BMS200 - Week 2

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Questions and Answers

What is the function of the pleuroperitoneal membranes during diaphragm development?

To separate the thoracic and abdominal cavities completely

To serve as a barrier preventing herniation of organs

To form the central tendon of the diaphragm without fusion

To provide a connective tissue scaffold for migrating muscle cells (correct)

What results from a failure of muscle cells to populate the pleuroperitoneal membranes?

Separation of the thoracic and abdominal cavities

Congenital diaphragmatic hernias (correct)

Formation of the serous membranes

Development of the pericardioperitoneal canals

Which embryonic layer is primarily responsible for forming the diaphragm?

Ectoderm

Epiblast

Endoderm

Mesoderm (correct)

What forms the central tendon of the diaphragm during its development?

Fused pleuroperitoneal membranes over the septum transversum Signup and view all the answers

What is the dorsal mesentery's primary function in relation to the gut tube?

Serves as a continuous layer with the visceral and parietal layers Signup and view all the answers

What is the effect of the different growth rates of the dorsal and ventral borders of the stomach during development?

It results in the formation of the lesser and greater curvatures. Signup and view all the answers

During stomach rotation, which direction does the dorsal border move?

To the left, towards the greater curvature. Signup and view all the answers

What is the role of the ventral mesogastrium in developing the liver?

It contributes to the formation of the lesser omentum connecting the stomach to the liver. Signup and view all the answers

Which structure connects the spleen to the posterior abdominal wall?

The lienorenal ligament. Signup and view all the answers

As the stomach rotates, what happens to the omental bursa?

It creates space behind the stomach. Signup and view all the answers

Which characteristic is true for water-soluble vitamins compared to lipid-soluble vitamins?

Water-soluble vitamins are absorbed directly into the blood. Signup and view all the answers

What is one of the specific reactions catalyzed by the coenzymes of Vitamin B2?

Oxidation of succinate to fumarate. Signup and view all the answers

Which of the following statements about Vitamin B3 coenzymes is correct?

They participate in glycolysis and lipid metabolism. Signup and view all the answers

What is a notable effect of the high toxicity potential of lipid-soluble vitamins?

They can accumulate in the body leading to toxicity. Signup and view all the answers

Which of the following vitamins is directly involved in the electron transport chain (ETC) through its coenzyme?

Vitamin B2 (Riboflavin) Signup and view all the answers

Why are coenzymes less likely to diffuse across cell membranes compared to vitamins?

Coenzymes are often larger and may be charged or polar. Signup and view all the answers

Which type of vitamins can most readily diffuse across cell membranes?

Lipid-soluble vitamins Signup and view all the answers

What is the primary reason a coenzyme cannot convert back into a vitamin?

The conversion process from vitamin to coenzyme is unidirectional. Signup and view all the answers

Which of the following statements is true regarding coenzymes?

They often contain complex components like nucleotide groups. Signup and view all the answers

How does the size and structure of vitamins compare to coenzymes?

Vitamins are typically smaller and simpler than coenzymes. Signup and view all the answers

Which vitamin form acts as the coenzyme in B6-related reactions?

Pyridoxal Phosphate Signup and view all the answers

Which process is B6 involved in to help convert an amino acid into NAD+?

Transamination Signup and view all the answers

Which of the following B6-assisted reactions is crucial for neurotransmitter synthesis?

Decarboxylation Signup and view all the answers

What is the major role of vitamin B6 in the glycogenolysis process?

To assist glycogen phosphorylase in releasing glucose Signup and view all the answers

Which addition helps form the phosphorylated form of B6 necessary for absorption?

Phosphate group Signup and view all the answers

What is the primary role of B6 in the glucose-alanine cycle?

Acts as a coenzyme for alanine-pyruvate transaminations Signup and view all the answers

Which amino acid is synthesized from homocysteine and serine?

Cysteine Signup and view all the answers

What is a key function of the glucose-alanine cycle in muscle metabolism?

Transports alanine to the liver for gluconeogenesis Signup and view all the answers

Which statement about the desaturation of fatty acids in relation to B6 is correct?

B6 aids in the production of anti-inflammatory prostaglandins via delta-6-desaturase Signup and view all the answers

How might increased levels of homocysteine affect cardiovascular health?

Increased homocysteine levels may be linked to cardiovascular disease risk Signup and view all the answers

Study Notes

Mesenteries and Septum Transversum

The visceral and parietal layers connect as the dorsal mesentery, running from the posterior body wall to the gut tube.
The ventral mesentery spans from the anterior body wall to the gut tube, existing from the caudal foregut to the upper duodenum.
The septum transversum is a thick mesodermal tissue located between the thoracic cavity and yolk sac, derived from visceral (splanchnic) mesoderm.
This septum doesn't separate the thoracic and abdominal cavities, leaving pericardioperitoneal canals.

Diaphragm Development

The diaphragm closes the opening between the future pleural and peritoneal cavities via pleuroperitoneal folds, which later fuse with mesentery to form crura of the diaphragm.
It develops from:
- Two pleuroperitoneal membranes.
- Muscular components from somites at C3-C5.
- The mesentery of the esophagus.
Congenital diaphragmatic hernias occur in 1 in 2,000 births due to muscle cell deficiencies preventing myoblast migration.

Stomach Development

The stomach emerges as a fusiform enlargement of the caudal foregut, with differential growth creating greater (dorsal) and lesser (ventral) curvatures.
It rotates 90° clockwise around its long axis, positioning the anterior border to the right and the posterior border to the left.
The left vagus nerve innervates the anterior wall, while the right vagus nerve innervates the posterior wall.

Mesenteries and Organs

The dorsal mesogastrium connects the stomach to the dorsal body wall, and the ventral mesogastrium connects it to the ventral body wall.
Components derived from the ventral mesogastrium include the peritoneum around the liver, lesser omentum, and falciform ligament.
The spleen begins forming from the dorsal mesogastrium in the 5th week and attaches to the posterior body wall via the lienorenal ligament and to the stomach by the gastrolienal ligament.

Pancreas Development

The pancreas develops from pancreatic buds arising from the caudal foregut; the ventral bud fuses with the dorsal bud during the duodenum's rotation.
An annular pancreas occurs when the ventral bud forms a ring around the duodenum, potentially causing obstruction.

Midgut Development

The midgut is suspended by an elongated mesentery, supplied by the Superior Mesenteric Artery (SMA).
It forms a U-shaped loop, expanding into the umbilical cord due to limited abdominal space.
Key structures include small intestine sections, cecum, appendix, ascending colon, and the upper two-thirds of the transverse colon.

Intestinal Rotation and Fixation

The midgut loop experiences two counterclockwise rotations, totaling 270°, returning to the abdomen around the 10th week.
Various intestines and structures become retroperitoneal due to pressure against the posterior abdominal wall, while some retain their mesentery.

Hindgut Development

The hindgut includes the left third of the transverse colon, descending colon, sigmoid colon, rectum, and parts of the urinary system, all supplied by the Inferior Mesenteric Artery.
The cloaca, the endpoint of the hindgut, is segmented into a urogenital sinus and a rectum by the urorectal septum.

Congenital Conditions

Congenital omphalocele involves persistent herniation of intestinal loops into an umbilical cord.
Gastroschisis results from the anterior abdominal wall's incomplete closure, causing visceral protrusion into the amniotic cavity.
Meckel's diverticulum arises from the yolk stalk, potentially inflamed and mimicking appendicitis.

Additional Conditions

Umbilical fistula forms when the vitelline duct remains patent, permitting communication between umbilicus and intestine.
Vitelline cyst occurs from the transformation of the vitelline duct's ends into fibrous cords while the middle part develops into a cyst.

Overall Outcomes

Understand vitamin absorption, conversion, and usage for optimal health.
Apply biochemical mechanisms of vitamins to treatment of specific conditions.

Intro Objectives

Classify vitamins into water-soluble and lipid-soluble categories.
Contrast absorption, transport, storage, excretion, toxicity, and dosing between the two types.
Discuss mechanisms leading to vitamin deficiencies.

B-Vitamin Coenzymes

B-vitamins converted to coenzymes that catalyze specific biochemical reactions.
Vitamin B2 (Riboflavin) forms FAD and FMN; key in various metabolic pathways.

Reactions for B2 and B3 Coenzymes

B2 (Riboflavin):
- FAD reduces during:
  - Citric acid cycle (succinate to fumarate)
  - Fatty acid oxidation
  - Electron transport chain (ETC) contributing to ATP production.
B3 (Niacin):
- NAD+ reduces during:
  - Glycolysis and citric acid cycle
  - Lipid and amino acid metabolism.
  - ETC generating ATP from NADH.

Vitamin vs. Coenzyme

Vitamins are smaller, simpler molecules that can sometimes diffuse across membranes, especially if lipid-soluble.
Coenzymes are larger, more complex and often charged, making diffusion across membranes less likely.
Coenzymes cannot revert back to their vitamin forms, marking a unidirectional metabolic process.

FMN and Energy Production

FMN acts as a prosthetic group in Complex I of the ETC.
FMN reduces to FMNH2 during electron transfer, important for ATP synthesis.

Functions of B2 (Riboflavin)

Participates in antioxidant regeneration, specifically glutathione.
Aids in neurotransmitter metabolism, important for degrading neurotransmitters like dopamine and norepinephrine.

Physiological Effects of B3 (Niacin)

Reduces fibrinogen levels, enhancing blood flow by preventing clot formation.
Improves lipid profiles by decreasing VLDL/LDL and increasing HDL levels.
Acts on adipose tissue to impact lipolysis and lipid metabolism, reducing LDL levels.

Pantothenic Acid (Vitamin B5)

Key in energy production and synthesis reactions including fatty acids and cholesterol.
Coenzyme A (CoA) is the most common form derived from B5, fundamental for several metabolic pathways.
Plays a role in the Citric Acid Cycle (CAC), beta-oxidation of fatty acids, and production of heme for hemoglobin synthesis.

CoA Functions

Acetyl-CoA serves as a vital substrate in energy production via the CAC.
CoA essential for fatty acid activation during beta-oxidation.
Succinyl-CoA and HMG-CoA derived from CoA are critical for cholesterol and ketone body synthesis.

Key Takeaways

Knowledge of vitamin absorption and coenzyme functioning is necessary for understanding their roles in health and disease.
B-vitamins significantly contribute to energy metabolism and antioxidant defenses, playing critical roles in physiological processes.

Vitamin B6 (Pyridoxine) Functions

Facilitates transamination, trans- and de-sulfhydration, and decarboxylation reactions.
Exists in six interchangeable forms known as "vitamers," differing only by their functional groups.
Key vitamers include pyridoxal (PL), pyridoxine (PN), and pyridoxamine (PM); the coenzyme form is pyridoxal phosphate (PLP).
Other B-vitamins assist in converting vitamers; B2 specifically converts PNP to PLP, the only active coenzyme.

Absorption and Metabolism of B6

Phosphorylated vitamers must undergo dephosphorylation for absorption.
Enzymes required for conversion include phosphatases for absorption and kinases to convert PL to PLP.
B6 plays a crucial role in energy metabolism by synthesizing NAD+ from the amino acid tryptophan.

Glycogenolysis and Gluconeogenesis

B6 aids glycogen phosphorylase to release glucose for energy during glycolysis.
In gluconeogenesis, B6 facilitates conversions of amino acids:
- Cysteine to pyruvate.
- Aspartate to oxaloacetate.
- Alanine to pyruvate, linking to the glucose-alanine cycle.

Role in Heme Synthesis

B6 condenses succinyl CoA with glycine, initiating heme synthesis.

Neurotransmitter Synthesis

Involved in the creation of neurotransmitters derived from amino acids.
Key neurotransmitters include GABA (inhibitory), seratonin, and dopamine.

B6 and Fatty Acid Metabolism

B6 supports the synthesis of gamma-linolenic acid, a precursor to anti-inflammatory prostaglandins.

Folate (Vitamin B9) Functions

Essential for one-carbon transfer and amino acid metabolism.
Functions as a coenzyme after undergoing reduction to THF (tetrahydrofolate) and attachment of glutamic acid residues.

Folate Absorption and Metabolism

Absorption requires removal of polyglutamate chains, facilitated by hydrolases in the intestinal tract.
Folate is stored in the liver and participates in enterohepatic circulation, maintaining B-vitamin levels in the body.

Implications of Folate in Health

Crucial for nucleotide synthesis, linked to conditions like spina bifida, anemia, and potential roles in cancer.
Exists in a methylation cycle that is disrupted when there is insufficient B12, leading to the methyl-folate trap.

Methyl-Folate Trap

B12 deficiency prevents regeneration of THF from methyl THF, crucial for purine and pyrimidine synthesis.
Folate supplementation may bypass this trap temporarily, aiding in treating B12-related anemia.

Deficiencies and Symptoms

B6 deficiency can lead to neurological (lethargy, depression) and dermatological (dermatitis, brittle nails) symptoms.
B12 deficiency may arise from hypochlorhydria, leading to similar symptoms as B9 deficiency, including megaloblastic anemia (pernicious anemia).

Clinical Testing for Deficiencies

Blood tests for B12, homocysteine, and methylmalonic acid are essential in diagnosing deficiencies.
Elevated levels of methylmalonic acid indicate a B12 deficiency as it is not adequately metabolized.

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Description

Explore the important concepts of visceral and parietal layers, dorsal and ventral mesentery in this embryology quiz. Understand how the septum transversum connects the thoracic cavity to the yolk sac, and learn about the development of mesodermal tissues. Test your knowledge on these key topics in human embryology.