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Questions and Answers
What occurs in Step 1 of Endochondral Ossification?
What occurs in Step 1 of Endochondral Ossification?
What happens in Step 2 of Endochondral Ossification?
What happens in Step 2 of Endochondral Ossification?
What characterizes Step 3 of Endochondral Ossification?
What characterizes Step 3 of Endochondral Ossification?
What happens during Step 4 of Endochondral Ossification?
What happens during Step 4 of Endochondral Ossification?
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What defines Step 5 of Endochondral Ossification?
What defines Step 5 of Endochondral Ossification?
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What occurs in Step 6 of Endochondral Ossification?
What occurs in Step 6 of Endochondral Ossification?
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Study Notes
Steps of Endochondral Ossification
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Step 1: Cartilage undergoes enlargement; Chondrocytes, the cells within cartilage, undergo apoptosis (die off).
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Step 2: Blood vessels penetrate the perichondrium (tissue surrounding cartilage); mesenchymal cells differentiate into osteoblasts, leading to the development of a bony layer around the shaft.
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Step 3: Increased blood supply and osteoblast activity lead to the production of spongy bone; this formation expands along the shaft of the developing bone.
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Step 4: Osteoclasts (cells that break down bone) create the medullary cavity (internal cavity of the bone); this process is accompanied by appositional growth, thickening the bone.
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Step 5: Centers of ossification develop in the epiphysis (end parts of the bone) leading to calcification; migration of blood vessels and osteoblasts occurs, establishing secondary ossification centers.
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Step 6: The epiphysis is filled with spongy bone; hyaline cartilage is retained at the joints; an epiphyseal plate (growth plate) remains in the metaphysis, allowing for further lengthening of the bone during growth.
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Description
Explore the six critical steps of endochondral ossification through these flashcards. Each step outlines vital processes involved in the transformation of cartilage into bone, essential for understanding skeletal development. Perfect for students of anatomy and physiology.
