Drug Hypersensitivity Reactions
30 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of hypersensitivity reaction is IgE mediated and occurs upon re-exposure to an allergen?

  • Type II
  • Type III
  • Type I (correct)
  • Type IV

    • What are the manifestations of Type I hypersensitivity?

  • Pruritus and urticaria, bronchospasm, respiratory distress, laryngeal edema, circulatory collapse, or death (correct)
  • Pruritus and urticaria only
  • Bronchospasm and respiratory distress only
  • Circulatory collapse and death only

    • What is the first-line treatment for anaphylaxis?

  • Dopamine
  • Epinephrine (correct)
  • Corticosteroids
  • Antihistamines

    • What should be prescribed to individuals with recurrent exposure to allergens likely to cause anaphylaxis?

    <p>Autoinjectable epinephrine</p> Signup and view all the answers

    Which type of drug reaction is typically mediated by T cells and may occur more than 1 hour after initial exposure?

    <p>Type B</p> Signup and view all the answers

    Which type of drug reaction is characterized by the formation of antigen-antibody (IgG or IgM) complexes that deposit on blood vessel walls and activate complement?

    <p>Type C</p> Signup and view all the answers

    Which type of drug reaction is characterized by the activation of T lymphocytes, release of cytokines, and recruitment of effector cells?

    <p>Type D</p> Signup and view all the answers

    Which type of drug reaction is typically mediated by allergen binding to IgE on basophils or mast cells, resulting in the release of inflammatory mediators?

    <p>Type A</p> Signup and view all the answers

    Which of the following is the first line treatment for an anaphylactic reaction?

    <p>Epinephrine</p> Signup and view all the answers

    What is the main objective of this lecture?

    <p>Describe the different types of allergic reactions and antibodies associated</p> Signup and view all the answers

    Which book chapter discusses the function and evaluation of the immune system?

    <p>Ch. e102</p> Signup and view all the answers

    What is the role of penicillin skin testing and drug desensitization in therapy?

    <p>To identify common offending agents for patients presenting with allergic reactions</p> Signup and view all the answers

    Which of the following is a proposed mechanism for drug hypersensitivity reactions?

    <p>Complement activation</p> Signup and view all the answers

    Which medication is the second most commonly reported allergy?

    <p>Aspirin</p> Signup and view all the answers

    Which of the following is a risk factor for immediate reactions to radiocontrast media?

    <p>No past reaction to contrast</p> Signup and view all the answers

    What type of reaction is L.M. experiencing?

    <p>Delayed hypersensitivity reaction</p> Signup and view all the answers

    Which type of reaction is characterized by the presence of autoantibodies and may present with clinical features of an autoimmune disorder?

    <p>Type III</p> Signup and view all the answers

    Which type of reaction is characterized by a positive Coombs test, jaundice, and dark-colored urine?

    <p>Type II</p> Signup and view all the answers

    Which type of reaction is characterized by dyspnea, decreased breath sounds, and wheezing after a bee sting?

    <p>Type I</p> Signup and view all the answers

    Which type of reaction is characterized by fever without cutaneous symptoms and clinical improvement with persistent leukocytosis and/or high-grade fever?

    <p>Type IV</p> Signup and view all the answers

    Which type of drug reaction is characterized by the formation of antigen-antibody complexes in blood, which often deposit in blood vessel walls or tissues?

    <p>Type III</p> Signup and view all the answers

    Which type of drug reaction is characterized by the binding of the drug antigen with sensitized T cells?

    <p>Type IV</p> Signup and view all the answers

    Which drug reaction is the most common type of severe drug eruption?

    <p>Stevens-Johnson Syndrome (SJS)</p> Signup and view all the answers

    Which drug reaction is characterized by symptoms such as high fever, widespread maculopapular-pustular rash, and late onset internal organ damage?

    <p>Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)</p> Signup and view all the answers

    Which of the following is the major determinant in the Penicillin Skin Testing Agent PPL procedure?

    <p>Puncture (scratch) test</p> Signup and view all the answers

    What is the concentration of the full-strength solution used in the PPL procedure?

    <p>6 x 10-5 mol/L</p> Signup and view all the answers

    What is the interpretation if no wheal or erythema or wheal <5 mm diameter is observed after 15 minutes in the PPL procedure?

    <p>Proceed with intradermal test</p> Signup and view all the answers

    What is the interpretation if a wheal or erythema >5-15 mm diameter is observed within 15 minutes in the PPL procedure?

    <p>Choose alternative agent</p> Signup and view all the answers

    What is the concentration of the Penicillin G potassium solution used in the scratch test?

    <p>10,000 unit/mL</p> Signup and view all the answers

    What is the interpretation if a positive response is observed in the Penicillin G potassium intradermal test?

    <p>Choose alternative agent</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser