Epigenetic Silencing and Tumor Suppressor Genes Quiz

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Which of the following is true about tumor suppressor genes?

They are the same as oncogenes

They promote cell proliferation

They are involved in cancer when their activity is disrupted (correct)

They are only found in familial Rb

What was the first tumor suppressor gene identified?

p53

NF1

APC

Rb (correct)

Which of the following is not a challenge in treating cancers caused by tumor suppressor genes?

Promoter methylation

Sporadic vs familial Rb

CDK inhibitors and synthetic lethality (correct)

Loss of heterozygosity (LOH)

Which tumor suppressor gene is associated with the function of NF1?

NF1 Signup and view all the answers

Which pathway is involved in normal and cancer cells, and is regulated by the APC gene?

Wnt, frizzled, and the APC/beta catenin pathway Signup and view all the answers

What is the role of promoter methylation in downregulating gene expression?

Inactivating gene expression Signup and view all the answers

Which of the following is true about cell fusion experiments?

Cell fusion experiments involve the fusion of cells growing adjacent to each other in culture Signup and view all the answers

What is the main role of tumor suppressor genes?

To suppress normal cell cycle progression Signup and view all the answers

Which tumor suppressor gene is associated with retinoblastoma?

Rb Signup and view all the answers

What is the significance of loss of heterozygosity (LOH) at a tumor suppressor locus?

It leads to the formation of cancer Signup and view all the answers

Which type of retinoblastoma is associated with an increased risk of developing other cancers later in life?

Familial retinoblastoma Signup and view all the answers

What is the most common type of cancer associated with loss of function of both alleles of Rb?

Retinoblastoma Signup and view all the answers

Which of the following treatments is often used for cancers caused by tumor suppressor genes?

Chemotherapy Signup and view all the answers

Which gene is associated with the development of benign tumors of the cell sheaths around nerves?

NF1 Signup and view all the answers

Which gene is highly protective against passing down mutated or damaged DNA to daughter cells?

p53 Signup and view all the answers

Which gene is one of the most common genetic alterations in cancer, found in about 50% of cancers?

p53 Signup and view all the answers

What is the role of the APC gene in colon cancer?

Regulating b-catenin Signup and view all the answers

What happens when the APC gene is mutated in colon cancer?

Cells proliferate excessively Signup and view all the answers

What is the function of the NF1 gene?

Stimulating hydrolysis Signup and view all the answers

What is the main role of the p53 protein?

Inducing apoptosis Signup and view all the answers

Which of the following is a potential consequence of too much proliferation in cells?

Development of Ras mutations Signup and view all the answers

What is the reference for Figure 7.24a in the book 'The Biology of Cancer' by Weinberg?

Chapter 5-7 of 'The Biology of Cancer' by Weinberg Signup and view all the answers

Which book contains Chapter 20 titled 'APC mutation in colon cancer'?

'Molecular Biology of the Cell' by Alberts Signup and view all the answers

Which of the following resources is NOT mentioned as helpful reading material?

'Cancer Sci.' by Yoshida and Miki Signup and view all the answers

What is the role of BRCA1 and BRCA2 in response to DNA damage?

Enhancement of DNA repair mechanisms Signup and view all the answers