Podcast
Questions and Answers
How does Quinidine cause digoxin toxicity?
How does Quinidine cause digoxin toxicity?
- By enhancing the renal clearance of digoxin
- By increasing the tissue binding of digoxin
- By inhibiting the metabolism of digoxin
- By reducing the renal clearance of digoxin (correct)
What is the mechanism by which Phenylbutazone causes excessive anticoagulation with warfarin?
What is the mechanism by which Phenylbutazone causes excessive anticoagulation with warfarin?
- It enhances the binding of warfarin to albumin
- It inhibits the metabolism of the active isomer of warfarin (correct)
- It increases the clearance of warfarin
- It enhances the metabolism of warfarin
What differentiates the effect of Indometacin from Phenylbutazone when displacing warfarin from binding sites on albumin?
What differentiates the effect of Indometacin from Phenylbutazone when displacing warfarin from binding sites on albumin?
- Indometacin enhances the metabolism of warfarin
- Indometacin does not affect prothrombin time with warfarin treatment (correct)
- Indometacin reduces the clearance of warfarin
- Indometacin has no impact on platelet function
How do transport proteins contribute to drug distribution?
How do transport proteins contribute to drug distribution?
In what way can Quinidine lead to digoxin toxicity?
In what way can Quinidine lead to digoxin toxicity?
What distinguishes Phenylbutazone's effect on warfarin from Indometacin's effect on warfarin?
What distinguishes Phenylbutazone's effect on warfarin from Indometacin's effect on warfarin?
How does Indometacin differ from Phenylbutazone in its effect on prothrombin time with warfarin treatment?
How does Indometacin differ from Phenylbutazone in its effect on prothrombin time with warfarin treatment?
What impact does Quinidine have on the renal clearance of digoxin?
What impact does Quinidine have on the renal clearance of digoxin?
How does Phenylbutazone affect the metabolism of S-warfarin?
How does Phenylbutazone affect the metabolism of S-warfarin?
How does Indometacin differ from other NSAIDs like Phenylbutazone in its effect on platelet function?
How does Indometacin differ from other NSAIDs like Phenylbutazone in its effect on platelet function?
