18 Questions
What causes the skin layers to separate and form blisters in epidermolysis bullosa?
Lack of protein anchors between the skin layers
What is the underlying reason for the extreme fragility of the skin in epidermolysis bullosa?
Inherited genetic mutations
What type of mechanical friction can cause blisters to form in epidermolysis bullosa?
Minor mechanical friction, such as rubbing or pressure
What is the risk associated with the blisters and painful sores in epidermolysis bullosa?
Increased risk of malignancies
Which of the following genes is affected in epidermolysis bullosa simplex?
KRT5 and KRT14
What is the inheritance pattern of epidermolysis bullosa simplex?
Autosomal dominant
What is the primary target of the autoantibody in pemphigus vulgaris?
Desmoglein-1
What is the main cause of cell-cell adhesion loss in pemphigus vulgaris?
Immunoglobulin G autoantibody
What is the most common sequence of symptoms in pemphigus vulgaris?
Oral manifestations followed by skin lesions
What is the name of the clinical sign where blisters can be formed by exerting a slight pressure on the epithelium?
Nikolsky sign
What is the age range when pemphigus vulgaris typically begins?
Mid to late adult life
What is the purpose of immunofluorescence studies in pemphigus vulgaris diagnosis?
To establish a definitive diagnosis
What is the primary characteristic of mucous membrane pemphigoid?
An autoimmune disorder
Which of the following mucous membranes is most often affected in mucous membrane pemphigoid?
Mouth and eyes
What is the name of the sign that may be present in mucous membrane pemphigoid?
Nikolsky sign
What is the percentage of cases where orally, mucous membrane pemphigoid affects the gingiva?
94%
What is the condition called when the pemphigoid lesions affect the gingiva?
Desquamative gingivitis
Which sex is more affected by mucous membrane pemphigoid?
Female
Identify the symptoms of Epidermolysis Bullosa, a group of inherited diseases causing blisters and ulcers on the skin and oral mucosa. Learn about the initial issues, skin problems, and other related symptoms.
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