Embryology and Oocyte Development

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The term 'flabbergasted' describes a state of confusion.

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String

A group of characters that can be letters, numbers, or other symbols.

String variable

A way to store and manipulate text data in a program.

Escape sequence

A special sequence of characters that has a specific meaning in a programming language.

String length

The number of characters in a string.

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Extracting a portion of a string.

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Study Notes

Embryology

  • Embryo development hinges upon uterine tissue function
  • Uterine tissue structure changes throughout the menstrual cycle (25-28 days)
  • Women are born with a finite number of oocytes (primary oocytes) arrested in prophase of the first meiotic division

Oocyte Development

  • At puberty, a monthly selection of primary oocytes begins development
  • Primordial follicles are formed by a single layer of granulosa cells surrounding primary oocytes
  • Primary follicles transform into secondary follicles as they grow, increasing the layers of granulosa cells and containing an antrum (fluid-filled cavity)
  • A single dominant follicle (Graafian follicle) matures, producing increased estrogen to thicken the uterine lining in preparation for potential implantation
  • A surge in luteinizing hormone (LH) triggers ovulation, releasing the secondary oocyte into the fallopian tube
  • The remnants of the Graafian follicle transform into the corpus luteum.
  • Progesterone secreted by the corpus luteum prepares the endometrium for implantation.

Implantation

  • Implantation starts at the beginning of week 6 at the ampulla of the uterus.
  • Fertilized egg (zygote forms an embryo), growing and dividing during one week's travel to the uterus, forms a blastocyst
  • Implantation requires a receptive uterine lining. It is facilitated by hormones, particularly progesterone, ensuring its receptiveness
  • Successful implantation can only occur if the uterus has reached a receptive phase
  • Embryo attaches to the endometrium and destroys some tissue to access nutrients during implantation which lasts for one week

Pregnancy

  • Pregnancy lasts 38 weeks (266 days) from fertilization
  • First 8 weeks form embryonic period.
  • Embryo→ Zygote→ morula→ Blastocyst stages of early development.
  • At the 8-cell stage, cells are totipotent.
  • These stages establish the components of the placenta (chorionic, amniotic, yolk sacs).
  • During the third week, gastrulation creates the three primary germ layers (ectoderm, mesoderm, and endoderm).

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