Endocrine Glands and Embryogenesis

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Questions and Answers

What defines the interaction of peptide hormones with target cells?

  • They bind to membrane receptors and utilize second messengers. (correct)
  • They freely diffuse through the cell membrane before binding.
  • They require specific intracellular receptors for activation.
  • They directly induce gene transcription in the nucleus.

Which characteristic is unique to cells producing steroid hormones?

  • More developed smooth endoplasmic reticulum. (correct)
  • Presence of abundant secretion granules.
  • Tubular cristae in the mitochondria. (correct)
  • Well-developed rough endoplasmic reticulum and Golgi apparatus.

In the classification of endocrine glands, what distinguishes unicellular glands from multicellular glands?

  • Multicellular glands always have a defined structure or shape. (correct)
  • Unicellular glands consist of one or a very small group of isolated cells. (correct)
  • Multicellular glands are incapable of paracrine activities.
  • Unicellular glands are found only in the gastrointestinal tract.

What is the primary role of autocrine activity in cell communication?

<p>To enable a cell to respond to its own secreted signals. (B)</p> Signup and view all the answers

Which type of hormones are derived from cholesterol and where are they primarily produced?

<p>Steroid hormones, primarily produced in the gonads and adrenal cortex. (B)</p> Signup and view all the answers

Which hormone primarily encourages the motility of the digestive tract?

<p>Motilin (D)</p> Signup and view all the answers

What is the main function of entero-endocrine cells in the Crypts of Lieberkühn?

<p>Secretion of peptide hormones (C)</p> Signup and view all the answers

The hypophyseal portal system connects which two structures?

<p>Hypothalamus and anterior pituitary (A)</p> Signup and view all the answers

Which of the following is a characteristic of the adenohypophysis?

<p>Contains cords or clumps of cells (A)</p> Signup and view all the answers

Which hormone stimulates the secretion of bicarbonate by the pancreas?

<p>Secretin (C)</p> Signup and view all the answers

Which of the following describes sensory input to the adenohypophysis?

<p>Triggered by signals from the hypothalamus (B)</p> Signup and view all the answers

What type of glands are characterized by a morphological arrangement of follicles?

<p>Thyroid glands (C)</p> Signup and view all the answers

What is the primary role of follicular cells in the thyroid?

<p>Synthesize T3 and T4 hormones (D)</p> Signup and view all the answers

Which factor primarily regulates the activity of C cells in the thyroid?

<p>Blood calcium levels (D)</p> Signup and view all the answers

What is the effect of calcitonin produced by parafollicular cells?

<p>Inhibits osteoclast function (B)</p> Signup and view all the answers

What is the function of parathyroid hormone (PTH) in calcium metabolism?

<p>Increases calcium release from bones and absorption in kidneys (B)</p> Signup and view all the answers

When are abnormalities in the production of thyroid hormones typically assessed in newborns?

<p>Immediately after birth (D)</p> Signup and view all the answers

What is the role of T3 and T4 hormones produced by follicular cells?

<p>Increase metabolism and body temperature (D)</p> Signup and view all the answers

Which of the following cells are primarily responsible for producing parathyroid hormone?

<p>Chief cells (D)</p> Signup and view all the answers

How does parathyroid hormone affect kidney function?

<p>Increases phosphate excretion (C)</p> Signup and view all the answers

What is the state of colloid in the thyroid when hormones are not actively released?

<p>It is stored extracellularly as inactive hormones (A)</p> Signup and view all the answers

What effect does hypophyseal gigantism have on a child's growth?

<p>Increases bone length while maintaining normal body proportions. (D)</p> Signup and view all the answers

What is the function of the hormone produced by the pineal gland?

<p>Regulates day-night circadian rhythm and timing of puberty. (C)</p> Signup and view all the answers

Which cell type is specifically responsible for producing calcitonin in the thyroid gland?

<p>C cells. (B)</p> Signup and view all the answers

What is the primary characteristic of Herring bodies within the endocrine system?

<p>They are storage sites for hormones. (B)</p> Signup and view all the answers

What key feature distinguishes acromegaly from hypophyseal gigantism?

<p>It affects only extremities after puberty. (D)</p> Signup and view all the answers

In the context of the pineal gland, which neurotransmitter is a precursor to melatonin?

<p>Serotonin. (C)</p> Signup and view all the answers

What role does calcitonin play in the human body?

<p>It helps decrease blood calcium levels. (C)</p> Signup and view all the answers

What structure is characteristic of the thyroid gland?

<p>Follicles containing colloid. (D)</p> Signup and view all the answers

Which condition is a result of hyposecretion of growth hormone during infancy?

<p>Hypophyseal dwarfism. (D)</p> Signup and view all the answers

Flashcards

Paracrine activity

A type of cell communication where a cell releases a signaling molecule that acts on nearby cells, without entering the bloodstream.

Autocrine activity

A type of cell communication where a cell produces a signaling molecule that acts on itself.

Steroid hormones

Hormones derived from cholesterol, produced by the gonads (testes and ovaries) and adrenal cortex.

Protein-based hormones

Hormones composed of protein or peptides, produced by the thyroid gland, pituitary gland, and endocrine pancreas (e.g., insulin).

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Diffuse Neuro-endocrine System (DNES)

A collection of scattered cells having both endocrine and neural characteristics, primarily located along the gastrointestinal tract. They release hormones that regulate digestive processes and other functions.

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Entero-endocrine cells

Cells in the gastrointestinal tract that secrete hormones, influencing digestive functions. They are named for being able to take up amine precursors that undergo decarboxylation, or 'amine precursor uptake and decarboxylation,' and can be stained with silver and chromium salts.

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Diffuse Endocrine System

A group of scattered cells with both endocrine and neural characteristics, located mainly in the digestive system, which release hormones influencing digestion and other functions.

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Gastrin

A hormone produced by the stomach that stimulates gastric secretion and intestinal motility.

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Cholecystokinin (CCK)

A hormone produced by the small intestine that stimulates the release of pancreatic enzymes and bile from the gallbladder.

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Secretin

A hormone produced by the small intestine that stimulates the secretion of bicarbonate by the pancreas.

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Growth Hormone Releasing Hormone (GHRH)

A hormone that promotes the release of growth hormone from the pituitary gland.

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Hypophyseal Portal System

A system of blood vessels connecting the hypothalamus to the anterior pituitary gland, allowing hormonal communication.

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What hormones does the posterior pituitary gland release?

The posterior pituitary gland releases two important hormones: ADH (antidiuretic hormone or vasopressin) and oxytocin. They are stored in the Herring bodies within the gland before release.

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What is hypophyseal dwarfism?

A condition where there's inadequate growth hormone (GH) production during childhood. This leads to slowed bone growth and abnormally short stature. The epiphyseal plates (growth plates) in the bones close prematurely.

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Describe hypophyseal gigantism.

A condition caused by excessive growth hormone production during childhood. This leads to significant increase in bone length and other organs, resulting in extremely tall individuals but with normal body proportions.

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What is acromegaly?

A condition due to hypersecretion of growth hormone (GH) after puberty. The overproduction primarily affects the extremities, causing enlargement of the hands, feet, head, and facial features.

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Describe the location and structure of the pineal gland.

The pineal gland is located near the base of the brain. It's small and shaped like a pine cone. The gland is composed of cells that produce hormones and calcium concretions.

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What is the pineal gland's sensitivity to light?

The pineal gland is light-sensitive and regulates the circadian rhythm.

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What hormone does the pineal gland produce?

The pineal gland produces melatonin, a hormone secreted mainly at night. Melatonin is involved in regulating the circadian rhythm (sleep/wake cycles) and influencing the release of gonadotropins (hormones controlling sexual development).

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Describe the location, shape, and structure of the thyroid gland.

The thyroid gland, located in the anterior portion of the neck, has a butterfly shape. It contains follicles, units that store thyroglobulin, the precursor for thyroid hormones T3 and T4. These units also contain C cells, which produce calcitonin.

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What are the main hormones produced by the thyroid gland?

The thyroid gland produces thyroid hormones T3 and T4, which regulate metabolism. It also produces calcitonin, a hormone involved in calcium regulation.

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What are follicular cells?

These cells are responsible for producing the thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). These hormones play a crucial role in regulating metabolism, oxygen consumption, and body temperature.

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What are parafollicular cells (C cells)?

These cells are responsible for producing calcitonin, a hormone that regulates calcium metabolism in the body. It acts to lower blood calcium levels by promoting calcium deposition in bones and inhibiting bone resorption.

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What is colloid?

The thyroid gland stores this inactive form of thyroid hormones extracellularly. It only releases active hormones when there's a signal from the body.

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What is TSH?

This hormone, produced by the pituitary gland, regulates the activity of follicular cells in the thyroid gland.

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What is parathyroid hormone (PTH)?

This hormone, produced by the parathyroid glands, plays a crucial role in regulating calcium levels in the blood. It increases calcium levels by stimulating bone resorption, inhibiting calcium excretion by the kidneys, and promoting the active form of vitamin D.

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What is bone resorption?

The process of removing calcium from bones, which is primarily mediated by osteoclasts.

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What are chief cells?

These cells are found in the parathyroid glands and are responsible for producing parathyroid hormone (PTH).

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What are oxyphil cells?

These cells are also found in the parathyroid glands, but their exact function is still unknown.

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What are osteoclasts?

These cells are responsible for breaking down bone tissue, releasing calcium ions into the bloodstream.

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Study Notes

Endocrine Glands

  • Endocrine glands communicate with distant cells via hormones.
  • Hormones are classified as steroid, derived from cholesterol (gonads, adrenal cortex), or protein-based (thyroid, pituitary, pancreas—insulin).
  • Hormones interact with specific receptors on target cells (membrane-bound or intracellular).
  • Peptide hormones bind to membrane receptors, initiating a cascade reaction (no cell entry).
  • Steroid hormones enter the cell and bind to intracellular receptors, directly affecting gene expression.
  • Protein-producing cells have well-developed RER and Golgi apparatus for synthesis and modification of proteins.
  • Steroid-hormone-producing cells have well-developed SER and lack secretion granules.
  • Endocrine glands can be unicellular (e.g., islets of Langerhans) or multicellular (different arrangements of cells, e.g., cords, follicles, interstitial).

Embryogenesis

  • Cell communication occurs via direct contact, synaptic communication, endocrine secretion, paracrine activity, and autocrine activity.
  • Direct contact: Direct between cells.
  • Synaptic: Between neurons.
  • Endocrine: Hormones secreted into blood stream. This reaches target cells.
  • Paracrine: Secretion affects nearby cells.
  • Autocrine: Target organ is the cell that produced the hormone.

Gastrointestinal Diffuse Endocrine System

  • Cells in the gastrointestinal tract secrete peptide hormones.
  • Gastrin stimulates gastric secretion and intestine motility.
  • Serotonin acts on the gastrointestinal motility.
  • CCK stimulates pancreatic secretion and bile production.
  • Secretin stimulates bicarbonate secretion and pancreatic enzyme production.
  • Motilin increases intestine motility.

Pituitary Gland

  • Consists of an anterior lobe (adenohypophysis) and a posterior lobe (neurohypophysis).
  • Adenohypophysis is regulated by hypothalamic hormones through the hypophyseal portal system. This transports hormones through blood vessels.

Hypothalamus

  • The hypothalamus is the control center for many endocrine processes.
  • It sends signals to the anterior pituitary through the hypophyseal portal system to release or not release hormones into the blood.
  • This triggers the release of regulating hormones.

Anterior Pituitary

  • Only secretes regulating hormones that control other glands.
  • Regulating hormones can be triggered by hypothalamic hormones

Posterior Pituitary

  • Secretes hormones that are directly secreted into the blood without any other intermediaries.

Hormone Types and Functions

  • See separate table for a list of hormones and their functions.

Multiple Endocrine Gland Arrangements

  • Types of arrangements: cords, islets, follicles, interstitial.

Clinical Points

  • Hypophyseal dwarfism: Hyposecretion of growth hormone in childhood leads to slow bone growth and short stature.
  • Hypophyseal gigantism: Hypersecretion of growth hormone in childhood results in excessive bone growth and extraordinarily tall stature.
  • Acromegaly: Hypersecretion of growth hormone in adulthood causes disproportionate growth of the hands, feet, and face.

Pineal Gland

  • Located near the base of the brain (diencephalon).
  • It contains pinealocytes and glial cells.
  • Photosensitive; regulates day-night cycles.
  • Produces melatonin.

Thyroid Gland

  • Butterfly-shaped gland in the neck.
  • Composed of follicles (that contain colloid) and C cells.
  • Follicular cells produce thyroid hormones (T3 and T4).
  • C cells produce calcitonin.
  • Thyroid hormone regulates metabolism.
  • Calcitonin regulates calcium levels.
  • The activity of follicular cells is controlled by TSH from the anterior pituitary.
  • The activity of parafollicular cells (C cells) is controlled by blood calcium levels.

Parathyroids

  • Four small glands posterior to the thyroid.
  • Chief cells produce parathyroid hormone (PTH).
  • PTH increases blood calcium levels.
  • Calcitonin decreases blood calcium levels.

Adrenal Glands

  • Located superior to the kidneys.
  • Composed of a cortex and medulla.
  • Cortex produces steroid hormones (mineralocorticoids, glucocorticoids, androgens).
  • Medulla produces catecholamines (epinephrine, norepinephrine).

Islets of Langerhans (Pancreas)

  • Endocrine cells within the pancreas.
  • Alpha cells produce glucagon (increases blood glucose),
  • Beta cells produce insulin (decreases blood glucose).
  • Delta cells produce somatostatin.
  • PP cells produce pancreatic polypeptide.

Other Endocrine Glands

  • Includes testes, ovaries, and other organs.
  • Testes produce testosterone (male sex hormone)
  • Ovary produces estrogen, progesterone (female sex hormones)
  • Other glands produce specific hormones with specialized roles (e.g., heart, kidneys, adipose tissue).

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