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Lecture 20
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Lecture 20

Created by
@RenownedCoralReef

Questions and Answers

Which molecular epigenetic mechanism involves specific posttranslational modifications combinations in different chromatin regions?

  • Chromatin condensation
  • microRNAs
  • DNA methylation
  • Histone modifications (correct)

    • What is the role of erasers in the histone code?

  • Introduce modifications on DNA and histone tails
  • Facilitate gene transcription
  • Remove the modifications introduced by writers (correct)
  • Bind to modifications using specialized domains

    • Which protein contributes to heterochromatin condensation by binding to histone H3 N-terminal tails trimethylated at lysine 9?

  • Chromatin remodeling enzyme
  • Heterochromatin protein 1 (HP1) (correct)
  • Histone methyltransferase
  • Histone acetylase

    • What is the proposed mechanism of histone deacetylation and hyperacetylation in yeast transcriptional control?

    <p>Ume6 repressor directed deacetylation of histone N-terminal tails</p> Signup and view all the answers

    What is the role of Gcn5 in yeast transcriptional control?

    <p>Hyperacetylates histone N-terminal tails</p> Signup and view all the answers

    What is the mechanism for maintaining histone H3 lysine 9 methylation during chromosome replication?

    <p>Random association of parent histones with daughter chromosomes</p> Signup and view all the answers

    What is the main role of pioneer transcription factors?

    <p>Facilitate chromatin decondensation</p> Signup and view all the answers

    What is the function of histone code writers?

    <p>Introduce modifications on DNA and histone tails</p> Signup and view all the answers

    Which protein removes the modifications introduced by histone code writers?

    <p>Erasers</p> Signup and view all the answers

    What is the role of Gcn4 in yeast transcriptional control?

    <p>Directs hyperacetylation of histone N-terminal tails</p> Signup and view all the answers

    What is the effect of chromatin condensation on gene transcription?

    <p>Blocks RNA pol and general TFs from interacting with gene promoters</p> Signup and view all the answers

    Which molecular mechanism involves modification of histone N-terminal tails in heterochromatin and euchromatin?

    <p>Histone acetylation</p> Signup and view all the answers

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