10 Questions
What is the process where only certain genes are accessible for activation and transcription due to modifications of chromatin in developing gametes?
Genomic imprinting
Which type of methylation alters CpG dinucleotides by DNA methyltransferases during germ line differentiation?
CpG methylation
What allows reactivation of imprinted genes by erasing most CpG methylations in primordial germ-line cells during embryonic development?
CpG demethylation
In which stage of embryo development do eggs and sperm end up with different, distinct imprints?
Fertilization stage
Why do relatively few genes, about 200 in humans and mice, undergo imprinting?
To avoid double dose of gene products
What process is responsible for dosage compensation in human females to avoid a double dose of X gene products?
Gene silencing
What is the term for the process where one of the two X chromosomes in every cell of an early embryo is inactivated?
"X" chromosome inactivation
"Crossing over" occurs between homologous chromosomes during which phase of cell division?
"Prophase I"
"RNA splicing" is a post-transcriptional modification that involves the removal of:
"Introns"
During which stage of embryonic development does a second wave of de-methylation occur in mouse embryos?
Blastocyst-stage
Test your knowledge on embryogenesis and gametogenesis, including the staining techniques used to label primordial germ cells and the influence of Sry on gonad development. Identify key features in micrographs and drawings related to these processes.
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