Enzyme Inhibition and Environmental Factors Quiz
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Questions and Answers

What is the main site for drug metabolism?

  • Liver (correct)
  • Spleen
  • Kidneys
  • Pancreas
  • In diseases affecting drug metabolism, which of the following could lead to lower plasma binding of drugs?

  • Elevated enzyme activity
  • Altered kidney function
  • Hypoalbuminemia (correct)
  • Increased hepatic blood flow
  • Which condition may impair glycine conjugation of salicylates and hydrolysis of procaine?

  • Diabetes mellitus
  • Alcoholic liver disease
  • Kidney disease (correct)
  • Cholestatic jaundice
  • What effect was observed in animals with thyroidectomy in relation to enzyme activity?

    <p>Impairment in enzyme activity</p> Signup and view all the answers

    Which factor may inhibit the activity of certain enzymes while inducing others?

    <p>Increased hormone levels</p> Signup and view all the answers

    Which type of reactions tend to produce less active metabolites than their substrates?

    <p>Conjugation reactions</p> Signup and view all the answers

    Which enzyme group catalyzes reactions involving the addition of large anionic groups like GSH?

    <p>Glutathione S-transferases</p> Signup and view all the answers

    What is the primary function of UDP-glucuronosyltransferases in drug metabolism?

    <p>Glucuronidation</p> Signup and view all the answers

    Which type of metabolism involves the formation of glycine conjugates?

    <p>Glycine conjugation</p> Signup and view all the answers

    What effect does the addition of large anionic groups have on the polarity of metabolites?

    <p>Increases polarity</p> Signup and view all the answers

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