37 Questions
Which type of adverse drug reaction (ADR) is the most common among hospitalized patients?
Cutaneous ADRs
What is the incidence of cutaneous ADRs (CADRs) in hospitalized patients?
0.7%
Which factor increases the probability of a drug producing an adverse reaction?
Impaired renal function
What is the mortality rate associated with adverse drug reactions (ADRs) in hospitalized patients?
0.15%
Which of the following is NOT a factor influencing the probability of a drug producing an adverse reaction?
Patient's age
In which setting are the numbers of cutaneous adverse drug reactions (CADRs) likely to be higher?
ICU setting
Which class of medications is stated to be the most likely to cause cutaneous ADRs?
Antibiotics
What type of drugs are more likely to act as haptens?
Large compounds
What is the key characteristic that defines an adverse drug reaction (ADR)?
Noxious, unintended, and undesired effect of a drug
What is the most frequent type of cutaneous adverse drug reaction (CADR) in hospitalized patients?
Morbilliform or maculopapular exanthems
Which severe type of CADR requires prompt recognition and initiation of treatment?
Stevens-Johnson syndrome (SJS)
What is a clue to the diagnosis of a cutaneous adverse drug reaction (CADR)?
An eruption that develops rapidly after drug administration
What is ALDEN used for in the context of cutaneous adverse drug reactions (CADRs)?
To identify the causative agent in SJS/TEN
In the ALDEN algorithm, what score range reflects a causality category of 'very probable'?
$6$ to $10$
What characteristic morphology is associated with the onset of CADRs?
Exanthematous
Which type of CADR has a predominantly truncal distribution?
Morbilliform pattern
'Fixed drug' morphology is a feature seen in which type of CADR?
Erythema multiforme
What is the incidence of adverse drug reactions (ADRs) in hospitalized patients based on a prospective analysis of 18,820 patients?
0.15%
Which route of drug delivery is associated with an increased incidence of adverse reactions?
Intravenous administration
Which of the following patient factors is mentioned to influence the probability of a drug causing an adverse reaction?
Renal function
Which class of medications is listed as most likely to cause cutaneous adverse drug reactions (CADRs)?
Antibiotics
What is the most common type of adverse drug reaction (ADR) mentioned in the text?
Cutaneous ADRs
Which characteristic of drugs is more likely to act as haptens?
Large compounds
What percentage of patients admitted over six months experienced an adverse drug reaction?
6.5%
What patient factor influences the probability of a drug producing an adverse reaction based on the text?
Alcohol use
Which category of medications is stated to be most likely to cause cutaneous ADRs based on the text?
Antibiotics
What is the predominant type of cutaneous adverse drug reaction (CADR) based on the text?
Pigmentary CADR
Which algorithm is used for assessing drug causality in epidermal necrolysis?
ALDEN
What is the score range that reflects a causality category of 'very probable' in the ALDEN algorithm?
6
In the context of cutaneous adverse drug reactions (CADRs), what type of morphology is associated with ALDEN scoring?
Lichenoid
Which severe type of CADR requires prompt recognition and initiation of treatment?
Toxic epidermal necrolysis (TEN)
What characteristic distribution is seen in CADRs according to the text?
Generalized and symmetrical
Which symptoms play a role in classifying CADRs into different types according to the text?
Fever and organ involvement
What timeframe is mentioned for the onset of most CADRs?
< 1 week after administration
'Fixed drug' morphology is associated with which type of CADR?
'Lupus-like' patterns
'Photosensitive' patterns are an example of which less common drug-associated morphology?
'Lichenoid'
'Stevens-Johnson syndrome (SJS)' falls under which category of CADR severity?
'Severe'
Explore the epidemiology of adverse drug reactions as defined by the World Health Organization (WHO). Learn about the types of noxious and unintended effects that can occur from drug use in humans. Delve into a prospective analysis of patient admissions to understand the prevalence of adverse drug reactions.
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