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Ageing Mechanisms (2)

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Questions and Answers

Free radical theory involves what radicals?

Superoxide and hydroxyl radicals

What are the cellular defences against ROS?

Superoxide dismutase, catalase, glutathionic perioxidase

Naked mole rats (insert here) than rats at high levels of oxidative damage

Live longer

Does over expression of ROS enzymes in yeast increase lifespan?

False Signup and view all the answers

What is an example of intrinsic source that affects DNA?

ROS (Reactive Oxidative Species) Signup and view all the answers

What is an example of an extrinsic source that affects DNA?

UV Light Signup and view all the answers

What is NOT an example of DNA repair pathways

WRN Signup and view all the answers

What does the WRN mutation of Werner Syndrome do?

Affect DNA helicase for double strand breakup repair Signup and view all the answers

Reduced expression HSF1 and HSP (Heat shock proteins) does what to yeast, c elegans and drosophila?

Reduces lifespan Signup and view all the answers

Transgenic expression of HSF1 and HSP (Heat shock proteins does what?

Increases lifespan Signup and view all the answers