Podcast
Questions and Answers
Which corticosteroid has the highest glucocorticoid activity?
Which corticosteroid has the highest glucocorticoid activity?
- Dexamethasone (correct)
- Prednisone
- Cortisone
- Hydrocortisone
What special administration instruction should be followed for patients receiving therapy for Cushing’s Syndrome?
What special administration instruction should be followed for patients receiving therapy for Cushing’s Syndrome?
- Increase dosage with any signs of fever.
- Monitor blood sugar levels regularly. (correct)
- Take medication only when symptoms appear.
- Administer medication with food.
Which of the following medications is a dopamine agonist used in the treatment of hyperprolactinemia?
Which of the following medications is a dopamine agonist used in the treatment of hyperprolactinemia?
- Spironolactone
- Bromocriptine (correct)
- Mitotane
- Metyrapone
Which medication is recognized for its mineralocorticoid activity?
Which medication is recognized for its mineralocorticoid activity?
What are the potential adverse effects common to corticosteroids?
What are the potential adverse effects common to corticosteroids?
Which CYP450 isoforms are primarily affected by ketoconazole?
Which CYP450 isoforms are primarily affected by ketoconazole?
What is a primary goal of treatment for adrenal insufficiency?
What is a primary goal of treatment for adrenal insufficiency?
What is a common misconception regarding the treatment of Cushing’s syndrome?
What is a common misconception regarding the treatment of Cushing’s syndrome?
What unique property does mitotane possess in relation to the adrenal cortex?
What unique property does mitotane possess in relation to the adrenal cortex?
Which of the following is a potential adverse effect of ketoconazole and levoketoconazole?
Which of the following is a potential adverse effect of ketoconazole and levoketoconazole?
What is a common result of inhibiting the synthesis of aldosterone?
What is a common result of inhibiting the synthesis of aldosterone?
Metyrapone and orlisodrostat can have which additional activity due to their actions on cortisol precursors?
Metyrapone and orlisodrostat can have which additional activity due to their actions on cortisol precursors?
Which metabolic pathways primarily metabolize metyrapone?
Which metabolic pathways primarily metabolize metyrapone?
What types of adverse effects can metyrapone, mitotane, and osilodrostat induce?
What types of adverse effects can metyrapone, mitotane, and osilodrostat induce?
Why do steroidogenic inhibitors require careful monitoring of adverse effects?
Why do steroidogenic inhibitors require careful monitoring of adverse effects?
Which of the following is NOT a isoform through which osilodrostat is metabolized?
Which of the following is NOT a isoform through which osilodrostat is metabolized?
What are the three general differences that corticosteroids exhibit relative to cortisol?
What are the three general differences that corticosteroids exhibit relative to cortisol?
Which corticosteroid is known as an endogenous glucocorticoid and also marketed as a drug?
Which corticosteroid is known as an endogenous glucocorticoid and also marketed as a drug?
What effect do corticosteroids have that is specifically mentioned as important and will be covered in future courses?
What effect do corticosteroids have that is specifically mentioned as important and will be covered in future courses?
Small chemical modifications to cortisol result in what classifications of corticosteroids?
Small chemical modifications to cortisol result in what classifications of corticosteroids?
What is the main pharmacological activity of hydrocortisone?
What is the main pharmacological activity of hydrocortisone?
What is the primary mechanism of action of ketoconazole in the treatment of Cushing's disease?
What is the primary mechanism of action of ketoconazole in the treatment of Cushing's disease?
What percentage of patients may experience normalization of serum free cortisol levels with ketoconazole treatment?
What percentage of patients may experience normalization of serum free cortisol levels with ketoconazole treatment?
Which of the following is NOT a side effect associated with ketoconazole treatment?
Which of the following is NOT a side effect associated with ketoconazole treatment?
What is a critical monitoring requirement for patients taking ketoconazole?
What is a critical monitoring requirement for patients taking ketoconazole?
Why should drug interactions be considered before starting ketoconazole therapy?
Why should drug interactions be considered before starting ketoconazole therapy?
What is a potential advantage of levoketoconazole compared to ketoconazole?
What is a potential advantage of levoketoconazole compared to ketoconazole?
What common side effects can result from metyrapone therapy?
What common side effects can result from metyrapone therapy?
What is the starting recommended dose of ketoconazole for treating Cushing's disease?
What is the starting recommended dose of ketoconazole for treating Cushing's disease?
What effect does the 9-fluoro substituent have on the 11-hydroxy group in corticosteroids?
What effect does the 9-fluoro substituent have on the 11-hydroxy group in corticosteroids?
Which is a common short-term effect of corticosteroids?
Which is a common short-term effect of corticosteroids?
What is a result of corticosteroids increasing the production of neutrophils?
What is a result of corticosteroids increasing the production of neutrophils?
Which long-term effect is associated with the use of corticosteroids?
Which long-term effect is associated with the use of corticosteroids?
What does corticosteroid therapy often lead to in terms of leukocyte levels?
What does corticosteroid therapy often lead to in terms of leukocyte levels?
Which of the following corticosteroid effects can contribute to psychological changes?
Which of the following corticosteroid effects can contribute to psychological changes?
Which corticosteroid effect may lead to a condition of excessive appetite?
Which corticosteroid effect may lead to a condition of excessive appetite?
What adverse effect is commonly associated with corticosteroids in the short term?
What adverse effect is commonly associated with corticosteroids in the short term?
