Dynamics in Lipid Bilayers

Study Notes

Lipid bilayers exhibit fluid dynamics with four primary modes of lipid mobility: fast lateral diffusion, flip-flop, intra-chain motion, and fast axial rotation.
Fast lateral diffusion allows lipids to move rapidly within the bilayer plane.
Flip-flop refers to lipid molecules moving from one side of the bilayer to the other on a one-for-one basis.
Intra-chain motion involves the formation of kinks in fatty acyl chains, enhancing structural variability.
Fast axial rotation refers to the quick spinning of lipid molecules around their axes.

Serve as a selective permeability barrier, controlling the entry and exit of substances.
Maintain control over the chemical environment of cells and organelles.
Facilitate cellular communication and information exchange with the environment.
Enable recognition functions through signaling molecules and adhesion proteins.
Generate signals in response to stimuli, essential for physiological responses.

Composed of approximately 40% lipids, 60% proteins, and 1-10% carbohydrates, with around 20% water contributing to hydration.

Form the dual-layered structure that constitutes cell membranes, composed of amphipathic molecules.
The three major classes of membrane lipids are phospholipids, glycolipids, and cholesterol.
Phospholipid structures include hydrophilic heads (glycerol and phosphate) and hydrophobic tails (fatty acids).

Unsaturated fatty acids disrupt orderly packing, enhancing membrane fluidity.
Cholesterol plays a critical role in membrane stability by hydrogen bonding with fatty acid chains, altering fluidity dynamics.

Integral to membrane function, serving as enzymes, transporters, pumps, ion channels, receptors, and energy transducers.
Protein content ranges from 18% in myelin to 75% in mitochondria, with an approximate average of 60% dry weight in membranes.

Proteins exhibit three types of motion: conformational change, rotational, and lateral movement; flip-flop movement is restricted due to protein structure.
Mobility restrictions are influenced by lipid interactions, membrane protein associations, and connections with peripheral proteins like the cytoskeleton.

Constitutes about 45% of total membrane lipids, with variations in distribution based on tissue function.
Stabilizes the membrane by reducing the endothermic phase transition and impacting phospholipid chain movement, which both increases and decreases membrane fluidity.

Formed spontaneously in water, driven by van der Waals forces between hydrophobic tails.
Stabilized by non-covalent interactions including hydrogen bonding and electrostatic forces.
Preferred structure for phospholipids and glycolipids, with low permeability to ions and polar molecules.

Predominant lipid in membranes; phosphatidylcholine is a common example.
Possess a variety of polar head groups (e.g., choline, amines, sugars).
Fatty acid chains are diverse, with C16 and C18 being most common; unsaturated chains decrease packing due to the kinks introduced by double bonds.

Plasmalogens: Non-classical phospholipids prevalent in nervous, immune, and cardiovascular systems.
Sphingomyelin: A type of sphingolipid found in cell membranes, crucial for myelin in nerve axons.
Glycolipids: Molecules combining carbohydrates with fatty acid tails; include cerebrosides (sugar head group monomers) and gangliosides (more complex sugars).