Emergency Department IV Infusion Guidelines
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Questions and Answers

What is the recommended loading dose for this antiarrhythmic agent in cases of cardiac arrest?

  • 1 to 1.5 mg/kg (correct)
  • 4 mg/kg
  • 2 to 3 mg/kg
  • 0.5 to 0.75 mg/kg
  • What is the maximum cumulative dose for this antiarrhythmic agent?

  • 1 mg/kg
  • 4 mg/kg
  • 3 mg/kg (correct)
  • 2 mg/kg
  • In the case of severe toxicity from this antiarrhythmic agent, what is the available antidote?

  • Naloxone
  • IV lipid emulsion (Intralipid®) (correct)
  • Flumazenil
  • Activated charcoal
  • What potential side effect should be monitored for during administration?

    <p>Local thrombophlebitis (A)</p> Signup and view all the answers

    Which of the following is a potential sign of CNS toxicity from this medication?

    <p>Circumoral numbness (C)</p> Signup and view all the answers

    What is the typical onset time for labetalol after intravenous administration?

    <p>Within 5 minutes (D)</p> Signup and view all the answers

    What is a potential cause of bradycardia?

    <p>Sinus pause (B)</p> Signup and view all the answers

    What is the usual maximum cumulative IV dose of labetalol for severe hypertension?

    <p>300 mg (B)</p> Signup and view all the answers

    In which situation should labetalol dosing be approached with caution?

    <p>In patients with hepatic dysfunction (C)</p> Signup and view all the answers

    Which medication is used for inotropic support?

    <p>Dobutamine (C)</p> Signup and view all the answers

    What is the recommended concentration for Dobutamine reconstitution?

    <p>12.5 mg/mL (C)</p> Signup and view all the answers

    Which of the following is a recommended practice for continuous IV infusion of labetalol?

    <p>Monitor BP every 5 minutes at the beginning and with each dosage change (D)</p> Signup and view all the answers

    What should be monitored before initiating Dobutamine if hypovolemia is present?

    <p>Fluid volume status (B)</p> Signup and view all the answers

    What should be monitored regularly during the administration of labetalol?

    <p>Urine output and serum glucose (D)</p> Signup and view all the answers

    What is the antidote available in case of Dobutamine extravasation?

    <p>Phentolamine (A)</p> Signup and view all the answers

    What is the initial bolus dose of labetalol administered over 1-2 minutes for IV use?

    <p>10-20 mg (A)</p> Signup and view all the answers

    What could a high-dose of labetalol potentially lead to?

    <p>Severe hypotension and bradycardia (A)</p> Signup and view all the answers

    What is the initial dosing range for Dobutamine infusion?

    <p>0.5 to 5 mcg/kg/min (C)</p> Signup and view all the answers

    What is a critical electrolyte disturbance to correct before using Dobutamine?

    <p>Hypokalemia (D)</p> Signup and view all the answers

    What is the method of preparing a continuous infusion of labetalol?

    <p>Withdraw 10 mL from a 250 mL bag and add 60 mL of labetalol (B)</p> Signup and view all the answers

    What is the onset time for Dobutamine after administration?

    <p>1-10 minutes (B)</p> Signup and view all the answers

    What is the correct duration for the onset of immediate release PO diltiazem?

    <p>3 minutes (A)</p> Signup and view all the answers

    What is the recommended frequency for monitoring blood pressure during a continuous IV infusion of diltiazem until hemodynamic stability is achieved?

    <p>Every 3 to 5 minutes for the first 15 minutes (B)</p> Signup and view all the answers

    What is the appropriate action regarding fluid removal from the D5W or NS bag before preparing the continuous IV infusion of diltiazem?

    <p>No removal is required (C)</p> Signup and view all the answers

    What is the maximum dose rate specified for continuous diltiazem IV administration as directed by a physician?

    <p>5-15 mg/h (C)</p> Signup and view all the answers

    Which of the following is NOT a sign to observe for during diltiazem administration?

    <p>Frequent urination (D)</p> Signup and view all the answers

    What is the maximum infusion rate for magnesium sulfate unless there is an urgent indication?

    <p>150 mg/min (B)</p> Signup and view all the answers

    Which of the following conditions is a contraindication for administering anxiety medication?

    <p>Acute narrow-angle glaucoma (B)</p> Signup and view all the answers

    What is the maximum allowable dose per hour for the administration of anxiety medication?

    <p>10 mg/h (D)</p> Signup and view all the answers

    What potential side effect is linked to the rapid administration of magnesium sulfate?

    <p>Asystole (A)</p> Signup and view all the answers

    What monitoring is recommended for direct IV administration of magnesium sulfate for ventricular arrhythmias?

    <p>Heart rate and ECG (A)</p> Signup and view all the answers

    What is a potential effect of benzodiazepine therapy that should be considered before administration?

    <p>Anterograde amnesia (C)</p> Signup and view all the answers

    How should the magnesium sulfate be administered for fluid-restricted patients?

    <p>IV over 1-5 hours (C)</p> Signup and view all the answers

    What is the initial dose for continuous infusion of anxiety-reducing medication?

    <p>1-3 mg/h (C)</p> Signup and view all the answers

    What is the maximum dose for the continuous IV infusion of Isoproterenol?

    <p>10 mcg/min (D)</p> Signup and view all the answers

    What monitoring should be done every 5 minutes during the continuous IV infusion of Isoproterenol?

    <p>Blood pressure (A)</p> Signup and view all the answers

    Which of the following is NOT recommended in the initial treatment of Isoproterenol?

    <p>Loading dose administration over 30 minutes (A)</p> Signup and view all the answers

    When should the infusion site for Isoproterenol be monitored for extravasation?

    <p>Every 15 minutes (A)</p> Signup and view all the answers

    What is the onset time for Isoproterenol administration?

    <p>Immediate (B)</p> Signup and view all the answers

    What should be done if the patient has pre-existing ventricular arrhythmias?

    <p>Avoid administering Isoproterenol (C)</p> Signup and view all the answers

    Which parameter should be monitored as per physician discretion during Isoproterenol treatment?

    <p>Serum potassium (A)</p> Signup and view all the answers

    What is the recommended volume for the loading dose of Isoproterenol?

    <p>50 mL (B)</p> Signup and view all the answers

    Flashcards

    Diltiazem Onset Time

    Diltiazem's onset of action is roughly 3 minutes.

    Diltiazem Bolus Dosage Time

    The bolus dose of diltiazem can be administered 1-3 hours beforehand.

    Diltiazem Continuous Infusion Duration

    A continuous diltiazem infusion can last from 30-60 minutes after the end of the infusion.

    Continuous Diltiazem IV Infusion Dilution

    Dilute 125mg diltiazem in 100mL D5W or NS for IV Continuous Infusion.

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    Monitoring during Diltiazem Infusion

    Continuous cardiac monitoring and frequent blood pressure checks are required during diltiazem administration.

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    Dobut Amine: What's it for?

    Dobut Amine is a medication used to support heart pumping function (inotropic support). It's an adrenergic agonist that speeds up your heart rate and strengthens the heart muscle.

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    Dobut Amine: How is it given?

    Dobut Amine is given as a continuous intravenous infusion (IV) in a large vein. It's typically diluted in saline (NS) or dextrose (D5W) to make a final concentration of 1 mg/mL.

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    Preparing Dobut Amine: What are the common doses?

    The starting dose of Dobut Amine is usually between 2.5 and 20 mcg/kg/min. You can start low and gradually increase the dose as needed.

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    Dobut Amine: What are the risks?

    Dobut Amine can lead to a rapid heart rate (tachycardia), low blood pressure (hypotension), headache, and chest pain. It can also increase the risk of irregular heartbeat.

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    Dobut Amine: What are the monitoring parameters?

    Patients on Dobut Amine should be closely monitored for heart rhythm changes (ECG), blood pressure, and overall heart function. Also, monitor for signs of hypovolemia (low blood volume).

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    Dobut Amine: What if there's an overdose?

    If a patient overdosed on Dobut Amine, it's crucial to have phentolamine (an antidote) readily available to counteract its effects.

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    Dobut Amine: What are essential checks before using it?

    Before starting Dobut Amine, assess and address any electrolyte imbalances, particularly low potassium (hypokalemia) or low magnesium (hypomagnesemia).

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    Dobut Amine: What else should be done before starting?

    Correct any fluid deficit (hypovolemia) before initiating Dobut Amine. It's important to make sure the patient has enough blood volume.

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    Isoproterenol Action

    Isoproterenol is a beta1 and beta2 agonist that stimulates the heart and bronchodilates.

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    Isoproterenol Route

    Isoproterenol is administered intravenously.

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    Isoproterenol Onset

    Isoproterenol takes effect immediately.

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    Isoproterenol Duration

    Isoproterenol's effects last for approximately 10-15 minutes.

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    Why Isoproterenol Infusion?

    Isoproterenol infusion is used to treat bradyarrhythmias or slow heart rates.

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    Isoproterenol Dosage Variations

    The dose of isoproterenol varies depending on the patient's needs and prescribed parameters.

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    Isoproterenol Monitoring

    Cardiac and respiratory monitoring are crucial during isoproterenol administration.

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    Contraindications for Isoproterenol

    Isoproterenol is contraindicated in patients with pre-existing ventricular arrhythmias or cardiac glycoside intoxication.

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    Lidocaine: Class?

    Lidocaine is classified as a Class Ib antiarrhythmic agent.

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    Lidocaine: Onset & Duration?

    Lidocaine has a rapid onset of action, typically 45-90 seconds, and a relatively short duration of 10-20 minutes for a single bolus dose.

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    Lidocaine: How is it given?

    Lidocaine is available for intravenous administration as a bolus injection, a continuous infusion, or a combination of both.

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    Lidocaine: What is the maximum dose?

    The maximum cumulative dose of lidocaine is 3 mg/kg.

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    Lidocaine: What is the antidote for toxicity?

    Intravenous lipid emulsion (Intralipid®) is the antidote for severe lidocaine toxicity.

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    Labetalol Administration Routes

    Labetalol can be administered intravenously (IV) either as an intermittent bolus or as a continuous infusion.

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    Labetalol IV Bolus Dosage

    The initial IV bolus dose of labetalol is 10-20 mg undiluted over 1-2 minutes, followed by 20-80 mg over 2 minutes every 10 minutes.

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    Labetalol IV Bolus Maximum Dose

    The maximum cumulative IV bolus dose of labetalol is typically 300 mg.

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    Labetalol IV Continuous Infusion Preparation

    For continuous infusion, prepare a solution by withdrawing 10 mL from a 250 mL bag and adding 60 mL of labetalol (300 mg) to create a concentration of 1 mg/mL.

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    Labetalol IV Continuous Infusion Dose

    Labetalol IV continuous infusion is typically administered at a rate of 0.5-2 mg/min, with higher doses potentially required.

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    Labetalol Accumulation Risk

    Labetalol accumulation can occur with high-dose continuous infusions, leading to severe hypotension and bradycardia.

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    Labetalol Monitoring During IV Administration

    Continuous cardiac and respiratory monitoring is crucial during labetalol administration, along with frequent blood pressure checks.

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    Labetalol Use in Hepatic Dysfunction

    Labetalol should be administered with caution in patients with hepatic dysfunction as they may require dose reduction.

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    Magnesium Sulfate Infusion Rate

    The maximum infusion rate for magnesium sulfate is 150 mg/min, unless there is an urgent indication.

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    Magnesium Sulfate Dilution

    Magnesium sulfate can be diluted in either D5W or Normal Saline (NS) for IV infusion.

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    Magnesium Sulfate: When is it urgent?

    Rapid IV administration of magnesium sulfate may be necessary in cases of life-threatening conditions like ventricular arrhythmias.

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    Monitoring Magnesium Sulfate

    Closely monitor vital signs like heart rate, blood pressure, and respiratory rate during magnesium sulfate administration.

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    Flumazenil: What is it for?

    Flumazenil is an antidote used to reverse severe benzodiazepine overdose.

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    Benzodiazepine Infusion: What's the rate?

    The dose for a continuous benzodiazepine infusion is 1-3 mg/h, with a maximum dose of 10 mg/h.

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    Benzodiazepine Overdose: Contraindications

    Do not administer benzodiazepines in cases of acute narrow-angle glaucoma or pre-existing severe respiratory insufficiency.

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    Study Notes

    Emergency Department Intravenous Infusion Guidelines

    • Initiation Time: Any infusion prepared on a nursing unit should be started within 1 hour of preparation and discarded 24 hours later for sterility reasons. Pharmacy-prepared infusions should be discarded according to label stability guidelines.

    Reconstitution, Concentration, and Doses for Common Indications in the ED

    • Drugs and Indications: Multiple medications are listed, each with specific reconstitution, concentration, and dosage information for various medical conditions, such as paroxysmal supraventricular tachycardia, pulmonary embolism, and others.
    • Preparation Instructions: Instructions detail how to prepare each medication (e.g., dilution techniques, syringe methods, use of transfer devices).
    • Comments/Considerations: Each drug includes essential information, precautions, and potential side effects (e.g., drug interactions, presence of propylene glycol, or potential for extravasation at administration site).
    • Monitoring Parameters: Detailed guidelines are given about the required monitoring for each medication (e.g., continuous 12-lead ECG, BP, HR, cardiac monitors, site monitoring for extravasation).
    • Contraindications: Specific contraindications for each medication based on patient conditions (e.g., AV block, symptomatic bradycardia, or heart transplant patients), are outlined.
    • Note: Includes crucial disclaimers regarding the provided information, emphasizing that more detailed information should be sought from qualified professionals such as pharmacists and physicians.

    Reconsitituion, Concentration, and Doses for Common Indications in the ED - Additional Notes for Specific Drugs

    • Drug name: Specific medications and their relevant information are listed.
    • Administration Route: (e.g., IV push, continuous infusion) for each medication is detailed.
    • Dose/concentration/reconstitution: Specific preparation techniques, concentrations, or dosages for the given conditions and medication are listed.
    • Comments/Considerations: Essential information, precautions, and potential adverse effects (drug interactions, extravasation, or toxicity).
    • Monitoring/Other Pertinent Information: Required monitoring procedures, additional information (such as baseline vital status monitoring frequencies, or specific monitoring based on the drug), and contraindications are given.

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    Description

    This quiz covers essential guidelines for intravenous infusions in the Emergency Department, including initiation timelines, reconstitution, concentrations, and dosages for common medications. It also highlights critical preparation instructions and important precautions for various medical conditions.

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