10 Questions
What is the main site for drug metabolism?
Liver
In diseases affecting drug metabolism, which of the following could lead to lower plasma binding of drugs?
Hypoalbuminemia
Which condition may impair glycine conjugation of salicylates and hydrolysis of procaine?
Kidney disease
What effect was observed in animals with thyroidectomy in relation to enzyme activity?
Impairment in enzyme activity
Which factor may inhibit the activity of certain enzymes while inducing others?
Increased hormone levels
Which type of reactions tend to produce less active metabolites than their substrates?
Conjugation reactions
Which enzyme group catalyzes reactions involving the addition of large anionic groups like GSH?
Glutathione S-transferases
What is the primary function of UDP-glucuronosyltransferases in drug metabolism?
Glucuronidation
Which type of metabolism involves the formation of glycine conjugates?
Glycine conjugation
What effect does the addition of large anionic groups have on the polarity of metabolites?
Increases polarity
Test your knowledge on enzyme inhibition, altered physiology, and environmental factors affecting drug metabolism. Learn about the importance of enzyme inhibition in clinical settings, with examples such as anticoagulants, antiepileptics, and hypoglycemic drugs.
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