Epidemiology of Adverse Drug Reactions

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Which type of adverse drug reaction (ADR) is the most common among hospitalized patients?

Cutaneous ADRs (correct)

Gastrointestinal ADRs

Cardiovascular ADRs

Respiratory ADRs

What is the incidence of cutaneous ADRs (CADRs) in hospitalized patients?

0.01%

1.5%

5%

0.7% (correct)

Which factor increases the probability of a drug producing an adverse reaction?

Oral route of delivery

Impaired renal function (correct)

Small compound size

Altered metabolism due to non-drug factors

What is the mortality rate associated with adverse drug reactions (ADRs) in hospitalized patients?

0.15% Signup and view all the answers

Which of the following is NOT a factor influencing the probability of a drug producing an adverse reaction?

Patient's age Signup and view all the answers

In which setting are the numbers of cutaneous adverse drug reactions (CADRs) likely to be higher?

ICU setting Signup and view all the answers

Which class of medications is stated to be the most likely to cause cutaneous ADRs?

Antibiotics Signup and view all the answers

What type of drugs are more likely to act as haptens?

Large compounds Signup and view all the answers

What is the key characteristic that defines an adverse drug reaction (ADR)?

Noxious, unintended, and undesired effect of a drug Signup and view all the answers

What is the most frequent type of cutaneous adverse drug reaction (CADR) in hospitalized patients?

Morbilliform or maculopapular exanthems Signup and view all the answers

Which severe type of CADR requires prompt recognition and initiation of treatment?

Stevens-Johnson syndrome (SJS) Signup and view all the answers

What is a clue to the diagnosis of a cutaneous adverse drug reaction (CADR)?

An eruption that develops rapidly after drug administration Signup and view all the answers

What is ALDEN used for in the context of cutaneous adverse drug reactions (CADRs)?

To identify the causative agent in SJS/TEN Signup and view all the answers

In the ALDEN algorithm, what score range reflects a causality category of 'very probable'?

$6$ to $10$ Signup and view all the answers

What characteristic morphology is associated with the onset of CADRs?

Exanthematous Signup and view all the answers

Which type of CADR has a predominantly truncal distribution?

Morbilliform pattern Signup and view all the answers

'Fixed drug' morphology is a feature seen in which type of CADR?

Erythema multiforme Signup and view all the answers

What is the incidence of adverse drug reactions (ADRs) in hospitalized patients based on a prospective analysis of 18,820 patients?

0.15% Signup and view all the answers

Which route of drug delivery is associated with an increased incidence of adverse reactions?

Intravenous administration Signup and view all the answers

Which of the following patient factors is mentioned to influence the probability of a drug causing an adverse reaction?

Renal function Signup and view all the answers

Which class of medications is listed as most likely to cause cutaneous adverse drug reactions (CADRs)?

Antibiotics Signup and view all the answers

What is the most common type of adverse drug reaction (ADR) mentioned in the text?

Cutaneous ADRs Signup and view all the answers

Which characteristic of drugs is more likely to act as haptens?

Large compounds Signup and view all the answers

What percentage of patients admitted over six months experienced an adverse drug reaction?

6.5% Signup and view all the answers

What patient factor influences the probability of a drug producing an adverse reaction based on the text?

Alcohol use Signup and view all the answers

Which category of medications is stated to be most likely to cause cutaneous ADRs based on the text?

Antibiotics Signup and view all the answers

What is the predominant type of cutaneous adverse drug reaction (CADR) based on the text?

Pigmentary CADR Signup and view all the answers

Which algorithm is used for assessing drug causality in epidermal necrolysis?

ALDEN Signup and view all the answers

What is the score range that reflects a causality category of 'very probable' in the ALDEN algorithm?

6 Signup and view all the answers

In the context of cutaneous adverse drug reactions (CADRs), what type of morphology is associated with ALDEN scoring?

Lichenoid Signup and view all the answers

Which severe type of CADR requires prompt recognition and initiation of treatment?

Toxic epidermal necrolysis (TEN) Signup and view all the answers

What characteristic distribution is seen in CADRs according to the text?

Generalized and symmetrical Signup and view all the answers

Which symptoms play a role in classifying CADRs into different types according to the text?

Fever and organ involvement Signup and view all the answers

What timeframe is mentioned for the onset of most CADRs?

< 1 week after administration Signup and view all the answers

'Fixed drug' morphology is associated with which type of CADR?

'Lupus-like' patterns Signup and view all the answers

'Photosensitive' patterns are an example of which less common drug-associated morphology?

'Lichenoid' Signup and view all the answers

'Stevens-Johnson syndrome (SJS)' falls under which category of CADR severity?

'Severe' Signup and view all the answers

Epidemiology of Adverse Drug Reactions

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Questions and Answers

Which type of adverse drug reaction (ADR) is the most common among hospitalized patients?

What is the incidence of cutaneous ADRs (CADRs) in hospitalized patients?

Which factor increases the probability of a drug producing an adverse reaction?

What is the mortality rate associated with adverse drug reactions (ADRs) in hospitalized patients?

Which of the following is NOT a factor influencing the probability of a drug producing an adverse reaction?

In which setting are the numbers of cutaneous adverse drug reactions (CADRs) likely to be higher?

Which class of medications is stated to be the most likely to cause cutaneous ADRs?

What type of drugs are more likely to act as haptens?

What is the key characteristic that defines an adverse drug reaction (ADR)?

What is the most frequent type of cutaneous adverse drug reaction (CADR) in hospitalized patients?

Which severe type of CADR requires prompt recognition and initiation of treatment?

What is a clue to the diagnosis of a cutaneous adverse drug reaction (CADR)?

What is ALDEN used for in the context of cutaneous adverse drug reactions (CADRs)?

In the ALDEN algorithm, what score range reflects a causality category of 'very probable'?

What characteristic morphology is associated with the onset of CADRs?

Which type of CADR has a predominantly truncal distribution?

'Fixed drug' morphology is a feature seen in which type of CADR?

What is the incidence of adverse drug reactions (ADRs) in hospitalized patients based on a prospective analysis of 18,820 patients?

Which route of drug delivery is associated with an increased incidence of adverse reactions?

Which of the following patient factors is mentioned to influence the probability of a drug causing an adverse reaction?

Which class of medications is listed as most likely to cause cutaneous adverse drug reactions (CADRs)?

What is the most common type of adverse drug reaction (ADR) mentioned in the text?

Which characteristic of drugs is more likely to act as haptens?

What percentage of patients admitted over six months experienced an adverse drug reaction?

What patient factor influences the probability of a drug producing an adverse reaction based on the text?

Which category of medications is stated to be most likely to cause cutaneous ADRs based on the text?

What is the predominant type of cutaneous adverse drug reaction (CADR) based on the text?

Which algorithm is used for assessing drug causality in epidermal necrolysis?

What is the score range that reflects a causality category of 'very probable' in the ALDEN algorithm?

In the context of cutaneous adverse drug reactions (CADRs), what type of morphology is associated with ALDEN scoring?

Which severe type of CADR requires prompt recognition and initiation of treatment?

What characteristic distribution is seen in CADRs according to the text?

Which symptoms play a role in classifying CADRs into different types according to the text?

What timeframe is mentioned for the onset of most CADRs?

'Fixed drug' morphology is associated with which type of CADR?

'Photosensitive' patterns are an example of which less common drug-associated morphology?

'Stevens-Johnson syndrome (SJS)' falls under which category of CADR severity?

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