10 Questions
Which fatty acid is the most abundant precursor of eicosanoids?
Arachidonic acid
Which type of lipase is most dominant in the acute release of arachidonic acid?
Cytosolic (c) PLA2
Which enzyme is involved in sustained or intense stimulation of arachidonic acid production?
Secretory (S) PLA2
Which of the following is NOT a route for arachidonic acid oxygenation?
Phospholipase C
What factors determine the type of eicosanoids synthesized?
The substrate lipid species
True or false: Eicosanoids are only found in animals.
False
True or false: Arachidonic acid is a 20-carbon fatty acid.
True
True or false: Phospholipase C and diglyceride lipase can release arachidonic acid from membrane phospholipids.
True
True or false: Arachidonic acid can be oxygenated by five separate routes.
False
True or false: The type of eicosanoids synthesized is determined by the type of cell.
True
Study Notes
Eicosanoids and Arachidonic Acid
- Arachidonic acid is the most abundant precursor of eicosanoids.
- Cytosolic phospholipase A2 is the most dominant type of lipase in the acute release of arachidonic acid.
- Phospholipase A2 is involved in sustained or intense stimulation of arachidonic acid production.
Arachidonic Acid Oxygenation
- One route that is NOT involved in arachidonic acid oxygenation is direct degradation by oxygenases.
Eicosanoid Synthesis
- The type of eicosanoids synthesized is determined by factors such as the type of cell, substrate availability, and the enzyme pathway.
- The type of cell is a factor that determines the type of eicosanoids synthesized.
General Facts
- Arachidonic acid is a 20-carbon fatty acid.
- Eicosanoids are not unique to animals and can be found in other organisms.
- Phospholipase C and diglyceride lipase can release arachidonic acid from membrane phospholipids.
- Arachidonic acid can be oxygenated by five separate routes.
Test your knowledge on eicosanoids and their role as oxygenation products of polyunsaturated long-chained fatty acids. Learn about the abundant precursor, arachidonic acid, and the process of its release from membrane phospholipids.
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