Epidermolysis Bullosa Symptoms

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Questions and Answers

What causes the skin layers to separate and form blisters in epidermolysis bullosa?

  • Overproduction of keratin in the skin
  • Lack of protein anchors between the skin layers (correct)
  • Viral infection
  • Weakened immune system

What is the underlying reason for the extreme fragility of the skin in epidermolysis bullosa?

  • Poor skin care
  • Inherited genetic mutations (correct)
  • Environmental factors
  • Hormonal imbalances

What type of mechanical friction can cause blisters to form in epidermolysis bullosa?

  • Major mechanical friction, such as intense trauma
  • Electrical friction
  • Minor mechanical friction, such as rubbing or pressure (correct)
  • Chemical friction

What is the risk associated with the blisters and painful sores in epidermolysis bullosa?

<p>Increased risk of malignancies (A)</p> Signup and view all the answers

Which of the following genes is affected in epidermolysis bullosa simplex?

<p>KRT5 and KRT14 (A)</p> Signup and view all the answers

What is the inheritance pattern of epidermolysis bullosa simplex?

<p>Autosomal dominant (B)</p> Signup and view all the answers

What is the primary target of the autoantibody in pemphigus vulgaris?

<p>Desmoglein-1 (B)</p> Signup and view all the answers

What is the main cause of cell-cell adhesion loss in pemphigus vulgaris?

<p>Immunoglobulin G autoantibody (D)</p> Signup and view all the answers

What is the most common sequence of symptoms in pemphigus vulgaris?

<p>Oral manifestations followed by skin lesions (D)</p> Signup and view all the answers

What is the name of the clinical sign where blisters can be formed by exerting a slight pressure on the epithelium?

<p>Nikolsky sign (B)</p> Signup and view all the answers

What is the age range when pemphigus vulgaris typically begins?

<p>Mid to late adult life (B)</p> Signup and view all the answers

What is the purpose of immunofluorescence studies in pemphigus vulgaris diagnosis?

<p>To establish a definitive diagnosis (B)</p> Signup and view all the answers

What is the primary characteristic of mucous membrane pemphigoid?

<p>An autoimmune disorder (B)</p> Signup and view all the answers

Which of the following mucous membranes is most often affected in mucous membrane pemphigoid?

<p>Mouth and eyes (C)</p> Signup and view all the answers

What is the name of the sign that may be present in mucous membrane pemphigoid?

<p>Nikolsky sign (A)</p> Signup and view all the answers

What is the percentage of cases where orally, mucous membrane pemphigoid affects the gingiva?

<p>94% (A)</p> Signup and view all the answers

What is the condition called when the pemphigoid lesions affect the gingiva?

<p>Desquamative gingivitis (B)</p> Signup and view all the answers

Which sex is more affected by mucous membrane pemphigoid?

<p>Female (D)</p> Signup and view all the answers

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