Embryonic Limb Development Process

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Questions and Answers

What happens when cell death in the apical ectodermal ridge (AER) occurs?

  • The ridge condenses into two segments
  • The AER expands
  • Hydroxyapatite crystals form
  • Fingers and toes form (correct)

What is the function of the secreted molecular WNT14 in limb development?

  • Ossification of long bones
  • Inductive signal (correct)
  • Formation of chondrocytes
  • Formation of joint cavities

How do joints in cartilaginous condensations form during limb development?

  • Induced by chondrogenesis (correct)
  • Through myoblast differentiation
  • By apoptosis
  • By cell proliferation

What happens in Week 7 related to the digital rays in limb development?

<p>Loose mesenchyme between the digital rays breaks down (B)</p> Signup and view all the answers

At what stage does muscle mass divide into extensor and ventral compartments during limb development?

<p>Week 8 (D)</p> Signup and view all the answers

What rotates 90 degrees on their longitudinal axis during limb development?

<p>Upper limbs (A)</p> Signup and view all the answers

At what point do primary ossification centers appear in all long bones?

<p>Week 9 (A)</p> Signup and view all the answers

When does the epiphyseal cartilage plate get replaced, leading to the end of bone growth?

<p>Around age 25 (A)</p> Signup and view all the answers

Where are secondary ossification centers found?

<p>In irregular bones like vertebrae (B)</p> Signup and view all the answers

When do synovial joints form?

<p>During mesenchymal condensations (D)</p> Signup and view all the answers

In what types of bones are primary centers of ossification typically present?

<p>Long bones (A)</p> Signup and view all the answers

What components form within a synovial joint capsule?

<p>Menisci and ligaments (B)</p> Signup and view all the answers

Where are limb musculature cells derived from?

<p>The somites (B)</p> Signup and view all the answers

How does muscle tissue in limb buds initially split?

<p>Into flexor and extensor components (D)</p> Signup and view all the answers

What do upper limb buds lie opposite to?

<p>Cervical and thoracic segments (A)</p> Signup and view all the answers

Which nerves are responsible for extensor musculature in the limbs?

<p>Radial nerve (B)</p> Signup and view all the answers

What role do spinal nerves play in limb musculature?

<p>Provide both sensory and motor innervation (A)</p> Signup and view all the answers

What determines the resulting complex pattern of muscles in limbs?

<p>The lateral plate mesoderm (A)</p> Signup and view all the answers

Which artery in the upper limb arises from the primary axial artery?

<p>Brachial artery (B)</p> Signup and view all the answers

What do radiologists use to determine proper maturation age in children?

<p>Appearance of various ossification centers (D)</p> Signup and view all the answers

At what rate do limb malformations occur in live births?

<p>3.4 per 10,000 (B)</p> Signup and view all the answers

Which artery does the primary axial artery form in the lower limb?

<p>Anterior tibial artery (C)</p> Signup and view all the answers

What provides useful information about bone age in children?

<p>Ossification studies in the hands and wrists (B)</p> Signup and view all the answers

In what part of the body does the marginal sinus break up into the dorsal venous arch?

<p>Upper limb (D)</p> Signup and view all the answers

What is the term for the complete absence of one or more extremities?

<p>Amelia (C)</p> Signup and view all the answers

Which term is used to describe the condition where two or more fingers or toes are fused?

<p>Syndactyly (A)</p> Signup and view all the answers

What is the term for an abnormally short limb?

<p>Micromelia (C)</p> Signup and view all the answers

If a person has extra fingers or toes present, what is this condition called?

<p>Polydactyly (B)</p> Signup and view all the answers

What is the term for the bilateral absence of a digit, such as a thumb?

<p>Ectrodactyly (C)</p> Signup and view all the answers

In which condition is there an abnormal cleft between the second and fourth metacarpal bones and soft tissues?

<p>Cleft hand (A)</p> Signup and view all the answers

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