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Enzyme Markers in Clinical Significance

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Questions and Answers

Which enzyme is commonly used as a marker for prostatic carcinoma?

Alanine transaminase (ALT)

Acid phosphatase (ACP) (correct)

Aspartate transaminase (AST)

Lactate dehydrogenase (LD)

What is the primary purpose of isoenzymes in identifying tissue damage?

To classify enzymes into different groups

To separate enzymes by electrophoresis

To catalyze the same reaction

To identify the site of tissue damage (correct)

Which enzyme is associated with hepatic disorders and viral hepatitis?

Gamma-glutamyl transferase (GGT)

Alanine transaminase (ALT) (correct)

Aspartate transaminase (AST)

Alkaline phosphatase (ALP)

What is the primary difference between isoenzymes?

Their genetic makeup Signup and view all the answers

Which enzyme is commonly used as a marker for myocardial infarction?

Creatine kinase (CK) Signup and view all the answers

What is the primary purpose of enzyme markers in clinical diagnosis?

To diagnose diseases and disorders Signup and view all the answers

What occurs to the cells of the affected region in myocardial infarction?

They release their enzyme content to the systematic circulation Signup and view all the answers

What is the result of enzyme induction?

Increase in enzyme production Signup and view all the answers

Which of the following enzymes is commonly used as a marker for liver function?

Glutamyl Transferase (GT) Signup and view all the answers

What is the site of increased activity of ϒ–glutamyltransferase in response to ethanol intake?

Liver Signup and view all the answers

Which of the following enzymes is specific to the prostate?

Acid Phosphatase (ACP) Signup and view all the answers

What is the clinical application of Aspartate Amino transferase (AST) and Alanine Amino transferase (ALT)?

Diagnosis of liver disorders Signup and view all the answers

What is the purpose of using a second enzyme in enzymatic assays?

To act on the product of the enzyme of primary interest Signup and view all the answers

What is the coenzyme used by the second enzyme in enzymatic assays?

NADH Signup and view all the answers

What is the wavelength at which the oxidation of NADH can be measured?

340nm Signup and view all the answers

Why do healthy individuals have a constant level of enzymes in their plasma?

Because the rate of release from damaged cells is balanced by the rate of removal from the plasma Signup and view all the answers

What is the significance of increased plasma levels of certain enzymes in disease diagnosis?

It indicates tissue damage to a specific tissue Signup and view all the answers

What can cause an increase in the release of intracellular enzymes into the plasma?

A direct attack on the cell membranes by viruses or organic chemicals Signup and view all the answers