Podcast
Questions and Answers
Which type of enzymes are responsible for the enzymatic biotransformation of drugs and xenobiotics?
Which type of enzymes are responsible for the enzymatic biotransformation of drugs and xenobiotics?
- Neurotransmitter enzymes
- Hormone-regulating enzymes
- Xenobiotic metabolizing enzymes (correct)
- Immune system enzymes
What is the primary site of drug metabolism?
What is the primary site of drug metabolism?
- Plasma
- Lung
- Liver (correct)
- Kidney
Which type of reactions are involved in Phase 1 biotransformations?
Which type of reactions are involved in Phase 1 biotransformations?
- Dehydration, condensation, polymerization
- Oxidation, reduction, hydrolysis (correct)
- Methylation, acetylation, phosphorylation
- Decarboxylation, esterification, saponification
What is the term for the process where enzymes mask functional groups by adding new groups to xenobiotics?
What is the term for the process where enzymes mask functional groups by adding new groups to xenobiotics?
What type of carriers actively remove hydrophilic metabolites from cells?
What type of carriers actively remove hydrophilic metabolites from cells?
How can genetic polymorphism affect drug metabolism?
How can genetic polymorphism affect drug metabolism?
What environmental factor can alter the kinetics of an enzyme and the pattern of metabolism?
What environmental factor can alter the kinetics of an enzyme and the pattern of metabolism?
Which factor can lead to bioactivation of metabolites from inactive parent drugs?
Which factor can lead to bioactivation of metabolites from inactive parent drugs?
What is the term for the ability of the liver and extrahepatic tissues to metabolize substances before reaching systemic blood levels?
What is the term for the ability of the liver and extrahepatic tissues to metabolize substances before reaching systemic blood levels?
Which organs, other than the liver, contain xenobiotic metabolizing enzymes?
Which organs, other than the liver, contain xenobiotic metabolizing enzymes?
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