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Questions and Answers
Aldosterone is produced by the zona reticularis of the adrenal cortex.
Aldosterone is produced by the zona reticularis of the adrenal cortex.
False (B)
Aldosterone plays a role in the homeostatic regulation of blood pressure.
Aldosterone plays a role in the homeostatic regulation of blood pressure.
True (A)
Aldosterone has the same function as the atrial natriuretic hormone.
Aldosterone has the same function as the atrial natriuretic hormone.
False (B)
Drugs that block aldosterone secretion are sometimes used as antihypertensives.
Drugs that block aldosterone secretion are sometimes used as antihypertensives.
Aldosterone promotes the excretion of sodium and retention of potassium.
Aldosterone promotes the excretion of sodium and retention of potassium.
The action of aldosterone increases water retention in the body.
The action of aldosterone increases water retention in the body.
The primary function of aldosterone is to regulate calcium levels in the body.
The primary function of aldosterone is to regulate calcium levels in the body.
Aldosterone is involved in the renin–angiotensin–aldosterone system.
Aldosterone is involved in the renin–angiotensin–aldosterone system.
Spironolactone is a potassium-sparing diuretic.
Spironolactone is a potassium-sparing diuretic.
Aldosterone receptor interference by spironolactone leads to increased blood pressure.
Aldosterone receptor interference by spironolactone leads to increased blood pressure.
Spironolactone belongs to the steroidal spirolactone group.
Spironolactone belongs to the steroidal spirolactone group.
Spironolactone has no effect on blood pressure.
Spironolactone has no effect on blood pressure.
Diuretics are used to maintain sodium levels in the body.
Diuretics are used to maintain sodium levels in the body.
The main action of spironolactone is related to its effect on the kidneys.
The main action of spironolactone is related to its effect on the kidneys.
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Study Notes
Hormones of Adrenal Glands
Aldosterone
- Main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex.
- Essential for sodium conservation across multiple organs: kidney, salivary glands, sweat glands, and colon.
- Central in regulating blood pressure, plasma sodium (Na+), and potassium (K+) levels.
- Functions by acting on mineralocorticoid receptors in the distal tubules and collecting ducts of the nephron.
- Influences sodium reabsorption and potassium excretion in the kidneys, indirectly affecting water retention, blood pressure, and blood volume.
- Dysregulation can lead to cardiovascular and kidney diseases, highlighting its pathogenic potential.
- Opposes the function of atrial natriuretic hormone, which is secreted by the heart.
- Part of the renin-angiotensin-aldosterone system (RAAS), crucial for blood pressure regulation.
Aldosterone Blockers
- Drugs that interfere with aldosterone secretion or action serve as antihypertensives.
- Lisinopril blocks angiotensin-converting enzyme (ACE), reducing aldosterone secretion and consequently lowering blood pressure.
- The impact of these drugs results in decreased sodium and water retention but increased potassium retention.
- Spironolactone acts as a potassium-sparing diuretic, interfering with aldosterone receptors, leading to lower blood pressure.
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