25 Questions
Which of the following is true about tumor suppressor genes?
They are involved in cancer when their activity is disrupted
What was the first tumor suppressor gene identified?
Rb
Which of the following is not a challenge in treating cancers caused by tumor suppressor genes?
CDK inhibitors and synthetic lethality
Which tumor suppressor gene is associated with the function of NF1?
NF1
Which pathway is involved in normal and cancer cells, and is regulated by the APC gene?
Wnt, frizzled, and the APC/beta catenin pathway
What is the role of promoter methylation in downregulating gene expression?
Inactivating gene expression
Which of the following is true about cell fusion experiments?
Cell fusion experiments involve the fusion of cells growing adjacent to each other in culture
What is the main role of tumor suppressor genes?
To suppress normal cell cycle progression
Which tumor suppressor gene is associated with retinoblastoma?
Rb
What is the significance of loss of heterozygosity (LOH) at a tumor suppressor locus?
It leads to the formation of cancer
Which type of retinoblastoma is associated with an increased risk of developing other cancers later in life?
Familial retinoblastoma
What is the most common type of cancer associated with loss of function of both alleles of Rb?
Retinoblastoma
Which of the following treatments is often used for cancers caused by tumor suppressor genes?
Chemotherapy
Which gene is associated with the development of benign tumors of the cell sheaths around nerves?
NF1
Which gene is highly protective against passing down mutated or damaged DNA to daughter cells?
p53
Which gene is one of the most common genetic alterations in cancer, found in about 50% of cancers?
p53
What is the role of the APC gene in colon cancer?
Regulating b-catenin
What happens when the APC gene is mutated in colon cancer?
Cells proliferate excessively
What is the function of the NF1 gene?
Stimulating hydrolysis
What is the main role of the p53 protein?
Inducing apoptosis
Which of the following is a potential consequence of too much proliferation in cells?
Development of Ras mutations
What is the reference for Figure 7.24a in the book 'The Biology of Cancer' by Weinberg?
Chapter 5-7 of 'The Biology of Cancer' by Weinberg
Which book contains Chapter 20 titled 'APC mutation in colon cancer'?
'Molecular Biology of the Cell' by Alberts
Which of the following resources is NOT mentioned as helpful reading material?
'Cancer Sci.' by Yoshida and Miki
What is the role of BRCA1 and BRCA2 in response to DNA damage?
Enhancement of DNA repair mechanisms
Test your knowledge on epigenetic silencing and tumor suppressor genes with this quiz. Learn about the role of p53 in DNA damage and cell growth, as well as other examples of tumor suppressor genes.
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