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Questions and Answers
What is the term for the phenomenon where one gene masks the effect of another gene?
What is the term for the phenomenon where one gene masks the effect of another gene?
- Linkage
- Codominance
- Incomplete dominance
- Epistasis (correct)
In Labrador retrievers, coat color is determined by epistatic interactions. What phenotypic ratio is indicative of recessive epistasis in a dihybrid cross?
In Labrador retrievers, coat color is determined by epistatic interactions. What phenotypic ratio is indicative of recessive epistasis in a dihybrid cross?
- 12:3:1
- 9:3:4 (correct)
- 15:1
- 9:3:3:1
In sweet peas, two genes (C and P) are involved in the production of purple flower color. What phenotypic ratio is indicative of complementary gene action?
In sweet peas, two genes (C and P) are involved in the production of purple flower color. What phenotypic ratio is indicative of complementary gene action?
- 9:7 (correct)
- 9:3:3:1
- 12:3:1
- 9:3:4
A plant with genotype AABB is crossed with a plant with genotype aabb. In the F2 generation, a 12:3:1 phenotypic ratio is observed. Which type of epistasis is likely occurring?
A plant with genotype AABB is crossed with a plant with genotype aabb. In the F2 generation, a 12:3:1 phenotypic ratio is observed. Which type of epistasis is likely occurring?
In mice, coat color is controlled by multiple genes. If gene 'C' controls color expression and 'cc' results in albinism, how would you describe the relationship of gene 'C' to other color genes?
In mice, coat color is controlled by multiple genes. If gene 'C' controls color expression and 'cc' results in albinism, how would you describe the relationship of gene 'C' to other color genes?
In wheat, seed shape is determined by two genes, T and V. A cross between two TtVv plants yields a 15:1 phenotypic ratio in the F2 generation. What type of gene interaction is indicated by this ratio?
In wheat, seed shape is determined by two genes, T and V. A cross between two TtVv plants yields a 15:1 phenotypic ratio in the F2 generation. What type of gene interaction is indicated by this ratio?
What is the purpose of performing a complementation test?
What is the purpose of performing a complementation test?
In the context of epistasis, what does it mean for a gene to be 'hypostatic'?
In the context of epistasis, what does it mean for a gene to be 'hypostatic'?
In summer squash, fruit color is determined by dominant epistasis, resulting in a 12:3:1 ratio. If 'A' allows color and 'B' masks color, what genotype(s) would produce white fruit?
In summer squash, fruit color is determined by dominant epistasis, resulting in a 12:3:1 ratio. If 'A' allows color and 'B' masks color, what genotype(s) would produce white fruit?
Considering a biochemical pathway where gene A produces an intermediate X, and gene B uses X to produce a final product Y. If a mutation in gene A completely blocks the production of X, what is the most likely epistatic relationship between A and B?
Considering a biochemical pathway where gene A produces an intermediate X, and gene B uses X to produce a final product Y. If a mutation in gene A completely blocks the production of X, what is the most likely epistatic relationship between A and B?
Two true-breeding mutant lines of petunias both produce white flowers instead of the wild-type purple. You cross the two lines and observe that all of the F1 progeny have purple flowers. What does this result suggest about the mutations in the two parental lines?
Two true-breeding mutant lines of petunias both produce white flowers instead of the wild-type purple. You cross the two lines and observe that all of the F1 progeny have purple flowers. What does this result suggest about the mutations in the two parental lines?
In a population of snails, albinism is observed at a higher rate than expected under Mendelian inheritance. Crossing albino snails often yields only albino offspring, but occasionally, a cross between two albino snails yields some pigmented offspring. Which genetic phenomenon is most likely responsible?
In a population of snails, albinism is observed at a higher rate than expected under Mendelian inheritance. Crossing albino snails often yields only albino offspring, but occasionally, a cross between two albino snails yields some pigmented offspring. Which genetic phenomenon is most likely responsible?
A researcher is studying flower color in a new species of plant. They cross two true-breeding lines, one with red flowers and one with white flowers. All the F1 offspring have purple flowers. When the F1 plants are self-crossed, the F2 generation shows a ratio of 9 purple: 3 red: 4 white. Which of the following genetic phenomena is likely occurring?
A researcher is studying flower color in a new species of plant. They cross two true-breeding lines, one with red flowers and one with white flowers. All the F1 offspring have purple flowers. When the F1 plants are self-crossed, the F2 generation shows a ratio of 9 purple: 3 red: 4 white. Which of the following genetic phenomena is likely occurring?
A dihybrid cross involving two genes that influence fruit shape in a certain plant species yields an unusual phenotypic ratio in the F2 generation. The ratio is 9:6:1, where 9/16 of the plants have round fruit, 6/16 have oval fruit, and 1/16 have long fruit. Assuming Mendelian inheritance at each locus, which type of gene interaction is most likely to explain this ratio?
A dihybrid cross involving two genes that influence fruit shape in a certain plant species yields an unusual phenotypic ratio in the F2 generation. The ratio is 9:6:1, where 9/16 of the plants have round fruit, 6/16 have oval fruit, and 1/16 have long fruit. Assuming Mendelian inheritance at each locus, which type of gene interaction is most likely to explain this ratio?
Imagine you are studying a novel metabolic pathway in bacteria, where gene X encodes an enzyme that converts a colorless precursor into compound A (yellow), and gene Y encodes an enzyme that converts compound A into compound B (blue). You isolate a mutant strain of the bacteria that has a non-functional gene X. If gene Y is still functional in this mutant strain, what color would you expect the bacteria to be, and what type of epistasis is occurring?
Imagine you are studying a novel metabolic pathway in bacteria, where gene X encodes an enzyme that converts a colorless precursor into compound A (yellow), and gene Y encodes an enzyme that converts compound A into compound B (blue). You isolate a mutant strain of the bacteria that has a non-functional gene X. If gene Y is still functional in this mutant strain, what color would you expect the bacteria to be, and what type of epistasis is occurring?
Flashcards
Independent Gene Action
Independent Gene Action
Genes affecting the same trait can operate independently, but this is rare.
Epistasis
Epistasis
The masking of one gene's effect by another gene.
Complementary gene action
Complementary gene action
Genes working together to produce a single phenotype.
Homozygous Recessive Epistasis
Homozygous Recessive Epistasis
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Epistatic Allele
Epistatic Allele
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Recessive Epistasis
Recessive Epistasis
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Dominant Epistasis
Dominant Epistasis
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Pathway Release
Pathway Release
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Duplicate Gene Action
Duplicate Gene Action
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Coat Color Control
Coat Color Control
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9:7 Ratio Significance
9:7 Ratio Significance
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Complementation Test
Complementation Test
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Genes in Different genes
Genes in Different genes
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Study Notes
- Genes affecting the same trait can operate independently, although this is rare.
Epistasis
- Genes interact and contribute to the same phenotype.
- Genes usually participate in the same pathway.
- It modifies Mendelian ratios and always reflects a departure from them at the phenotype level.
- Various genes interact with each other to control most phenotypes.
Complementary Gene Action
- Genes acting in tandem produce a phenotype.
- A homozygous recessive genotype at either locus produces the same phenotype.
- A 9:7 ratio is indicative of a complementary gene action relationship between two genes.
- Purple-flowered plants appear only when two independent dominant alleles are present together.
- Color only results from an interaction between them
Biochemical explanation for a 9:7 ratio
- Pigment production (anthocyanin) needs both enzymes.
- A mutant allele at the C locus will mask the allele at P
- C is epistatic to P
- The 9:7 ratio strongly suggests an epistatic relationship between genes
Recessive Epistasis
- A-bb and aabb individuals have the same phenotype.
- One locus, when recessive, affects the other gene, but not the other way around.
- The recessive genotype at one locus will mask the genotype at the A locus.
- A 9:3:4 ratio indicates a recessive epistasis relationship between two genes
Dominant Epistasis
- A dominant allele of one gene masks the effect of the genotype at another locus.
- A-B- displays the same phenotype as aaB-.
- Dominant B is epistatic to A.
- Phenotypic ratio in the offspring from a dihybrid cross is 12:3:1.
- A 12:3:1 ratio in the F2 is always indicative of a dominant epistasis relationship between two genes.
Duplicate Gene Action
- Duplicate gene action occurs when both genes perform the same function.
Other Key Points
- Most genes do not operate in isolation
- Modified dihybrid-phenotypic ratios arise due to gene interaction
Coat Color in Mice
- Coat color is controlled by at least 5 genes:
- A - distribution of pigment
- B - pigment itself (B black)
- C - expression of colour (cc - albino, epistatic to all other genes)
- D - intensity of pigment
- S - spots, controls migration of melanocytes
Identifying Genes That Control Traits
- Use model organisms and the complementation test.
- Introduce mutations in the organism of interest to identify genetic determinants.
Determining Allelism
- Use the genetic test to determine allelism among a group of mutations.
Complementation Test
- Cross the mutants with each other to determine if the wild type is recovered from the progeny.
- No: Recessive mutations represent alleles of the same gene, so they will never complement
- Yes: Recessive mutations represent alleles of different genes, so wild-type function is provided.
- The mutations are in different genes, each parent of the cross provides what the other one lacks.
- Complementation is the regeneration of the wild type phenotype.
- The number of complementation groups is equal to the number of genes that have been mutated.
Key Concepts
- Most traits are controlled by a number of genes that interact with each other (epistasis).
- Genes that control a trait can be identified by mutating a model organism.
- Gene interaction leads to a departure from Mendelian ratios (at the phenotypic level).
- The number of genes mutated can be determined by the complementation test.
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