> Signup and view all the answers

[Blank] gives structural support to the overlying epithelium, semipermeable barriers and provides interaction site for many cell adhesion molecules.

<p>functions</p> Signup and view all the answers

Epithelial cells are characterized according to their ______ and dimensions.

<p>Shape</p> Signup and view all the answers

In squamous epithelial cells, the height is ______ than the width.

<p>Less</p> Signup and view all the answers

In cuboidal epithelial cells, the height is ______ to the width.

<p>Equal</p> Signup and view all the answers

In columnar epithelial cells, the height is ______ than the width.

<p>Greater</p> Signup and view all the answers

Epithelial cells exhibit distinct polarity, presenting three domains: apical, basal, and ______.

<p>Lateral</p> Signup and view all the answers

The basement membrane consists of the basal lamina and the ______ lamina.

<p>Reticular</p> Signup and view all the answers

The reticular lamina of the basement membrane contains collagen ______ fibers.

<p>III</p> Signup and view all the answers

[Blank] junctions seal the space between adjacent cells and prevents passive flow of materials between the cells`.

<p>Tight</p> Signup and view all the answers

The enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junctions.

<p>Tight</p> Signup and view all the answers

[Blank] junctions are characterized as sites of strong cell adhesion.

<p>Anchoring</p> Signup and view all the answers

[Blank] junctions permit intercellular exchange of small molecules.

<p>Gap</p> Signup and view all the answers

Finger-like cytoplasmic projections on the apical surface of epithelial tissue are known as ______.

<p>Microvilli</p> Signup and view all the answers

Stereocilia contain a core of ______ filaments and actin-binding proteins.

<p>Actin</p> Signup and view all the answers

[Blank] are long and exhibit beating patterns that move materials in one direction.

<p>Cilia</p> Signup and view all the answers

Covering and lining epithelia are classified according to cell shape and number of ______.

<p>Layers</p> Signup and view all the answers

The term 'epithelial' is derived from 'epi,' meaning upon, and 'thele,' which translates to ______.

<p>Nipple</p> Signup and view all the answers

Epithelial tissue is ______ but innervated, meaning ti lacks blood vessels but has nerve supply.

<p>Avascular</p> Signup and view all the answers

Celiac disease results in loss of ______ brush border of the absorptive cellsof small intestine, caused by immune reaction against wheat protein gluten during its digestion, causing diffuse enteritis.

<p>Microvilli</p> Signup and view all the answers

Flashcards

Characterize Epithelial Cells

Shape and dimensions of the cell and its nucleus.

Squamous Epithelial Cells

Cells with width greater than height, like floor tiles.

Cuboidal Epithelial Cells

Cells with equal height and width, found in kidney tubules.

Columnar Epithelial Cells

Cells taller than they are wide; found in the intestines.

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Epithelial Polarity

Epithelial cell's distinct regions.

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Apical Domain

Faces the lumen or external environment.

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Basal Domain

Rests on the basement membrane.

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Lateral Domain

Connects to adjacent cells.

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Basement Membrane

Located at the basal surface; supports epithelium.

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Basal Lamina

20-100 nm thick layer made of glycoproteins, collagen and proteoglycans; supports overlying epithelium.

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Reticular Lamina

Contains collagen III fibers. Produced by fibroblasts in connective tissue.

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Tight/Occluding Junctions

Junctions that seal cells, preventing material flow.

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Anchoring Junctions

Physical links for strong cell to cell adhesion.

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Gap Junctions

Patch of connexons for intercellular exchange.

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Microvilli

Finger-like projections for absorption.

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Microvilli Internal Structure

Core of actin filaments and actin binding proteins.

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Celiac Disease

Loss of microvilli brush border leading to malabsorption.

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Stereocilia

Seen lining the male reproductive system and sensory cells of the inner ear.

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Cilia

Long, motile structures with microtubules.

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Tissue

Aggregated cells for specific functions.

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Epithelial Tissue

Upon + nipple. Aggregate cells adhering strongly.

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Cellularity

Cells are tightly packed together.

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Specialized Contacts

Cells connected by junctions for attachment and communication.

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Polarity

Epithelial tissue has apical, basal and lateral surface.

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Connective Tissue Support

Epithelial tissue supported. Source of nutrients, metabolites and oxygen.

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Covering/Lining Epithelia

Classifying epithelia

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Study Notes

  • A prayer asks for light, wisdom, understanding, memory, accuracy, and clarity to guide work from start to finish.

Epithelial Tissue Overview

  • This is lecture MT120225, Unit 2
  • The intended learning outcome is to identify and describe epithelial tissue types.
  • The course content includes epithelial cells, epithelial domains, covering or lining epithelia, secretory epithelia and glands, transport across epithelia, and renewal of epithelial cells.

Epithelial Cells

  • Epithelial cells are characterized by shape and dimensions
  • The nuclear shape corresponds roughly to the cell shape.
  • Epithelial cell shapes can be squamous (H<W), cuboidal (H=W), or columnar (H>W).

Epithelial Polarity

  • Epithelial cells exhibit distinct polarity with three domains: apical, basal, and lateral.

Epithelial Domains: Basal Surface

  • The basal surface rests on the basement membrane
  • The basment membrame includes the basal lamina and reticular lamina

Basal Lamina

  • The basal lamina is 20-100 nm thick
  • Its composed of glycoproteins, collagen, and proteoglycans
  • The basal lamina is produced by epithelial cells
  • Basal lamina functions include:
    • Providing structural support to the overlying epithelium
    • Acting as a semipermeable barrier
    • Providing an interaction site for cell adhesion molecules

Reticular Lamina

  • Reticular Lamina contains collagen III fibers
  • Reticular Lamina is produced by fibroblasts

Epithelial Domains: Lateral Surface

  • The lateral surface has intercellular adhesion and other junctions, including:
    • Tight/Occluding Junctions (Zonula Occludens): These seal between adjacent cells and prevent passive flow of materials.
    • Anchoring Junctions: These are sites of strong cell adhesion.
    • Gap Junctions (Nexus): These consist of patches of connexons, permitting intercellular exchange of small molecules.
  • Medical Application: Clostridium perfringens secretes enterotoxin, causing food poisoning by preventing tight junction maintenance and causing loss of tissue fluid into the intestinal lumen.

Epithelial Domains: Apical Surface

  • Includes specializations such as microvilli, stereocilia and cilia

Apical Surface - Microvilli

  • Microvilli are finger-like cytoplasmic projections specialized for absorption.
  • Microvilli are 1 um long and 0.1 um wide, uniform in length
  • Microvilli increase surface area by 20-30 fold.
  • The internal structure of microvilli contains a core of actin filaments and actin binding proteins.
  • Medical Application: Celiac disease involves the loss of microvilli brush border in the small intestine's absorptive cells, caused by an immune reaction against wheat protein gluten, leading to diffuse enteritis and malabsorption.

Apical Surface - Stereocilia

  • Stereocilia are seen on absorptive epithelial cells, lining the male reproductive system as well as sensory cells of the inner ear.
  • The internal structure of stereocilia contains a core of actin filaments and actin binding proteins.
  • Stereocilia are longer and are often less motile than microvilli, also having distal branching.

Apical Surface - Cilia

  • Cilia are long, larger than microvilli, and abundant on cuboidal or columnar cells.
  • Cilia measure 5-10 um long and 0.2 um wide.
  • The internal structure of cilia contains microtubules. -Cilia exhibit beating patterns that move materials in one direction.
  • Primary cilium is not motile but detects light, odor, motion, and fluid flow.

Epithelial Tissues

  • This is a group of similarly specialized cells working together to perform specific functions
  • Epithelia covering or lining are classified according to cell layers (C_L) and cell shape (C_S).

Characteristics of Epithelial Tissue

  • Cellularity: Cells are in close contact.
  • Specialized contacts: Have junctions for attachment and communication.
  • Polarity: Has apical, basal, and lateral surfaces. -Supported by connective tissue: Source of nutrients.
  • Avascular but innervated.
  • Regeneration: Has a high mitotic rate.

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