Drug-Protein Binding Impact Quiz
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Questions and Answers

Which component is required for a protein to be active in drug distribution?

  • Ligand
  • Active protein
  • Protein without modulator
  • Modulator (correct)

What happens to a protein without a modulator in terms of its activity in drug distribution?

  • Its ligand-binding capacity increases
  • It becomes more active
  • It remains active
  • It becomes non-functional (correct)

In which condition may a low plasma protein level occur?

  • High protein diet
  • Young adulthood
  • Old age (correct)
  • Obesity

What effect is responsible for prolonging the effect of the drug digoxin?

<p>Low plasma protein level (D)</p> Signup and view all the answers

What role does the ligand play in drug distribution?

<p>Activates the protein (C)</p> Signup and view all the answers

What factor can affect drug distribution according to the text?

<p>Malnutrition (D)</p> Signup and view all the answers

How do modulators affect the activity of proteins involved in drug distribution?

<p>Increase their activity (B)</p> Signup and view all the answers

How does the binding of a drug affect its elimination?

<p>May delay drug elimination (D)</p> Signup and view all the answers

Which phenomenon is mentioned in the text as related to drug distribution?

<p>Allosteric inhibition (B)</p> Signup and view all the answers

What happens to drug elimination if the concentration of free drug is high?

<p>Drug elimination is not delayed (A)</p> Signup and view all the answers

Why may the elimination of a highly bound drug be delayed?

<p>The concentration of free drug is low (B)</p> Signup and view all the answers

What effect does a low concentration of free drug have on metabolism and excretion?

<p>Delays drug elimination (D)</p> Signup and view all the answers

Which type of protein is NOT active in drug distribution?

<p>Inactive protein (A)</p> Signup and view all the answers

What effect does a low plasma protein level have on the effect of digoxin?

<p>Prolongs the effect (D)</p> Signup and view all the answers

Why might highly bound drugs have delayed metabolism and excretion?

<p>Low concentration of free drug (C)</p> Signup and view all the answers

How does a decrease in the proportion of drug in bound form affect the concentration of free drug in the plasma?

<p>Increases (B)</p> Signup and view all the answers

What is the primary consequence of having more free drug in the plasma?

<p>Increased drug efficacy (C)</p> Signup and view all the answers

How does an increase in the proportion of drug in bound form affect the availability of free drug in the plasma?

<p>Decreases (C)</p> Signup and view all the answers

Which of the following is likely to occur when there is a higher proportion of drug in bound form?

<p>Decreased drug clearance (B)</p> Signup and view all the answers

What impact does an increased proportion of bound drug have on the distribution of the drug within the body?

<p>Reduces distribution within tissues (C)</p> Signup and view all the answers

What may lead to competition between drugs according to the text?

<p>Agents that are bound very tightly (A)</p> Signup and view all the answers

In drug competition, which type of agents are likely to displace others from their binding sites?

<p>Tightly bound agents like coumarin anticoagulants (D)</p> Signup and view all the answers

What is the consequence of tightly bound drugs being able to displace others?

<p>Enhanced drug effectiveness (C)</p> Signup and view all the answers

Which type of drugs are mentioned as having the capability to compete with others effectively?

<p>Coumarin anticoagulants (A)</p> Signup and view all the answers

How can competition between drugs impact their efficacy?

<p>By altering their binding specificity (A)</p> Signup and view all the answers

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