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Questions and Answers
What does high binding site specificity in a drug imply?
What does high binding site specificity in a drug imply?
- The drug acts selectively on specific cells and tissues. (correct)
- The drug requires a high dosage to be effective.
- The drug can interact with multiple types of receptors.
- The drug can produce side effects on various tissues.
Which curve in Graph 1 represents a drug with the highest potency and efficacy?
Which curve in Graph 1 represents a drug with the highest potency and efficacy?
- Curve A
- Curve C (correct)
- Curve B
- Curve D
In Graph 2, what does the higher response of ligand A at lower concentrations compared to ligand B indicate?
In Graph 2, what does the higher response of ligand A at lower concentrations compared to ligand B indicate?
- Ligand A is less potent than ligand B.
- Ligand A is more selective and activates the receptor with higher affinity. (correct)
- Ligand A has a larger binding site than ligand B.
- Ligand A has a slower onset of action than ligand B.
What is the primary focus of drug-receptor interaction selectivity as illustrated in the graphs?
What is the primary focus of drug-receptor interaction selectivity as illustrated in the graphs?
What is indicated by proteins that act as drug targets having high ligand specificity?
What is indicated by proteins that act as drug targets having high ligand specificity?
Flashcards
Drug-receptor selectivity
Drug-receptor selectivity
The ability of a drug to bind to a specific receptor, excluding other receptors.
Affinity
Affinity
The strength of the interaction between a drug and its receptor.
Efficacy
Efficacy
The ability of a drug to elicit a response after binding to its receptor.
Potency
Potency
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Agonist
Agonist
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Study Notes
Drug-Receptor Interaction
- Drugs must be selective to be useful therapeutically or scientifically.
- Selectivity means acting on specific cells and tissues.
- Binding site specificity is crucial for drugs.
- Drug targets (proteins) also exhibit high ligand specificity, binding only to certain molecules.
Drug-Receptor Interaction: Specificity
- Drugs need high binding site specificity to target the right cells and tissues.
- Proteins acting as drug targets also have high ligand specificity, interacting only with certain molecules.
Drug-Receptor Interaction: Selectivity
- Selectivity is the degree to which a drug affects different receptors.
- Graphs illustrate that different ligands (A and B) show different responses at different concentrations.
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