Embryology and Developmental Toxicity Quiz

What is the purpose of whole-embryo culture (WEC) in embryology?

At what stage are explanted rodent embryos used in the whole-embryo culture?

What is the process of organ development in the embryo from the third to eighth week after conception known as?

Which platform uses limb bud micromass culture in embryology?

What is the primary risk associated with teratogenic factors during pregnancy?

What is the disturbed growth process involved in the production of a malformed neonate called?

Which factors can cause teratogenesis in embryos?

What is the time frame for organ development in the embryo when teratogenesis poses a significant risk?

What factors are examined during whole-embryo culture (WEC) to assess developmental toxicity?

Embryology is the field of developmental and cell-line-derived stem cell-derived platforms, which are used to assess developmental toxicity. These platforms include the whole-embryo culture (WEC), the limb bud micromass culture, and the mouse embryonic stem cell test (mEST). The whole embryo culture uses explanted rodent embryos at the 1-5 somite stage, the early organogenesis stage, and is cultured in roller bottles for 48-72 h. At the beginning of the culture, test compounds are added to the culture medium at various concentrations, and embryos are examined for factors such as heartbeat, yolk sac circulation, and growth, as measured by crown-rump length and/or protein content and morphology.

Developmental toxicity is a significant risk during the early fetal stages and organogenesis, which is the process of organ development in the embryo from the third to eighth week after conception. Teratogenesis is the disturbed growth process involved in the production of a malformed neonate, and there are six principles of teratology as defined by Wilson. Teratogenic factors pose a greater risk to the fetus, as these abnormalities may go undetected until birth.

Teratogenesis can be caused by various factors, including genetic abnormalities passed on from the parents or environmental factors such as drugs, chemicals, or infections. The developing fetus is fragile, especially in early embryogenesis, when the body starts to build tissues and organs. Mindfulness and avoidance of teratogenic factors are of the up

Test your knowledge of embryology, developmental toxicity, and teratogenesis with this quiz. Explore the principles of teratology, whole-embryo culture, limb bud micromass culture, and the mouse embryonic stem cell test (mEST). Understand the factors contributing to teratogenesis and the risks posed to the developing fetus.