Podcast
Questions and Answers
Which of the following is a characteristic of a clonic seizure?
Which of the following is a characteristic of a clonic seizure?
What does 'atonic' refer to in the context of epilepsy?
What does 'atonic' refer to in the context of epilepsy?
What is the most common type of seizure that does NOT involve muscle movement?
What is the most common type of seizure that does NOT involve muscle movement?
Which type of seizure is characterized by a brief, involuntary twitching of a muscle or group of muscles?
Which type of seizure is characterized by a brief, involuntary twitching of a muscle or group of muscles?
Signup and view all the answers
Which of the following is NOT a classification criterion used to categorize seizures?
Which of the following is NOT a classification criterion used to categorize seizures?
Signup and view all the answers
What are common non-motor symptoms of epilepsy?
What are common non-motor symptoms of epilepsy?
Signup and view all the answers
Which of the following is a potential risk factor for developing epilepsy?
Which of the following is a potential risk factor for developing epilepsy?
Signup and view all the answers
Which of the following non-pharmacological treatments is recommended for managing epilepsy?
Which of the following non-pharmacological treatments is recommended for managing epilepsy?
Signup and view all the answers
What is the main characteristic of Childhood Absence Epilepsy?
What is the main characteristic of Childhood Absence Epilepsy?
Signup and view all the answers
What is the primary theory behind the pathophysiology of epilepsy?
What is the primary theory behind the pathophysiology of epilepsy?
Signup and view all the answers
What is the difference between a seizure and epilepsy?
What is the difference between a seizure and epilepsy?
Signup and view all the answers
Which of the following is NOT a characteristic of Lennox-Gastaut Syndrome?
Which of the following is NOT a characteristic of Lennox-Gastaut Syndrome?
Signup and view all the answers
What is the role of GABA in the pathophysiology of epilepsy?
What is the role of GABA in the pathophysiology of epilepsy?
Signup and view all the answers
What is a key characteristic of Juvenile Myoclonic Epilepsy?
What is a key characteristic of Juvenile Myoclonic Epilepsy?
Signup and view all the answers
What is the meaning of the term 'epilepsy syndrome'?
What is the meaning of the term 'epilepsy syndrome'?
Signup and view all the answers
Which of these is NOT a common symptom of epilepsy?
Which of these is NOT a common symptom of epilepsy?
Signup and view all the answers
What are the two main classifications of epileptic seizures, based on the level of awareness?
What are the two main classifications of epileptic seizures, based on the level of awareness?
Signup and view all the answers
Which of the following is NOT considered a risk factor for epilepsy in children?
Which of the following is NOT considered a risk factor for epilepsy in children?
Signup and view all the answers
What is the most common non-pharmacological treatment for epilepsy?
What is the most common non-pharmacological treatment for epilepsy?
Signup and view all the answers
Which of the following is NOT a common complication of epilepsy?
Which of the following is NOT a common complication of epilepsy?
Signup and view all the answers
What is the gold standard diagnostic tool for epilepsy?
What is the gold standard diagnostic tool for epilepsy?
Signup and view all the answers
What is the recommended course of action if a person experiences a seizure for the first time?
What is the recommended course of action if a person experiences a seizure for the first time?
Signup and view all the answers
What is the recommended lifestyle advice for people with epilepsy?
What is the recommended lifestyle advice for people with epilepsy?
Signup and view all the answers
Which of the following is a common side effect associated with antiepileptic drugs?
Which of the following is a common side effect associated with antiepileptic drugs?
Signup and view all the answers
Which of the following antiepileptic drugs is associated with the side effect of gingival hyperplasia?
Which of the following antiepileptic drugs is associated with the side effect of gingival hyperplasia?
Signup and view all the answers
Which of the following antiepileptic drugs is NOT typically used for acute treatment of epilepsy?
Which of the following antiepileptic drugs is NOT typically used for acute treatment of epilepsy?
Signup and view all the answers
Which of the following antiepileptic drugs is known to have a potential for tolerance and dependence?
Which of the following antiepileptic drugs is known to have a potential for tolerance and dependence?
Signup and view all the answers
Which of the following is a potential side effect associated with the antiepileptic drug carbamazepine?
Which of the following is a potential side effect associated with the antiepileptic drug carbamazepine?
Signup and view all the answers
Which of the following is a TRUE statement regarding antiepileptic drugs (AEDs)?
Which of the following is a TRUE statement regarding antiepileptic drugs (AEDs)?
Signup and view all the answers
Which of the following anti-epileptic drugs works by inhibiting the reuptake of GABA?
Which of the following anti-epileptic drugs works by inhibiting the reuptake of GABA?
Signup and view all the answers
What is the mechanism of action of Levetiracetam?
What is the mechanism of action of Levetiracetam?
Signup and view all the answers
Which of the following is NOT a characteristic of generalized tonic-clonic seizures?
Which of the following is NOT a characteristic of generalized tonic-clonic seizures?
Signup and view all the answers
What is the primary role of benzodiazepines in the management of epilepsy?
What is the primary role of benzodiazepines in the management of epilepsy?
Signup and view all the answers
Which of the following is a common side effect associated with both Carbamazepine and Phenytoin?
Which of the following is a common side effect associated with both Carbamazepine and Phenytoin?
Signup and view all the answers
Which of the following is an example of an antiepileptic drug that acts as a calcium channel blocker?
Which of the following is an example of an antiepileptic drug that acts as a calcium channel blocker?
Signup and view all the answers
What is the main difference between a focal seizure with awareness and a focal seizure without awareness?
What is the main difference between a focal seizure with awareness and a focal seizure without awareness?
Signup and view all the answers
Which of the following lifestyle modifications is NOT generally recommended for people with epilepsy?
Which of the following lifestyle modifications is NOT generally recommended for people with epilepsy?
Signup and view all the answers
Which drug(s) should be avoided during pregnancy due to their teratogenic effects?
Which drug(s) should be avoided during pregnancy due to their teratogenic effects?
Signup and view all the answers
When is it generally recommended to gradually withdraw AEDs?
When is it generally recommended to gradually withdraw AEDs?
Signup and view all the answers
Which drug interactions should be considered when prescribing AEDs?
Which drug interactions should be considered when prescribing AEDs?
Signup and view all the answers
What is a recommended approach if an AED is not effectively controlling seizures?
What is a recommended approach if an AED is not effectively controlling seizures?
Signup and view all the answers
Which of the following is NOT considered a potential reason for an AED to become ineffective?
Which of the following is NOT considered a potential reason for an AED to become ineffective?
Signup and view all the answers
What is the recommended approach when changing an AED regimen?
What is the recommended approach when changing an AED regimen?
Signup and view all the answers
Which of the following is NOT a reason for adding or changing an AED regimen?
Which of the following is NOT a reason for adding or changing an AED regimen?
Signup and view all the answers
Which of the following AEDs is considered safer to use during pregnancy?
Which of the following AEDs is considered safer to use during pregnancy?
Signup and view all the answers
Flashcards
Epilepsy
Epilepsy
A brain disorder characterized by two or more unprovoked seizures.
Seizure
Seizure
A sudden, uncontrolled electrical disturbance in the brain.
Pathophysiology of epilepsy
Pathophysiology of epilepsy
The abnormal electrical activity due to neurotransmitter imbalances.
Epilepsy syndrome
Epilepsy syndrome
Signup and view all the flashcards
Childhood Absence Epilepsy
Childhood Absence Epilepsy
Signup and view all the flashcards
Lennox-Gastaut Syndrome
Lennox-Gastaut Syndrome
Signup and view all the flashcards
Juvenile Myoclonic Epilepsy
Juvenile Myoclonic Epilepsy
Signup and view all the flashcards
Risk factors for epilepsy
Risk factors for epilepsy
Signup and view all the flashcards
Classification of seizures
Classification of seizures
Signup and view all the flashcards
Motor symptoms of epilepsy
Motor symptoms of epilepsy
Signup and view all the flashcards
Non-motor symptoms of epilepsy
Non-motor symptoms of epilepsy
Signup and view all the flashcards
Diagnosis of epilepsy
Diagnosis of epilepsy
Signup and view all the flashcards
Non-pharmacological treatments for epilepsy
Non-pharmacological treatments for epilepsy
Signup and view all the flashcards
Antiepileptic drugs
Antiepileptic drugs
Signup and view all the flashcards
Side effects of antiepileptic drugs
Side effects of antiepileptic drugs
Signup and view all the flashcards
Antiepileptic Drugs (AEDs)
Antiepileptic Drugs (AEDs)
Signup and view all the flashcards
Common Side Effects of AEDs
Common Side Effects of AEDs
Signup and view all the flashcards
Phenytoin Side Effects
Phenytoin Side Effects
Signup and view all the flashcards
Carbamazepine Side Effects
Carbamazepine Side Effects
Signup and view all the flashcards
Antiepileptic Hypersensitivity Syndrome
Antiepileptic Hypersensitivity Syndrome
Signup and view all the flashcards
Classification of epilepsy
Classification of epilepsy
Signup and view all the flashcards
GABA openers in epilepsy treatment
GABA openers in epilepsy treatment
Signup and view all the flashcards
Calcium channel blockers
Calcium channel blockers
Signup and view all the flashcards
Lifestyle changes for epilepsy
Lifestyle changes for epilepsy
Signup and view all the flashcards
Cross-sensitivity in AEDs
Cross-sensitivity in AEDs
Signup and view all the flashcards
Starting AED treatment
Starting AED treatment
Signup and view all the flashcards
Stopping AED treatment
Stopping AED treatment
Signup and view all the flashcards
Enzyme inducers in AEDs
Enzyme inducers in AEDs
Signup and view all the flashcards
Teratogenic effects of Valproate
Teratogenic effects of Valproate
Signup and view all the flashcards
Folate supplementation during pregnancy
Folate supplementation during pregnancy
Signup and view all the flashcards
Changing AEDs due to ineffectiveness
Changing AEDs due to ineffectiveness
Signup and view all the flashcards
Reasons AED may not work
Reasons AED may not work
Signup and view all the flashcards
Epilepsy Definition
Epilepsy Definition
Signup and view all the flashcards
Risk Factors in Children
Risk Factors in Children
Signup and view all the flashcards
Diagnosis Methods
Diagnosis Methods
Signup and view all the flashcards
Complications of Epilepsy
Complications of Epilepsy
Signup and view all the flashcards
Non-Pharmacological Treatments
Non-Pharmacological Treatments
Signup and view all the flashcards
Lifestyle Advice
Lifestyle Advice
Signup and view all the flashcards
Status Epilepticus
Status Epilepticus
Signup and view all the flashcards
Genetic Link to Epilepsy
Genetic Link to Epilepsy
Signup and view all the flashcards
Study Notes
Epilepsy Objectives
- Students should understand the definition and pathophysiology of epilepsy.
- Students should be able to determine the classification of epilepsy based on onset, level of awareness, and movement involvement.
- Students should identify motor and non-motor symptoms of epilepsy.
- Students should understand the risk factors, diagnosis, and complications of epilepsy.
- Students should determine non-pharmacological treatment and lifestyle advice for epilepsy.
- Students should differentiate the drugs used for epilepsy and understand their mechanisms of action.
- Students should list examples, side effects, generic, and trade names of antiepileptic drugs.
- Students should be able to relate general information regarding antiepileptic drugs.
Epilepsy Definition
- A seizure is a single occurrence of sudden and uncontrolled electrical disturbance in the brain.
- Epilepsy is a brain disorder characterized by two or more unprovoked seizures.
- Epilepsy syndrome is a specific set of clinical features defining a unique type of epilepsy.
- Childhood Absence Epilepsy: Characterized by frequent absence seizures in children, typically with a good prognosis.
- Lennox-Gastaut Syndrome: A severe form of epilepsy includes multiple types of seizures and often has a poor prognosis.
- Juvenile Myoclonic Epilepsy: Features myoclonic jerks, typically in the morning, with a strong genetic component.
Epilepsy Pathophysiology
- Epilepsy is caused by excessive electrical activity due to an imbalance of excitatory (e.g., glutamate) and inhibitory (e.g., GABA) neurotransmitters.
- Focal seizures originate in one part of the brain, while generalized seizures affect both brain hemispheres.
- EEG (electroencephalogram) can show abnormal electrical patterns during seizures.
Epilepsy Risk Factors
- Injury to the brain (bleeding, swelling, tumors, infections like meningitis).
- Children: small size at birth, seizures during the first month of life, brain structural problems, seizures due to high fever.
- Genetics: a family history of epilepsy increases risk (1 in 3 people with epilepsy have a family member with epilepsy).
Epilepsy Diagnosis
- At least two unprovoked seizures occurring more than 24 hours apart.
- Neurologist assessment, including EEG and CT/MRI scans.
Epilepsy Complications
- Difficulty with learning, breathing (aspiration), pneumonia, falls, driving/operating machinery during a seizure, injuries, and mood problems.
Epilepsy Classification of Seizures
- Seizures are classified based on:
- Onset location in the brain
- Level of awareness
- Presence and type of movements.
Motor Symptoms of Epilepsy
- Myoclonus: Muscle twitching
- Clonic: Muscle jerking
- Tonic: Muscle rigidity
- Atonic: Weak muscle paralysis.
Non-Motor Symptoms of Epilepsy
- Absence: Blanking (or staring) during a seizure.
Epilepsy Non-Pharmacological Treatment and Lifestyle Advice
- Avoid swimming or dangerous activities alone.
- Address potential individual triggers (stress, lack of sleep).
- Keep a seizure diary.
- Don't stop taking or change medications.
- Know when to call 911.
- Follow-up with physicians for proper management.
Epilepsy Classification of AEDs
- Category 1: phenytoin, carbamazepine, phenobarbital, primidone
- Category 2: valproate, lamotrigine, perampanel, rufinamide, clobazam, clonazepam, oxcarbazepine, eslicarbazepine, zonisamide, topiramate
- Category 3: levetiracetam, lacosamide, tiagabine, gabapentin, pregabalin, ethosuximide, vigabatrin, brivaracetam
Epilepsy: AED Treatment General Information
- Not a cure, aim to stop seizures.
- Factors to consider: seizure types, concomitant medications, comorbidity, age, sex.
- Some AEDs are used for neuropathic pain (e.g., gabapentin, pregabalin).
- AEDs should be taken at regular times to avoid triggering seizures.
- Antiepileptic Hypersensitivity Syndrome (AHS) can occur with fever, rash, and multiorgan involvement.
- Unknown mechanism, often cross-sensitivity among certain AED classes.
Epilepsy: AED Treatment General Information - Special Considerations
- When to start: Begin with a low dose, gradually increasing based on response.
- When to stop: Withdraw AEDs gradually over several years when seizure-free for at least 2 years.
- Drug interactions: Enzyme inducers or inhibitors can modify AED effectiveness (e.g., enzyme inducers decrease the effectiveness of oral contraceptives, requiring an adjustment).
Epilepsy: AED Treatment Special Considerations - Pregnancy and Breastfeeding
- Valproate is teratogenic and should be avoided in pregnancy.
- If seizures are not threatening during pregnancy, consider withdrawal of the AED.
- Folate supplementation and vitamin K injections may be crucial for newborn infants.
- AEDs like carbamazepine, oxcarbazepine, and lamotrigine are generally safer in pregnancy.
- Some AEDs can be used during breastfeeding if monotherapy is used or closed monitoring is ensured.
Epilepsy: AED Treatment Other General Information – Important Points
- Add or change medications if seizures continue, patient experiencing unacceptable side effects, or the initial regimen does not work.
- Slowly withdraw the first drug when adding or changing an AED—ensure sufficient medication remains in the body to control seizure frequency.
- Maintaining consistent administration from the same manufacturer helps avoid confusion, but consult with physicians and carers.
Epilepsy: AEDs and other information - When AEDs stop working
- Person may not be consistently taking the medication.
- Epilepsy itself may have changed.
- Cause of epilepsy may have changed.
- The person's body may have adapted to the AED and it is no longer effective.
Epilepsy: Recommended AEDs according to seizure type
- Provides a table of epilepsy types and the recommended AED based on treatment options, including ones suitable for treatment resistance.
Epilepsy: Examples of Brand and Generic Names of AEDs
- Includes examples of commonly used brand and generic names of antiepileptic drugs.
Epilepsy: Side Effects of AEDs
- Common side effects (e.g., nausea, abdominal pain, dizziness, mood swings).
- Specific side effects based on certain AEDs (e.g., gingival hyperplasia with carbamazepine).
- Long-term use can cause thinner/brittle bones, tolerance, dependence, or respiratory depression.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your knowledge on various types of seizures and their characteristics in this quiz focused on epilepsy. Explore non-motor symptoms, risk factors, and treatment options related to epilepsy. Perfect for students or anyone interested in understanding epilepsy better.