12 Questions
What is epigenetics defined as?
A heritable change in gene expression not related to nucleotide sequence variation
How are CPG islands defined?
Nucleotide sequences rich in cytosines and guanines, usually located in the promotor regions upstream of genes
What is the biochemical basis of epigenetics related to?
Readability of genes based on chromatin structure and chemical modifications of histones
What leads to gene 'switched off' state?
Methylated cytosines and deacetylated histones
In X chromosome inactivation, which of the following is true?
Subsequent DNA methylation is what makes X-inactivation permanent in all daughter cells
Which statement about imprinting is true?
Imprinted genes are shut down in a parent-of-origin specific manner
Regarding X-inactivation, which is NOT true?
X-inactivation occurs in all cell types
What is true about biallelic expression?
Both alleles of a gene are expressed
What is true about monoallelic expression?
Only one of the two alleles is expressed
What is the consequence of skewed X-inactivation in women?
Increased risk of X-linked disorders
Which is true about Duchenne Muscular Dystrophy (DMD)?
It is caused by a mutation in the dystrophin gene on the X chromosome
What is true about epigenetics?
Methylation of CpG dinucleotides is a primary epigenetic factor
Test your knowledge of epigenetics with this quiz. Explore the concept of heritable changes in gene expression and the impact of chemical modifications on gene sequences. Understand how epigenetics is related to chromatin confirmation and its enduring effects on cell life.
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