Endocrinology Quiz: Pituitary Function
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Questions and Answers

What is the role of the anterior pituitary in relation to growth and metabolism?

  • It has no impact on growth or metabolism.
  • It produces and secretes hormones that influence growth and metabolism. (correct)
  • It solely manages blood pressure regulation.
  • It exclusively stores hormones produced by the hypothalamus.
  • Which of the following conditions is associated with underactivity of the pituitary gland?

  • Acromegaly
  • Cushing's Syndrome
  • Hypopituitarism (correct)
  • Hyperthyroidism
  • What is a common symptom of hyperpituitarism due to excess growth hormone?

  • Cold intolerance
  • Decreased appetite
  • Enlarged hands and feet (correct)
  • Fatigue
  • Which hormonal deficiency can lead to growth retardation in children?

    <p>Insufficient growth hormone (D)</p> Signup and view all the answers

    What is the primary treatment approach for pituitary disorders characterized by hormone deficiencies?

    <p>Hormone replacement therapy (D)</p> Signup and view all the answers

    Which hormone deficiency is likely to cause low blood pressure and fatigue?

    <p>Insufficient adrenocorticotropic hormone (A)</p> Signup and view all the answers

    Which statement about the posterior pituitary is true?

    <p>It stores and releases hormones made by the hypothalamus. (C)</p> Signup and view all the answers

    What disorder results from excessive levels of luteinizing hormone in adults?

    <p>Infertility (B)</p> Signup and view all the answers

    What is the primary cause of primary hyperparathyroidism?

    <p>Benign adenoma or hyperplasia (B)</p> Signup and view all the answers

    Which of the following is NOT a symptom of hypoparathyroidism?

    <p>Osteoporosis (D)</p> Signup and view all the answers

    Which diagnostic test is used to confirm primary adrenal insufficiency?

    <p>ACTH Stimulation Test (A)</p> Signup and view all the answers

    What is the most common type of hypoparathyroidism?

    <p>Post-Surgical Hypoparathyroidism (B)</p> Signup and view all the answers

    How does hyperparathyroidism typically affect calcium levels in the blood?

    <p>Causes elevated calcium levels (D)</p> Signup and view all the answers

    What physiological condition can result from long-term secondary hyperparathyroidism?

    <p>Kidney stones (C)</p> Signup and view all the answers

    Cushing's Syndrome can arise from which of the following causes?

    <p>Adrenal tumors producing cortisol (D)</p> Signup and view all the answers

    Which of the following symptoms is associated with primary adrenal insufficiency?

    <p>Hyperpigmentation (C)</p> Signup and view all the answers

    What is the typical blood calcium level considered normal?

    <p>8.5–10.2 mg/dL (A)</p> Signup and view all the answers

    Which of the following is a treatment option for severe hypoparathyroidism?

    <p>Calcium and Vitamin D Supplements (B)</p> Signup and view all the answers

    What is the main consequence of prolonged corticosteroid therapy?

    <p>Secondary adrenal insufficiency (A)</p> Signup and view all the answers

    What is the role of aldosterone produced by the adrenal cortex?

    <p>Regulate sodium and potassium balance (A)</p> Signup and view all the answers

    What characterizes secondary hyperparathyroidism?

    <p>Compensatory PTH secretion due to low calcium (D)</p> Signup and view all the answers

    Which condition is characterized by the excessive production of catecholamines due to an adrenal medulla tumor?

    <p>Pheochromocytoma (D)</p> Signup and view all the answers

    What is a common complication associated with Primary Ovarian Insufficiency (POI)?

    <p>Cardiovascular risks (D)</p> Signup and view all the answers

    Which of the following symptoms is NOT typically associated with menopause?

    <p>Hirsutism (C)</p> Signup and view all the answers

    What is the commonly used imaging technique to localize pheochromocytoma?

    <p>CT/MRI (A)</p> Signup and view all the answers

    Which medication is used to reduce cortisol production in Cushing’s syndrome?

    <p>Ketoconazole (C)</p> Signup and view all the answers

    In the context of androgen insensitivity syndrome, what is true for individuals with complete AIS?

    <p>They have female external anatomy without functional reproductive organs. (C)</p> Signup and view all the answers

    Which hormonal disorder is primarily characterized by irregular menstrual cycles and high androgen levels?

    <p>Polycystic Ovary Syndrome (B)</p> Signup and view all the answers

    What is the primary purpose of the ACTH Stimulation Test?

    <p>To assess adrenal response to synthetic ACTH (B)</p> Signup and view all the answers

    Which treatment option is typically recommended for managing symptoms of increased estrogen levels during menopause?

    <p>Hormone Replacement Therapy (C)</p> Signup and view all the answers

    In which condition does primary adrenal insufficiency, caused by autoimmune destruction, occur?

    <p>Addison’s Disease (D)</p> Signup and view all the answers

    What is a significant risk associated with Polycystic Ovary Syndrome (PCOS)?

    <p>Type 2 diabetes (D)</p> Signup and view all the answers

    What surgical procedure is frequently performed to treat pheochromocytoma?

    <p>Adrenalectomy (C)</p> Signup and view all the answers

    Which of the following conditions is associated with delayed puberty and reduced muscle mass in males?

    <p>Hypogonadism (D)</p> Signup and view all the answers

    Which condition primarily involves elevated prolactin levels impacting testosterone production?

    <p>Hyperprolactinemia (B)</p> Signup and view all the answers

    What is a common symptom associated with Klinefelter Syndrome?

    <p>Gynecomastia (A)</p> Signup and view all the answers

    Which of the following symptoms is not typically associated with Primary Testicular Failure?

    <p>Pelvic pain (D)</p> Signup and view all the answers

    Which treatment is commonly used for alleviating symptoms of Hyperprolactinemia?

    <p>Dopamine agonists (D)</p> Signup and view all the answers

    Which cognitive disorder is characterized by fluctuating disturbances in attention and awareness?

    <p>Delirium (B)</p> Signup and view all the answers

    Which treatment option is not typically effective in managing Irreversible Dementias?

    <p>Antidepressants (D)</p> Signup and view all the answers

    What genetic condition is characterized by males having an extra X chromosome?

    <p>Klinefelter Syndrome (B)</p> Signup and view all the answers

    Which of the following is a hallmark symptom of Mild Cognitive Impairment (MCI)?

    <p>Forgetfulness (C)</p> Signup and view all the answers

    Which condition is represented by a triad of urinary incontinence, gait disturbance, and cognitive decline?

    <p>Normal Pressure Hydrocephalus (C)</p> Signup and view all the answers

    In which condition is fertility most often compromised due to elevated prolactin levels?

    <p>Hyperprolactinemia (D)</p> Signup and view all the answers

    Which of the following best describes Pseudodementia?

    <p>Cognitive dysfunction due to depression (C)</p> Signup and view all the answers

    Which treatment is commonly used for restoring testosterone in males with Klinefelter Syndrome?

    <p>Testosterone therapy (D)</p> Signup and view all the answers

    Which cognitive disorder typically shows signs of improvement with treatment for its underlying cause?

    <p>Delirium (D)</p> Signup and view all the answers

    What defines Secondary Hypogonadism?

    <p>Hypothalamic or pituitary dysfunction (D)</p> Signup and view all the answers

    What is the primary hormone produced by the thyroid gland responsible for metabolic regulation?

    <p>Triiodothyronine (T3) (A)</p> Signup and view all the answers

    Which symptom is associated with Cushing’s Disease due to high cortisol levels?

    <p>Weight gain around the trunk (B)</p> Signup and view all the answers

    Which condition results from overproduction of ADH, leading to low sodium levels?

    <p>Syndrome of Inappropriate Antidiuretic Hormone (SIADH) (A)</p> Signup and view all the answers

    What is a common treatment for primary hypothyroidism?

    <p>Synthetic T4 replacement therapy (D)</p> Signup and view all the answers

    What distinguishes Graves’ Disease from other forms of hyperthyroidism?

    <p>It is caused by autoimmune overstimulation of the thyroid. (D)</p> Signup and view all the answers

    What is a severe complication of untreated hypothyroidism known as?

    <p>Myxedema Coma (B)</p> Signup and view all the answers

    Which is a characteristic symptom of hyperthyroidism?

    <p>Exophthalmos (B)</p> Signup and view all the answers

    What role does parathyroid hormone (PTH) play in the body?

    <p>Increases blood calcium levels (D)</p> Signup and view all the answers

    Which form of treatment is typically used for prolactinoma?

    <p>Dopamine agonists (D)</p> Signup and view all the answers

    What causes secondary hypothyroidism?

    <p>Pituitary gland failure to produce TSH (B)</p> Signup and view all the answers

    What is a key diagnostic indicator for primary hypothyroidism on blood tests?

    <p>Elevated TSH levels (B)</p> Signup and view all the answers

    What condition is likely indicated by a goiter?

    <p>Hyperthyroidism or hypothyroidism (B)</p> Signup and view all the answers

    Which medication is used to treat hyperthyroidism?

    <p>Methimazole (B)</p> Signup and view all the answers

    In an adult, what condition results from prolonged excessive GH secretion?

    <p>Acromegaly (B)</p> Signup and view all the answers

    What is a common characteristic of thyroid nodules detected in adults?

    <p>3-5% risk of being malignant (C)</p> Signup and view all the answers

    Which is a consequence of the ischemic cascade that occurs during a stroke?

    <p>Calcium influx into neurons (A)</p> Signup and view all the answers

    What characterizes Wernicke’s/Korsakoff Syndrome?

    <p>Memory deficits and confabulation (B)</p> Signup and view all the answers

    Which fluid compartment makes up approximately 60% of total body water?

    <p>Intracellular Fluid (ICF) (A)</p> Signup and view all the answers

    Which symptom is associated with hypokalemia?

    <p>Muscle weakness (A)</p> Signup and view all the answers

    What is the primary role of sodium in the body?

    <p>Promoting water balance and nerve impulses (C)</p> Signup and view all the answers

    What condition is characterized by excessive fluid retention in the body?

    <p>Fluid Overload (Hypervolemia) (A)</p> Signup and view all the answers

    What is a common symptom of hypernatremia?

    <p>Thirst and agitation (B)</p> Signup and view all the answers

    Which treatment is recommended for hemorrhagic stroke?

    <p>Blood pressure control and surgical intervention (D)</p> Signup and view all the answers

    Which patient condition is typically characterized by tremors, hallucinations, and agitation?

    <p>Delirium Tremens (B)</p> Signup and view all the answers

    What treatment is most effective for hypocalcemia?

    <p>Calcium and vitamin D supplementation (D)</p> Signup and view all the answers

    What is the function of aldosterone in fluid regulation?

    <p>Stimulates potassium excretion and sodium retention (D)</p> Signup and view all the answers

    Which of the following is a defining symptom of ataxia?

    <p>Loss of coordination (C)</p> Signup and view all the answers

    What distinguishes Pick’s Disease from other dementias?

    <p>Distinct neuronal changes (D)</p> Signup and view all the answers

    Which electrolyte is most important for muscle contraction?

    <p>Calcium (Ca²⁺) (C)</p> Signup and view all the answers

    What is the underlying cause of Bruton’s Agammaglobulinemia?

    <p>B cell maturation failure (D)</p> Signup and view all the answers

    Which of the following statements correctly describes DiGeorge Syndrome?

    <p>Leads to T cell deficiency due to thymic hypoplasia. (B)</p> Signup and view all the answers

    In Type I hypersensitivity reactions, which immunoglobulin is predominantly involved?

    <p>IgE (C)</p> Signup and view all the answers

    What is a significant consequence of severe combined immunodeficiency (SCID)?

    <p>Life-threatening bacterial infections early in life. (C)</p> Signup and view all the answers

    Which type of hypersensitivity involves immune complex deposition in tissues?

    <p>Type III (A)</p> Signup and view all the answers

    What characterizes the adaptive immunity response?

    <p>Involvement of B and T cells. (D)</p> Signup and view all the answers

    Which autoimmune disease is characterized by an autoimmune attack on the thyroid gland?

    <p>Hashimoto’s Thyroiditis (B)</p> Signup and view all the answers

    Which of the following is a common symptom of systemic lupus erythematosus?

    <p>Butterfly rash (B)</p> Signup and view all the answers

    What is a primary cause of secondary immunodeficiency disorders?

    <p>Infections and medications (C)</p> Signup and view all the answers

    In the context of congenital abnormalities, what do teratogens do?

    <p>Disrupt normal fetal development (D)</p> Signup and view all the answers

    What type of hypersensitivity is mediated by T cells?

    <p>Type IV (A)</p> Signup and view all the answers

    Which treatment is typically utilized for hyper-IgM syndrome?

    <p>Immunoglobulin replacement (C)</p> Signup and view all the answers

    What potential effect can high doses of teratogens have on fetal development?

    <p>Embryonic death or severe malformations (D)</p> Signup and view all the answers

    What defines immunodeficiency in the context of the immune system?

    <p>Inadequate immune response (A)</p> Signup and view all the answers

    Which organ is primarily affected by T cell deficiencies in DiGeorge Syndrome?

    <p>Thymus (D)</p> Signup and view all the answers

    What is the most common cause of chronic pancreatitis?

    <p>Chronic alcohol abuse (C)</p> Signup and view all the answers

    Which diagnostic test is used to confirm cystic fibrosis?

    <p>Sweat chloride test (C)</p> Signup and view all the answers

    What symptom is most commonly associated with adenocarcinoma of the pancreas?

    <p>Jaundice (D)</p> Signup and view all the answers

    What potential complication is associated with severe chronic pancreatitis?

    <p>Pancreatic necrosis (B)</p> Signup and view all the answers

    Which of the following treatments is appropriate for managing frontotemporal dementia?

    <p>Symptom management with antidepressants (D)</p> Signup and view all the answers

    What condition is a consequence of Congenital heart defects?

    <p>Ovarian failure (D)</p> Signup and view all the answers

    Which cognitive disorder is characterized by a transitional phase between normal aging and dementia?

    <p>Mild cognitive impairment (MCI) (A)</p> Signup and view all the answers

    What is a common treatment for insulinoma?

    <p>Surgical removal (C)</p> Signup and view all the answers

    Which chromosomal disorder is characterized by infertility and reduced muscle mass?

    <p>Klinefelter Syndrome (C)</p> Signup and view all the answers

    Which of the following defines vascular dementia?

    <p>Cognitive decline due to reduced blood flow to the brain (A)</p> Signup and view all the answers

    How does hyperthermia affect fetal development?

    <p>Increases risk of neural tube defects (C)</p> Signup and view all the answers

    What symptom is NOT typically associated with Lewy Body Dementia?

    <p>Severe memory loss (D)</p> Signup and view all the answers

    Which condition results from the accumulation of copper in the body?

    <p>Wilson’s Disease (B)</p> Signup and view all the answers

    What is a potential complication of untreated diabetes mellitus?

    <p>Diabetic ketoacidosis (B)</p> Signup and view all the answers

    What is the primary feature of pseudodementia?

    <p>Response of 'I don’t know' during questioning (C)</p> Signup and view all the answers

    Which treatment is commonly prescribed for managing diabetic ketoacidosis (DKA)?

    <p>Intravenous fluids and insulin therapy (A)</p> Signup and view all the answers

    What surgical intervention might be used for congenital anomalies?

    <p>Corrective surgeries (D)</p> Signup and view all the answers

    What type of therapy is primarily used to treat iron overload in hemochromatosis?

    <p>Phlebotomy (A)</p> Signup and view all the answers

    Which of the following is a symptom of chronic pancreatitis?

    <p>Persistent abdominal pain (B)</p> Signup and view all the answers

    Which method is utilized for prenatal screening specifically for genetic conditions?

    <p>Chorionic villus sampling (B)</p> Signup and view all the answers

    What is a defining characteristic of Alzheimer’s disease?

    <p>Amyloid plaques and neurofibrillary tangles (A)</p> Signup and view all the answers

    Which genetic disorder affects the exocrine glands and causes thick mucus production?

    <p>Cystic fibrosis (A)</p> Signup and view all the answers

    Which external defect involves the failure of the neural tube to close?

    <p>Spina bifida (B)</p> Signup and view all the answers

    What hormonal effect does somatostatin have in the pancreas?

    <p>Inhibits insulin and glucagon release (B)</p> Signup and view all the answers

    What is the primary cause of Type 1 Diabetes Mellitus?

    <p>Autoimmune destruction of beta cells (A)</p> Signup and view all the answers

    What is an effect of teratogens during pregnancy?

    <p>Cause limb deficiencies (C)</p> Signup and view all the answers

    Which treatment is necessary for individuals with Menkes Disease?

    <p>Copper injections (D)</p> Signup and view all the answers

    What is an expected symptom of gestational diabetes?

    <p>Large-for-gestational-age babies (C)</p> Signup and view all the answers

    Which of the following is a major symptom of Parkinson's Disease?

    <p>Bradykinesia (B)</p> Signup and view all the answers

    What is the primary genetic mutation associated with Huntington's Disease?

    <p>HTT gene (D)</p> Signup and view all the answers

    Acute Kidney Injury (AKI) can be classified into several types based on its cause. Which of the following is a characteristic of intrinsic AKI?

    <p>Direct kidney damage (B)</p> Signup and view all the answers

    Which treatment option is effective for symptom management of chorea in Huntington's Disease?

    <p>Tetrabenazine (A)</p> Signup and view all the answers

    What is a common non-motor symptom experienced by individuals with Parkinson's Disease?

    <p>Depression (A)</p> Signup and view all the answers

    What is the defining characteristic of stage 5 Chronic Kidney Disease (CKD)?

    <p>End-stage renal disease (A)</p> Signup and view all the answers

    Which treatment is indicated for ischemic stroke within the first few hours?

    <p>Thrombolysis with tPA (A)</p> Signup and view all the answers

    A patient with hematuria and recurrent urinary tract infections may have which condition?

    <p>Polycystic Kidney Disease (D)</p> Signup and view all the answers

    Which of the following medications is used to slow disease progression in Amyotrophic Lateral Sclerosis (ALS)?

    <p>Edaravone (A), Riluzole (B)</p> Signup and view all the answers

    What is typically the initial indication of a lower urinary tract infection (UTI)?

    <p>Dysuria (B)</p> Signup and view all the answers

    Calcium oxalate stones are the most common type of kidney stones. What lifestyle change can help prevent them?

    <p>Increased hydration (A)</p> Signup and view all the answers

    What is a significant risk factor leading to Chronic Kidney Disease (CKD)?

    <p>Diabetes mellitus (C)</p> Signup and view all the answers

    Which symptom is indicative of a hemorrhagic stroke?

    <p>Severe headache (C)</p> Signup and view all the answers

    In the context of renal disorders, what does hyperkalemia refer to?

    <p>High potassium levels (B)</p> Signup and view all the answers

    Flashcards

    Pituitary Gland Function

    The 'master gland' regulating many bodily functions via hormone secretion.

    Hypopituitarism

    Insufficient production of one or more pituitary hormones.

    Hyperpituitarism

    Overproduction of pituitary hormones.

    Pituitary Tumors

    Abnormal growths in the pituitary gland.

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    Growth Hormone (GH)

    Pituitary hormone crucial for growth.

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    Acromegaly

    Excess GH in adults causing enlarged features.

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    Adrenal Insufficiency

    Low ACTH causing fatigue, low blood pressure.

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    Hypogonadism

    Low LH/FSH causing reduced sexual function/infertility.

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    Cushing's Disease

    A condition caused by excess ACTH, resulting in high cortisol levels.

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    Prolactinoma

    A benign pituitary tumor that produces excess prolactin.

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    Diabetes Insipidus (DI)

    A deficiency in ADH, causing excessive water loss by the kidneys.

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    SIADH

    Overproduction of ADH, resulting in water retention and low sodium.

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    Adenohypophysis

    The anterior part of the pituitary gland that secretes hormones.

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    Neurohypophysis

    The posterior portion of the pituitary gland.

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    Hypothyroidism

    A condition where the thyroid gland doesn't produce enough thyroid hormones.

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    Hyperthyroidism

    A condition where the thyroid gland produces excessive thyroid hormones.

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    Graves' Disease

    The most common cause of hyperthyroidism, an autoimmune disorder.

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    Goiter

    Enlargement of the thyroid gland.

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    Hashimoto's Thyroiditis

    An autoimmune condition causing inflammation and destruction of the thyroid, leading to hypothyroidism.

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    Thyroxine (T4)

    A precursor thyroid hormone converted to T3.

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    Parathyroid Hormone (PTH)

    A hormone that regulates calcium levels in the blood.

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    Hyperparathyroidism

    A condition characterized by excessive PTH production leading to high blood calcium (hypercalcemia).

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    Primary Hyperparathyroidism

    Caused by a problem within the parathyroid glands themselves, like a tumor or overgrowth.

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    Secondary Hyperparathyroidism

    Occurs due to other conditions like kidney disease or vitamin D deficiency, making the parathyroid glands overwork.

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    Tertiary Hyperparathyroidism

    Long-standing secondary hyperparathyroidism leading to the gland becoming independent and overproducing PTH.

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    Hypoparathyroidism

    A condition characterized by insufficient PTH production leading to low blood calcium (hypocalcemia).

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    Post-Surgical Hypoparathyroidism

    Occurs after surgery on the thyroid or neck, potentially damaging the parathyroid glands.

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    Tetany

    Involuntary muscle spasms and cramps caused by low blood calcium.

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    Chvostek's Sign

    Facial muscle twitching when tapping the facial nerve, indicating low calcium.

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    Trousseau's Sign

    Hand and wrist spasm caused by inflating a blood pressure cuff, indicating low calcium.

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    Adrenal Glands

    Two small glands sitting on top of the kidneys, responsible for hormone production related to stress, metabolism, and electrolyte balance.

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    Adrenal Cortex

    The outer layer of the adrenal gland producing various hormones like aldosterone, cortisol, and androgens.

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    Aldosterone

    A hormone produced by the adrenal cortex, regulating sodium and potassium balance.

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    Cortisol

    A hormone produced by the adrenal cortex, controlling metabolism and stress responses.

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    Adrenal Medulla

    The inner part of the adrenal gland producing adrenaline and noradrenaline, crucial for the fight-or-flight response.

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    Pheochromocytoma

    A rare adrenal medulla tumor that produces excessive catecholamines, leading to sudden and severe hypertension, rapid heart rate, sweating, headaches, anxiety, and weight loss.

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    Catecholamines

    Hormones such as adrenaline (epinephrine) and noradrenaline (norepinephrine) produced by the adrenal medulla.

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    Paroxysmal Hypertension

    Sudden and severe episodes of high blood pressure, often associated with pheochromocytoma.

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    Metanephrines

    Breakdown products of catecholamines, elevated in the blood and urine of patients with pheochromocytoma.

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    Adrenalectomy

    Surgical removal of the adrenal gland, a common treatment for pheochromocytoma.

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    Primary Ovarian Insufficiency (POI)

    Premature ovarian failure where ovaries stop working before age 40, causing low estrogen levels and irregular or absent menstruation.

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    Oogenesis

    The process of egg maturation and release during ovulation.

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    Hormone Replacement Therapy (HRT)

    Treatment that restores estrogen levels to alleviate symptoms of primary ovarian insufficiency and menopause.

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    Polycystic Ovary Syndrome (PCOS)

    A hormonal disorder with multiple ovarian cysts, high androgen levels, and irregular menstrual cycles.

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    Hirsutism

    Excess hair growth, a common symptom of PCOS.

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    Metformin

    A medication used to improve insulin sensitivity in PCOS.

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    Menopause

    Natural cessation of ovarian function around age 50, causing reduced hormone production and menopausal symptoms.

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    Testosterone Replacement Therapy (TRT)

    Treatment that restores testosterone levels in hypogonadism.

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    Stroke

    An event where blood flow to the brain is interrupted, causing damage to brain cells.

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    Ischemic Stroke

    Caused by a blood clot obstructing a blood vessel in the brain.

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    Hemorrhagic Stroke

    Caused by a bleeding vessel in the brain.

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    Ischemic Cascade

    A chain of events triggered when blood flow to brain cells is interrupted, leading to cell death.

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    Watershed Infarcts

    Areas of brain tissue damage that occur where major cerebral arteries meet, due to limited blood flow.

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    Delirium Tremens (DTs)

    A severe alcohol withdrawal syndrome characterized by tremors, hallucinations, and agitation.

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    Aphasia

    Difficulty speaking or understanding language.

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    Pick's Disease

    A subtype of frontotemporal dementia characterized by specific neuronal changes in the brain.

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    Amyloid Plaques

    Protein aggregates found in the brain, associated with Alzheimer's disease.

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    Chorea

    Involuntary, rapid, and irregular movements often seen in Huntington's disease.

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    Confabulation

    Making up memories to fill in gaps caused by amnesia.

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    Intracellular Fluid (ICF)

    Fluid inside cells, making up about 60% of total body water.

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    Extracellular Fluid (ECF)

    Fluid outside cells, containing interstitial fluid, plasma, and transcellular fluid.

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    Dehydration

    A condition caused by excessive fluid loss or insufficient fluid intake.

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    Fluid Overload (Hypervolemia)

    Excessive fluid retention in the body leading to increased blood volume.

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    Innate Immunity

    The body's first line of defense against pathogens, providing a rapid but nonspecific response.

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    Adaptive Immunity

    A slower but highly specific immune response, involving lymphocytes like B and T cells, providing long-term protection.

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    Primary Immunodeficiency

    A congenital disorder caused by genetic mutations, resulting in a weakened immune system.

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    Secondary Immunodeficiency

    An acquired weakened immune system due to external factors like infections, medications, or diseases.

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    Autoimmunity

    The immune system mistakenly attacks the body's own tissues.

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    Hypersensitivity Reaction

    An overly strong immune response, leading to tissue damage.

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    Type I Hypersensitivity

    Immediate allergic reaction mediated by IgE antibodies.

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    Type II Hypersensitivity

    Antibody-mediated destruction of cells.

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    Type III Hypersensitivity

    Immune complex deposition in tissues causing inflammation.

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    Type IV Hypersensitivity

    Delayed immune response mediated by T cells.

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    Teratogen

    An environmental agent that can cause birth defects.

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    Organogenesis Phase

    The most vulnerable stage of fetal development, when organ formation occurs.

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    Androgen Insensitivity Syndrome (AIS)

    A condition where the body is unable to respond to male hormones (androgens), leading to a range of physical characteristics from female-like to partial male development.

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    Klinefelter Syndrome

    A chromosomal condition in males where they have an extra X chromosome (XXY), resulting in lower testosterone levels and various symptoms like tall stature, reduced muscle mass, and fertility issues.

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    Hyperprolactinemia

    An imbalance where prolactin levels in the body are abnormally high, affecting testosterone production and male reproductive function.

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    Primary Testicular Failure

    A condition where the testicles themselves are unable to produce enough testosterone or sperm, leading to infertility and other symptoms.

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    Secondary Hypogonadism

    A condition where the hypothalamus or pituitary gland is not functioning properly, disrupting the production of testosterone.

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    Cognition

    Refers to the mental processes involved in thinking, learning, remembering, and understanding information.

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    Mild Cognitive Impairment (MCI)

    A condition characterized by subtle cognitive decline that is more pronounced than normal aging but not severe enough to be classified as dementia.

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    Delirium

    A sudden and fluctuating disturbance in attention, awareness, and cognition, often caused by underlying medical conditions or substance withdrawal.

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    Pseudodementia

    Cognitive dysfunction that appears as dementia but is actually caused by underlying psychological conditions like depression.

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    Normal Pressure Hydrocephalus (NPH)

    A condition causing cognitive decline, gait problems, and urinary incontinence due to excess cerebrospinal fluid (CSF) in the brain.

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    Alzheimer's Disease

    A progressive brain disorder causing memory loss, language issues, and impaired thinking, gradually worsening over time.

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    Vascular Dementia

    A condition caused by multiple small strokes damaging the brain, leading to cognitive decline and memory issues.

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    Lewy Body Dementia

    A brain disorder involving clumps of proteins (Lewy bodies) in the brain, leading to cognitive fluctuations, hallucinations, and movement issues.

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    Frontotemporal Dementia

    A type of dementia impacting the frontal and temporal lobes, primarily affecting personality, behavior, and language.

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    Parkinson's Disease Dementia

    A progressive neurodegenerative disorder that can lead to dementia, characterized by tremors, rigidity, and movement difficulties.

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    Huntington's Disease

    An inherited neurodegenerative disorder characterized by involuntary movements, cognitive decline, and psychiatric symptoms.

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    Parkinson's Disease

    A movement disorder caused by the loss of dopamine-producing neurons in the brain.

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    Resting Tremor

    Shaking that occurs when the body is at rest, a common symptom of Parkinson's Disease.

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    Bradykinesia

    Slowness of movement, a key symptom of Parkinson's Disease.

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    Amyotrophic Lateral Sclerosis (ALS)

    A progressive neurodegenerative disease affecting motor neurons, causing muscle weakness, atrophy, and eventually paralysis.

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    Tissue Plasminogen Activator (tPA)

    A clot-busting medication used to treat ischemic stroke within a limited time frame.

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    Acute Kidney Injury (AKI)

    Sudden loss of kidney function causing a buildup of waste products in the blood.

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    Chronic Kidney Disease (CKD)

    Gradual loss of kidney function over time, often irreversible.

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    Glomerulus

    The filtering unit within the nephron of the kidney, responsible for removing waste from blood.

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    Nephron

    The functional unit of the kidney, responsible for filtering blood and producing urine.

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    Urinary Tract Infection (UTI)

    An infection anywhere in the urinary tract, typically caused by bacteria.

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    Kidney Stones

    Solid, crystalline masses that form in the urinary tract, often causing pain.

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    Rubella

    A viral infection that can lead to serious birth defects, including cataracts, microcephaly, and heart defects.

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    Toxoplasmosis

    A parasitic infection often contracted through contact with cat feces or undercooked meat, which can cause brain damage in developing fetuses, like hydrocephalus (excess fluid in the brain) and intracranial calcifications (calcium deposits in the brain).

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    Varicella

    A viral infection, commonly known as chickenpox, that can cause limb defects (like missing limbs or webbing) and scarring in babies if contracted during pregnancy.

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    Hyperthermia

    High body temperature, often caused by prolonged exposure to heat, can lead to neural tube defects (issues with spinal cord development), a serious birth defect.

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    Radiation

    Exposure to radiation, even in small amounts, can cause birth defects, such as microcephaly (small head) and intellectual disabilities.

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    Maternal Diabetes

    Uncontrolled diabetes in pregnant women increases the risk of birth defects, including neural tube defects and congenital heart defects.

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    Phenylketonuria (PKU)

    A genetic disorder where the body can't properly break down phenylalanine, an amino acid. Without proper management, it can lead to microcephaly (small head) and intellectual disabilities.

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    Neural Tube Defects (NTDs)

    A group of birth defects that occur when the neural tube, a structure that develops into the brain and spinal cord, does not close completely during pregnancy. Common examples include spina bifida and anencephaly.

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    Orofacial Clefts

    Birth defects involving incomplete closure of the lip and/or palate, resulting in a gap or split.

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    Limb Deficiencies

    Birth defects where a limb is missing or not fully formed, such as clubfoot.

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    Congenital Heart Defects

    Birth defects affecting the heart's structure or function, examples include tetralogy of Fallot and transposition of the great arteries.

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    Gastrointestinal Anomalies

    Birth defects involving the digestive system, such as esophageal atresia, where the esophagus doesn't fully connect to the stomach.

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    Genitourinary Anomalies

    Birth defects affecting the reproductive and urinary systems, like renal agenesis, where a kidney is absent.

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    Trisomy 21 (Down Syndrome)

    A genetic disorder caused by an extra copy of chromosome 21, resulting in characteristic physical and mental features.

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    Turner Syndrome (45, X)

    A genetic disorder affecting females caused by the absence of one X chromosome, leading to short stature, ovarian failure, and cardiovascular defects.

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    Klinefelter Syndrome (47, XXY)

    A genetic disorder affecting males characterized by an extra X chromosome, resulting in hypogonadism (reduced male hormones), reduced muscle mass, and infertility.

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    Chronic Pancreatitis

    Progressive damage to the pancreas, often due to repeated episodes of acute pancreatitis, leading to irreversible changes.

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    Chronic Pancreatitis Causes

    Alcohol abuse, genetic predisposition (e.g., cystic fibrosis), and autoimmune diseases are common causes.

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    Chronic Pancreatitis Symptoms

    Persistent abdominal pain, fatty stools (steatorrhea) due to malabsorption, weight loss, and diabetes.

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    Cystic Fibrosis (CF)

    A genetic disorder affecting exocrine glands, like the pancreas, causing thick mucus build-up and blockage.

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    CF Symptoms

    Pancreatic insufficiency (malabsorption, steatorrhea), recurrent lung infections, poor growth, and vitamin deficiencies.

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    Pancreatic Tumor

    Abnormal growth within the pancreas that can be benign or malignant.

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    Adenocarcinoma

    The most common and aggressive pancreatic tumor, leading to jaundice, weight loss, and abdominal pain.

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    Insulinoma

    A benign tumor in the pancreas that causes too much insulin, leading to low blood sugar (hypoglycemia).

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    Alzheimer's Disease (AD)

    The most common form of dementia, causing progressive memory loss, cognitive decline, and behavioral changes.

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    Lewy Body Dementia (LBD)

    Dementia caused by protein deposits called Lewy bodies, leading to fluctuating cognition, hallucinations, and Parkinsonism.

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    Frontotemporal Dementia (FTD)

    Dementia affecting the frontal and temporal lobes, leading to personality and behavior changes, and language issues.

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    Study Notes

    Altered Functions of the Pituitary Gland

    • The pituitary gland, the "master gland," is a small endocrine organ at the base of the brain.
    • It has two parts:
      • Anterior pituitary (adenohypophysis): Produces and releases growth hormone (GH), prolactin (PRL), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), and luteinizing hormone (LH).
      • Posterior pituitary (neurohypophysis): Stores and releases oxytocin and vasopressin (ADH), produced in the hypothalamus.
    • Pituitary disorders cause hormone imbalances:
      • Hypopituitarism (underactivity): Insufficient hormone production, often due to tumors, trauma, radiation, infections, or autoimmune conditions.
        • Symptoms include fatigue, weight loss, cold intolerance, low blood pressure, decreased appetite, infertility. In children, growth retardation is notable.
        • Associated disorders include adrenal insufficiency, hypothyroidism, hypogonadism, and growth hormone deficiency.
        • Treatment is hormone replacement therapy.
      • Hyperpituitarism (overactivity): Excessive hormone production, often due to pituitary adenoma (tumor).
        • Examples include acromegaly/gigantism (excess GH), Cushing's disease (excess ACTH), and prolactinoma (excess prolactin).
        • Symptoms vary depending on the affected hormone.
        • Treatment includes tumor removal, medication, or radiation therapy.
    • Other pituitary-related conditions include diabetes insipidus (deficiency in ADH) and syndrome of inappropriate antidiuretic hormone (SIADH).

    Altered Functions of the Thyroid Gland

    • The thyroid gland is a butterfly-shaped gland in the neck, regulating metabolism and blood calcium.
    • Key hormones:
      • Thyroxine (T4): A precursor converted to active T3.
      • Triiodothyronine (T3): The active hormone regulating metabolism.
      • Calcitonin: Regulates blood calcium levels.
    • Thyroid function is regulated by the hypothalamus-pituitary-thyroid axis.
    • Hypothyroidism (underactive thyroid): Insufficient hormone production, often caused by Hashimoto's thyroiditis, iodine deficiency, or thyroidectomy.
      • Symptoms include fatigue, weight gain, cold intolerance, dry skin, hair loss, constipation, and bradycardia.
      • Types include primary (direct thyroid dysfunction), secondary (pituitary failure), subclinical (mild), and myxedema (severe).
      • Diagnosis involves blood tests (elevated TSH, low T3/T4).
      • Treatment: Levothyroxine (synthetic T4).
    • Hyperthyroidism (overactive thyroid): Excessive hormone production, often due to Graves' disease, toxic multinodular goiter, or thyroid adenoma.
      • Symptoms include weight loss, heat intolerance, increased appetite, tachycardia, anxiety, tremors, and excessive sweating. In Graves' disease, exophthalmos (bulging eyes) is more prevalent.
      • Types include Graves' disease, toxic nodular goiter, and thyroid storm.
      • Diagnosis involves blood tests (low TSH, high T3/T4) and imaging.
      • Treatment options are antithyroid medications, radioactive iodine therapy, or surgery.

    Altered Functions of the Parathyroid Glands

    • The parathyroid glands (4) regulate blood calcium, phosphate, and magnesium levels, primarily through parathyroid hormone (PTH).
    • PTH functions: Increasing blood calcium by: stimulating osteoclasts (bone calcium release), enhancing kidney calcium reabsorption, and promoting vitamin D activation for calcium absorption, while reducing phosphate kidney reabsorption.
    • Hyperparathyroidism (excess PTH):
      • Types: Primary (intrinsic gland issues, often adenomas), secondary (compensatory response to other conditions), and tertiary (autonomous PTH secretion).
      • Symptoms include bone pain, fractures, kidney stones, muscle weakness, gastrointestinal issues (nausea, constipation), and psychological symptoms (depression, confusion).
      • Diagnosis includes blood tests (elevated calcium and PTH) and imaging (ultrasound, sestamibi scan).
      • Treatment involves surgery (parathyroidectomy), medication (cinacalcet), and lifestyle adjustments.
    • Hypoparathyroidism (deficient PTH):
      • Causes: Surgery, autoimmune destruction, genetics, or radiation.
      • Symptoms include neuromuscular signs (tetany, Chvostek's and Trousseau's signs), tingling/numbness, seizures, and cardiac arrhythmias.
      • Diagnosis involves blood tests (low calcium and PTH).
      • Treatment includes calcium and vitamin D supplements.

    Altered Functions of the Adrenal Glands

    • The adrenal glands sit atop the kidneys, regulating stress responses and electrolyte balance.
    • Structure: Two parts: Adrenal cortex (produces corticosteroids) and adrenal medulla (produces catecholamines).
    • Adrenal insufficiency (hypofunction): insufficient hormone production, includes Primary (Addison's disease; damage to adrenal cortex) and secondary (reduced ACTH from pituitary).
      • Symptoms include fatigue, weakness, low blood pressure, dehydration, altered pigmentation, nausea, vomiting, and electrolyte imbalances.
      • Diagnosis includes ACTH stimulation test and blood tests.
      • Treatment includes glucocorticoid and mineralocorticoids replacement therapy.
    • Cushing's syndrome (hyperfunction): prolonged exposure to high cortisol levels, often from ACTH overproduction or adrenal tumors.
      • Symptoms include central obesity, hypertension, hyperglycemia, muscle weakness, thin skin (easy bruising), osteoporosis, infection susceptibility, mood changes.
      • Diagnosis includes dexamethasone suppression test and blood tests.
      • Treatment involves tumor removal, medication, and/or corticosteroid tapering.
    • Pheochromocytoma: an adrenal medulla tumor releasing excessive catecholamines, causing paroxysmal hypertension, tachycardia, sweating, headaches, and anxiety.
      • Diagnosis includes blood and urine tests and imaging.
      • Treatment includes tumor removal and pre-operative blood pressure management.

    Endocrine Disorders in Female and Male Reproductive Functions

    • Female Reproductive Hormonal Disorders:
      • Primary ovarian insufficiency (POI): Premature ovarian failure (before age 40), causing low estrogen and irregular periods.
        • Causes include genetic factors, toxins, autoimmune issues, and idiopathic.
        • Symptoms include irregular periods, infertility, hot flashes, and vaginal dryness.
        • Treatment includes hormone replacement therapy, lifestyle changes, and psychological support.
      • Polycystic ovary syndrome (PCOS): Hormonal imbalance with multiple cysts, high androgens, and irregular periods.
        • Symptoms include irregular periods, excess hair growth (hirsutism), acne, and weight gain.
        • Can lead to diabetes and cardiovascular issues.
        • Treatment includes lifestyle changes, hormonal contraceptives, metformin, and anti-androgens.
      • Menopause: Natural cessation of ovarian function (around age 50), reducing hormone production.
        • Symptoms include hot flashes, vaginal dryness, sleep problems, and mood swings.
        • Complications include osteoporosis and cardiovascular issues.
        • Treatment involves hormone replacement therapy, lifestyle changes, and calcium/vitamin D supplementation.
    • Male Reproductive Hormonal Disorders:
      • Hypogonadism: Insufficient testosterone production (primary: testicular failure; secondary: hypothalamic/pituitary dysfunction).
        • Symptoms include delayed puberty, reduced libido, erectile dysfunction, and infertility.
        • Treatment includes testosterone replacement therapy and fertility treatments.
      • Androgen insensitivity syndrome (AIS): Genetic inability to respond to androgens (testosterone).
        • Causes varying degrees of sexual ambiguity and female presentation when XY.
        • Treatment involves hormone therapy and possible surgeries.
      • Klinefelter syndrome: Extra X chromosome in males, leading to hypogonadism.
        • Symptoms include tall stature, reduced muscle mass, gynecomastia (breast development), and infertility.
        • Treatment includes testosterone replacement.
      • Hyperprolactinemia: High prolactin levels affecting testosterone and spermatogenesis (often due to pituitary tumors).
        • Symptoms include reduced libido, erectile dysfunction, infertility, and gynecomastia.
        • Treatment includes dopamine agonists and potentially surgery.

    Cognitive and Neurological Disorders

    • Cognitive disorders affect memory, learning, reasoning, and perception.

    • Mild Cognitive Impairment (MCI): Subtle cognitive decline, more than normal aging, but not severe enough for dementia diagnosis.

      • Often forgetful, difficulties with complex tasks, mild daily life interference.
    • Delirium: Acute confusion, disorientation, fluctuating attention, often from underlying medical conditions.

    • Pseudodementia: Cognitive impairment mimicking dementia from psychiatric conditions (often depression).

    • Dementia: Progressive cognitive decline without cure.

      • Reversible dementias:
        • Normal Pressure Hydrocephalus (NPH): Enlarged ventricles, urinary incontinence, gait disturbance, and cognitive decline. Treatment is VP shunt.
        • Vitamin B12 deficiency: Memory loss, numbness, and mood changes, blood levels are low to diagnose. Treatment is B12 supplementation.
      • Irreversible dementias:
        • Alzheimer's Disease: Gradual memory loss, language problems, and impaired executive function. Pathological signs are brain atrophy, amyloid plaques, and neurofibrillary tangles. Treatment involves cholinesterase inhibitors and NMDA receptor antagonists.
        • Vascular Dementia: Stepwise cognitive decline, often from small strokes. Treatment is underlying vascular risk factor management.
        • Lewy Body Dementia: Fluctuating cognition, visual hallucinations, and Parkinsonism. Treatments include cholinesterase inhibitors and limiting antipsychotic use.
        • Frontotemporal Dementia: Personality changes, impaired judgment, disinhibition in frontal and temporal lobe atrophy cases (often Pick's disease). Treatment is symptomatic, often with antidepressants/antipsychotics.
        • Parkinson's Disease Dementia: Parkinsonian motor problems with gradual cognitive decline. Treatment is Parkinsonian symptom management.
        • Huntington's Disease: Progressive genetic disorder causing chorea (involuntary movements) and cognitive decline. Treatment is symptomatic (tetrabenazine).
        • Wernicke-Korsakoff Syndrome: Thiamine deficiency from alcohol abuse, causes severe memory problems, confabulation (false memories), and ataxia (loss of coordination). Treat with Thiamine and cessation of alcohol.
    • Stroke and Cerebral Ischemia: Interruption of blood flow to the brain causing neuronal death.

      • Types: Ischemic (clot/narrowing), hemorrhagic (bleeding).
      • Ischemic stroke treatment includes thrombolytic therapy (e.g., tPA) within timeframe. Hemorrhagic stroke treatment focuses on blood pressure control and potential surgery.

    Fluid and Electrolyte Imbalances

    • Fluid and electrolyte balance is crucial for cellular and metabolic function.
    • Body fluid compartments: Intracellular fluid (60%), extracellular fluid (plasma, interstitial, transcellular).
    • Key electrolytes: Sodium (Na+), Potassium (K+), Calcium (Ca2+), Magnesium (Mg2+), Phosphate (PO43-).
    • Dehydration: Excessive fluid loss; caused by vomiting, diarrhea, sweating; symptoms include dry skin/mucous membranes, reduced urine output, hypotension, and confusion.
    • Fluid overload (hypervolemia): Excessive fluid retention in the body. Caused by heart failure, kidney failure, excessive sodium. Symptoms include edema, hypertension, and pulmonary congestion.
    • Electrolyte imbalances:
      • Hyponatremia (low sodium): Often from SIADH. Symptoms include nausea, confusion, and seizures.
      • Hypernatremia (high sodium): Often from dehydration or diabetes insipidus. Symptoms include thirst, agitation, and seizures/coma.
      • Hypokalemia (low potassium): Due to diuretics or GI issues. Symptoms include weakness and arrhythmias.
      • Hyperkalemia (high potassium): From kidney failure, acidosis, or tissue damage. Symptoms are muscle weakness and/or cardiac arrest.
      • Hypocalcemia (low calcium):
      • Hypercalcemia (high calcium):
    • Fluid regulation: Homeostasis involves ADH, aldosterone, natriuretic peptides, osmosis/diffusion, and active transport.

    Immune System Disorders

    • The immune system protects the body from pathogens, abnormal cells, and foreign substances. Innate (nonspecific) immunity is a first-line defense. Adaptive (specific) immunity involves B and T lymphocytes.
    • Primary immunodeficiencies: Congenital, from genetic defects, leading to defective immune components. Examples include SCID (both B and T cell defects), Bruton's agammaglobulinemia (B cell deficiency), DiGeorge syndrome (T cell deficiency), and Hyper-IgM syndrome (immunoglobulin class switching problems).
    • Secondary immunodeficiencies: Acquired due to conditions like HIV/AIDS, cancer, chemotherapy, or malnutrition.
    • Autoimmune diseases: Mistaken immune response to the body's own tissues. Examples include SLE (multisystem autoimmune attack), RA (joint inflammation), Hashimoto's (thyroid), and type 1 diabetes (pancreatic beta cell destruction).
    • Hypersensitivity reactions: Overactive immune response. Types are categorized (Type I – immediate, Type II – cytotoxicity, Type III – immune complexes, Type IV – delayed).

    Congenital Abnormalities and Teratogenic Disorders

    • Congenital abnormalities are structural or functional defects present at birth.
    • Teratogens cause congenital abnormalities, disrupting fetal development. Factors like timing of exposure and dose are key to severity.
    • Examples:
      • Drugs (alcohol, androgens, phenytoin, excess vitamin A).
      • Infections (rubella, toxoplasmosis, varicella).
      • Physical agents (hyperthermia, radiation).
      • Maternal factors (diabetes, PKU).
    • Congenital Anomalies:
      • External: Neural tube defects (spina bifida, anencephaly), orofacial clefts (cleft lip/palate), limb deficiencies (clubfoot).
      • Internal: Congenital heart defects (tetralogy of Fallot, transposition), gastrointestinal anomalies (esophageal atresia), genitourinary anomalies (renal agenesis).
      • Chromosomal disorders: Trisomy 21 (Down syndrome), Turner syndrome, Klinefelter syndrome.
    • Abnormalities of metal metabolism:
      • Hemochromatosis (iron overload)
      • Wilson's disease (copper accumulation)
      • Menkes disease (copper deficiency).
    • Management and prevention: Prenatal screening (ultrasound, blood tests), folic acid supplementation, teratogen avoidance, and maternal condition management. Treatment involves surgical correction and supportive care.

    Altered Functions of the Pancreas

    • The pancreas has exocrine (digestive enzymes) and endocrine (blood sugar regulation) functions.
    • Pancreatic hormones: Insulin (lowers blood glucose), glucagon (raises blood glucose), somatostatin (inhibits insulin/glucagon), and pancreatic polypeptide.
    • Diabetes mellitus (DM): Chronic hyperglycemia.
      • Type 1 DM: Autoimmune destruction of beta cells; requires lifelong insulin therapy.
      • Type 2 DM: Insulin resistance and inadequate insulin secretion; often linked to lifestyle factors; lifestyle modifications and oral hypoglycemics are common initial approaches. Gestational diabetes occurs during pregnancy.
    • Acute pancreatitis: Sudden inflammation. Common causes are gallstones and alcohol abuse; severe abdominal pain radiating to the back and nausea/vomiting are notable symptoms.
    • Chronic pancreatitis: Progressive damage, often from chronic alcohol abuse; persistent abdominal pain, steatorrhea (fatty stools), and significant weight loss are typical characteristics.
    • Cystic fibrosis (CF): A genetic disorder impacting exocrine glands; causing thick mucus buildup. CF can lead to pancreatic insufficiency, recurrent lung infections, and growth problems.
    • Pancreatic tumors: Benign or malignant; adenocarcinomas (most common pancreatic cancer) have symptoms like jaundice, weight loss, and abdominal pain. Insulinoma (a benign tumor of beta cells) causes hypoglycemia.

    Renal Disorders

    • The renal system filters blood, regulates fluids, controls blood pressure, and produces hormones.
    • Acute Kidney Injury (AKI): Sudden kidney dysfunction; causes (prerenal - decreased blood flow, intrinsic - direct kidney damage, postrenal - urinary outflow obstruction); symptoms include oliguria, fluid retention, elevated BUN/creatinine. Treatment focuses on underlying causes.
    • Chronic Kidney Disease (CKD): Gradual kidney function loss; common causes include diabetes and hypertension. Treatment focuses on managing underlying conditions and managing symptoms.
    • Urinary Tract Infections (UTIs): Infections of urinary tract, commonly caused by Escherichia coli. Symptoms and treatment depend on localization (cystitis vs. pyelonephritis).
    • Kidney Stones (Nephrolithiasis): Crystalline masses formed in urinary tract. Most stones are calcium oxalate. Symptoms include severe flank pain, hematuria. Treatment varies depending on stone size and location.
    • Polycystic Kidney Disease (PKD): Genetic disorder causing fluid-filled cysts within kidneys; symptoms include hypertension, hematuria, flank pain, and potential kidney enlargement; diagnosis often involves ultrasound and genetic testing.

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    Test your knowledge on the anterior pituitary's role in growth and metabolism, as well as disorders related to its activity. This quiz covers key concepts about hormonal deficiencies and excesses, symptoms of pituitary disorders, and treatment approaches.

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