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Questions and Answers
What was the primary purpose of surgical procedures in the treatment of epilepsy in the last century?
What was the primary purpose of surgical procedures in the treatment of epilepsy in the last century?
What is the primary mechanism by which the ketogenic diet is believed to control seizures?
What is the primary mechanism by which the ketogenic diet is believed to control seizures?
Who first reported that fasting could cure epilepsy in humans?
Who first reported that fasting could cure epilepsy in humans?
In what year did Rollin Woodyatt and Dr. Stanley Cobb first use the ketogenic diet to treat epilepsy?
In what year did Rollin Woodyatt and Dr. Stanley Cobb first use the ketogenic diet to treat epilepsy?
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What type of patients are currently considered candidates for the ketogenic diet?
What type of patients are currently considered candidates for the ketogenic diet?
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What is the primary advantage of the ketogenic diet over surgical procedures for epilepsy treatment?
What is the primary advantage of the ketogenic diet over surgical procedures for epilepsy treatment?
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Study Notes
History of Epilepsy Treatment
- In the last century, surgical procedures involved removing the cerebral hemisphere where seizures were generated, but this method was not effective in controlling seizures.
- The ketogenic diet was once eliminated from treatment options, but it has been reconsidered as a potential solution.
Ketogenic Diet Hypothesis
- The hypothesis is that epilepsy is a metabolic alteration that can be treated with a ketogenic diet, which induces a state of ketosis.
- This diet is suitable for patients who are candidates for surgery and those with pharmacorefractory etiologies of any type.
Suitable Candidates
- Patients with congenital etiologies such as Angelman syndrome may benefit from the ketogenic diet.
- Those with symptomatic, cryptogenic, or tumor syndrome Tofico and Ohtahara etiologies can also benefit.
- The diet can be used for patients of any age.
History of the Ketogenic Diet
- Hippocrates reported in 400 BC that fasting could cure epilepsy in humans.
- The modern use of the ketogenic diet as a treatment for epilepsy began in 1921 with the work of Rollin Woodyatt and Dr. Stanley Cobb from Harvard Medical School.
- They found that glycolysis and beta-hydroxybutyrate were responsible for eliminating seizures in patients.
Development of the Ketogenic Diet
- The ketogenic diet has become part of several treatments for epilepsy in both medical and surgical fields.
- Despite early reports, it was not until the 20th century that the diet became a widely accepted treatment option.
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Description
This quiz covers the historical treatment of epilepsy, including surgical procedures and the ketogenic diet. It also touches on the idea that epilepsy may be a metabolic alteration.
