Drugs for Peptic Ulcer and GERD

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Questions and Answers

Which drugs are part of the quadruple therapy for peptic ulcer disease and gastroesophageal reflux disease?

  • Dexlansoprazole, omeprazole, esomeprazole, pantoprazole
  • Cimetidine, famotidine, nizatidine, ranitidine
  • Amoxicillin, clarithromycin, PPI
  • Bismuth subsalicylate, metronidazole, tetracycline, PPI (correct)

What is the action of H2 receptor antagonists in the stomach?

  • Enhance the secretion of gastric acid
  • Inhibit basal, food-stimulated, nocturnal secretion of gastric acid (correct)
  • Eliminate the secretion of gastric acid completely
  • Increase the risk of gynecomastia and galactorrhea

What are the therapeutic uses of H2 receptor antagonists?

  • Diabetes
  • Arthritis
  • Hypertension
  • Peptic ulcers (correct)

What are the adverse effects associated with H2 receptor antagonists?

<p>Gynecomastia and galactorrhea (D)</p> Signup and view all the answers

Which drugs belong to the class of Proton Pump Inhibitors?

<p>Dexlansoprazole, omeprazole, esomeprazole, lansoprazole (D)</p> Signup and view all the answers

What is the primary action of Proton Pump Inhibitors?

<p>Inhibit the enzyme responsible for gastric acid secretion (C)</p> Signup and view all the answers

Which enzyme system is irreversibly inhibited by omeprazole?

<p>H+ -K+ -ATPase (C)</p> Signup and view all the answers

What is the clinical use of misoprostol?

<p>Prophylactic use in patients who take NSAIDs (D)</p> Signup and view all the answers

Which of the following is an unwanted effect of sucralfate?

<p>Constipation (B)</p> Signup and view all the answers

What is the mechanism of action of bismuth subsalicylate?

<p>Antimicrobial actions and inhibition of pepsin activity (A)</p> Signup and view all the answers

What is a common side effect of antacids containing magnesium salts?

<p>Diarrhea (C)</p> Signup and view all the answers

What is the main therapeutic use of proton pump inhibitors (PPIs)?

<p>Treatment of GORD (D)</p> Signup and view all the answers

Which proton pump inhibitor inhibits CYP2C19?

<p>Omeprazole (B)</p> Signup and view all the answers

What is the mechanism of action of sodium bicarbonate?

<p>Neutralizes acid (C)</p> Signup and view all the answers

What is the action of sucralfate in the presence of acid?

<p>Releases aluminium (A)</p> Signup and view all the answers

What are the therapeutic uses of proton pump inhibitors (PPIs)?

<p>Treatment of GORD, erosive esophagitis, and active duodenal ulcer (A)</p> Signup and view all the answers

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