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Questions and Answers
What is one key characteristic of prokaryotic cells?
What is one key characteristic of prokaryotic cells?
Which of the following statements about eukaryotic cells is true?
Which of the following statements about eukaryotic cells is true?
What is the primary function of the plasma membrane?
What is the primary function of the plasma membrane?
Which of the following is NOT a characteristic of prokaryotic cells?
Which of the following is NOT a characteristic of prokaryotic cells?
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What is the main structural component that separates the cytoplasm from the extracellular environment?
What is the main structural component that separates the cytoplasm from the extracellular environment?
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Which statement accurately describes the role of phospholipids in cell membranes?
Which statement accurately describes the role of phospholipids in cell membranes?
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What is the significance of the double bond in one of the hydrophobic tails of phospholipids?
What is the significance of the double bond in one of the hydrophobic tails of phospholipids?
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Which of the following correctly describes the fluid-mosaic model of membrane structure?
Which of the following correctly describes the fluid-mosaic model of membrane structure?
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How do lipid-soluble molecules typically interact with the plasma membrane compared to water-soluble molecules?
How do lipid-soluble molecules typically interact with the plasma membrane compared to water-soluble molecules?
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What is the primary function of cell junctions in multicellular organisms?
What is the primary function of cell junctions in multicellular organisms?
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Study Notes
Biology - Cell Biology - Cytology
- Biology is the study of living things and provides an understanding of life.
- Cell biology is a specialized branch of biology that focuses on the study of cell structures and their functions.
- Cytology deals with the scientific study of cells.
- Cells are the fundamental building blocks of all living organisms.
Types of Cells
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Prokaryotic cells:
- Examples: Bacteria
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Characteristics:
- Smaller size (1-5 µm)
- Have a cell wall outside the cell membrane
- Lack a nuclear envelope separating DNA from other cellular constituents
- Lack histones bound to their DNA
- Lack membranous organelles
- Divide by binary fission
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Eukaryotic cells:
- Examples: Amoeba
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Characteristics:
- Larger than prokaryotic cells
- Have a distinct nucleus surrounded by a nuclear envelope
- Histones are associated with genetic material
- Numerous membrane-bound organelles are present in the cytoplasm
- Divide by mitosis and meiosis
Eukaryotic Cell Components
- The eukaryotic cell consists of two main parts:
- Cytoplasm: Contains matrix (cytosol), organelles, cytoskeleton, and deposits of carbohydrates, lipids, and pigments. The cytoplasm of eukaryotic cells is divided into several distinct compartments by membranes that regulate the intracellular traffic of ions and molecules.
- Nucleus: Contains the cell's genetic material (DNA)
Plasma Membrane (Plasmalemma)
- The outermost component of the cell, separating the cytoplasm from the extracellular environment.
- Acts as a barrier between the cell's interior and its surroundings
- Regulates the passage of substances in and out of the cell
- Acts as a unique identifier for the organism
- In multicellular organisms, cell junctions with specialized features of the plasma membranes connect cells together and facilitate communication between neighboring cells.
Structure and Function of the Plasma Membrane
- The structure and function of the cell's plasma membrane depend on:
- Lipid solubility: Lipid-soluble molecules enter cells more rapidly than water-soluble molecules suggesting lipids are a component of the plasma membrane.
- Lipid properties: The formation of biological membranes is based on lipid properties, and all cell membranes share a common structural organization - a bilayer of phospholipids with associated proteins.
- Fluid-mosaic model: The widely accepted model proposes that the membrane is a fluid phospholipid bilayer in which protein molecules are partially or wholly embedded.
- These various proteins vary in structure and function, creating a mosaic pattern within the membrane.
Membrane Lipids
- Lipids constitute 50% of the mass of most cell membranes. The proportion can vary depending on the type of membrane.
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Phospholipids:
- The fundamental building blocks of all cell membranes
- Amphipathic molecules with two hydrophobic fatty acid chains linked to a phosphate-containing hydrophilic head group.
- Hydrophilic (polar) heads of the phospholipids molecules face the intercellular and extracellular fluids.
- Hydrophobic (nonpolar) tails face each other in the membrane interior.
- At body temperature, the phospholipid bilayer has the consistency of olive oil, making the cell flexible
- One of the hydrophobic tails contain a double bound which creates a bend that prevents the phospholipids from packing too tightly together, maintaining membrane fluidity.
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Glycolipids: Similar to phospholipids but with a variety of sugars joined to form a straight or branching carbohydrate chain in the hydrophilic head group.
- Glycoslipids have a protective function, present only in the outer part of the membrane.
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Cholesterol:
- Found in animal plasma membranes.
- Distributed equally in both the outer and inner sides of the membrane.
- Reduces the permeability of the membrane to most biological molecules.
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Phospholipids:
The Lipid Bilayer as a Two-Dimensional Fluid
- The aqueous environment inside and outside the cell prevents membrane lipids from escaping the bilayer.
- Membrane lipids can move about and change places within the plane of the bilayer, making the membrane a two-dimensional fluid, essential for its function.
Membrane Proteins
- Proteins constitute 25-75% of the mass of various cell membranes.
- Membrane proteins carry out specific functions for different membranes.
- Two general classes of membrane proteins:
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Integral membrane proteins: Directly embedded in the lipid bilayer. Transmembrane proteins span the lipid bilayer with proteins exposed on both sides.
- Other types include membrane-associated or lipid-linked proteins.
- Peripheral membrane proteins: Not inserted into the lipid bilayer, associated with the membrane indirectly, generally called protein attached through interactions with integral membrane proteins.
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Integral membrane proteins: Directly embedded in the lipid bilayer. Transmembrane proteins span the lipid bilayer with proteins exposed on both sides.
Carbohydrate Coat
- The carbohydrate chains of glycolipids and glycoproteins serve as the cell's "fingerprints," unique identification markers.
- The carbohydrate chains form a carbohydrate coat enveloping the outer surface of the plasma membrane.
- Proteins serve as links to the cytoskeletal filaments on the inside and to the extracellular matrix on the outside.
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