Endocrine Disruptors and Thyroid Function
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Questions and Answers

What is the effect of chlorinated parabens on wastewater treatment plants?

  • They are not easily removed by WWTPs. (correct)
  • They do not accumulate in aquatic environments.
  • They are easily removed by filtration.
  • They are biodegradable by natural processes.
  • Which chemical is known to act as a mimic of estrogen and disrupt endocrine function?

  • Nonyl-phenol (correct)
  • Methyl-tert-butyl ether
  • Bisphenol-A
  • Triclosan
  • How do persistent organic pollutants (POPs) affect thyroid function?

  • By increasing hormone distribution.
  • By impairing iodine uptake. (correct)
  • By promoting natural hormone binding.
  • By enhancing hormone production.
  • What role do thyroid hormones play in early development?

    <p>They are critical for brain development. (A)</p> Signup and view all the answers

    What is the function of an antagonist in biochemistry?

    <p>To block a specific biological response. (B)</p> Signup and view all the answers

    Which of the following chemicals is a known endocrine disruptor affecting thyroid systems?

    <p>Polychlorinated biphenyls (PCBs) (A)</p> Signup and view all the answers

    What is the potential impact of increased ester chain length in parabens?

    <p>Increased endocrine disrupting potential. (C)</p> Signup and view all the answers

    What is a common consequence of exposing laboratory animals to Triclosan?

    <p>Disruption of thyroid systems. (A)</p> Signup and view all the answers

    What is a major consequence of increased atmospheric carbon dioxide on ocean chemistry?

    <p>Increased acidity due to carbonic acid formation (B)</p> Signup and view all the answers

    How much did the pH of the oceans decrease between 1751 and 1996?

    <p>From 8.25 to 8.14 (D)</p> Signup and view all the answers

    Which group of organisms is particularly affected by ocean acidification due to its impact on calcium carbonate?

    <p>Calcifying organisms (C)</p> Signup and view all the answers

    What significant finding did WWF's 2014 Living Planet Report reveal about wildlife populations?

    <p>They have declined by 52% since 1970 (B)</p> Signup and view all the answers

    Which substance forms when carbon dioxide dissolves in water and contributes to ocean acidification?

    <p>Carbonic acid (A)</p> Signup and view all the answers

    What is the average annual decline of ozone observed since the 1970s?

    <p>4% (D)</p> Signup and view all the answers

    Who first discovered the ozone hole and in what year?

    <p>Joe Farman in 1984 (C)</p> Signup and view all the answers

    Which substance is identified as a major source of ozone depletion?

    <p>Chlorofluorocarbons (CFCs) (D)</p> Signup and view all the answers

    What is the expected recovery period for holes in polar regions if Ozone Depleting Substances are no longer released?

    <p>2060-2080 (C)</p> Signup and view all the answers

    What is a significant harmful effect of increased UV-B radiation due to ozone depletion?

    <p>Increased occurrence of cataracts (B)</p> Signup and view all the answers

    Which component is NOT a contributor to photochemical smog?

    <p>Carbon Dioxide (CO2) (D)</p> Signup and view all the answers

    What causes the majority of photochemical smog production?

    <p>Fuel and coal burning (D)</p> Signup and view all the answers

    What type of compounds result from incomplete combustion of carbon-based fuels?

    <p>Volatile Polycyclic Aromatic Hydrocarbons (PAHs) (B)</p> Signup and view all the answers

    What was the targeted reduction of SO2 emissions in the 1990 amendments to the Acid Deposition Act?

    <p>10 million tons (A)</p> Signup and view all the answers

    Which gas is primarily responsible for the increase in global warming since the industrial revolution?

    <p>Carbon Dioxide (A)</p> Signup and view all the answers

    What is the Global Warming Potential (GWP) of CO2 considered to be?

    <p>1 (A)</p> Signup and view all the answers

    What percentage of anthropogenic greenhouse gas emissions is attributed to livestock?

    <p>14.5% (D)</p> Signup and view all the answers

    What major factor contributes to global dimming since the 1950s?

    <p>Artificial clouds formed by aerosols (D)</p> Signup and view all the answers

    By what percentage did SO2 emissions drop in the US since 1990?

    <p>40% (D)</p> Signup and view all the answers

    What event was significantly impacted by pollution-driven artificial clouds according to the content?

    <p>1980s subsaharan drought (D)</p> Signup and view all the answers

    What is one consequence if pollutant aerosols are cleaned from the atmosphere while greenhouse emissions continue?

    <p>Extremely warm temperatures (D)</p> Signup and view all the answers

    What is the primary health risk associated with PM2.5 particles?

    <p>They can lead to lung damage and enter the bloodstream. (D)</p> Signup and view all the answers

    Which historical incident is noted for causing numerous deaths due to air pollution?

    <p>The Great Smog of London in 1952. (B)</p> Signup and view all the answers

    What was the estimated number of deaths worldwide due to PM2.5 in 2015?

    <p>4.2 million deaths. (C)</p> Signup and view all the answers

    What is the primary source of acidity in acid rain?

    <p>Sulfur dioxide (SO2) and nitrogen oxides (NOx). (A)</p> Signup and view all the answers

    How much does complete cessation of fossil fuel emissions potentially increase life expectancy, according to estimates?

    <p>1.1 years. (B)</p> Signup and view all the answers

    What was the reported number of premature mortalities in India attributed to PM2.5 exposure in 2011?

    <p>570,000. (A)</p> Signup and view all the answers

    What were the total deaths reported in Europe due to PM2.5 in 2012?

    <p>403,000. (D)</p> Signup and view all the answers

    What is the typical pH level of natural rain?

    <p>5.7. (B)</p> Signup and view all the answers

    What characterizes halogen bonds in the context of protein-ligand interactions?

    <p>They are strong, directional, and result in specific binding angles. (A)</p> Signup and view all the answers

    What is the cocktail effect in toxicology?

    <p>Four chemicals that are non-toxic individually become toxic when combined. (D)</p> Signup and view all the answers

    Which of the following statements about epigenetics is true?

    <p>Environmental factors can activate or deactivate genes without changing the DNA sequence. (A)</p> Signup and view all the answers

    Which substance would likely lead to thyroid health problems?

    <p>Certain heavy metals (A)</p> Signup and view all the answers

    What consequence can result from high concentrations of pesticides in soil?

    <p>Contamination of water sources (B)</p> Signup and view all the answers

    Which epigenetic modification is commonly discussed?

    <p>DNA methylation (B)</p> Signup and view all the answers

    What is a significant limitation in understanding the cocktail effect?

    <p>Current research on it is limited and still evolving. (B)</p> Signup and view all the answers

    Which of the following is NOT a symptom related to thyroid health problems?

    <p>Enhanced cognitive function (B)</p> Signup and view all the answers

    What can contribute to a change in gene expression without altering the gene sequence?

    <p>Environmental factors affecting epigenetic markers (C)</p> Signup and view all the answers

    What is primarily studied in the context of organochlorine and organophosphorus pesticides?

    <p>Their contamination levels in soil and crops (D)</p> Signup and view all the answers

    What is a common feature of charge-transfer bonds involving halogens in biology?

    <p>They often involve polarizable halogens and specific functional groups. (B)</p> Signup and view all the answers

    What best describes the relationship between epigenetics and genetic inheritance?

    <p>Some epigenetic changes can be heritable if environmental factors persist. (B)</p> Signup and view all the answers

    Which of the following is a potential health impact of pesticide toxicity?

    <p>Development of chronic respiratory diseases (B)</p> Signup and view all the answers

    Flashcards

    Parabens

    A type of chemical found in many personal care products. Parabens can be harmful to aquatic life and their endocrine disrupting potential increases with longer ester chains.

    Polyfluorinated organic substances (PFOS)

    A group of chemicals that are extremely persistent in the environment and can be absorbed by the body. These chemicals can make cell membranes more permeable and some can disrupt thyroid function.

    Methyl-tert-butyl ether (MTBE)

    A chemical used in gasoline that can affect the nervous system and potentially cause cancer depending on the dose.

    Bisphenol-A (BPA)

    A type of chemical that can mimic the hormone estrogen and disrupt endocrine function. It is often used in plastics.

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    Agonist

    Chemicals that bind to receptors and activate them to produce a biological response. They can be natural (hormones) or synthetic (drugs, pollutants).

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    Antagonist

    Chemicals that block the action of agonists by binding to their receptors and preventing them from activating a response.

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    Thyroid Gland and Thyroid Hormones

    Thyroid gland and thyroid hormones are essential for development and brain function. This gland is particularly important for baby's brain development during pregnancy and early life.

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    Triclosan

    This is a chemical that can disrupt the thyroid system by potentially blocking the uptake of iodine, blocking hormone production, and displacing natural hormones in the body.

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    Particulate Matter (PM)

    Microscopic particles suspended in the air, either solid or liquid, that can be naturally occurring or caused by human activities.

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    PM10

    Particulate matter with a diameter of 10 micrometers or less, meaning it can be inhaled into the lungs.

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    Ozone Depletion

    A significant decrease in the amount of ozone in the stratosphere, observed since the 1970s, with an average rate of 4% reduction per decade.

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    PM2.5

    Particulate matter with a diameter of 2.5 micrometers or less. This makes them even smaller and more easily inhaled, posing a greater risk to health.

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    Photochemical Smog

    A type of air pollution formed by chemical reactions involving sunlight, nitrogen oxides, and volatile organic compounds.

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    Ozone Hole

    A much larger and more rapid depletion of ozone, occurring primarily in the polar regions during specific seasons, with losses reaching up to 65%.

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    Ozone Depleting Substances (ODS)

    Substances that contribute to the depletion of the ozone layer. Examples include chlorofluorocarbons (CFCs), hydrochlorofluorocarbons (HCFCs), freons, and halons.

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    Great Smog of 1952

    A deadly event in London in 1952 caused by severe air pollution, resulting in thousands of deaths.

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    pH

    A measure of how acidic or basic a substance is, with a lower pH indicating higher acidity.

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    Ozone Depletion Mechanism

    The process by which ODSs break down ozone molecules in the stratosphere. One chlorine atom can destroy thousands of ozone molecules.

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    Acid Rain

    Rain with a pH lower than 5.7, caused by the presence of acidic pollutants like sulfur dioxide and nitrogen oxides.

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    Photochemical Smog

    A type of air pollution that forms due to chemical reactions involving sunlight, nitrogen oxides, and volatile organic compounds.

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    Content of Photochemical Smog

    The main components of photochemical smog, including nitrogen oxides, ozone, aldehydes, peroxyacetyl nitrates (PAN), and volatile organic compounds.

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    Sulfur Dioxide (SO2)

    A colorless gas with a pungent odor, a major air pollutant often released from burning fossil fuels.

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    Formation of Ozone in Photochemical Smog

    The process by which nitrogen dioxide (NO2) is converted to nitric oxide (NO) and atomic oxygen (O), which then reacts with molecular oxygen (O2) to form ozone (O3).

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    Major Contributors to Photochemical Smog

    Substances that contribute to photochemical smog, including sulfur dioxide (SO2), carbon monoxide (CO), and nitrogen dioxide (NO2).

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    Ocean Acidification

    The process where dissolved carbon dioxide (CO2) in water reacts to form carbonic acid (H2CO3), lowering the pH of the water and making it more acidic.

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    Calcifying Organisms

    Organisms like corals, shellfish, and plankton that use calcium carbonate to build their shells or skeletons.

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    Calcium Carbonate

    A chemical compound found in the shells of calcifying organisms, like corals.

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    Undersaturated

    The state where a solution is unable to dissolve any more of a particular substance, such as calcium carbonate, leading to the breakdown of shells.

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    Halogen Bond

    A type of non-covalent interaction that occurs when a halogen atom (e.g., chlorine, bromine) interacts with a more electronegative atom (e.g., oxygen, nitrogen).

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    Cocktail Effect

    The combined effect of multiple chemicals, with the potential for greater overall harm than the sum of their individual effects.

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    Epigenetics

    A change in gene expression that is not caused by a change in the DNA sequence itself. This can be caused by environmental factors or other factors influencing gene expression.

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    DNA Methylation

    A process where a methyl group (CH3) is added to a DNA molecule, which can influence gene expression without altering the underlying DNA sequence.

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    Histone Modification

    A process where chemical modifications are made to proteins called histones, which package and organize DNA, influencing gene expression.

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    Organochlorine Pesticides (OCPs)

    A type of pesticide that contains chlorine atoms. They are often persistent in the environment and can bioaccumulate in food chains.

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    Organophosphorus Pesticides (OPPs)

    A type of pesticide that contains phosphorus atoms. These pesticides can inhibit the activity of certain enzymes in the body, impacting various processes.

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    Pesticide Contamination in Konya, Turkey

    The levels of pesticide residue in wheat and soil in the Konya region of Turkey were studied.

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    Risk Assessment

    A measure of the likelihood of an adverse effect occurring from exposure to a hazardous substance.

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    Risk Assessment for Contaminated Food Consumption

    A process used to determine the probability of a specific hazardous event occurring, taking into account the exposure and potential harm.

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    LD50 (Lethal Dose 50)

    The amount of a substance that is needed to cause an adverse effect in half of the tested population.

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    Environmental Pollution

    A type of pollution that is caused by the release of contaminants into the environment.

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    Pesticide Pollution

    Chemicals that are used to control plant pests or diseases, often contributing to environmental pollution.

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    Bioaccumulation

    The process of building up of a substance in the body over time, often as a result of exposure to toxins, such as pesticides.

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    Biomagnification

    The transfer of substances from one organism to another through food chains.

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    What is Acid Rain?

    Acid rain is a form of precipitation that is unusually acidic, meaning it has a lower pH than normal rainwater. This acidity is primarily caused by the presence of sulfur dioxide (SO2) and nitrogen oxides (NOx) released into the atmosphere, which are then transformed into sulfuric acid and nitric acid.

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    How is Acid Rain formed?

    Acid rain is formed when sulfur dioxide (SO2) and nitrogen oxides (NOx) react with water, oxygen, and other substances in the atmosphere. These reactions form sulfuric acid and nitric acid, which are then carried down to Earth by precipitation.

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    What are the impacts of Acid Rain?

    Acid rain can have harmful effects on ecosystems, particularly aquatic life. The increased acidity in lakes and streams can make it difficult for fish and other organisms to survive. Acid rain can also damage trees and crops by leaching nutrients from the soil and making them more susceptible to diseases.

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    What was the Acid Deposition Act?

    The Acid Deposition Act was passed in 1980 in the United States to reduce sulfur dioxide emissions from power plants. Amendments were made in 1990 to further reduce the amount of SO2 released as well.

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    What is Global Warming?

    The increase in the average temperature of Earth's atmosphere and oceans since the late 19th century is known as global warming. It's caused by the greenhouse effect: certain gases in the atmosphere trap heat from the sun. Human activities, like burning fossil fuels, release a lot of greenhouse gases into the atmosphere, mainly carbon dioxide (CO2), which is why global warming is a concern.

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    What is Global Dimming?

    Global dimming refers to a decrease in the amount of sunlight reaching Earth's surface. This is primarily caused by aerosols, tiny particles suspended in the air. These aerosols reflect sunlight back into space, leading to less solar radiation reaching the Earth's surface. Aerosols include industrial dust, particularly SO2 particulates from coal burning.

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    Is global dimming related to global warming?

    Global dimming is a form of climate change. It is related to global warming, but instead of increasing temperature, global dimming decreases the amount of solar radiation reaching Earth's surface. The primary cause of global dimming are sulfate aerosols which are a byproduct of burning fossil fuels like coal. These aerosols reflect sunlight and have a cooling effect on the planet.

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    How do livestock contribute to greenhouse gases?

    Livestock, such as cows, pigs, and chickens, play a significant role in contributing to greenhouse gas emissions. They produce methane and other greenhouse gases as part of their normal bodily functions. The amount of greenhouse gases produced by livestock is significant and contributes significantly to climate change.

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    Study Notes

    Parabens

    • Found in about half of personal care products
    • Released heavily from wastewater effluents
    • Chlorinated parabens are difficult to remove from wastewater treatment plants (WWTPs)
    • Endocrine disrupting potential increases with longer ester chains
    • Harmful to aquatic life

    Polyfluorinated Organic Substances (PFOS)

    • Extremely persistent
    • Absorbed in the body, increasing cell permeability
    • Some are endocrine disruptors (e.g., affecting the thyroid)

    Other Ubiquitous Anthropogenic Chemicals

    • Methyl-tert-butyl ether (MTBE): Affects the nervous system and can cause cancer (effects depend on the dose).
    • Alkyl Phenols (e.g., Nonylphenol): Mimics estrogen hormone, an endocrine disruptor.
    • Bisphenol-A (BPA): Used in plastic production, has high endocrine disrupting chemical (EDC) activity at very low doses.

    Chemical Structure of PFOS and PFOA

    • Both are perfluorinated compounds (PFCs)
    • PFOA and PFOS are thyroid hormone disruptors
    • They lack structural similarity to thyroid hormones

    Thyroid Gland and Hormones

    • Thyroid glands regulate the production and balance of thyroid hormones
    • Crucial for brain development in babies during prenatal stages and early years
    • Several persistent organic pollutants (POPs), with similar structures to PCBs and dioxins, impair thyroid function by:
      • Impairing iodine uptake by the gland
      • Blocking hormone production enzymes
      • Displacing natural hormones in blood proteins, affecting distribution and entry

    Iodine Deficiency

    • Global statistics on iodine deficiency are documented in WHO 2004.
    • Levels are categorized as: Severe, Moderate, Mild, Optimal, Risk of iodine induced hyperthyroidism, and Risk of Adverse consequences (Based on median UI values).

    Agonist/Antagonist

    • Agonist: Endogenous or exogenous chemical that binds to a specific receptor, activating the receptor and producing a biological response.
    • Antagonist: Chemical that blocks the biological response or activity of an agonist by binding to and blocking the target receptor (also called a "blocker").
      • Example: Triclosan, a common antibacterial agent, can disrupt thyroid systems in lab animals, potentially through agonist or antagonist pathways involving specific nuclear receptors regulating catabolic and transport activity.
      • Triclosan may be an estrogen or androgen receptor antagonist (or a weak agonist).

    Deiodinase Enzymes

    • All deiodinase enzymes are selenoenzymes, meaning they contain selenium

    Mercury

    • Organic mercury (e.g., methyl or ethyl mercury) can be converted to inorganic mercury by microorganisms in the intestines
    • Inorganic mercury can persist in the brain for long periods.
    • Inorganic mercury interacts with selenium, forming mercury selenite (HgSe), which is thought to accumulate in the central nervous system
    • Cadmium has similar interactions with selenium

    Structural Comparison of Endocrine Disruptors (EDCs) to Thyroid Hormones

    • All EDCs share strong structural homology with thyroid hormones (like T4)
    • BPA is formed when TBBPA breaks down in the environment

    Triclosan

    • Antibacterial agent; commonly found in various products
    • Banned by FDA in US for some applications (for antiseptic washes).
    • Weak endocrine disruptor and allergen.
    • Similar to Triclocarban, another antibacterial agent

    Halogen Bonds

    • Both chlorine and iodine in Triclosan and Triiodothyronine can form halogen bonds.
    • Halogen bonds are strong, directional, and lead to specific binding angles in interactions (e.g. protein-ligand interactions).
    • These bonds often involve polarizable halogens which interact with carbonyl or hydroxyl groups of amino acids.

    Cocktail Effect

    • Four chemicals tested individually below LD50 may have no harmful effect
    • But when tested in combination at the same doses, they have harmful effects

    Epigenetics

    • Environmental factors affect gene function by activating or deactivating genes without changing the gene sequence.
    • These epigenetic changes can be passed down to the next generation if the environmental factors persist.
    • DNA methylation and histone modification alter gene expression without changing the underlying DNA sequence (affects how genes are read)

    Air Pollution

    • Ozone Depletion: Stratospheric ozone layer is declining globally at approximately 4% per decade; localized depletion, known as "ozone holes," can reach 65% of the ozone layer; - The Ozone layer shields Earth from harmful ultraviolet radiation. - Ozone depleting substances (ODS) such as CFCs, are major contributors to this issue and are responsible for increased concentrations of UV radiation reaching Earth.
    • Photochemical Smog: Consists of various pollutants including aldehydes, nitrogen oxides, peroxyacetyl nitrates (PAN), volatile organic compounds, and heavy metals formed from fuel and coal burning; harmful to eyes, throat, and the respiratory systems, impacting agriculture.
    • Particulate Matter (PM): Microscopic/sub-microscopic solid/liquid particles suspended in the air; causes climate and rain pattern issues, and harmful health outcomes (e.g. lung problems, exposure); sources include industries, construction sites, vehicles, and wildfires.
    • Acid Rain: Acid rain is caused by the release of sulfur dioxide (SO₂) and nitrogen oxides (NOx). These gases react with water in the atmosphere to create sulfuric and nitric acids that fall to the ground with the rain. This lowers the pH of rain, increasing acidity.
      - Acid rain affects both human and environmental health. Sources of these gases include fossil fuels burning. - Steps were, and continue to be taken, to reduce SO₂ emissions to mitigate the effects of acid rain.

    Global Warming and Dimming

    • Global Warming: Increase in average earth temperature due to increased greenhouse gases, particularly CO2.
      - CO2 concentrations have risen from 280 ppm to 400 ppm since the Industrial Revolution, primarily from the burning of fossil fuels (coal, oil, natural gas). - Many other anthropogenic gases also contribute to global warming (include N2O, CFCs, etc.)
    • Global Dimming: Gradual decline in the amount of global direct solar radiation due to aerosols (e.g., industrial dust).
      • Causes disruptions in weather patterns.

    Ocean Acidification

    • Dissolved atmospheric CO₂ forms carbonic acid in oceans, leading to increased acidity
    • Impacts calcifying organisms like corals and shellfish as decreasing pH compromises minerals needed to create shells

    Multi-Faceted Environmental Alterations

    • WWF's Living Planet Index (LPI) shows significant population declines (birds, reptiles, mammals, amphibians and fish) by 52% since 1970. Insect declines are also notable.

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    Description

    This quiz explores the effects of chlorinated parabens, persistent organic pollutants, and other chemicals known to disrupt endocrine function. Test your knowledge on the role of thyroid hormones in development and the implications of exposure to various disruptors. Gain insights into biochemistry and environmental health.

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