Epidemiology of Adverse Drug Reactions
37 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of adverse drug reaction (ADR) is the most common among hospitalized patients?

  • Cutaneous ADRs (correct)
  • Gastrointestinal ADRs
  • Cardiovascular ADRs
  • Respiratory ADRs

What is the incidence of cutaneous ADRs (CADRs) in hospitalized patients?

  • 0.01%
  • 1.5%
  • 5%
  • 0.7% (correct)

Which factor increases the probability of a drug producing an adverse reaction?

  • Oral route of delivery
  • Impaired renal function (correct)
  • Small compound size
  • Altered metabolism due to non-drug factors

What is the mortality rate associated with adverse drug reactions (ADRs) in hospitalized patients?

<p>0.15% (B)</p> Signup and view all the answers

Which of the following is NOT a factor influencing the probability of a drug producing an adverse reaction?

<p>Patient's age (D)</p> Signup and view all the answers

In which setting are the numbers of cutaneous adverse drug reactions (CADRs) likely to be higher?

<p>ICU setting (B)</p> Signup and view all the answers

Which class of medications is stated to be the most likely to cause cutaneous ADRs?

<p>Antibiotics (B)</p> Signup and view all the answers

What type of drugs are more likely to act as haptens?

<p>Large compounds (C)</p> Signup and view all the answers

What is the key characteristic that defines an adverse drug reaction (ADR)?

<p>Noxious, unintended, and undesired effect of a drug (C)</p> Signup and view all the answers

What is the most frequent type of cutaneous adverse drug reaction (CADR) in hospitalized patients?

<p>Morbilliform or maculopapular exanthems (A)</p> Signup and view all the answers

Which severe type of CADR requires prompt recognition and initiation of treatment?

<p>Stevens-Johnson syndrome (SJS) (A)</p> Signup and view all the answers

What is a clue to the diagnosis of a cutaneous adverse drug reaction (CADR)?

<p>An eruption that develops rapidly after drug administration (B)</p> Signup and view all the answers

What is ALDEN used for in the context of cutaneous adverse drug reactions (CADRs)?

<p>To identify the causative agent in SJS/TEN (A)</p> Signup and view all the answers

In the ALDEN algorithm, what score range reflects a causality category of 'very probable'?

<p>$6$ to $10$ (A)</p> Signup and view all the answers

What characteristic morphology is associated with the onset of CADRs?

<p><strong>Exanthematous</strong> (D)</p> Signup and view all the answers

Which type of CADR has a predominantly truncal distribution?

<p><strong>Morbilliform</strong> pattern (B)</p> Signup and view all the answers

'Fixed drug' morphology is a feature seen in which type of CADR?

<p><strong>Erythema multiforme</strong> (D)</p> Signup and view all the answers

What is the incidence of adverse drug reactions (ADRs) in hospitalized patients based on a prospective analysis of 18,820 patients?

<p>0.15% (A)</p> Signup and view all the answers

Which route of drug delivery is associated with an increased incidence of adverse reactions?

<p>Intravenous administration (A)</p> Signup and view all the answers

Which of the following patient factors is mentioned to influence the probability of a drug causing an adverse reaction?

<p>Renal function (D)</p> Signup and view all the answers

Which class of medications is listed as most likely to cause cutaneous adverse drug reactions (CADRs)?

<p>Antibiotics (A)</p> Signup and view all the answers

What is the most common type of adverse drug reaction (ADR) mentioned in the text?

<p>Cutaneous ADRs (B)</p> Signup and view all the answers

Which characteristic of drugs is more likely to act as haptens?

<p>Large compounds (A)</p> Signup and view all the answers

What percentage of patients admitted over six months experienced an adverse drug reaction?

<p>6.5% (B)</p> Signup and view all the answers

What patient factor influences the probability of a drug producing an adverse reaction based on the text?

<p>Alcohol use (D)</p> Signup and view all the answers

Which category of medications is stated to be most likely to cause cutaneous ADRs based on the text?

<p>Antibiotics (B)</p> Signup and view all the answers

What is the predominant type of cutaneous adverse drug reaction (CADR) based on the text?

<p>Pigmentary CADR (C)</p> Signup and view all the answers

Which algorithm is used for assessing drug causality in epidermal necrolysis?

<p>ALDEN (B)</p> Signup and view all the answers

What is the score range that reflects a causality category of 'very probable' in the ALDEN algorithm?

<p>6 (B)</p> Signup and view all the answers

In the context of cutaneous adverse drug reactions (CADRs), what type of morphology is associated with ALDEN scoring?

<p>Lichenoid (A)</p> Signup and view all the answers

Which severe type of CADR requires prompt recognition and initiation of treatment?

<p>Toxic epidermal necrolysis (TEN) (D)</p> Signup and view all the answers

What characteristic distribution is seen in CADRs according to the text?

<p>Generalized and symmetrical (A)</p> Signup and view all the answers

Which symptoms play a role in classifying CADRs into different types according to the text?

<p>Fever and organ involvement (D)</p> Signup and view all the answers

What timeframe is mentioned for the onset of most CADRs?

<p>&lt; 1 week after administration (B)</p> Signup and view all the answers

'Fixed drug' morphology is associated with which type of CADR?

<p>'Lupus-like' patterns (D)</p> Signup and view all the answers

'Photosensitive' patterns are an example of which less common drug-associated morphology?

<p>'Lichenoid' (D)</p> Signup and view all the answers

'Stevens-Johnson syndrome (SJS)' falls under which category of CADR severity?

<p>'Severe' (A)</p> Signup and view all the answers

More Like This

Epidemiology Chapter 10 Flashcards
10 questions
Epidemiology Exam 3 Flashcards
84 questions

Epidemiology Exam 3 Flashcards

WellReceivedSquirrel7948 avatar
WellReceivedSquirrel7948
Epidemiology 4 Flashcards
78 questions

Epidemiology 4 Flashcards

BeneficialThermodynamics avatar
BeneficialThermodynamics
Use Quizgecko on...
Browser
Browser