Embryonic Development: Week 2

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Questions and Answers

Which process is completed during the second week of human development?

  • Implantation of the blastocyst (correct)
  • Neurulation
  • Organogenesis
  • Formation of the trilaminar embryonic disc

What two distinct layers compose the bilaminar embryonic disc?

  • The epiblast and hypoblast (correct)
  • The ectoderm and endoderm
  • The trophoblast and inner cell mass
  • The mesoderm and coelem

Which of the following structures is NOT considered an extraembryonic structure that forms during the second week of development?

  • Amniotic cavity
  • Yolk sac
  • Notochord (correct)
  • Connecting stalk

Which layer of the trophoblast is mitotically active and forms new cells that migrate into the syncytiotrophoblast?

<p>Cytotrophoblast (D)</p> Signup and view all the answers

What is the main functional characteristic of the syncytiotrophoblast during implantation?

<p>Invading the endometrial connective tissue (B)</p> Signup and view all the answers

What cellular process do endometrial cells undergo to facilitate implantation?

<p>Apoptosis (D)</p> Signup and view all the answers

Which hormone is produced by the syncytiotrophoblast and is the basis for pregnancy tests?

<p>Human chorionic gonadotropin (hCG) (A)</p> Signup and view all the answers

What role does human chorionic gonadotropin(hCG) play during Week 2?

<p>Maintains the development of spiral arteries in the myometrium (D)</p> Signup and view all the answers

By approximately what day after fertilization is the didermic embryonic disc formed?

<p>Day 8 (A)</p> Signup and view all the answers

During the second week of development, which layer consists of high columnar cells related to the amniotic cavity?

<p>Epiblast (B)</p> Signup and view all the answers

What is the exocoelomic cavity directly adjacent to?

<p>The hypoblast (C)</p> Signup and view all the answers

What is the origin of the amnioblasts that form the amnion?

<p>Epiblast (B)</p> Signup and view all the answers

What structure surrounds the blastocystic cavity and lines the internal surface of the cytotrophoblast?

<p>The exocoelomic membrane (D)</p> Signup and view all the answers

What does the exocoelomic membrane and cavity eventually form?

<p>The primary umbilical vesicle (yolk sac) (B)</p> Signup and view all the answers

What layer of loosely arranged connective tissue is formed from the outer layer of cells from the umbilical vesicle?

<p>Extraembryonic mesoderm (A)</p> Signup and view all the answers

Around the 9th day of development, what replaces the initial implantation site?

<p>A fibrin plug (A)</p> Signup and view all the answers

As the destructive lytic activity progresses, which anatomical structure do the trophoblastic lacunae connect with?

<p>Maternal capillaries (B)</p> Signup and view all the answers

What is the fluid in the lacunae, which passes to the embryonic disc by diffusion, called?

<p>Embryotroph (B)</p> Signup and view all the answers

What is the clinical significance of the communication between eroded uterine vessels and the lacunae?

<p>It initiates the primordial uteroplacental circulation. (D)</p> Signup and view all the answers

During the second week, uterine connective tissue cells around the implantation site become what?

<p>Loaded with glycogen and lipids (A)</p> Signup and view all the answers

What stimulates enlargement of decidual cells?

<p>Glycogen and lipid accumulation (D)</p> Signup and view all the answers

What is the decidua?

<p>The uterine lining (endometrium) during pregnancy (C)</p> Signup and view all the answers

What primarily influences formation of the decidua?

<p>Progesterone (D)</p> Signup and view all the answers

What covers the defect in the endometrium around day 12?

<p>Newly grown uterine epithelium (D)</p> Signup and view all the answers

What are the thin-walled terminal vessels that result from the congestion and dilation of endometrial capillaries around the implanted embryo?

<p>Sinusoids (C)</p> Signup and view all the answers

During the 11th and 12th day of development, what is the relation of the endometrial stromal cells and glands material to which structure?

<p>A rich source of material for embryonic nutrition (C)</p> Signup and view all the answers

What structures surround the amnion and umbilical vesicle, except for where they attach to the chorion by the connecting stalk?

<p>Extraembryonic coelom (D)</p> Signup and view all the answers

How is the secondary umbilical vesicle formed?

<p>Via pinching off of a large part of the primary umbilical vesicle (C)</p> Signup and view all the answers

What does the extraembryonic coelom split the extraembryonic mesoderm into?

<p>The somatic and splanchnic mesoderm (B)</p> Signup and view all the answers

What forms the chorion?

<p>The extraembryonic somatic mesoderm and the two layers of trophoblast (C)</p> Signup and view all the answers

What structures characterize the end of the second week of embryonic development?

<p>The primary chorionic villi (D)</p> Signup and view all the answers

What stage is the cellular projections form primary chorionic villi during?

<p>The first (B)</p> Signup and view all the answers

What is the function of the umbilical vessel in the chorionic plate?

<p>Oxygenate the floating villus (D)</p> Signup and view all the answers

What connects the location of the amnion and yolk sac to the chorion?

<p>Connecting Stalk (A)</p> Signup and view all the answers

Flashcards

Second week of development

Implantation is completed during this period of development.

Bilaminar embryonic disc

A two-layered structure formed during the second week, consisting of the epiblast and hypoblast.

Epiblast

The thicker layer of the bilaminar disc, made of columnar cells and related to the amniotic cavity..

Hypoblast

A thinner layer of the bilaminar disc, made up of small, cuboidal cells adjacent to the exocoelomic cavity.

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Amniotic cavity, amnion, umbilical vesicle, connecting & chorionic sac

Extraembryonic structures formed during the second week that surround the embryo.

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Cytotrophoblast

The outer layer of the trophoblast, a layer of mononucleated cells, mitotically active.

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Syncytiotrophoblast

Rapidly expanding, mutinucleated mass in which no cell boundaries are discernible.

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Syncytiotrophoblastic cells

The cells that displace endometrial cells in the implantation site.

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Human Chorionic Gonadotropin (hCG)

The hormone produced by the syncytiotrophoblast that is the basis for pregnancy tests.

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Epiblast Layer

Consisting of high, columnar cells related to the amniotic cavity.

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Hypoblast Layer

The thinner layer, consisting of small, cuboidal cells adjacent to the exocoelomic cavity.

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Amniotic Cavity

Cavity that starts to be formed on the 8th day.

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Amnioblasts

Cells that separate from the epiblast and organize to form the amnion.

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Embryotroph

The fluid in the lacunae that passes to the embryonic disc by diffusion.

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Decidual Cells

The uterine connective tissue cells that become loaded with glycogen and lipids during implantation.

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Decidua

Term for the uterine lining during pregnancy, which forms the maternal part of the placenta.

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Closing plug

The term of defect in the endometrial epithelium that is filled.

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Extraembryonic Coelom

Fluid-filled cavity that surrounds the amnion and umbilical vesicle.

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Secondary Umbilical Vesicle

A smaller vesicle.

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Chorion

The wall of chorionic sac.

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The cellular projections.

What structure forms the primary chorionic villi

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Connecting Stalk

Structure that suspends embryo, amniotic sac, umbilical vesicle inside chorionic sac.

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Study Notes

  • During the second week of development, implantation of the blastocyst is completed.
  • This process results in a bilaminar embryonic disc composed of the epiblast and hypoblast layers.
  • The embryonic disc leads to germ layers, which form all the body's tissues and organs.
  • Structures that form during the second week include the amniotic cavity, amnion, umbilical vesicle (yolk sac), connecting stalk, and chorionic sac.
  • Implantation typically occurs in the endometrium.
  • As the blastocyst implants, more trophoblast contacts the endometrium and differentiates into two layers: the cytotrophoblast and the syncytiotrophoblast.

Cytotrophoblast

  • Layer of mitotically active mononucleated cells.
  • Forms new trophoblastic cells that migrate into the increasing mass of syncytiotrophoblast where they fuse and lose their cell membranes.

Syncytiotrophoblast

  • Rapidly expanding, multinucleated mass without discernible cell boundaries.
  • Actively erodes endometrial connective tissue that supports the uterine capillaries and glands.
  • Produces proteolytic enzymes involved in implantation
  • Displaces endometrial cells in the central part of the implantation site.
  • Produces human chorionic gonadotropin (hCG), that enters the maternal blood through syncytiotrophoblast lacunae.
  • The development of spiral arteries in the myometrium and the formation of syncytiotrophoblast is maintained by hCG.
  • Forms the basis for pregnancy tests.
  • Can be detected as early as the end of the second week of pregnancy.

Days 7-8

  • After 8 days, the didermic embryonic disc forms (hypoblast and epiblast).
  • The ST continues its invasive, lytic activity into the maternal tissue

Blastocyst Implantation

  • As implantation progresses, changes in the embryoblast result in the formation of a circular, bilaminar plate of cells that consists of two layers that form the embryonic disc.
  • The Amniotic cavity starts to form around day 8

Epiblast

  • The thicker layer is composed of columnar cells related to the amniotic cavity.
  • Forms the the floor of the amniotic cavity and is continuous peripherally with the amnion.
  • Amniogenic (amnion-forming) amnioblasts separate from here.

Hypoblast

  • Thinner layer of small, cuboidal cells adjacent to the exocoelomic cavity.
  • Forms the roof of the exocoelomic cavity.
  • Continuous with the cells that migrated from the hypoblast to form the exocoelomic membrane
  • Begins to multiply around the 9th day.

Amnion

  • A small cavity appears in the embryoblast, the primordium of this.
  • Amniogenic cells organize to form this thin membrane.
  • Encloses the amniotic cavity

Exocoelomic Cavity

  • The hypoblast forms its roof.

Second Week Details

  • The exocoelomic membrane and cavity change to form the primary umbilical vesicle (yolk sac).
  • The embryonic disc is located between the amniotic cavity and primary umbilical vesicle.
  • The outer layer of cells from the umbilical vesicle creates a layer of loosely organized connective tissue called the extraembryonic mesoderm.

Day 9 Details

  • Implantation location covered by a fibrin plug
  • Expanding amniotic cavity, a cellular layer (amnioblasts) separates it from the CT.
  • Extracellular vacuoles appear in the ST and join to form lacunae.

Days 9-10

  • The destructive lytic activity of the ST reaches the capillaries of the endometrium.
  • Maternal blood flows into the lacunae.

Maternal Blood Exchange

  • Lacunae fill with of maternal blood, ruptured endometrial capillaries, and cellular debris from eroded uterine glands.
  • Embryotroph passes to the embryonic disc by diffusion from fluid.
  • The communication of the eroded uterine vessels with the lacuna represents the beginning of the primordial uteroplacental circulation.
  • Oxygenated blood from spiral endometrial arteries and nutritive substances becomes available to the extraembryonic tissues over the large surface of the syncytiotrophoblast when maternal blood flows into the lacunae.
  • Oxygenated blood passes into the lacunae from the spiral endometrial arteries.
  • Deoxygenated blood is removed from the lacunae through endometrial veins.

Decidual Cells

  • The uterine connective tissue cells around the implantation site are loaded with glycogen and lipids.
  • Some of these cells (decidual cells) degenerate adjacent to the penetrating syncytiotrophoblast.
  • Syncytiotrophoblast engulfs these degenerating cells providing a rich source of embryonic nutrition.
  • Decidual cells are large round, oval, or polygonal cells.
  • Decidua is the term for the uterine lining (endometrium) during pregnancy, which forms the maternal part of the placenta.
  • Formed under the influence of progesterone and forms highly characteristic cells.
  • Provides an immunologically privileged site for the conceptus.

Closing Plug

  • The embryo and extraembryonic membrane is completely embedded in the endometrium.
  • A defect exists in the endometrial epithelium for ~2 days is filled by a closing plug, a fibrinous coagulum of blood.
  • Around day 12, an almost completely regenerated uterine epithelium covers the closing plug

Days10-11 Details

  • The ST envelops the maternal capillaries
  • Expands its lacunae network
  • Forms an arterial inflow and a venous outflow system.

Days 11-12 Details

  • Adjacent syncytiotrophoblastic lacunae fuse to form lacunar networks (primordia of the intervillous space of the placenta).
  • Endometrial capillaries around the implanted embryo become congested, dilating to become sinusoids (thin-walled terminal vessels that are larger than capillaries).
  • The syncytiotrophoblast then erodes the sinusoids and maternal blood flows into the lacunar networks.
  • Growth of the bilaminar embryonic disc is slow compared with the trophoblast.
  • The degenerated endometrial stromal cells and glands, together with the maternal blood, provide a rich source of material for embryonic nutrition.

Extraembryonic Mesoderm

  • The extraembryonic mesoderm increases and isolated extraembryonic coelomic spaces appear within the trophoblast and endometrium.
  • These spaces rapidly fuse to form a large, isolated cavity called the extraembryonic coelom (fluid-filled cavity that surrounds the amnion and umbilical vesicle, except where they are attached to the chorion by the connecting stalk).
  • As the extraembryonic coelom forms, the primary umbilical vesicle decreases in size where a smaller secondary umbilical vesicle forms.
  • The umbilical vesicle contains no yolk, but may play a role in the selection of nutritive materials to the embryonic disc.
  • The extraembryonic coelom splits the extraembryonic mesoderm into two layers: extraembryonic somatic mesoderm and extraembryonic splanchnic mesoderm.
  • Cytotrophoblastic extensions are induced by the underlying extraembryonic somatic mesoderm.

Extraembryonic Somatic Mesoderm

  • Lines the trophoblast and covers the amnion.

Extraembryonic Splanchnic Mesoderm

  • Surrounds the umbilical vesicle

Chorionic Sac Development

  • The extraembryonic somatic mesoderm and the two layers of trophoblast form the chorion; thus, the chorion forms the wall of the chorionic sac.
  • Transvaginal ultrasonography (endovaginal sonography) is used to measure the diameter of the chorionic sac.
  • Measurement of the chorionic sac is useful for evaluating early embryonic development and pregnancy outcome.

Chorionic Villi Development

  • Characterized by the appearance of primary chorionic villi towards the end of the second week.
  • Proliferation of the cytotrophoblastic cells results in cellular extensions that grow into the overlying syncytiotrophoblast forming primitive chorionic villi, the first stage in the development of the chorionic villi of the placenta.

Final Details

  • The embryo, amniotic sac, and umbilical vesicle are suspended in the chorionic cavity by the connecting stalk.

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