Podcast
Questions and Answers
Which of the following is true about tumor suppressor genes?
Which of the following is true about tumor suppressor genes?
- They are the same as oncogenes
- They promote cell proliferation
- They are involved in cancer when their activity is disrupted (correct)
- They are only found in familial Rb
What was the first tumor suppressor gene identified?
What was the first tumor suppressor gene identified?
- p53
- NF1
- APC
- Rb (correct)
Which of the following is not a challenge in treating cancers caused by tumor suppressor genes?
Which of the following is not a challenge in treating cancers caused by tumor suppressor genes?
- Promoter methylation
- Sporadic vs familial Rb
- CDK inhibitors and synthetic lethality (correct)
- Loss of heterozygosity (LOH)
Which tumor suppressor gene is associated with the function of NF1?
Which tumor suppressor gene is associated with the function of NF1?
Which pathway is involved in normal and cancer cells, and is regulated by the APC gene?
Which pathway is involved in normal and cancer cells, and is regulated by the APC gene?
What is the role of promoter methylation in downregulating gene expression?
What is the role of promoter methylation in downregulating gene expression?
Which of the following is true about cell fusion experiments?
Which of the following is true about cell fusion experiments?
What is the main role of tumor suppressor genes?
What is the main role of tumor suppressor genes?
Which tumor suppressor gene is associated with retinoblastoma?
Which tumor suppressor gene is associated with retinoblastoma?
What is the significance of loss of heterozygosity (LOH) at a tumor suppressor locus?
What is the significance of loss of heterozygosity (LOH) at a tumor suppressor locus?
Which type of retinoblastoma is associated with an increased risk of developing other cancers later in life?
Which type of retinoblastoma is associated with an increased risk of developing other cancers later in life?
What is the most common type of cancer associated with loss of function of both alleles of Rb?
What is the most common type of cancer associated with loss of function of both alleles of Rb?
Which of the following treatments is often used for cancers caused by tumor suppressor genes?
Which of the following treatments is often used for cancers caused by tumor suppressor genes?
Which gene is associated with the development of benign tumors of the cell sheaths around nerves?
Which gene is associated with the development of benign tumors of the cell sheaths around nerves?
Which gene is highly protective against passing down mutated or damaged DNA to daughter cells?
Which gene is highly protective against passing down mutated or damaged DNA to daughter cells?
Which gene is one of the most common genetic alterations in cancer, found in about 50% of cancers?
Which gene is one of the most common genetic alterations in cancer, found in about 50% of cancers?
What is the role of the APC gene in colon cancer?
What is the role of the APC gene in colon cancer?
What happens when the APC gene is mutated in colon cancer?
What happens when the APC gene is mutated in colon cancer?
What is the function of the NF1 gene?
What is the function of the NF1 gene?
What is the main role of the p53 protein?
What is the main role of the p53 protein?
Which of the following is a potential consequence of too much proliferation in cells?
Which of the following is a potential consequence of too much proliferation in cells?
What is the reference for Figure 7.24a in the book 'The Biology of Cancer' by Weinberg?
What is the reference for Figure 7.24a in the book 'The Biology of Cancer' by Weinberg?
Which book contains Chapter 20 titled 'APC mutation in colon cancer'?
Which book contains Chapter 20 titled 'APC mutation in colon cancer'?
Which of the following resources is NOT mentioned as helpful reading material?
Which of the following resources is NOT mentioned as helpful reading material?
What is the role of BRCA1 and BRCA2 in response to DNA damage?
What is the role of BRCA1 and BRCA2 in response to DNA damage?
