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Mechanisms of Ageing (1)

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Questions and Answers

What does parabiosis do?

Disrupts blood/stem cell function in young specimen

Rejuvenate blood/stem cell function in aged specimen (correct)

Circulates life-altering immunological cells around specimen

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What is the example of hormones modulating ageing?

Mice over expressing GH age faster (correct)

Mice under expressing GH age faster

Mice with no expression of GH die

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What are short telomeres recognised as?

Immunological damage

DNA damage (correct)

Protein damage

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What is the stage where irreversible cell cycle arrest occurs?

G1/S (B) Signup and view all the answers

Why do telomeres become short?

Primer removal for DNA polymerase (A) Signup and view all the answers

What is the telomere repetitive DNA sequence?

TTAGGG (C) Signup and view all the answers

Mice with short telomeres have a

Longer lifespan Signup and view all the answers

Telomere shortening is an example of what theory of ageing?

Antagonistic pleiotropy - telomere shortening acts as a tumour suppressor mechanic at a young age Signup and view all the answers