Epilepsy and Seizure Types Quiz
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Questions and Answers

Which of the following is a characteristic of a clonic seizure?

  • Muscle twitching
  • Muscle rigidity
  • Loss of consciousness
  • Muscle jerking (correct)
  • What does 'atonic' refer to in the context of epilepsy?

  • Sudden, brief loss of muscle tone (correct)
  • Repetitive, rhythmic muscle contractions
  • Involuntary repetitive movements
  • Sustained muscle contraction
  • What is the most common type of seizure that does NOT involve muscle movement?

  • Absence (correct)
  • Tonic
  • Clonic
  • Myoclonic
  • Which type of seizure is characterized by a brief, involuntary twitching of a muscle or group of muscles?

    <p>Myoclonic (D)</p> Signup and view all the answers

    Which of the following is NOT a classification criterion used to categorize seizures?

    <p>Duration of the seizure (D)</p> Signup and view all the answers

    What are common non-motor symptoms of epilepsy?

    <p>Anxiety, fear, and emotional changes (C)</p> Signup and view all the answers

    Which of the following is a potential risk factor for developing epilepsy?

    <p>Family history of epilepsy (B)</p> Signup and view all the answers

    Which of the following non-pharmacological treatments is recommended for managing epilepsy?

    <p>Regular exercise (D)</p> Signup and view all the answers

    What is the main characteristic of Childhood Absence Epilepsy?

    <p>Frequent absence seizures in children, typically with a good prognosis (A)</p> Signup and view all the answers

    What is the primary theory behind the pathophysiology of epilepsy?

    <p>Excessive electrical activity due to an imbalance of excitatory and inhibitory neurotransmitters (C)</p> Signup and view all the answers

    What is the difference between a seizure and epilepsy?

    <p>Epilepsy is a brain disorder, while a seizure is a symptom of this disorder. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Lennox-Gastaut Syndrome?

    <p>Frequent absence seizures in children (C)</p> Signup and view all the answers

    What is the role of GABA in the pathophysiology of epilepsy?

    <p>GABA is an inhibitory neurotransmitter that helps regulate electrical activity in the brain, reducing the likelihood of seizures. (B)</p> Signup and view all the answers

    What is a key characteristic of Juvenile Myoclonic Epilepsy?

    <p>Myoclonic jerks, typically in the morning, with a strong genetic component (D)</p> Signup and view all the answers

    What is the meaning of the term 'epilepsy syndrome'?

    <p>A specific set of clinical features that define a unique type of epilepsy (C)</p> Signup and view all the answers

    Which of these is NOT a common symptom of epilepsy?

    <p>Sudden increase in body temperature (A)</p> Signup and view all the answers

    What are the two main classifications of epileptic seizures, based on the level of awareness?

    <p>Focal and Generalized (B)</p> Signup and view all the answers

    Which of the following is NOT considered a risk factor for epilepsy in children?

    <p>High fever (A)</p> Signup and view all the answers

    What is the most common non-pharmacological treatment for epilepsy?

    <p>Vagus nerve stimulator (A)</p> Signup and view all the answers

    Which of the following is NOT a common complication of epilepsy?

    <p>High blood pressure (A)</p> Signup and view all the answers

    What is the gold standard diagnostic tool for epilepsy?

    <p>EEG (B)</p> Signup and view all the answers

    What is the recommended course of action if a person experiences a seizure for the first time?

    <p>Call the emergency services immediately (C)</p> Signup and view all the answers

    What is the recommended lifestyle advice for people with epilepsy?

    <p>Keep a diary of seizures and triggers, and avoid those triggers (A)</p> Signup and view all the answers

    Which of the following is a common side effect associated with antiepileptic drugs?

    <p>Drowsiness and fatigue (B)</p> Signup and view all the answers

    Which of the following antiepileptic drugs is associated with the side effect of gingival hyperplasia?

    <p>Phenytoin (B)</p> Signup and view all the answers

    Which of the following antiepileptic drugs is NOT typically used for acute treatment of epilepsy?

    <p>Phenytoin (C)</p> Signup and view all the answers

    Which of the following antiepileptic drugs is known to have a potential for tolerance and dependence?

    <p>Phenobarbital (A)</p> Signup and view all the answers

    Which of the following is a potential side effect associated with the antiepileptic drug carbamazepine?

    <p>Diplopia (B)</p> Signup and view all the answers

    Which of the following is a TRUE statement regarding antiepileptic drugs (AEDs)?

    <p>Missing AED doses can trigger seizures. (B)</p> Signup and view all the answers

    Which of the following anti-epileptic drugs works by inhibiting the reuptake of GABA?

    <p>Tiagabine (B)</p> Signup and view all the answers

    What is the mechanism of action of Levetiracetam?

    <p>Inhibition of synaptic vesicle protein 2A (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of generalized tonic-clonic seizures?

    <p>Amnesia for the event (B)</p> Signup and view all the answers

    What is the primary role of benzodiazepines in the management of epilepsy?

    <p>Treatment of status epilepticus (C)</p> Signup and view all the answers

    Which of the following is a common side effect associated with both Carbamazepine and Phenytoin?

    <p>Skin rash (B)</p> Signup and view all the answers

    Which of the following is an example of an antiepileptic drug that acts as a calcium channel blocker?

    <p>Zonisamide (D)</p> Signup and view all the answers

    What is the main difference between a focal seizure with awareness and a focal seizure without awareness?

    <p>The presence or absence of memory loss during the seizure (C)</p> Signup and view all the answers

    Which of the following lifestyle modifications is NOT generally recommended for people with epilepsy?

    <p>Taking herbal supplements to control seizures (B)</p> Signup and view all the answers

    Which drug(s) should be avoided during pregnancy due to their teratogenic effects?

    <p>Valproate (D)</p> Signup and view all the answers

    When is it generally recommended to gradually withdraw AEDs?

    <p>After two years of seizure-free periods (B)</p> Signup and view all the answers

    Which drug interactions should be considered when prescribing AEDs?

    <p>Enzyme Inducers and Enzyme Inhibitors (D)</p> Signup and view all the answers

    What is a recommended approach if an AED is not effectively controlling seizures?

    <p>Consider adding another AED to the regimen (C)</p> Signup and view all the answers

    Which of the following is NOT considered a potential reason for an AED to become ineffective?

    <p>The patient has developed an allergy to the AED (C)</p> Signup and view all the answers

    What is the recommended approach when changing an AED regimen?

    <p>Gradually withdraw the old AED once the new regimen is established (B)</p> Signup and view all the answers

    Which of the following is NOT a reason for adding or changing an AED regimen?

    <p>The patient reports significant improvement in seizure frequency (B)</p> Signup and view all the answers

    Which of the following AEDs is considered safer to use during pregnancy?

    <p>Carbamazepine (C)</p> Signup and view all the answers

    Flashcards

    Epilepsy

    A brain disorder characterized by two or more unprovoked seizures.

    Seizure

    A sudden, uncontrolled electrical disturbance in the brain.

    Pathophysiology of epilepsy

    The abnormal electrical activity due to neurotransmitter imbalances.

    Epilepsy syndrome

    A specific set of clinical features defining a unique type of epilepsy.

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    Childhood Absence Epilepsy

    Characterized by frequent absence seizures in children with a good prognosis.

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    Lennox-Gastaut Syndrome

    A severe form of epilepsy with multiple seizure types and poor prognosis.

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    Juvenile Myoclonic Epilepsy

    Features myoclonic jerks typically in the morning with genetic links.

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    Risk factors for epilepsy

    Variables that increase the likelihood of developing epilepsy.

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    Classification of seizures

    Seizures are classified by onset, awareness level, and movement involvement.

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    Motor symptoms of epilepsy

    Physical symptoms include myoclonus, clonic, tonic, and atonic movements.

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    Non-motor symptoms of epilepsy

    Symptoms that do not involve physical movements, such as absence seizures.

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    Diagnosis of epilepsy

    Diagnosis often includes EEGs and medical imaging to identify seizure types.

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    Non-pharmacological treatments for epilepsy

    Includes lifestyle changes, diet (like ketogenic), and therapy.

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    Antiepileptic drugs

    Medications that help control seizures by affecting neurotransmitters or channels.

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    Side effects of antiepileptic drugs

    Common side effects include dizziness, fatigue, and mood changes.

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    Antiepileptic Drugs (AEDs)

    Medications used to prevent seizures in epilepsy.

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    Common Side Effects of AEDs

    Nausea, dizziness, sleepiness, irritability, mood changes.

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    Phenytoin Side Effects

    Includes hirsutism, gingival hyperplasia, and cleft palate risk.

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    Carbamazepine Side Effects

    Diplopia, bruising, jaundice, and bone thinning risk.

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    Antiepileptic Hypersensitivity Syndrome

    May cause fever, rash, and multiorgan abnormalities.

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    Classification of epilepsy

    Categorization based on seizure onset, awareness, and movement involvement.

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    GABA openers in epilepsy treatment

    Drugs that increase GABA activity to help control seizures and prevent excitatory signals.

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    Calcium channel blockers

    Drugs that inhibit calcium channels to decrease calcium influx, thereby reducing seizure activity.

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    Lifestyle changes for epilepsy

    Non-pharmacological approaches that include stress management, healthy sleep, and avoiding triggers.

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    Cross-sensitivity in AEDs

    The potential for a patient to react to multiple antiepileptic drugs like phenytoin and carbamazepine due to a shared mechanism.

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    Starting AED treatment

    Once diagnosed with epilepsy, begin the medication at a low dose, adjusting upwards based on response, which can take weeks or months to reach the maintenance dose.

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    Stopping AED treatment

    Gradually withdraw antiepileptic drugs after at least 2 years seizure-free, doing this one drug at a time.

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    Enzyme inducers in AEDs

    Drugs like phenytoin and carbamazepine that speed up enzyme activity, potentially reducing effectiveness of other contraceptives.

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    Teratogenic effects of Valproate

    Valproate increases the risk of neural tube defects in fetuses by disrupting folate metabolism during pregnancy.

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    Folate supplementation during pregnancy

    Essential when taking antiepileptic drugs during pregnancy to minimize risk of neural tube defects and bleeding in newborns.

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    Changing AEDs due to ineffectiveness

    If seizures persist, switch or add a new antiepileptic drug and withdraw the old one carefully.

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    Reasons AED may not work

    AED may fail due to irregular intake, changes in epilepsy condition, or desensitization to the medication.

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    Epilepsy Definition

    A neurological disorder marked by recurrent unprovoked seizures.

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    Risk Factors in Children

    Include small size at birth, seizures in the first month, and brain structure problems.

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    Diagnosis Methods

    Diagnosis is conducted through assessments like EEG and CT/MRI scans.

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    Complications of Epilepsy

    Can include learning difficulties, injury from accidents, and mood problems.

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    Non-Pharmacological Treatments

    Includes surgery to remove seizure-causing areas or implanting a vagus nerve stimulator.

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    Lifestyle Advice

    Avoid triggers, keep a seizure diary, and manage medications properly.

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    Status Epilepticus

    A medical emergency when seizures last over 5 minutes or multiple seizures occur without regaining consciousness.

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    Genetic Link to Epilepsy

    1 in 3 people with epilepsy have a family history of the condition.

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    Study Notes

    Epilepsy Objectives

    • Students should understand the definition and pathophysiology of epilepsy.
    • Students should be able to determine the classification of epilepsy based on onset, level of awareness, and movement involvement.
    • Students should identify motor and non-motor symptoms of epilepsy.
    • Students should understand the risk factors, diagnosis, and complications of epilepsy.
    • Students should determine non-pharmacological treatment and lifestyle advice for epilepsy.
    • Students should differentiate the drugs used for epilepsy and understand their mechanisms of action.
    • Students should list examples, side effects, generic, and trade names of antiepileptic drugs.
    • Students should be able to relate general information regarding antiepileptic drugs.

    Epilepsy Definition

    • A seizure is a single occurrence of sudden and uncontrolled electrical disturbance in the brain.
    • Epilepsy is a brain disorder characterized by two or more unprovoked seizures.
    • Epilepsy syndrome is a specific set of clinical features defining a unique type of epilepsy.
      • Childhood Absence Epilepsy: Characterized by frequent absence seizures in children, typically with a good prognosis.
      • Lennox-Gastaut Syndrome: A severe form of epilepsy includes multiple types of seizures and often has a poor prognosis.
      • Juvenile Myoclonic Epilepsy: Features myoclonic jerks, typically in the morning, with a strong genetic component.

    Epilepsy Pathophysiology

    • Epilepsy is caused by excessive electrical activity due to an imbalance of excitatory (e.g., glutamate) and inhibitory (e.g., GABA) neurotransmitters.
    • Focal seizures originate in one part of the brain, while generalized seizures affect both brain hemispheres.
    • EEG (electroencephalogram) can show abnormal electrical patterns during seizures.

    Epilepsy Risk Factors

    • Injury to the brain (bleeding, swelling, tumors, infections like meningitis).
    • Children: small size at birth, seizures during the first month of life, brain structural problems, seizures due to high fever.
    • Genetics: a family history of epilepsy increases risk (1 in 3 people with epilepsy have a family member with epilepsy).

    Epilepsy Diagnosis

    • At least two unprovoked seizures occurring more than 24 hours apart.
    • Neurologist assessment, including EEG and CT/MRI scans.

    Epilepsy Complications

    • Difficulty with learning, breathing (aspiration), pneumonia, falls, driving/operating machinery during a seizure, injuries, and mood problems.

    Epilepsy Classification of Seizures

    • Seizures are classified based on:
      • Onset location in the brain
      • Level of awareness
      • Presence and type of movements.

    Motor Symptoms of Epilepsy

    • Myoclonus: Muscle twitching
    • Clonic: Muscle jerking
    • Tonic: Muscle rigidity
    • Atonic: Weak muscle paralysis.

    Non-Motor Symptoms of Epilepsy

    • Absence: Blanking (or staring) during a seizure.

    Epilepsy Non-Pharmacological Treatment and Lifestyle Advice

    • Avoid swimming or dangerous activities alone.
    • Address potential individual triggers (stress, lack of sleep).
    • Keep a seizure diary.
    • Don't stop taking or change medications.
    • Know when to call 911.
    • Follow-up with physicians for proper management.

    Epilepsy Classification of AEDs

    • Category 1: phenytoin, carbamazepine, phenobarbital, primidone
    • Category 2: valproate, lamotrigine, perampanel, rufinamide, clobazam, clonazepam, oxcarbazepine, eslicarbazepine, zonisamide, topiramate
    • Category 3: levetiracetam, lacosamide, tiagabine, gabapentin, pregabalin, ethosuximide, vigabatrin, brivaracetam

    Epilepsy: AED Treatment General Information

    • Not a cure, aim to stop seizures.
    • Factors to consider: seizure types, concomitant medications, comorbidity, age, sex.
    • Some AEDs are used for neuropathic pain (e.g., gabapentin, pregabalin).
    • AEDs should be taken at regular times to avoid triggering seizures.
    • Antiepileptic Hypersensitivity Syndrome (AHS) can occur with fever, rash, and multiorgan involvement.
    • Unknown mechanism, often cross-sensitivity among certain AED classes.

    Epilepsy: AED Treatment General Information - Special Considerations

    • When to start: Begin with a low dose, gradually increasing based on response.
    • When to stop: Withdraw AEDs gradually over several years when seizure-free for at least 2 years.
    • Drug interactions: Enzyme inducers or inhibitors can modify AED effectiveness (e.g., enzyme inducers decrease the effectiveness of oral contraceptives, requiring an adjustment).

    Epilepsy: AED Treatment Special Considerations - Pregnancy and Breastfeeding

    • Valproate is teratogenic and should be avoided in pregnancy.
    • If seizures are not threatening during pregnancy, consider withdrawal of the AED.
    • Folate supplementation and vitamin K injections may be crucial for newborn infants.
    • AEDs like carbamazepine, oxcarbazepine, and lamotrigine are generally safer in pregnancy.
    • Some AEDs can be used during breastfeeding if monotherapy is used or closed monitoring is ensured.

    Epilepsy: AED Treatment Other General Information – Important Points

    • Add or change medications if seizures continue, patient experiencing unacceptable side effects, or the initial regimen does not work.
    • Slowly withdraw the first drug when adding or changing an AED—ensure sufficient medication remains in the body to control seizure frequency.
    • Maintaining consistent administration from the same manufacturer helps avoid confusion, but consult with physicians and carers.

    Epilepsy: AEDs and other information - When AEDs stop working

    • Person may not be consistently taking the medication.
    • Epilepsy itself may have changed.
    • Cause of epilepsy may have changed.
    • The person's body may have adapted to the AED and it is no longer effective.
    • Provides a table of epilepsy types and the recommended AED based on treatment options, including ones suitable for treatment resistance.

    Epilepsy: Examples of Brand and Generic Names of AEDs

    • Includes examples of commonly used brand and generic names of antiepileptic drugs.

    Epilepsy: Side Effects of AEDs

    • Common side effects (e.g., nausea, abdominal pain, dizziness, mood swings).
    • Specific side effects based on certain AEDs (e.g., gingival hyperplasia with carbamazepine).
    • Long-term use can cause thinner/brittle bones, tolerance, dependence, or respiratory depression.

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    L9 Epilepsy Lecture Notes PDF

    Description

    Test your knowledge on various types of seizures and their characteristics in this quiz focused on epilepsy. Explore non-motor symptoms, risk factors, and treatment options related to epilepsy. Perfect for students or anyone interested in understanding epilepsy better.

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