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Questions and Answers
What is the main site for drug metabolism?
What is the main site for drug metabolism?
- Liver (correct)
- Spleen
- Kidneys
- Pancreas
In diseases affecting drug metabolism, which of the following could lead to lower plasma binding of drugs?
In diseases affecting drug metabolism, which of the following could lead to lower plasma binding of drugs?
- Elevated enzyme activity
- Altered kidney function
- Hypoalbuminemia (correct)
- Increased hepatic blood flow
Which condition may impair glycine conjugation of salicylates and hydrolysis of procaine?
Which condition may impair glycine conjugation of salicylates and hydrolysis of procaine?
- Diabetes mellitus
- Alcoholic liver disease
- Kidney disease (correct)
- Cholestatic jaundice
What effect was observed in animals with thyroidectomy in relation to enzyme activity?
What effect was observed in animals with thyroidectomy in relation to enzyme activity?
Which factor may inhibit the activity of certain enzymes while inducing others?
Which factor may inhibit the activity of certain enzymes while inducing others?
Which type of reactions tend to produce less active metabolites than their substrates?
Which type of reactions tend to produce less active metabolites than their substrates?
Which enzyme group catalyzes reactions involving the addition of large anionic groups like GSH?
Which enzyme group catalyzes reactions involving the addition of large anionic groups like GSH?
What is the primary function of UDP-glucuronosyltransferases in drug metabolism?
What is the primary function of UDP-glucuronosyltransferases in drug metabolism?
Which type of metabolism involves the formation of glycine conjugates?
Which type of metabolism involves the formation of glycine conjugates?
What effect does the addition of large anionic groups have on the polarity of metabolites?
What effect does the addition of large anionic groups have on the polarity of metabolites?
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