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Epibatidine: Chemistry and Effects
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Epibatidine: Chemistry and Effects

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Questions and Answers

What is the primary effect of epibatidine on nicotinic acetylcholine receptors?

  • It acts as an agonist, activating the receptors' function (correct)
  • It has a neutral effect, neither activating nor blocking the receptors' function
  • It enhances the receptors' sensitivity to other toxins
  • It acts as an antagonist, blocking the receptors' function

    • What is the primary limitation of using epibatidine as a pain reliever?

  • It is not effective for certain types of pain
  • It is only effective for a short duration
  • Its toxicity is too high, making therapeutic use difficult (correct)
  • It is not synthesized efficiently

    • What is the source of epibatidine?

  • A type of poisonous plant
  • The skin of the Ecuadorian poison dart frog (correct)
  • A bacterium found in soil
  • A species of venomous snake

    • How does the potency of epibatidine as a pain reliever compare to morphine?

    <p>Epibatidine is 200 times more effective than morphine</p> Signup and view all the answers

    What has been developed to improve the therapeutic potential of epibatidine?

    <p>Synthetic analogs with improved therapeutic windows and selectivity</p> Signup and view all the answers

    Study Notes

    Epibatidine

    • Derived from the Ecuadorian poison dart frog (Epipedobates tricolor)
    • Chemical nature: Chlorinated alkaloid secreted through the skin of the frog

    Pharmacological Effects

    • Acts as a nicotinic acetylcholine receptors (nAChRs) agonist
    • Extremely potent, with even a small amount capable of paralyzing or killing an animal

    Analgesic Properties

    • 200 times more effective as a pain reliever compared to morphine

    Therapeutic Limitations

    • High toxicity hampers therapeutic use of epibatidine

    Synthetic Analogs

    • New analogs have been developed with improved therapeutic window and selectivity

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    Description

    Learn about epibatidine, a powerful toxin found in the Ecuadorian poison dart frog, its chemical nature, effects on nicotinic acetylcholine receptors, and its potential as a pain reliever.

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