EMBRYOLOGY-6

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Questions and Answers

Which hormone does the placenta produce to maintain the functionality of the corpus luteum initially?

  • Human chorionic gonadotropin (hCG) (correct)
  • Progesterone
  • Human chorionic somatotropin
  • Estrogens

What role does human chorionic somatotropin (placental lactogen) serve during pregnancy?

  • It directly stimulates fetal growth.
  • It aids in the formation of the placenta.
  • It regulates maternal metabolism of glucose. (correct)
  • It suppresses the immune response in the mother.

Which decidual region is located between the implanted embryo and the myometrium?

  • Decidua Basalis (correct)
  • Decidua Reciprocalis
  • Decidua Parietalis
  • Decidua Capsularis

What is the role of the decidua capsularis during pregnancy?

<p>It covers the embryo and degenerates at the 3rd month. (B)</p> Signup and view all the answers

Which of the following infectious agents can cross the placenta?

<p>Toxoplasma gondii (B)</p> Signup and view all the answers

Which statement accurately describes the function of the chorion frondosum?

<p>It harbors the placenta's connections to maternal tissue. (A)</p> Signup and view all the answers

How does the placenta protect the embryo from the mother’s immune system?

<p>By lacking major histocompatibility complex (MHC) in specific cell types. (D)</p> Signup and view all the answers

What changes occur in hormone production related to the corpus luteum by the third trimester?

<p>The corpus luteum ceases its hormone production. (C)</p> Signup and view all the answers

What happens to the decidua capsularis by the end of the third month?

<p>It disappears. (B)</p> Signup and view all the answers

How do the amnion and chorion interact during pregnancy?

<p>They fuse to create the amniochorionic membrane. (B)</p> Signup and view all the answers

What is a potential consequence of vasa previa during pregnancy?

<p>Fetal bradycardia (B)</p> Signup and view all the answers

Which condition is characterized by the presence of only paternal chromosomes and no fetal tissue?

<p>Complete hydatiform mole (C)</p> Signup and view all the answers

What type of twins are formed when two oocytes are fertilized at the same time?

<p>Dizygotic twins (A)</p> Signup and view all the answers

What is a serious potential condition that can develop from a complete hydatiform mole?

<p>Choriocarcinoma (D)</p> Signup and view all the answers

What is a common symptom of hyperemesis gravidarum associated with hydatiform mole?

<p>Acute nausea and vomiting (D)</p> Signup and view all the answers

Which of the following is NOT a complication associated with placental abruptio?

<p>Excessive emotional disturbances (B)</p> Signup and view all the answers

What characteristic differentiates monozygotic twins from dizygotic twins?

<p>Same genetic material (C)</p> Signup and view all the answers

During which pregnancy complication might a hematoma form with no external bleeding?

<p>Placental abruptio (A)</p> Signup and view all the answers

What is the main reason for conducting amniocentesis after the 15th week of pregnancy?

<p>To minimize risks of harming the fetus (D)</p> Signup and view all the answers

Which of the following is NOT a complication associated with oligohydramnios?

<p>Excessive fetal movement (A)</p> Signup and view all the answers

What primarily composes amniotic fluid during the second trimester?

<p>Water, proteins, electrolytes, and fetal epithelial cells (A)</p> Signup and view all the answers

Which condition is caused by renal agenesis resulting in oligohydramnios?

<p>Potter syndrome (A)</p> Signup and view all the answers

What factors may contribute to the development of polyhydramnios?

<p>Maternal infections and cardiac issues (C), Maternal diabetes and hypertension (D)</p> Signup and view all the answers

How frequently is amniotic fluid turned over in the third trimester?

<p>Every 3 hours (B)</p> Signup and view all the answers

What is the primary mechanism through which amniotic fluid is reabsorbed?

<p>Through the amniochorionic membrane (A)</p> Signup and view all the answers

Which abnormality is indicated by elevated levels of alpha-fetoprotein in the amniotic fluid?

<p>Esophageal atresia (A)</p> Signup and view all the answers

What is the primary characteristic of the fetal side of a mature placenta?

<p>It is shiny due to the amnion. (C)</p> Signup and view all the answers

Which of the following complications is associated with the abnormal adherence of chorionic villi to the myometrium?

<p>Placenta accreta (B)</p> Signup and view all the answers

What condition is described as the complete penetration of the myometrium, often reaching nearby organs?

<p>Placenta percreta (D)</p> Signup and view all the answers

What could potentially cause placenta abruption?

<p>Maternal hypertension (A)</p> Signup and view all the answers

Which of the following statements about placenta previa is true?

<p>It occurs when the placenta attaches at the internal uterine os. (D)</p> Signup and view all the answers

What is the primary risk associated with placenta that digs too deep into the uterine wall?

<p>Severe hemorrhaging during delivery (D)</p> Signup and view all the answers

What is the thickness of a mature placenta?

<p>Around 3 cm (A)</p> Signup and view all the answers

What is the primary function of the vitelline stalk or canal during embryonic development?

<p>To facilitate communication between the midgut and the vitelline sac (A)</p> Signup and view all the answers

What condition involves a premature separation of the placenta from the uterine wall?

<p>Placenta abruption (D)</p> Signup and view all the answers

During which week of embryonic development does extraembryonic hematopoiesis occur in the yolk sac?

<p>Sixth week (A)</p> Signup and view all the answers

What is the fate of the allantois in human embryonic development?

<p>It degenerates and becomes a ligament of the urinary bladder (C)</p> Signup and view all the answers

Which structures contribute to the formation of the umbilical cord?

<p>Body stalk and vitelline duct (D)</p> Signup and view all the answers

What happens to the intestinal loop during the early stages of embryonic development?

<p>It is absorbed back into the abdominal cavity (D)</p> Signup and view all the answers

What is the approximate length and diameter of the umbilical cord at term?

<p>55-60 cm long and 2-2.5 cm in diameter (D)</p> Signup and view all the answers

What is contained within the umbilical cord at its initial stage of development?

<p>Body stalk, allantois, umbilical vessels and vitelline duct (A)</p> Signup and view all the answers

What is the role of Wharton’s jelly in the umbilical cord?

<p>To protect the blood vessels (A)</p> Signup and view all the answers

Flashcards

What are cytotrophoblastic cells?

These cells are responsible for forming the placental barrier, which acts as a shield between the mother and the fetus.

What is Passive Immunity?

These antibodies pass through the placenta and provide temporary immunity to the fetus, protecting it against various infections.

What are Infectious Diseases?

These infections can cross the placenta and potentially harm the developing fetus, or be transmitted during birth through the birth canal.

What is TORCH?

TORCH is an acronym representing a group of common organisms that can cross the placenta and potentially pose risks to the developing fetus.

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What is hCG?

This hormone is produced by the placenta to maintain the corpus luteum, an important structure in the ovary that supports early pregnancy.

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Amniocentesis

The process of sampling amniotic fluid, typically done after the 15th week of pregnancy.

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Oligohydramnios

A condition where there is too little amniotic fluid, often caused by problems with the placenta, ruptured membranes, or fetal kidney issues.

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Potter Syndrome

A syndrome resulting from reduced amniotic fluid, characterized by underdeveloped lungs, limb deformities, and facial abnormalities in a baby.

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Amniotic Fluid

The fluid that surrounds and protects a developing fetus in the womb.

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Amniotic Fluid Turnover

The process of the amniotic fluid being replaced every three hours in the third trimester of pregnancy.

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Polyhydramnios

A condition where there is too much amniotic fluid, often linked to maternal health issues like diabetes, heart problems, or infections.

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Bidirectional Exchange between Amniotic Fluid and Fetal Tissues

The process of the fetal tissues exchanging fluids with the amniotic fluid, going in both directions.

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Amniochorionic Membrane

The fusion of the amniotic sac and chorion, forming a single membrane.

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Decidua

The layer of the endometrium that surrounds the implanted embryo. It's divided into three parts: basalis, capsularis, and parietalis.

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Decidua Basalis

Part of the decidua located between the implanted embryo and the myometrium (the muscular wall of the uterus). It's where the chorion frondosum develops.

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Decidua Capsularis

Part of the decidua that covers the embryo and its chorionic cavity. It degenerates by the 3rd month of pregnancy.

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Decidua Parietalis

The remaining part of the decidua, not directly involved with the implanted embryo. It fuses with the amnion later.

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Breaking of waters

The rupturing of the amniochorionic membrane, marking the start of labor.

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Fetal side of the placenta

The side of the placenta connected to the baby's umbilical cord. It is shiny due to the presence of the amnion and chorion frondosum.

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Maternal side of the placenta

The side of the placenta attached to the uterine wall. It is covered by the decidua basalis and has a dull appearance.

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Placenta accreta

An abnormally firm attachment of the chorionic villi to the myometrium. It can be partial or complete absence of the decidua basalis, resulting in difficult placental separation during delivery.

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Placenta increta

A severe form of placenta accreta, where the chorionic villi penetrate deep into the myometrium, potentially reaching the uterine lining (perimetrium).

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Placenta percreta

The most severe form of placenta accreta, where the chorionic villi completely penetrate the uterine wall, reaching the perimetrium and possibly other organs.

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Placenta previa

Occurs when the placenta attaches itself to the lower part of the uterus, covering or partially covering the cervix, leading to potential bleeding during pregnancy due to vessel rupture.

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Placenta abruption

This occurs when the placenta prematurely detaches, either partially or completely, from the uterine wall, leading to bleeding and potential risks for both the mother and baby.

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What is the vitelline stalk?

The vitelline stalk or canal is a connection between the midgut and the vitelline sac. It is incorporated into the umbilical cord.

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Where does extraembryonic hematopoiesis occur and for how long?

During the 3rd week of development, undifferentiated mesodermal cells migrate to the vitelline sac wall and form blood islands. This process, called extraembryonic hematopoiesis, occurs in the yolk sac until the 6th week.

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What is the allantois and why is it important?

The allantois is an outpouching of the yolk sac into the body stalk. It's a vestigial organ in humans, meaning it has no function and eventually degenerates. However, the allantois is important because it triggers the formation of blood vessels where it protrudes.

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What is the umbilical cord derived from and where is it located?

The umbilical cord develops from the body stalk (initially attached to the embryonic disc's tail end) and the vitelline duct. It is located on the ventral surface of the embryonic disc at the umbilical region.

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How does the umbilical region change during embryonic development?

Initially, the umbilical region starts wide and then narrows as folding progresses, bringing the vitelline duct and body stalk closer until they fuse.

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What are the initial components of the umbilical cord?

The initial contents of the umbilical cord include the body stalk (with the allantois and umbilical vessels), vitelline duct (vitelline vessels), extraembryonic coelom, and the intestinal loop from week 6 to 10.

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Describe the umbilical cord at term.

The intestine temporarily moves outside the embryo to develop and then returns to the abdominal cavity. At term, the umbilical cord is typically 55-60cm long and 2-2.5cm in diameter. It contains two arteries and one vein and is surrounded by Wharton's jelly.

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What happens to the remaining portion of the allantois?

The portion of the allantois that remains outside the umbilical cord connects to the cloaca of the intestinal tube. It eventually becomes the urachus, a ligament of the urinary bladder.

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Vasa previa?

A condition where the umbilical cord blood vessels run over or near the opening of the cervix, causing painless bleeding and potential fetal bradycardia.

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Choriocarcinoma?

A cancerous growth of the trophoblast, the layer of cells that normally develops into the placenta, occurring during pregnancy. It can be metastatic or non-metastatic.

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Hydatiform mole?

A condition where the chorionic villi, finger-like projections of the placenta, are abnormally enlarged, resembling grapes. This occurs due to a genetic problem that prevents the formation of an embryo.

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Monochorionic diamniotic twins?

A rare condition where two embryos implant in the uterus and share a common placenta and chorion. This can lead to uneven blood flow and complications for one or both embryos.

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Dizygotic twins?

Twins that develop from two separate fertilized eggs (zygotes). They have separate placentas, chorions, and amnions.

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Disseminated Intravascular Coagulation (DIC)?

A condition where blood clots form throughout the body's small blood vessels, often in the context of complications like placental abruption or amniotic fluid embolism.

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High hCG levels?

An overproduction of the hormone hCG (human chorionic gonadotropin), often associated with conditions like hydatiform mole.

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Study Notes

Embryonic Development and Support Systems

  • The embryo establishes a parasitic relationship with the mother for oxygen, nutrients, and waste removal. It must avoid rejection as a foreign body.
  • The placenta and extraembryonic membranes facilitate communication with the mother.
  • The placenta and chorion originate from the trophoblast, while the amnion, yolk sac, allantois, and extraembryonic mesoderm originate from the inner cell mass.

Amniotic Membrane and Cavity

  • The amniotic sac completely covers the embryo.
  • Functions of the amniotic sac include: buffering against mechanical injury, accommodating growth, allowing fetal movements, protecting the fetus from adhesion, acting as a barrier to infections (bacteriostatic properties), maintaining a constant temperature, and assisting in fluid and electrolyte homeostasis.

Amniotic Membrane Functions

  • Contains significant cytokines and essential growth factors.
  • Reduces pain when applied to wounds.
  • Increases and enhances wound healing.
  • Has antibacterial properties.
  • Is non-immunogenic.
  • Provides a biological barrier.
  • Provides a matrix for cell migration and proliferation.
  • Reduces inflammation and scar tissue formation.
  • Stem cells are present within the amniotic membrane, which are of significant research interest.

Amniotic Fluid Composition

  • Amniotic fluid is primarily composed of the embryo's urine after the 11th week, though lung secretions are also a component.
  • Fetal urine lacks waste products, as these are secreted by the placenta.

Disorders in Amniotic Fluid Volume

  • Oligohydramnios: reduced amniotic fluid volume, potentially caused by diminished placental blood flow, premature amniochorionic membrane rupture, renal agenesis, or urinary tract obstruction.
  • Polyhydramnios: increased amniotic fluid volume; causes are often unknown but potentially linked to maternal factors like diabetes, and/or fetal issues such as esophageal or duodenal atresia, anencephaly, or congenital diaphragmatic hernia.

Placenta and Chorion

  • The placenta and chorion cooperate.
  • The placenta is formed by cytotrophoblast, syncytiotrophoblast, and extraembryonic mesoderm.
  • The placenta is an endocrine organ, producing human chorionic gonadotropin (hCG) to maintain the corpus luteum, and estrogen and progesterone later in pregnancy .

Further Development

  • The chorionic villi help with maternal blood circulation within the intervillous space.
  • Cytotrophoblast from anchoring villi invades spiral arteries within the uterine wall.
  • Oxygen levels in fetal blood are different from maternal oxygens.
  • Inadequate placental perfusion can affect fetus.

Other Developmental Aspects

  • The allantois and umbilical cord are involved in embryonic development.
  • Amniotic bands can cause fetal abnormalities.
  • Placental attachment types (eccentric, marginal, membranous) exist
  • Hydatiform moles and choriocarcinomas are abnormal placental conditions.
  • Twins (monozygotic and dizygotic) result from different developmental processes.

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