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Questions and Answers
Which fatty acid is the most abundant precursor of eicosanoids?
Which fatty acid is the most abundant precursor of eicosanoids?
- Stearic acid
- Arachidonic acid (correct)
- Oleic acid
- Linoleic acid
Which type of lipase is most dominant in the acute release of arachidonic acid?
Which type of lipase is most dominant in the acute release of arachidonic acid?
- Phospholipase C
- Cytosolic (c) PLA2 (correct)
- Secretory (S) PLA2
- Calcium-independent (i) PLA2
Which enzyme is involved in sustained or intense stimulation of arachidonic acid production?
Which enzyme is involved in sustained or intense stimulation of arachidonic acid production?
- P450 epoxygenase
- Cyclooxygenase (COX)
- Secretory (S) PLA2 (correct)
- Lipoxygenase
Which of the following is NOT a route for arachidonic acid oxygenation?
Which of the following is NOT a route for arachidonic acid oxygenation?
What factors determine the type of eicosanoids synthesized?
What factors determine the type of eicosanoids synthesized?
True or false: Eicosanoids are only found in animals.
True or false: Eicosanoids are only found in animals.
True or false: Arachidonic acid is a 20-carbon fatty acid.
True or false: Arachidonic acid is a 20-carbon fatty acid.
True or false: Phospholipase C and diglyceride lipase can release arachidonic acid from membrane phospholipids.
True or false: Phospholipase C and diglyceride lipase can release arachidonic acid from membrane phospholipids.
True or false: Arachidonic acid can be oxygenated by five separate routes.
True or false: Arachidonic acid can be oxygenated by five separate routes.
True or false: The type of eicosanoids synthesized is determined by the type of cell.
True or false: The type of eicosanoids synthesized is determined by the type of cell.
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Study Notes
Eicosanoids and Arachidonic Acid
- Arachidonic acid is the most abundant precursor of eicosanoids.
- Cytosolic phospholipase A2 is the most dominant type of lipase in the acute release of arachidonic acid.
- Phospholipase A2 is involved in sustained or intense stimulation of arachidonic acid production.
Arachidonic Acid Oxygenation
- One route that is NOT involved in arachidonic acid oxygenation is direct degradation by oxygenases.
Eicosanoid Synthesis
- The type of eicosanoids synthesized is determined by factors such as the type of cell, substrate availability, and the enzyme pathway.
- The type of cell is a factor that determines the type of eicosanoids synthesized.
General Facts
- Arachidonic acid is a 20-carbon fatty acid.
- Eicosanoids are not unique to animals and can be found in other organisms.
- Phospholipase C and diglyceride lipase can release arachidonic acid from membrane phospholipids.
- Arachidonic acid can be oxygenated by five separate routes.
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