Epidermolysis Bullosa Symptoms
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Questions and Answers

What causes the skin layers to separate and form blisters in epidermolysis bullosa?

  • Overproduction of keratin in the skin
  • Lack of protein anchors between the skin layers (correct)
  • Viral infection
  • Weakened immune system
  • What is the underlying reason for the extreme fragility of the skin in epidermolysis bullosa?

  • Poor skin care
  • Inherited genetic mutations (correct)
  • Environmental factors
  • Hormonal imbalances
  • What type of mechanical friction can cause blisters to form in epidermolysis bullosa?

  • Major mechanical friction, such as intense trauma
  • Electrical friction
  • Minor mechanical friction, such as rubbing or pressure (correct)
  • Chemical friction
  • What is the risk associated with the blisters and painful sores in epidermolysis bullosa?

    <p>Increased risk of malignancies</p> Signup and view all the answers

    Which of the following genes is affected in epidermolysis bullosa simplex?

    <p>KRT5 and KRT14</p> Signup and view all the answers

    What is the inheritance pattern of epidermolysis bullosa simplex?

    <p>Autosomal dominant</p> Signup and view all the answers

    What is the primary target of the autoantibody in pemphigus vulgaris?

    <p>Desmoglein-1</p> Signup and view all the answers

    What is the main cause of cell-cell adhesion loss in pemphigus vulgaris?

    <p>Immunoglobulin G autoantibody</p> Signup and view all the answers

    What is the most common sequence of symptoms in pemphigus vulgaris?

    <p>Oral manifestations followed by skin lesions</p> Signup and view all the answers

    What is the name of the clinical sign where blisters can be formed by exerting a slight pressure on the epithelium?

    <p>Nikolsky sign</p> Signup and view all the answers

    What is the age range when pemphigus vulgaris typically begins?

    <p>Mid to late adult life</p> Signup and view all the answers

    What is the purpose of immunofluorescence studies in pemphigus vulgaris diagnosis?

    <p>To establish a definitive diagnosis</p> Signup and view all the answers

    What is the primary characteristic of mucous membrane pemphigoid?

    <p>An autoimmune disorder</p> Signup and view all the answers

    Which of the following mucous membranes is most often affected in mucous membrane pemphigoid?

    <p>Mouth and eyes</p> Signup and view all the answers

    What is the name of the sign that may be present in mucous membrane pemphigoid?

    <p>Nikolsky sign</p> Signup and view all the answers

    What is the percentage of cases where orally, mucous membrane pemphigoid affects the gingiva?

    <p>94%</p> Signup and view all the answers

    What is the condition called when the pemphigoid lesions affect the gingiva?

    <p>Desquamative gingivitis</p> Signup and view all the answers

    Which sex is more affected by mucous membrane pemphigoid?

    <p>Female</p> Signup and view all the answers

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