Drug-Protein Binding Impact Quiz

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Which component is required for a protein to be active in drug distribution?

Ligand

Active protein

Protein without modulator

Modulator (correct)

What happens to a protein without a modulator in terms of its activity in drug distribution?

Its ligand-binding capacity increases

It becomes more active

It remains active

It becomes non-functional (correct)

In which condition may a low plasma protein level occur?

High protein diet

Young adulthood

Old age (correct)

Obesity

What effect is responsible for prolonging the effect of the drug digoxin?

Low plasma protein level (D) Signup and view all the answers

What role does the ligand play in drug distribution?

Activates the protein (C) Signup and view all the answers

What factor can affect drug distribution according to the text?

Malnutrition (D) Signup and view all the answers

How do modulators affect the activity of proteins involved in drug distribution?

Increase their activity (B) Signup and view all the answers

How does the binding of a drug affect its elimination?

May delay drug elimination (D) Signup and view all the answers

Which phenomenon is mentioned in the text as related to drug distribution?

Allosteric inhibition (B) Signup and view all the answers

What happens to drug elimination if the concentration of free drug is high?

Drug elimination is not delayed (A) Signup and view all the answers

Why may the elimination of a highly bound drug be delayed?

The concentration of free drug is low (B) Signup and view all the answers

What effect does a low concentration of free drug have on metabolism and excretion?

Delays drug elimination (D) Signup and view all the answers

Which type of protein is NOT active in drug distribution?

Inactive protein (A) Signup and view all the answers

What effect does a low plasma protein level have on the effect of digoxin?

Prolongs the effect (D) Signup and view all the answers

Why might highly bound drugs have delayed metabolism and excretion?

Low concentration of free drug (C) Signup and view all the answers

How does a decrease in the proportion of drug in bound form affect the concentration of free drug in the plasma?

Increases (B) Signup and view all the answers

What is the primary consequence of having more free drug in the plasma?

Increased drug efficacy (C) Signup and view all the answers

How does an increase in the proportion of drug in bound form affect the availability of free drug in the plasma?

Decreases (C) Signup and view all the answers

Which of the following is likely to occur when there is a higher proportion of drug in bound form?

Decreased drug clearance (B) Signup and view all the answers

What impact does an increased proportion of bound drug have on the distribution of the drug within the body?

Reduces distribution within tissues (C) Signup and view all the answers

What may lead to competition between drugs according to the text?

Agents that are bound very tightly (A) Signup and view all the answers

In drug competition, which type of agents are likely to displace others from their binding sites?

Tightly bound agents like coumarin anticoagulants (D) Signup and view all the answers

What is the consequence of tightly bound drugs being able to displace others?

Enhanced drug effectiveness (C) Signup and view all the answers

Which type of drugs are mentioned as having the capability to compete with others effectively?

Coumarin anticoagulants (A) Signup and view all the answers

How can competition between drugs impact their efficacy?

By altering their binding specificity (A) Signup and view all the answers