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Questions and Answers
What is the main difference between products of conjugation reactions and Phase I reactions?
What is the main difference between products of conjugation reactions and Phase I reactions?
- Conjugation products have increased molecular weight and are more active, while Phase I reactions often produce inactive metabolites
- Conjugation products have decreased molecular weight and are less active, while Phase I reactions often produce active metabolites
- Conjugation products have increased molecular weight and are less active, while Phase I reactions often produce active metabolites (correct)
- Conjugation products have decreased molecular weight and are more active, while Phase I reactions often produce inactive metabolites
Which type of reaction detoxifies reactive electrophiles by adding large anionic groups like GSH?
Which type of reaction detoxifies reactive electrophiles by adding large anionic groups like GSH?
- Acetylation
- Methylation
- Glutathione conjugation (correct)
- Sulphation
What type of transferases can metabolize almost any hydrophobic compound containing nucleophilic or electrophilic groups?
What type of transferases can metabolize almost any hydrophobic compound containing nucleophilic or electrophilic groups?
- Methyltransferase
- Glutathione S-transferases (correct)
- Sulfotransferases
- Glucuronosyltransferases
Which enzyme forms a xenobiotic acyl-CoA as part of the glycine conjugation pathway?
Which enzyme forms a xenobiotic acyl-CoA as part of the glycine conjugation pathway?
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What is the primary function of bile acid-CoA: amino acid N-acyltransferases?
What is the primary function of bile acid-CoA: amino acid N-acyltransferases?
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