12 Questions
What is the function of the endoplasmic reticulum (ER) in a eucaryotic cell?
Protein biosynthesis
Which organelles receive proteins initially delivered to the endoplasmic reticulum (ER) lumen?
Golgi apparatus and lysosomes
What marks proteins for translocation into the lumen of the endoplasmic reticulum (ER)?
Signal sequence (SS)
What is the internal space enclosed by the endoplasmic reticulum (ER) membrane called?
ER lumen
Which cellular organelles benefit from the ER membrane contribution?
Golgi apparatus and mitochondria
What happens to the signal sequence (SS) of a protein after it reaches its final destination?
It is removed during transport or after reaching its destination.
What is the purpose of the signal peptidase within the ER lumen?
To remove the signal sequence from the polypeptide
What role does the signal recognition particle (SRP) play in the protein targeting pathway?
It binds to the SS emerging from the ribosome and halts elongation of the polypeptide
Where does N-linked glycosylation predominantly take place?
ER
What happens to misfolded or incompletely assembled proteins in the ER?
They are retained and transported back into the cytosol proteasomes
What is the role of the peptide translocation complex in the ER?
Interact directly with the ribosome to deliver the nascent polypeptide
What is the function of dolichol phosphate in protein processing?
Transfer a sugar-residue precursor to a specific asparagine residue
Learn about the structure and function of the endoplasmic reticulum (ER) in eukaryotic cells. Understand how the ER membrane encloses a continuous sheet called the ER lumen, separating it from the cytosol. Explore the importance of the ER in various cellular processes.
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