12 Questions
What is the primary focus of most new drugs in development, according to the text?
Targeting specific ion channels or cellular components
How do emerging therapies aim to make rhythm control a realistic option for a broad range of arrhythmias?
By being more selective and less proarrhythmic
What revolutionary approach to specific arrhythmia types has been made possible by understanding the molecular basis of arrhythmias?
Gene therapy for modulating ion channel function
Which emerging therapy shows potential in treating arrhythmia pathologies, especially in tachycardia syndromes?
Cell-based therapy with stem cell transplantation
What has made it challenging to develop and market new antiarrhythmic drugs, as mentioned in the text?
The Cardiac Arrhythmia Suppression Trial (CAST) and drug proarrhythmic effects
What has raised hopes for treating cardiac ion channelopathies through gene therapy, as per the text?
The development of an ion channel gene transfer therapy for cystic fibrosis
What is the main goal of pharmacogenomics in the context of drug therapy?
To individualize drug therapy based on genetic determinants
How does gene therapy differ from cell-based therapy in treating arrhythmias?
Gene therapy corrects abnormalities by inserting genes, while cell-based therapy involves transplanting normal cells.
Which enzyme is highlighted as being responsible for the phase I metabolism of most drugs?
CYP2D6
Why do poor metabolizers of CYP2D6 require only half the standard dose of flecainide?
They have a slower clearance rate of the drug.
What is a potential application of genotype information in relation to antiarrhythmic drug therapy?
Guiding dosing requirements based on genetic factors
How does cell-based therapy aim to cure arrhythmias?
By targeting underlying molecular and cellular mechanisms
Learn about the advancements in treating arrhythmias through new drugs and approaches. Discover how these therapies target specific ion channels and cellular components to provide more selective and less proarrhythmic effects, making rhythm control a viable option for a variety of arrhythmias.
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