Endocrine and Metabolic Disorders

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Questions and Answers

A patient presents with fatigue, weight loss, and increased skin pigmentation. Initial lab results show hyponatremia and hyperkalemia. Which endocrine disorder is MOST consistent with these findings?

  • Diabetes insipidus
  • Addison's disease (correct)
  • Acromegaly
  • Cushing's syndrome

A patient with known diabetes insipidus is prescribed desmopressin (DDAVP). What therapeutic outcome indicates that the medication is effective?

  • Elevated serum osmolarity
  • Increased urine specific gravity (correct)
  • Reduced thirst
  • Decreased blood pressure

Post-hypophysectomy, a patient exhibits symptoms of diabetes insipidus. Which physiological disturbance is the MOST likely cause of this condition?

  • Impaired ADH secretion (correct)
  • Excessive ADH secretion
  • Deficiency of insulin production
  • Increased sodium retention

A patient undergoing treatment for Cushing's syndrome is at risk for protein wasting due to excessive cortisol levels. Which nursing intervention is MOST important to implement to address this risk?

<p>Providing a high-protein diet (D)</p> Signup and view all the answers

Following surgical removal of a testicular tumor and subsequent chemotherapy, what information should the nurse emphasize when teaching the patient about potential long-term complications?

<p>Strategies for preserving fertility options (C)</p> Signup and view all the answers

Flashcards

Addison's Disease

A disease resulting from adrenal gland hypofunction, leading to weakness, fatigue, weight loss, and skin hyperpigmentation.

Hypophysectomy

Pituitary gland removal, often done to treat hormone-related conditions.

Diabetes Insipidus

A condition of excessive fluid loss due to ADH deficiency, leading to frequent urination and dehydration.

Water Deprivation Test

A test used to diagnose diabetes insipidus by monitoring urine output and osmolality under fluid restriction.

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Cushing's Syndrome Manifestations

Excessive cortisol leading to protein wasting, hypertension, mood swings and delayed wound healing.

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Study Notes

  • Addison's Disease primary features include progressive weakness, fatigue, anorexia, weight loss, skin hyperpigmentation, orthostatic hypotension, hyponatremia, hyperkalemia, nausea/vomiting, diarrhea, irritability, depression, and low blood pressure.
  • Hypophysectomy involves the removal of the pituitary gland.
  • Low blood pressure may be indicative of diabetes insipidus.
  • Diabetes insipidus results in fluid deficit and fluid loss.
  • Management for hypoglycemia involves administering 5% dextrose and glucagon.
  • A1C test checks if a diabetes patient is compliant with their medication.
  • Hypoglycemia in the range of 38-30 mg/dL is dangerous and can cause neurological damage.
  • High serum osmolarity is characteristic of Hyperosmolar Hyperglycemic Nonketotic Syndrome (HHNK), indicating a high dehydration rate.
  • Testicular cancer treatment includes radiation, chemotherapy, and surgery, teach self examination, and awareness that treatment can destroy sperm.
  • Long-term management focuses on addressing complications from type 2 diabetes.
  • Adrenal deficiency treatment involves restoring circulation and managing fluids.
  • Diabetes insipidus and diabetes mellitus are distinct and unrelated conditions.
  • SIADH (Syndrome of Inappropriate Antidiuretic Hormone) is characterized by low serum osmolarity.
  • Non-pharmaceutical interventions for diabetes include diet and exercise.
  • High blood pressure warrants further testing and diagnosis to identify the underlying issue.

Acromegaly

  • A key assessment finding in acromegaly is a deeply voice, due to overproduction of growth hormone.

  • Water deprivation test is used to diagnose diabetes insipidus.

  • Declomycin is used for SIADH.

  • Desmopressin (DDAVP) is used in diabetes insipidus as a hormone replacement for ADH.

  • Fatigue is a clinical manifestation of SIADH.

  • There is a risk of adrenal deficiency following surgery.

Cushing's Syndrome Clinical Manifestions

  • Protein wasting and catabolic effects of cortisol lead to weakness, especially in extremities.
  • Protein loss in bones results in osteoporosis, bone and back pain.
  • Loss of collagen delays wound healing.
  • Mood disturbances, insomnia, irrationality, and psychosis may occur.
  • Mineralocorticoid excess can cause hypertension secondary to fluid retention.
  • Adrenal androgen excess may cause pronounced acne, virilization in women, and feminization in men often seen in adrenal carcinomas.
  • Women may experience menstrual disorders and hirsutism.
  • Men may experience gynecomastia and impotence.
  • Purplish red striae may appear on the abdomen, breast, or buttocks.
  • Adrenal gland hypofunction is associated with Addison's syndrome, while hyperfunction is associated with Cushing's syndrome.
  • Hypoglycemia management includes administering 5% dextrose IV or glucagon if IV access is unavailable, along with medications.
  • High serum osmolarity in HHNK signifies dehydration.
  • Teaching self examination, is important for Testicular cancer patients, and to understand medications can destroy sperm.

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