Embryogenesis: Weeks 1-8

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following processes occurs during the pre-embryonic stage?

  • Histogenesis
  • Morphogenesis
  • Cleavage (correct)
  • Organogenesis

The uteroplacental circulation is typically established:

  • Starting at the end of the second week of gestation. (correct)
  • By the end of the first week of gestation.
  • During the first trimester.
  • During the fourth week of gestation.

What is the primary event occurring during neurulation?

  • Formation of the neural tube from the neural plate. (correct)
  • Development of the digestive system.
  • Formation of the mesoderm.
  • Development of the circulatory system.

The neural crest cells, formed during neurulation, are crucial for the development of which of the following?

<p>The peripheral nervous system. (C)</p> Signup and view all the answers

Which primary germ layer gives rise to the epidermis and its related structures?

<p>Ectoderm (A)</p> Signup and view all the answers

Histogenesis, the differentiation of cells into specialized tissues, occurs prominently during which period?

<p>Fourth week gestation (C)</p> Signup and view all the answers

Which of the following structures is NOT derived from the ectoderm?

<p>Lining of the respiratory tract (C)</p> Signup and view all the answers

What adult structure is derived from the mesoderm?

<p>Heart (D)</p> Signup and view all the answers

The paraxial mesoderm is responsible for the development of:

<p>The skeletal muscles of the trunk. (D)</p> Signup and view all the answers

What structure forming during embryogenesis derives from the endoderm?

<p>Lining of the respiratory tract (B)</p> Signup and view all the answers

Which of the following events characterizes the embryonic period from weeks 4 to 8?

<p>Morphogenesis (C)</p> Signup and view all the answers

During which week of development does the bilaminar disc form?

<p>Second week (C)</p> Signup and view all the answers

The formation of somites is a characteristic feature of which stage of development?

<p>Organogenesis (D)</p> Signup and view all the answers

Which of the following is derived from the lateral mesoderm?

<p>The heart (A)</p> Signup and view all the answers

What is the primary function of the trophoblastic lacunae during early embryonic development?

<p>Establishing contact with maternal blood vessels (B)</p> Signup and view all the answers

Which of the following processes is directly facilitated by cavitation during embryogenesis?

<p>Formation of the blastocyst cavity. (D)</p> Signup and view all the answers

During gastrulation, the primitive streak plays a critical role in:

<p>Establishing the body axes and forming the germ layers. (C)</p> Signup and view all the answers

Which of the following structures is formed during the third week of human development?

<p>Trilaminar disc (D)</p> Signup and view all the answers

The initial formation of the heart begins in which of the following weeks of human development?

<p>Third week (C)</p> Signup and view all the answers

Which of the following events involves the rapid mitotic cell division of the zygote?

<p>Cleavage (B)</p> Signup and view all the answers

Which of the following is a hallmark event indicative of the transition from the bilaminar to the trilaminar disc in human embryogenesis?

<p>Epithelial-to-mesenchymal transition (EMT) of epiblast cells through the primitive streak. (B)</p> Signup and view all the answers

Consider a scenario where the notochord fails to properly induce the overlying ectoderm during neurulation. Which of the following developmental defects is most likely to occur?

<p>Failure of neural tube closure, resulting in conditions such as spina bifida or anencephaly. (C)</p> Signup and view all the answers

During week 3 of human development, the formation of the intraembryonic coelom by cavitation within the lateral plate mesoderm directly contributes to which of the following?

<p>Partitioning of the body cavity into the pleural, pericardial, and peritoneal cavities. (D)</p> Signup and view all the answers

A researcher discovers a novel mutation in a gene expressed exclusively in the intermediate mesoderm. Which of the following developmental processes would be most directly affected?

<p>Development of the gonads and kidneys. (C)</p> Signup and view all the answers

Aberrant migration of neural crest cells can lead to a variety of developmental disorders. Failure of neural crest cells to properly populate the developing pharyngeal arches would most likely result in abnormalities of which structures?

<p>The bones and cartilage of the head and neck. (A)</p> Signup and view all the answers

The precise timing of somitogenesis is critical for proper segmentation of the vertebrate body plan. Disruptions in the Notch signaling pathway during this process are most likely to result in which of the following?

<p>Asymmetrical or irregular somite formation along the anterior-posterior axis. (C)</p> Signup and view all the answers

Which alteration during gastrulation would MOST severely impact the formation of ALL three primary germ layers?

<p>Impairment of epiblast migration through the primitive node. (C)</p> Signup and view all the answers

The development of the vertebrate limb involves complex interactions between the ectoderm and the underlying mesoderm. Specifically, what is the primary role of the apical ectodermal ridge (AER) in limb development?

<p>To secrete fibroblast growth factors (FGFs) that maintain the proliferation of the underlying mesenchyme. (B)</p> Signup and view all the answers

Which of the following cellular processes is most crucial for the correct positioning and segregation of tissue types during organogenesis?

<p>Differential cell adhesion mediated by cadherins. (B)</p> Signup and view all the answers

The development of the pancreas involves intricate inductive interactions between the endoderm and the surrounding mesenchyme. What specific factor, secreted by the notochord and blood vessels, inhibits the formation of the pancreas in the dorsal region of the foregut?

<p>Sonic hedgehog (Shh). (B)</p> Signup and view all the answers

What is the consequence if the allantois fails to develop completely?

<p>The embryo will be unable to exchange gases and dispose of liquid waste. (B)</p> Signup and view all the answers

Which of the following is the most accurate description of the role of the stratum intermedium during the fourth month of fetal integument development?

<p>A well-defined, multi-layered structure that allows for the differentiation of melanocytes and immune cells. (A)</p> Signup and view all the answers

Defects in ventral body wall closure can result in conditions such as gastroschisis or omphalocele. What specific developmental process is disrupted in these malformations?

<p>Incomplete migration of the lateral body wall folds towards the midline. (C)</p> Signup and view all the answers

Considering the complex interactions of multiple signaling pathways: what would occur if there were complete absence of Wnt signaling in a developing limb?

<p>The limb would develop without dorsal-ventral polarity. (A)</p> Signup and view all the answers

Genetic analysis reveals that a developing embryo has a homozygous loss-of-function mutation in the TBX5 gene. Which of the following structures would most likely exhibit severe developmental abnormalities?

<p>The upper limbs. (C)</p> Signup and view all the answers

The development of the secondary palate is essential for separating the nasal and oral cavities. Failure of the palatal shelves to fuse properly results in cleft palate. Which of the following cellular processes is most critical for the elevation and fusion of the palatal shelves?

<p>Apoptosis of the medial edge epithelium (MEE) after palatal shelf contact. (A)</p> Signup and view all the answers

During the fetal period, significant changes occur in the circulatory system to prepare for postnatal life. Which of the following fetal structures allows oxygenated blood to bypass the liver and directly enter the inferior vena cava?

<p>The ductus venosus. (C)</p> Signup and view all the answers

Which of the following best describes the function of the foramen ovale?

<p>Connects the right and left atria. (B)</p> Signup and view all the answers

What would be prevented by an improperly closed foramen ovale?

<p>Full oxygenation to the organs. (B)</p> Signup and view all the answers

In which congenital defect is the urachus still present?

<p>Urachal cyst. (B)</p> Signup and view all the answers

Flashcards

Neurulation

The process by which the neural plate folds and closes to form the neural tube, the precursor to the central nervous system.

Ectoderm

The outermost of the three primary germ layers formed in early embryonic development, giving rise to the epidermis, nervous system, and various other structures.

Mesoderm

The middle of the three primary germ layers in the early embryo that gives rise to a variety of tissues including muscle, bone, blood vessels, and connective tissue.

Endoderm

The innermost of the three primary germ layers, lining the gut and other internal organs.

Signup and view all the flashcards

Histogenesis

The period from 4th to 8th week of development, involving the differentiation of cells and tissues in the three germ layers to form specialized tissues and organs.

Signup and view all the flashcards

Bilaminar Disc

A flat disc-shaped structure composed of two layers of cells (epiblast and hypoblast) derived from the inner cell mass of the blastocyst.

Signup and view all the flashcards

Trilaminar Disc

The stage following the bilaminar disc stage, characterized by the formation of the three primary germ layers: ectoderm, mesoderm, and endoderm.

Signup and view all the flashcards

Gastrulation

The process of forming the three germ layers (ectoderm, mesoderm and endoderm) from the epiblast in the trilaminar disc.

Signup and view all the flashcards

Organogenesis

The stage of development when the organs of the embryo begin to form.

Signup and view all the flashcards

Morphogenesis

The stage of development involving the formation of shape and structure of the embryo.

Signup and view all the flashcards

Ectoderm Superficial Derivatives

The outermost of superficial ectoderm derivatives, including epidermis, hair, glands, and mammary glands.

Signup and view all the flashcards

Neural Tube

A structure in the early embryo that forms the central nervous system.

Signup and view all the flashcards

Neural Crest

A transient structure in the developing chordate embryo that gives rise to a variety of cell types including pigment cells, craniofacial cartilage and bone, smooth muscle, peripheral nerves and endocrine cells.

Signup and view all the flashcards

Study Notes

  • Embryogenesis occurs during the 1st through 8th weeks of development.

Stages of Development

  • Pre-Embryonic: Includes cleavage, cavitation, and transport.
  • Embryonic: Includes gastrulation, implantation, morphogenesis, histogenesis, and organogenesis.
  • Fetal: Body growth occurs at this stage which is week 9-38

Utero-Placental Circulation

  • Established at the end of the second week, beginning of the third week of gestation.
  • Trophoblastic lacunae in the embryonic pole are in contact with maternal vessels of the endometrial stroma.
  • The exocoelomic membrane lines the primitive yolk sac.
  • Extraembryonic coelom formation takes place.

Third Week

  • At the end of the third week, the primitive node, primitive streak, bucopharyngeal membrane, prenotochordal cells, and cloacal membrane can be seen

Neurulation

  • This is a process that begins around day 17
  • The neural plate forms the neural tube.

Neural Tube Formation

  • Neuroectodermal tissues differentiate from the ectoderm, thickening into the neural plate.
  • The neural plate border separates the ectoderm from the neural plate.
  • The neural plate bends dorsally, its ends joining at the borders, now the neural crests.
  • Closure of the neural tube separates the neural crest from the epidermis.
  • Neural crest cells differentiate to create the peripheral nervous system.
  • The notochord degenerates, remaining only as the nucleus pulposus of intervertebral discs.
  • Other mesoderm cells differentiate into somites, which are precursors of the axial skeleton and skeletal muscle.

22 Days

  • Seven distinct somites are visible on each side of the neural tube

23 Days

  • The pericardial bulge is visible on each side in the cephalic part of the embryo

Ectoderm Derivatives

  • Organs and systems that have contact with the external world
  • Central and peripheral nervous systems
  • Sensory epithelium of the ear, nose, and eye
  • Epidermis and adnexa
  • Other adnexa such as subcutaneous glands, mammary glands, hypophysis, and dental enamel.

Histogenesis

  • This is the first stage of Week 4 of gestation
  • The embryo cells begin to differentiate and become more specialized

Germ Layer Derivatives

  • Ectoderm (Superficial): Epidermis, hair, nails, skin and mammary glands, anterior pituitary, dental enamel, inner ear, and crystalline lens
  • Ectoderm (Neural Tube): Central nervous system, retina, pineal gland, and posterior pituitary
  • Ectoderm (Neural Crest): Connective tissue and bones of the face and skull, adrenal medulla, melanocytes, dermis of the face and neck, C cells, cranial nerve ganglia, sympathetic and parasympathetic ganglia, the heart's trunconal septum, Schwann cells, glia, odontoblasts, and smooth muscle of vessels in the face and prosencephalon.
  • Mesoderm: Forms the skeletal muscle of the head, trunk, and extremities, and the skeleton except for the cranium, and dermis and connective tissue.
  • Mesoderm (Intermediate): Forms the urogenital system
  • Mesoderm (Lateral): Forms connective tissue and muscle of the viscera, serous membranes (pleura, pericardium, and peritoneum), the heart, blood and lymphatic cells, the spleen, and the suprarenal cortex.
  • Mesoderm (Head): Forms the cranium, connective tissue of the head, and dentin.
  • Endoderm Derivatives: Epithelial lining of the respiratory tract, parenchyma of the thyroid and parathyroid glands, liver and pancreas, epithelial lining of the urinary bladder and urethra, reticular stroma of the tonsils and thymus, and epithelial lining of the tympanic cavity and auditory canal.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Use Quizgecko on...
Browser
Browser