Podcast
Questions and Answers
Which type of pair in PYRIDINE is involved in resonance?
Which type of pair in PYRIDINE is involved in resonance?
- sp2 (correct)
- sp3
- sp
- sp3d
What is the pKa value of the basic pair in PYRROLE?
What is the pKa value of the basic pair in PYRROLE?
- 5.25
- 8.75
- -0.27 (correct)
- 14.27
How do electron-donating groups affect base strength?
How do electron-donating groups affect base strength?
- Have no impact on base strength
- Strengthen the base (correct)
- Weaken the base
- Do not affect the base
What effect do electron-withdrawing groups have on base strength?
What effect do electron-withdrawing groups have on base strength?
What percentage of marketed drugs contain functional groups that are ionised at physiological pH?
What percentage of marketed drugs contain functional groups that are ionised at physiological pH?
What factor differentiates a strong acid from a weak acid in terms of the conjugate base?
What factor differentiates a strong acid from a weak acid in terms of the conjugate base?
Which type of solvation follows ionization in acids?
Which type of solvation follows ionization in acids?
What factor leads to the stabilization of the conjugate base and makes the acid stronger?
What factor leads to the stabilization of the conjugate base and makes the acid stronger?
Which factor plays a role in stabilizing the conjugate base of an acid based on its electronegativity?
Which factor plays a role in stabilizing the conjugate base of an acid based on its electronegativity?
What process can make the involvement of the lower energy ion (stronger acid) exothermic?
What process can make the involvement of the lower energy ion (stronger acid) exothermic?
In terms of steric effects, what is the general impact on the stabilization of the conjugate base?
In terms of steric effects, what is the general impact on the stabilization of the conjugate base?
What is the pH of the aqueous humour in the body?
What is the pH of the aqueous humour in the body?
In which part of the body will basic compounds not be well absorbed compared to acidic compounds?
In which part of the body will basic compounds not be well absorbed compared to acidic compounds?
For a compound with a pKa of 9.4, at what pH will it be 99% ionised?
For a compound with a pKa of 9.4, at what pH will it be 99% ionised?
What is the pKa of 2,4-dinitrophenol?
What is the pKa of 2,4-dinitrophenol?
Where in the body would you find a pH range of 1.4-2.1 in the fasting state?
Where in the body would you find a pH range of 1.4-2.1 in the fasting state?
What does a small value of pKa for a base indicate?
What does a small value of pKa for a base indicate?
At what pH will 4-aminopyridine be 50% cationic?
At what pH will 4-aminopyridine be 50% cationic?
How does the presence of an electron withdrawing group affect the basicity of aliphatic amines?
How does the presence of an electron withdrawing group affect the basicity of aliphatic amines?
Which of the following simple amines has the highest pKa?
Which of the following simple amines has the highest pKa?
In the context of bases, what does a large value of Kb indicate?
In the context of bases, what does a large value of Kb indicate?
How does the pKb value relate to the basicity of a cyclic amine?
How does the pKb value relate to the basicity of a cyclic amine?
What effect will destabilize the conjugate base of an acid and make the acid weaker?
What effect will destabilize the conjugate base of an acid and make the acid weaker?
Which factor can cause major changes in the pKa of a compound?
Which factor can cause major changes in the pKa of a compound?
In aliphatic systems, what electron effect do halogens have?
In aliphatic systems, what electron effect do halogens have?
Which effect is generally more influential than inductive effects, except for halides?
Which effect is generally more influential than inductive effects, except for halides?
What property defines the strength of a base?
What property defines the strength of a base?
Which value is usually given in literature for bases instead of their $Kb$ values?
Which value is usually given in literature for bases instead of their $Kb$ values?
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