PCOL 9-1~9-2 Treatment of Addiction
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Questions and Answers

Which route of heroin administration results in the most rapid surge of euphoria?

  • Smoking
  • Intranasal administration
  • Injecting (correct)
  • Oral consumption
  • What effect does MOR activation have on GABA action?

  • Enhances GABA action
  • Replaces GABA action
  • Inhibits GABA action (correct)
  • Has no effect on GABA action
  • What is responsible for the opioid crisis, often referred to as 'hillbilly heroin'?

  • Street heroin in white/brown powder or black 'tar' form
  • Prescription opioids like slow-release oxycodone or morphine tablets (correct)
  • Illicit fentanyl
  • Methadone clinics
  • What is a common consequence of heroin use related to injection of contaminated drugs?

    <p>Collapsed veins</p> Signup and view all the answers

    What is the mechanism of action of buprenorphine?

    <p>It is a partial agonist that occupies the receptor and prevents the effect of full agonists</p> Signup and view all the answers

    What is a potential risk associated with methadone use?

    <p>It has a high risk of overdose due to its long half-life</p> Signup and view all the answers

    What is the implication of GAT1 in the process of counter-adaptation?

    <p>It is upregulated, leading to less inhibition of GABA</p> Signup and view all the answers

    What is the effect of naloxone when combined with buprenorphine?

    <p>It inhibits the effects of buprenorphine when taken orally</p> Signup and view all the answers

    What is a characteristic of rapid detox treatment?

    <p>It does not support through withdrawal symptoms</p> Signup and view all the answers

    What is the primary effect of nicotine on dopamine (DA) neurons?

    <p>Increases DA release</p> Signup and view all the answers

    What is a common effect of nicotine on the body's physiological functions?

    <p>Increases blood pressure and heart rate</p> Signup and view all the answers

    What is the effect of nicotine on adrenal glands?

    <p>Increases adrenaline release, leading to increased blood pressure and heart rate</p> Signup and view all the answers

    What is a reason for the difficulty in studying addicted populations?

    <p>Overlap of mental disorders and multiple addictions</p> Signup and view all the answers

    Which type of treatment reduces cravings and satisfaction of smoking due to receptor occupancy?

    <p>Partial Agonists</p> Signup and view all the answers

    Which treatment option may help in combination with Nicotine Replacement Therapy (NRT) and has side effects including significant drowsiness and constipation?

    <p>Mecamylamine</p> Signup and view all the answers

    Which treatment results in antibodies that bind nicotine, has no effect on craving, and is no better than placebo?

    <p>Vaccine</p> Signup and view all the answers

    Which antidepressant has a similar efficacy to NRT, with side effects including lower seizure threshold and sedation?

    <p>Bupropion</p> Signup and view all the answers

    What are the effects of alcohol on the body?

    <p>Enhances GABA and Gly transmission</p> Signup and view all the answers

    What are the counter-adaptations to alcohol use?

    <p>Causes hypersensitivity to glutamate</p> Signup and view all the answers

    What are the potential neurological effects of alcohol dependence?

    <p>Neurological degeneration in the cortex and cerebellum</p> Signup and view all the answers

    What is the implication of alcohol on normal breathing?

    <p>Inhibits normal breathing</p> Signup and view all the answers

    Which medication has the potential to be hepatotoxic at high doses but is safer when injected?

    <p>Naltrexone</p> Signup and view all the answers

    Which medication is known to cause flush, palpitations, and nausea as a result of blocking aldehyde dehydrogenase?

    <p>Disulfiram</p> Signup and view all the answers

    Which medication may inhibit NMDA-Rs and has a similar efficacy to naltrexone?

    <p>Acamprosate</p> Signup and view all the answers

    Which medication is an anti-epileptic and may alter phosphorylation state of Na+, Ca2+, GABA, and Gly channels/receptors?

    <p>Topiramate</p> Signup and view all the answers

    Which medication has the potential to significantly reduce drinking but with variable results, and has some evidence of better outcomes based on polymorphisms in kainate receptors?

    <p>Topiramate</p> Signup and view all the answers

    Which type of treatment reduces cravings and satisfaction of smoking due to receptor occupancy?

    <p>Agonist</p> Signup and view all the answers

    What is a potential use of vaccines in addiction treatment?

    <p>Reducing cravings and satisfaction</p> Signup and view all the answers

    Study Notes

    Addiction and Drug Use in Australia

    • Addiction is defined as a state where drug use continues despite potential or actual harm to the user.
    • In Australia, 84% of the population uses alcohol, 17% uses nicotine, and 11% uses cannabis recreationally.

    Demographics and Reasons for Drug Use

    • The 20-29 year old age group is the highest user of drugs.
    • Drugs are used for various reasons, including:
      • To feel good: new sensations, pleasure, and community.
      • To feel better: self-medication, escape problems, lessen anxiety, reduce fear, and reduce depression.

    Economic Costs of Drug Use

    • The total cost of drug use in Australia is estimated to be:
      • $18.3 billion for alcohol.
      • $31.5 billion for nicotine, which accounts for 1/8 of the Australian disease burden.
      • $8.2 billion for illicit drugs.
    • The costs arise from lost productivity, criminal activity, healthcare, accidents, and damage.

    Prevalence of Addiction

    • Not all users are addicted, with:
      • Only 7.2% of alcohol users drinking daily, and 39.5% drinking weekly.
      • 15.9% of nicotine users smoking daily.
      • No specific data available for cannabis users.

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    Test your knowledge about drug use and addiction in Australia with this quiz. Explore the prevalence of recreational drug use among different age groups and understand the reasons behind it. Learn about the potential harm and effects associated with drug addiction.

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