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Questions and Answers
[Blank] cells are characterized according to shape and dimensions.
[Blank] cells are characterized according to shape and dimensions.
Epithelial
Epithelial cells exhibit distinct polarity, having three domains: apical, basal, and ______.
Epithelial cells exhibit distinct polarity, having three domains: apical, basal, and ______.
lateral
The ______ surface of epithelial cells rests on the basement membrane.
The ______ surface of epithelial cells rests on the basement membrane.
basal
The basal lamina is composed of glycoproteins, collagen, and ______.
The basal lamina is composed of glycoproteins, collagen, and ______.
The reticular lamina contains collagen ______ fibers and is produced by fibroblasts.
The reticular lamina contains collagen ______ fibers and is produced by fibroblasts.
Tight/Occluding Junctions, also known as ______, seal adjacent cells to prevent passive flow of materials.
Tight/Occluding Junctions, also known as ______, seal adjacent cells to prevent passive flow of materials.
Enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junction by inhibiting insertion of claudin molecules of intestinal cells.
Enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junction by inhibiting insertion of claudin molecules of intestinal cells.
[Blank] junctions are sites of strong cell adhesion on the lateral surface of epithelial cells.
[Blank] junctions are sites of strong cell adhesion on the lateral surface of epithelial cells.
Gap junctions, also known as ______ permit the exchange of small molecules between cells.
Gap junctions, also known as ______ permit the exchange of small molecules between cells.
[Blank] are finger-like cytoplasmic projections of epithelial tissue specialized for absorption.
[Blank] are finger-like cytoplasmic projections of epithelial tissue specialized for absorption.
The internal structure of microvilli contains a core of actin filaments and ______-binding proteins.
The internal structure of microvilli contains a core of actin filaments and ______-binding proteins.
Celiac disease leads to loss of microvilli brush border in the small intestine due to an immune reaction against wheat protein ______.
Celiac disease leads to loss of microvilli brush border in the small intestine due to an immune reaction against wheat protein ______.
[Blank] are seen on absorptive epithelial cells lining the male reproductive system and sensory cells of the inner ear.
[Blank] are seen on absorptive epithelial cells lining the male reproductive system and sensory cells of the inner ear.
[Blank] are long, larger than microvilli, and exhibit beating patterns to move materials on cuboidal or columnar cells.
[Blank] are long, larger than microvilli, and exhibit beating patterns to move materials on cuboidal or columnar cells.
A primary cilium, unlike motile cilia, detects light, odor, motion, and the flow of ______.
A primary cilium, unlike motile cilia, detects light, odor, motion, and the flow of ______.
Covering or ______ epithelia are classified based on the number of cell layers and the shape of the cells.
Covering or ______ epithelia are classified based on the number of cell layers and the shape of the cells.
A ______ is a group of similarly specialized cells that work together to perform a specific function.
A ______ is a group of similarly specialized cells that work together to perform a specific function.
The term 'epithelial' comes from 'epi' meaning upon, and 'thele' meaning ______.
The term 'epithelial' comes from 'epi' meaning upon, and 'thele' meaning ______.
[Blank]: cells are in close contact with each other.
[Blank]: cells are in close contact with each other.
Epithelial tissues are supported by ______ tissue, which provides them with nutrients and metabolites.
Epithelial tissues are supported by ______ tissue, which provides them with nutrients and metabolites.
Epithelial tissues are ______ but innervated.
Epithelial tissues are ______ but innervated.
[Blank] is a characteristic of epithelial tissue that enables quick repair via high mitotic rate.
[Blank] is a characteristic of epithelial tissue that enables quick repair via high mitotic rate.
Epithelial cells are ______ polyhedral cells that adhere strongly to one another and to the extracellular matrix.
Epithelial cells are ______ polyhedral cells that adhere strongly to one another and to the extracellular matrix.
[Blank] cells are tall and column-shaped, with the height greater than the width, typically found in absorptive or secretory tissues.
[Blank] cells are tall and column-shaped, with the height greater than the width, typically found in absorptive or secretory tissues.
Epithelial tissue is often classified based on cell layers: simple, indicating a single layer, or ______, indicating multiple layers.
Epithelial tissue is often classified based on cell layers: simple, indicating a single layer, or ______, indicating multiple layers.
The basement membrane is located between the ______ tissue and connective tissue.
The basement membrane is located between the ______ tissue and connective tissue.
Apical, basal, and lateral are all names of ______ domains.
Apical, basal, and lateral are all names of ______ domains.
The basal lamina supports the epithelium by filtration and attachment, and it is composed mainly of ______, glycoproteins, and proteoglycans.
The basal lamina supports the epithelium by filtration and attachment, and it is composed mainly of ______, glycoproteins, and proteoglycans.
A defining feature of cuboidal cells compared to columnar cells of epithelial tissue is that the height of the cuboidal cells is roughly ______ to the width.
A defining feature of cuboidal cells compared to columnar cells of epithelial tissue is that the height of the cuboidal cells is roughly ______ to the width.
The paracellular pathway controlled by tight junctions is important in the epithelia of various organs, and the pathway is regulated by proteins such as ______ and claudins.
The paracellular pathway controlled by tight junctions is important in the epithelia of various organs, and the pathway is regulated by proteins such as ______ and claudins.
Desmosomes and adherens junctions are the main types of ______ junctions, crucial for adhesion in epithelial tissues.
Desmosomes and adherens junctions are the main types of ______ junctions, crucial for adhesion in epithelial tissues.
Actin filaments are typically found inside of the sterocilia as a ______ structure.
Actin filaments are typically found inside of the sterocilia as a ______ structure.
The epithelial tissue lines the ______ tract organs, and it serves as a barrier and carries out absorption and protection.
The epithelial tissue lines the ______ tract organs, and it serves as a barrier and carries out absorption and protection.
Connexins are what help in the intercellular space, so that ______ junctions can occur.
Connexins are what help in the intercellular space, so that ______ junctions can occur.
Tissues can be classified into: epithelial, connective, muscle and ______.
Tissues can be classified into: epithelial, connective, muscle and ______.
Cuboidal cells are abundant on either columnar or ______ cells and are long.
Cuboidal cells are abundant on either columnar or ______ cells and are long.
[Blank] epithelium are located in the oesophagus.
[Blank] epithelium are located in the oesophagus.
[Blank] are composed of small amounts of connective tissues.
[Blank] are composed of small amounts of connective tissues.
[Blank] are specialized regions on the cell surface.
[Blank] are specialized regions on the cell surface.
Intercellular adhesion and other junctions of epithelial tissue, contain tight occluding junctions, that help seal adjacent cells, therefore passive flow of material in cells are ______.
Intercellular adhesion and other junctions of epithelial tissue, contain tight occluding junctions, that help seal adjacent cells, therefore passive flow of material in cells are ______.
[Blank] gives structural support to the overlying epithelium, semipermeable barriers and provides interaction site for many cell adhesion molecules.
[Blank] gives structural support to the overlying epithelium, semipermeable barriers and provides interaction site for many cell adhesion molecules.
Epithelial cells are characterized according to their ______ and dimensions.
Epithelial cells are characterized according to their ______ and dimensions.
In squamous epithelial cells, the height is ______ than the width.
In squamous epithelial cells, the height is ______ than the width.
In cuboidal epithelial cells, the height is ______ to the width.
In cuboidal epithelial cells, the height is ______ to the width.
In columnar epithelial cells, the height is ______ than the width.
In columnar epithelial cells, the height is ______ than the width.
Epithelial cells exhibit distinct polarity, presenting three domains: apical, basal, and ______.
Epithelial cells exhibit distinct polarity, presenting three domains: apical, basal, and ______.
The basement membrane consists of the basal lamina and the ______ lamina.
The basement membrane consists of the basal lamina and the ______ lamina.
The reticular lamina of the basement membrane contains collagen ______ fibers.
The reticular lamina of the basement membrane contains collagen ______ fibers.
[Blank] junctions seal the space between adjacent cells and prevents passive flow of materials between the cells`.
[Blank] junctions seal the space between adjacent cells and prevents passive flow of materials between the cells`.
The enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junctions.
The enterotoxin secreted by Clostridium perfringens prevents maintenance of ______ junctions.
[Blank] junctions are characterized as sites of strong cell adhesion.
[Blank] junctions are characterized as sites of strong cell adhesion.
[Blank] junctions permit intercellular exchange of small molecules.
[Blank] junctions permit intercellular exchange of small molecules.
Finger-like cytoplasmic projections on the apical surface of epithelial tissue are known as ______.
Finger-like cytoplasmic projections on the apical surface of epithelial tissue are known as ______.
Stereocilia contain a core of ______ filaments and actin-binding proteins.
Stereocilia contain a core of ______ filaments and actin-binding proteins.
[Blank] are long and exhibit beating patterns that move materials in one direction.
[Blank] are long and exhibit beating patterns that move materials in one direction.
Covering and lining epithelia are classified according to cell shape and number of ______.
Covering and lining epithelia are classified according to cell shape and number of ______.
The term 'epithelial' is derived from 'epi,' meaning upon, and 'thele,' which translates to ______.
The term 'epithelial' is derived from 'epi,' meaning upon, and 'thele,' which translates to ______.
Epithelial tissue is ______ but innervated, meaning ti lacks blood vessels but has nerve supply.
Epithelial tissue is ______ but innervated, meaning ti lacks blood vessels but has nerve supply.
Celiac disease results in loss of ______ brush border of the absorptive cellsof small intestine, caused by immune reaction against wheat protein gluten during its digestion, causing diffuse enteritis.
Celiac disease results in loss of ______ brush border of the absorptive cellsof small intestine, caused by immune reaction against wheat protein gluten during its digestion, causing diffuse enteritis.
Flashcards
Characterize Epithelial Cells
Characterize Epithelial Cells
Shape and dimensions of the cell and its nucleus.
Squamous Epithelial Cells
Squamous Epithelial Cells
Cells with width greater than height, like floor tiles.
Cuboidal Epithelial Cells
Cuboidal Epithelial Cells
Cells with equal height and width, found in kidney tubules.
Columnar Epithelial Cells
Columnar Epithelial Cells
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Epithelial Polarity
Epithelial Polarity
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Apical Domain
Apical Domain
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Basal Domain
Basal Domain
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Lateral Domain
Lateral Domain
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Basement Membrane
Basement Membrane
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Basal Lamina
Basal Lamina
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Reticular Lamina
Reticular Lamina
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Tight/Occluding Junctions
Tight/Occluding Junctions
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Anchoring Junctions
Anchoring Junctions
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Gap Junctions
Gap Junctions
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Microvilli
Microvilli
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Microvilli Internal Structure
Microvilli Internal Structure
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Celiac Disease
Celiac Disease
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Stereocilia
Stereocilia
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Cilia
Cilia
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Tissue
Tissue
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Epithelial Tissue
Epithelial Tissue
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Cellularity
Cellularity
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Specialized Contacts
Specialized Contacts
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Polarity
Polarity
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Connective Tissue Support
Connective Tissue Support
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Covering/Lining Epithelia
Covering/Lining Epithelia
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Study Notes
- A prayer asks for light, wisdom, understanding, memory, accuracy, and clarity to guide work from start to finish.
Epithelial Tissue Overview
- This is lecture MT120225, Unit 2
- The intended learning outcome is to identify and describe epithelial tissue types.
- The course content includes epithelial cells, epithelial domains, covering or lining epithelia, secretory epithelia and glands, transport across epithelia, and renewal of epithelial cells.
Epithelial Cells
- Epithelial cells are characterized by shape and dimensions
- The nuclear shape corresponds roughly to the cell shape.
- Epithelial cell shapes can be squamous (H<W), cuboidal (H=W), or columnar (H>W).
Epithelial Polarity
- Epithelial cells exhibit distinct polarity with three domains: apical, basal, and lateral.
Epithelial Domains: Basal Surface
- The basal surface rests on the basement membrane
- The basment membrame includes the basal lamina and reticular lamina
Basal Lamina
- The basal lamina is 20-100 nm thick
- Its composed of glycoproteins, collagen, and proteoglycans
- The basal lamina is produced by epithelial cells
- Basal lamina functions include:
- Providing structural support to the overlying epithelium
- Acting as a semipermeable barrier
- Providing an interaction site for cell adhesion molecules
Reticular Lamina
- Reticular Lamina contains collagen III fibers
- Reticular Lamina is produced by fibroblasts
Epithelial Domains: Lateral Surface
- The lateral surface has intercellular adhesion and other junctions, including:
- Tight/Occluding Junctions (Zonula Occludens): These seal between adjacent cells and prevent passive flow of materials.
- Anchoring Junctions: These are sites of strong cell adhesion.
- Gap Junctions (Nexus): These consist of patches of connexons, permitting intercellular exchange of small molecules.
- Medical Application: Clostridium perfringens secretes enterotoxin, causing food poisoning by preventing tight junction maintenance and causing loss of tissue fluid into the intestinal lumen.
Epithelial Domains: Apical Surface
- Includes specializations such as microvilli, stereocilia and cilia
Apical Surface - Microvilli
- Microvilli are finger-like cytoplasmic projections specialized for absorption.
- Microvilli are 1 um long and 0.1 um wide, uniform in length
- Microvilli increase surface area by 20-30 fold.
- The internal structure of microvilli contains a core of actin filaments and actin binding proteins.
- Medical Application: Celiac disease involves the loss of microvilli brush border in the small intestine's absorptive cells, caused by an immune reaction against wheat protein gluten, leading to diffuse enteritis and malabsorption.
Apical Surface - Stereocilia
- Stereocilia are seen on absorptive epithelial cells, lining the male reproductive system as well as sensory cells of the inner ear.
- The internal structure of stereocilia contains a core of actin filaments and actin binding proteins.
- Stereocilia are longer and are often less motile than microvilli, also having distal branching.
Apical Surface - Cilia
- Cilia are long, larger than microvilli, and abundant on cuboidal or columnar cells.
- Cilia measure 5-10 um long and 0.2 um wide.
- The internal structure of cilia contains microtubules. -Cilia exhibit beating patterns that move materials in one direction.
- Primary cilium is not motile but detects light, odor, motion, and fluid flow.
Epithelial Tissues
- This is a group of similarly specialized cells working together to perform specific functions
- Epithelia covering or lining are classified according to cell layers (C_L) and cell shape (C_S).
Characteristics of Epithelial Tissue
- Cellularity: Cells are in close contact.
- Specialized contacts: Have junctions for attachment and communication.
- Polarity: Has apical, basal, and lateral surfaces. -Supported by connective tissue: Source of nutrients.
- Avascular but innervated.
- Regeneration: Has a high mitotic rate.
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