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Drug Interactions Lecture 1 Summary

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Questions and Answers

How does Quinidine cause digoxin toxicity?

By enhancing the renal clearance of digoxin

By increasing the tissue binding of digoxin

By inhibiting the metabolism of digoxin

By reducing the renal clearance of digoxin (correct)

What is the mechanism by which Phenylbutazone causes excessive anticoagulation with warfarin?

It enhances the binding of warfarin to albumin

It inhibits the metabolism of the active isomer of warfarin (correct)

It increases the clearance of warfarin

It enhances the metabolism of warfarin

What differentiates the effect of Indometacin from Phenylbutazone when displacing warfarin from binding sites on albumin?

Indometacin enhances the metabolism of warfarin

Indometacin does not affect prothrombin time with warfarin treatment (correct)

Indometacin reduces the clearance of warfarin

Indometacin has no impact on platelet function

How do transport proteins contribute to drug distribution?

By aiding in drug delivery to protected organ systems Signup and view all the answers

In what way can Quinidine lead to digoxin toxicity?

By displacing digoxin from tissue binding sites Signup and view all the answers

What distinguishes Phenylbutazone's effect on warfarin from Indometacin's effect on warfarin?

Phenylbutazone inhibits warfarin metabolism Signup and view all the answers

How does Indometacin differ from Phenylbutazone in its effect on prothrombin time with warfarin treatment?

Indometacin has no effect on prothrombin time unlike Phenylbutazone Signup and view all the answers

What impact does Quinidine have on the renal clearance of digoxin?

Quinidine reduces the renal clearance of digoxin Signup and view all the answers

How does Phenylbutazone affect the metabolism of S-warfarin?

Phenylbutazone inhibits the metabolism of S-warfarin Signup and view all the answers

How does Indometacin differ from other NSAIDs like Phenylbutazone in its effect on platelet function?

Indometacin has no impact on platelet function unlike Phenylbutazone Signup and view all the answers